Olfactory bulb anomalies in KBG syndrome mouse model and patients
ANKRD11 (ankyrin repeat domain 11) is a chromatin regulator and the only gene associated with KBG syndrome, a rare neurodevelopmental disorder. We have previously shown that Ankrd11 regulates murine embryonic cor... (Source: BMC Medicine)
Source: BMC Medicine - April 15, 2024 Category: Internal Medicine Authors: Kara Goodkey, Anita Wischmeijer, Laurence Perrin, Adrianne E. S. Watson, Leenah Qureshi, Duccio Maria Cordelli, Francesco Toni, Maria Gnazzo, Francesco Benedicenti, Monique Elmaleh-Berg ès, Karen J. Low and Anastassia Voronova Tags: Research article Source Type: research
What is quality in long covid care? Lessons from a national quality improvement collaborative and multi-site ethnography
Long covid (post covid-19 condition) is a complex condition with diverse manifestations, uncertain prognosis and wide variation in current approaches to management. There have been calls for formal quality sta... (Source: BMC Medicine)
Source: BMC Medicine - April 15, 2024 Category: Internal Medicine Authors: Trisha Greenhalgh, Julie L. Darbyshire, Cassie Lee, Emma Ladds and Jenny Ceolta-Smith Tags: Research article Source Type: research
Association and biological pathways between lung function and incident depression: a prospective cohort study of 280,032 participants
Lung health is increasingly recognized as an essential factor in mental health. However, prospective evidence on lung function with incident depression remains to be determined. The study aimed to examine the ... (Source: BMC Medicine)
Source: BMC Medicine - April 15, 2024 Category: Internal Medicine Authors: Wei Hu, Bao-Peng Liu and Cun-Xian Jia Tags: Research article Source Type: research
Shared genetic architecture between autoimmune disorders and B-cell acute lymphoblastic leukemia: insights from large-scale genome-wide cross-trait analysis
To study the shared genetic structure between autoimmune diseases and B-cell acute lymphoblastic leukemia (B-ALL) and identify the shared risk loci and genes and genetic mechanisms involved. (Source: BMC Medicine)
Source: BMC Medicine - April 15, 2024 Category: Internal Medicine Authors: Xinghao Yu, Yiyin Chen, Jia Chen, Yi Fan, Huimin Lu, Depei Wu and Yang Xu Tags: Research article Source Type: research
COVID-19 inequalities in England: a mathematical modelling study of transmission risk and clinical vulnerability by socioeconomic status
The COVID-19 pandemic resulted in major inequalities in infection and disease burden between areas of varying socioeconomic deprivation in many countries, including England. Areas of higher deprivation tend to... (Source: BMC Medicine)
Source: BMC Medicine - April 15, 2024 Category: Internal Medicine Authors: Lucy Goodfellow, Edwin van Leeuwen and Rosalind M. Eggo Tags: Research article Source Type: research
Cervical lymph node metastasis prediction from papillary thyroid carcinoma US videos: a prospective multicenter study
Prediction of lymph node metastasis (LNM) is critical for individualized management of papillary thyroid carcinoma (PTC) patients to avoid unnecessary overtreatment as well as undesired under-treatment. Artifi... (Source: BMC Medicine)
Source: BMC Medicine - April 12, 2024 Category: Internal Medicine Authors: Ming-Bo Zhang, Zhe-Ling Meng, Yi Mao, Xue Jiang, Ning Xu, Qing-Hua Xu, Jie Tian, Yu-Kun Luo and Kun Wang Tags: Research article Source Type: research
PREX2 contributes to radiation resistance by inhibiting radiotherapy-induced tumor immunogenicity via cGAS/STING/IFNs pathway in colorectal cancer
Colorectal cancer (CRC) lacks established biomarkers or molecular targets for predicting or enhancing radiation response. Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 (PREX2) exhibit... (Source: BMC Medicine)
Source: BMC Medicine - April 12, 2024 Category: Internal Medicine Authors: Mingzhou Li, Jianbiao Xiao, Shasha Song, Fangyi Han, Hongling Liu, Yang Lin, Yunfei Ni, Sisi Zeng, Xin Zou, Jieqiong Wu, Feifei Wang, Shaowan Xu, You Liang, Peishuang Xu, Huirong Hong, Junfeng Qiu & hellip; Tags: Research article Source Type: research
Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study
The timing of puberty may have an important impact on adolescent mental health. In particular, earlier age at menarche has been associated with elevated rates of depression in adolescents. Previous research su... (Source: BMC Medicine)
Source: BMC Medicine - April 12, 2024 Category: Internal Medicine Authors: Adrian Dahl Askelund, Robyn E. Wootton, Fartein A. Torvik, Rebecca B. Lawn, Helga Ask, Elizabeth C. Corfield, Maria C. Magnus, Ted Reichborn-Kjennerud, Per M. Magnus, Ole A. Andreassen, Camilla Stoltenberg, George Davey Smith, Neil M. Davies, Alexandra Ha Tags: REGISTERED REPORT Source Type: research
