Efficacy of a CDK4/6 Inhibitor in a Patient with Breast Cancer and Liposarcoma: A Case Report and Review of the Literature
Conclusion: CDK4/6 inhibitors exhibit a high therapeutic potential, although reliable prognostic markers need to be identified.Breast Care (Source: Breast Care)
Source: Breast Care - November 13, 2018 Category: Cancer & Oncology Source Type: research

Mismatch Repair Deficiency Drives Durable Complete Remission by Targeting Programmed Death Receptor 1 in a Metastatic Luminal Breast Cancer Patient
Conclusion: Within the overall goal to establish operating procedures for breast cancer immunotherapy, we propose to re-evaluate testing for deficient mismatch repair and to further intensify the search for biomarkers predictive for the success of immune checkpoint modulation including all tumor biologic subtypes of breast cancer.Breast Care (Source: Breast Care)
Source: Breast Care - November 13, 2018 Category: Cancer & Oncology Source Type: research

Relationship between Ribosomal Protein S6-pS240 Expression and other Prognostic Factors in Non-Special Type Invasive Breast Cancer
Background: The aim of this study was to investigate the immunohistochemical expression of ribosomal protein (RP) S6-pS240 in non-special type invasive breast cancer in relation to other prognostic markers and gain new insights to facilitate more individualized treatment.Methods: The following clinical and histopathological parameters of 120 patients were determined: S6-pS240 expression, age, menopausal status, tumor size and grade, TNM stage, Nottingham Prognostic Index (NPI), lymph node stage, estrogen and progesterone receptor (ER/PR) expression, HER2/neu amplification, lymphovascular invasion, and proliferative index a...
Source: Breast Care - November 13, 2018 Category: Cancer & Oncology Source Type: research

Autologous Lipotransfer - Daily Therapeutic Practice in Breast Cancer: An Intergroup Analysis Encompassing NOGGO, WSG, GBG, AWO Gyn and DGPR ÄC
Conclusions: The lack of randomized controlled data, especially in high-risk patients, demonstrates the necessity for a registry study on this topic. Our survey describes, in detail, the indications for lipofilling as well as its appropriate application in breast cancer patients in Germany and may thereby reduce the present therapeutic uncertainties.Breast Care (Source: Breast Care)
Source: Breast Care - November 13, 2018 Category: Cancer & Oncology Source Type: research

Re-Excision Rates in Breast-Conserving Surgery for Invasive Breast Cancer after Neoadjuvant Chemotherapy with and without the Use of a Radiopaque Tissue Transfer and X-ray System
Conclusion: Our analysis provides a rationale for the routine use of a radiopaque tissue transfer system for specimen radiography in BCS after neoadjuvant chemotherapy for invasive breast cancer in order to reduce re-excision rates.Breast Care (Source: Breast Care)
Source: Breast Care - November 13, 2018 Category: Cancer & Oncology Source Type: research

Gynecomastia - Conservative and Surgical Management
Gynecomastia is defined as a unilateral or bilateral persistent benign mammary gland enlargement in men. Prevalence of asymptomatic gynecomastia is up to 65%. True gynecomastia must be distinguished from pseudogynecomastia. Typically, in true gynecomastia, a solid tissue mass is palpable below the nipple-areolar complex. Malignant changes such as male mammary carcinoma must always be ruled out. The causes of gynecomastia are diverse. An imbalance of female to male hormones triggers the onset of the disease. This imbalance can be caused by endogenous diseases like hyperthyroidism, chronic liver disease, primary or secondary...
Source: Breast Care - November 13, 2018 Category: Cancer & Oncology Source Type: research

Validation of a Nomogram Predicting Non-Sentinel Lymph Node Metastases among Patients with Breast Cancer after Primary Systemic Therapy - a transSENTINA Substudy
Conclusion: We validated 7 models of prediction of non-SLN among patients showing axillary conversion through PST. Our own ‘SENTINA nomogram' yielded AUC values comparable to previous nomograms.Breast Care (Source: Breast Care)
Source: Breast Care - November 7, 2018 Category: Cancer & Oncology Source Type: research

