Additional considerations before using a ctDNA-guided approach for informing adjuvant chemotherapy in colorectal cancer
The DYNAMIC trial investigated the use of circulating tumor DNA (ctDNA) to guide adjuvant treatment decisions in stage II colon cancer. Despite the DYNAMIC trial ’s assertion that a ctDNA-guided approach could ... (Source: BMC Medicine)
Source: BMC Medicine - September 8, 2023 Category: Internal Medicine Authors: Timoth ée Olivier, Alyson Haslam and Vinay Prasad Tags: Correspondence Source Type: research
Integrated epigenome, whole genome sequence and metabolome analyses identify novel multi-omics pathways in type 2 diabetes: a Middle Eastern study
T2D is of high prevalence in the middle east and thus studying its mechanisms is of a significant importance. Using 1026 Qatar BioBank samples, epigenetics, whole genome sequencing and metabolomics were combin... (Source: BMC Medicine)
Source: BMC Medicine - September 8, 2023 Category: Internal Medicine Authors: Noha A. Yousri, Omar M. E. Albagha and Steven C. Hunt Tags: Research article Source Type: research
Association of caesarean delivery with offspring health outcomes in full-cohort versus sibling-comparison studies: a comparative meta-analysis and simulation study
Full-cohort and sibling-comparison designs have yielded inconsistent results about the impacts of caesarean delivery on offspring health outcomes, with the effect estimates from the latter being more likely di... (Source: BMC Medicine)
Source: BMC Medicine - September 8, 2023 Category: Internal Medicine Authors: Hong-zhao Yu, Xiao-wei Wang, Zhen-yu Guo, Zhi Lin, Yu-bo Zhou, Hong-tian Li and Jian-meng Liu Tags: Research article Source Type: research
Integrated unbiased multiomics defines disease-independent placental clusters in common obstetrical syndromes
Placental dysfunction, a root cause of common syndromes affecting human pregnancy, such as preeclampsia (PE), fetal growth restriction (FGR), and spontaneous preterm delivery (sPTD), remains poorly defined. Th... (Source: BMC Medicine)
Source: BMC Medicine - September 8, 2023 Category: Internal Medicine Authors: Oren Barak, Tyler Lovelace, Samantha Piekos, Tianjiao Chu, Zhishen Cao, Elena Sadovsky, Jean-Francois Mouillet, Yingshi Ouyang, W. Tony Parks, Leroy Hood, Nathan D. Price, Panayiotis V. Benos and Yoel Sadovsky Tags: Research article Source Type: research
Prenatal ambient air pollution exposure and child weight trajectories from the 3rd trimester of pregnancy to 2 years of age: a cohort study
This study will evaluate the associations o... (Source: BMC Medicine)
Source: BMC Medicine - September 7, 2023 Category: Internal Medicine Authors: Nan Ji, Mark Johnson, Sandrah P. Eckel, William J. Gauderman, Thomas A. Chavez, Kiros Berhane, Dema Faham, Fred Lurmann, Nathan R. Pavlovic, Brendan H. Grubbs, Deborah Lerner, Rima Habre, Shohreh F. Farzan, Theresa M. Bastain and Carrie V. Breton Tags: Research article Source Type: research