The effects of telehealth-delivered mindfulness meditation, cognitive therapy, and behavioral activation for chronic low back pain: a randomized clinical trial
Chronic low back pain (CLBP) is a significant problem affecting millions of people worldwide. Three widely implemented psychological techniques used for CLBP management are cognitive therapy (CT), mindfulness ... (Source: BMC Medicine)
Source: BMC Medicine - April 12, 2024 Category: Internal Medicine Authors: Melissa A. Day, Marcia A. Ciol, M. Elena Mendoza, Jeffrey Borckardt, Dawn M. Ehde, Andrea K. Newman, Joy F. Chan, Sydney A. Drever, Janna L. Friedly, John Burns, Beverly E. Thorn and Mark P. Jensen Tags: Research article Source Type: research
Identification and support of autistic individuals within the UK Criminal Justice System: a practical approach based upon professional consensus with input from lived experience
Autism spectrum disorder (hereafter referred to as autism) is characterised by difficulties with (i) social communication, social interaction, and (ii) restricted and repetitive interests and behaviours. Estim... (Source: BMC Medicine)
Source: BMC Medicine - April 12, 2024 Category: Internal Medicine Authors: Emma Woodhouse, Jack Hollingdale, Lisa Davies, Zainab Al-Attar, Susan Young, Luke P. Vinter, Kwaku Agyemang, Carla Bartlett, Colleen Berryessa, Eddie Chaplin, Quinton Deeley, Ian Freckelton, Felicity Gerry, Gisli Gudjonsson, Katie Maras, Michelle Mattison Tags: Guideline Source Type: research
Canadians ’ use of cannabis for therapeutic purposes since legalization of recreational cannabis: a cross-sectional analysis by medical authorization status
This study examines the demographic and health- and medical cannabis-rela... (Source: BMC Medicine)
Source: BMC Medicine - April 8, 2024 Category: Internal Medicine Authors: Lynda G. Balneaves, Ashleigh Brown, Matthew Green, Erin Prosk, Lucile Rapin, Max Monahan-Ellison, Eva McMillan, Jonathan Zaid, Michael Dworkind and Cody Z. Watling Tags: Research article Source Type: research
Patterns of comorbidities in patients with atrial fibrillation and impact on management and long-term prognosis: an analysis from the Prospective Global GLORIA-AF Registry
Clinical complexity, as the interaction between ageing, frailty, multimorbidity and polypharmacy, is an increasing concern in patients with AF. There remains uncertainty regarding how combinations of comorbidi... (Source: BMC Medicine)
Source: BMC Medicine - April 8, 2024 Category: Internal Medicine Authors: Giulio Francesco Romiti, Bernadette Corica, Davide Antonio Mei, Arnaud Bisson, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti and Gregory Y. H. Lip Tags: Research article Source Type: research
Characterizing the polygenic overlap and shared loci between rheumatoid arthritis and cardiovascular diseases
Despite substantial research revealing that patients with rheumatoid arthritis (RA) have excessive morbidity and mortality of cardiovascular disease (CVD), the mechanism underlying this association has not bee... (Source: BMC Medicine)
Source: BMC Medicine - April 8, 2024 Category: Internal Medicine Authors: Xiaohui Sun, Yu Qian, Weiqiu Cheng, Ding Ye, Bin Liu, Dan Zhou, Chengping Wen, Ole A. Andreassen and Yingying Mao Tags: Research article Source Type: research
Interventions on gender equity in the workplace: a scoping review
This study identifies and examines evidence from randomized controlled trials (RCTs) on interve... (Source: BMC Medicine)
Source: BMC Medicine - April 5, 2024 Category: Internal Medicine Authors: Andrea C. Tricco, Amanda Parker, Paul A. Khan, Vera Nincic, Reid Robson, Heather MacDonald, Rachel Warren, Olga Cleary, Elaine Zibrowski, Nancy Baxter, Karen E. A. Burns, Doug Coyle, Ruth Ndjaboue, Jocalyn P. Clark, Etienne V. Langlois, Sofia B. Ahmed & h Tags: Research article Source Type: research
A practical evidence-based approach to management of type 2 diabetes in children and young people (CYP): UK consensus
Type 2 diabetes in young people is an aggressive disease with a greater risk of complications leading to increased morbidity and mortality during the most productive years of life. Prevalence in the UK and glo... (Source: BMC Medicine)
Source: BMC Medicine - April 2, 2024 Category: Internal Medicine Authors: Billy White, S. M. Ng, J. C. Agwu, T. G. Barrett, N. Birchmore, M. Kershaw, J. Drew, F. Kavvoura, J. Law, C. Moudiotis, E. Procter, P. Paul, F. Regan, P. Reilly, P. Sachdev, R. Sakremath & hellip; Tags: Guideline Source Type: research