Meetings and Conferences
Breast Care 2018;13:390-392 (Source: Breast Care)
Source: Breast Care - October 29, 2018 Category: Cancer & Oncology Source Type: research

Editorial Board / Contents / Imprint
Breast Care 2018;13:313-319 (Source: Breast Care)
Source: Breast Care - October 29, 2018 Category: Cancer & Oncology Source Type: research

Society Bulletins
Breast Care 2018;13:388-389 (Source: Breast Care)
Source: Breast Care - October 29, 2018 Category: Cancer & Oncology Source Type: research

PharmaNews
Breast Care 2018;13:386-387 (Source: Breast Care)
Source: Breast Care - October 29, 2018 Category: Cancer & Oncology Source Type: research

Application of a Three-Dimensional Reconstruction System in Breast Cancer with Ipsilateral Supraclavicular Lymph Node Metastasis: A Case Series
Background: The role of supraclavicular lymph node dissection (SCLND) in breast cancer patients with ipsilateral supraclavicular lymph node metastasis (ISLM) remains controversial. So far, there have been no effective imaging methods to precisely judge the feasibility of SCLND and the modes of ISLM.Case Report: We innovatively applied a three-dimensional (3D) reconstruction system to assess the feasibility of SCLND preoperatively for 13 breast cancer patients with ISLM. Based on the 3D reconstruction system and intraoperative findings, we performed lymph node dissection of their lesion areas. Compared to computed tomograph...
Source: Breast Care - October 29, 2018 Category: Cancer & Oncology Source Type: research

Evaluating the Demand for Integrative Medicine Practices in Breast and Gynecological Cancer Patients
Conclusion: There is a considerable demand for integrative medicine among breast and gynecological cancer patients. Our results underline the need for the implementation of evidence-based integrative treatments in cancer care in order to meet the standards of modern oncology.Breast Care (Source: Breast Care)
Source: Breast Care - October 24, 2018 Category: Cancer & Oncology Source Type: research

What Is the Best Management of cN0pN1(sn) Breast Cancer Patients?
Breast Care (Source: Breast Care)
Source: Breast Care - October 11, 2018 Category: Cancer & Oncology Source Type: research

Lymph Nodes in Breast Cancer - What Can We Learn from Translational Research?
Breast Care (Source: Breast Care)
Source: Breast Care - October 11, 2018 Category: Cancer & Oncology Source Type: research

Lymph Node Management in Breast Cancer: A Highly Dynamic Evolution
Breast Care (Source: Breast Care)
Source: Breast Care - October 11, 2018 Category: Cancer & Oncology Source Type: research

Breast Ultrasound during Lactation: Benign and Malignant Lesions
Conclusion: US can demonstrate or exclude a true mass against the background of a nodular breast parenchyma. Radiologists must be aware of malignant US features to avoid delays in the diagnosis of pregnancy-associated breast cancer.Breast Care (Source: Breast Care)
Source: Breast Care - October 11, 2018 Category: Cancer & Oncology Source Type: research

Clinical Validation of < b > < i > PITX2 < /i > < /b > DNA Methylation to Predict Outcome in High-Risk Breast Cancer Patients Treated with Anthracycline-Based Chemotherapy
Background: Breast cancer patients at high risk for recurrence are treated with anthracycline-based chemotherapy, but not all patients do equally benefit from such a regimen. To further improve therapy decision-making, biomarkers predicting outcome are of high unmet medical need.Methods: The percent DNA methylation ratio (PMR) of the promoter gene coding for the Paired-like homeodomain transcription factor 2 (PITX2) was determined by a validated methylation-specific real-time polymerase chain reaction (PCR) test. The multicenter study was conducted in routinely collected archived formalin-fixed paraffin-embedded (FFPE) tis...
Source: Breast Care - October 5, 2018 Category: Cancer & Oncology Source Type: research

Lymph Nodes in Breast Cancer - What Can We Learn from Translational Research
Breast Care (Source: Breast Care)
Source: Breast Care - October 4, 2018 Category: Cancer & Oncology Source Type: research

Current Status and Future Perspectives of Axillary Management in the Neoadjuvant Setting
Axillary surgery has undergone considerable changes in recent years, especially in relation to patients who undergo neoadjuvant chemotherapy (NACT). Due to constantly decreasing rates of recurrence and death from breast cancer, modern surgical strategies aim at de-escalating the extent of local treatment and avoiding unnecessary procedures. This relates especially to lymph node surgery which is associated with considerable morbidity. In patients who initially present with clinically node-negative disease, sentinel lymph node biopsy (SLNB) is increasingly performed after NACT. The determination of the post-NACT nodal status...
Source: Breast Care - October 4, 2018 Category: Cancer & Oncology Source Type: research

Clinical Validation of PITX2 DNA Methylation to Predict Outcome in High-Risk Breast Cancer Patients Treated with Anthracycline-Based Chemotherapy
Background: Breast cancer patients at high risk for recurrence are treated with anthracycline-based chemotherapy, but not all patients do equally benefit from such a regimen. To further improve therapy decision-making, biomarkers predicting outcome are of high unmet medical need.Methods: The percent DNA methylation ratio (PMR) of the promoter gene coding for the Paired-like homeodomain transcription factor 2 (PITX2) was determined by a validated methylation-specific real-time polymerase chain reaction (PCR) test. The multicenter study was conducted in routinely collected archived formalin-fixed paraffin-embedded (FFPE) tis...
Source: Breast Care - October 4, 2018 Category: Cancer & Oncology Source Type: research

New Technologies for Sentinel Lymph Node Detection
Breast Care (Source: Breast Care)
Source: Breast Care - September 18, 2018 Category: Cancer & Oncology Source Type: research

Updated Survival Analysis after a Median Follow-up of 12 Years of an Anthracycline-Containing Adjuvant Prospective Multicentre, Randomised Phase III Trial on Dose-Dense Chemotherapy in Primary Node-Positive, High-Risk Breast Cancer Patients
Breast Care (Source: Breast Care)
Source: Breast Care - September 7, 2018 Category: Cancer & Oncology Source Type: research

What Is the Best Management of cN0pN1(sn) Breast Cancer Patients
Breast Care (Source: Breast Care)
Source: Breast Care - September 7, 2018 Category: Cancer & Oncology Source Type: research

Early-Onset Breast Cancer: Effect of Diagnosis and Therapy on Fertility Concerns, Endocrine System, and Sexuality of Young Mothers in Germany
Breast Care (Source: Breast Care)
Source: Breast Care - September 7, 2018 Category: Cancer & Oncology Source Type: research

From Standard of Care to the Neoadjuvant Model as an Innovative Platform for Exploring Promising Combinations in Breast Cancer
Breast Care 2018;13:236-237 (Source: Breast Care)
Source: Breast Care - September 2, 2018 Category: Cancer & Oncology Source Type: research

Meetings and Conferences
Breast Care 2018;13:309-311 (Source: Breast Care)
Source: Breast Care - September 2, 2018 Category: Cancer & Oncology Source Type: research

PharmaNews
Breast Care 2018;13:305-307 (Source: Breast Care)
Source: Breast Care - September 2, 2018 Category: Cancer & Oncology Source Type: research

HR+/HER2- lokal fortgeschrittener oder metastasierter Brustkrebs. «Ich beobachte eine hohe Patientenzufriedenheit» Interview mit Prof. Dr. med. Marcus Schmidt
Breast Care 2018;13:303 (Source: Breast Care)
Source: Breast Care - September 2, 2018 Category: Cancer & Oncology Source Type: research

Editorial Board / Contents / Imprint
Breast Care 2018;13:229-234 (Source: Breast Care)
Source: Breast Care - September 2, 2018 Category: Cancer & Oncology Source Type: research

Is Axillary Sentinel Lymph Node Biopsy Required in Patients Who Undergo Primary Breast Surgery
Breast Care (Source: Breast Care)
Source: Breast Care - August 23, 2018 Category: Cancer & Oncology Source Type: research

Intraductal Papilloma Without Atypia on Image-Guided Breast Biopsy: Upgrade Rates to Carcinoma at Surgical Excision
Breast Care (Source: Breast Care)
Source: Breast Care - August 22, 2018 Category: Cancer & Oncology Source Type: research

Neoadjuvant Model as a Platform for Research in Breast Cancer and Novel Targets under Development in this Field
Breast Care (Source: Breast Care)
Source: Breast Care - August 14, 2018 Category: Cancer & Oncology Source Type: research

Jumping Breast Phenomenon Following Subcutaneous Mastectomy: First Description and Grading of a Well-Known Breast Deformity
Breast Care (Source: Breast Care)
Source: Breast Care - August 2, 2018 Category: Cancer & Oncology Source Type: research

Standard Neoadjuvant Treatment in Early/Locally Advanced Breast Cancer
Breast Care (Source: Breast Care)
Source: Breast Care - August 2, 2018 Category: Cancer & Oncology Source Type: research

Surgical Management of Breast Cancer Treated with Neoadjuvant Therapy
Breast Care (Source: Breast Care)
Source: Breast Care - July 24, 2018 Category: Cancer & Oncology Source Type: research

Predictive Factors for Non-Sentinel Lymph Node Metastasis in Patients with ACOSOG Z0011 Criteria
Breast Care (Source: Breast Care)
Source: Breast Care - July 13, 2018 Category: Cancer & Oncology Source Type: research

The Warwick Experience of the Oncotype DX ® Breast Recurrence Score® Assay as a Predictor of Chemotherapy Administration
Breast Care (Source: Breast Care)
Source: Breast Care - July 13, 2018 Category: Cancer & Oncology Source Type: research

Intraductal Papilloma Without Atypia on Image- Guided Breast Biopsy: Upgrade Rates to Carcinoma at Surgical Excision
Breast Care (Source: Breast Care)
Source: Breast Care - July 13, 2018 Category: Cancer & Oncology Source Type: research

Late Administration of Trastuzumab Emtansine Might Lead to Loss of Chance for Better Outcome in Patients with HER2-Positive Metastatic Breast Cancer
Breast Care (Source: Breast Care)
Source: Breast Care - July 13, 2018 Category: Cancer & Oncology Source Type: research

News from ASCO 2018
Breast Care (Source: Breast Care)
Source: Breast Care - July 12, 2018 Category: Cancer & Oncology Source Type: research

Granulomatous Lobular Mastitis: Antituberculous Treatment and Outcome in 22 Patients
Breast Care (Source: Breast Care)
Source: Breast Care - July 5, 2018 Category: Cancer & Oncology Source Type: research

Neue Option beim HER2-positiven Mammakarzinom. Erstes Trastuzumab-Biosimilar verf ügbar
Breast Care 2018;13:221 (Source: Breast Care)
Source: Breast Care - July 3, 2018 Category: Cancer & Oncology Source Type: research

PARP Inhibitors in Breast Cancer: Why, How, and When?
Breast Care 2018;13:216-219 (Source: Breast Care)
Source: Breast Care - July 2, 2018 Category: Cancer & Oncology Source Type: research

Society Bulletins
Breast Care 2018;13:224-226 (Source: Breast Care)
Source: Breast Care - July 2, 2018 Category: Cancer & Oncology Source Type: research

PharmaNews
Breast Care 2018;13:222-223 (Source: Breast Care)
Source: Breast Care - July 2, 2018 Category: Cancer & Oncology Source Type: research

Obituary
Breast Care 2018;13:220 (Source: Breast Care)
Source: Breast Care - July 2, 2018 Category: Cancer & Oncology Source Type: research

Editorial Board / Contents / Imprint
Breast Care 2018;13:149-154 (Source: Breast Care)
Source: Breast Care - July 2, 2018 Category: Cancer & Oncology Source Type: research

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2018
Breast Care (Source: Breast Care)
Source: Breast Care - June 22, 2018 Category: Cancer & Oncology Source Type: research

PARP Inhibitors in Breast Cancer: Why, How, and When
Breast Care (Source: Breast Care)
Source: Breast Care - June 21, 2018 Category: Cancer & Oncology Source Type: research