A new histone deacetylase inhibitor remodels the tumor microenvironment by deletion of polymorphonuclear myeloid-derived suppressor cells and sensitizes prostate cancer to immunotherapy
Prostate cancer (PCa) is the most common malignancy diagnosed in men. Immune checkpoint blockade (ICB) alone showed disappointing results in PCa. It is partly due to the formation of immunosuppressive tumor mi... (Source: BMC Medicine)
Source: BMC Medicine - October 25, 2023 Category: Internal Medicine Authors: Zude Chen, Xiaoshuang Yang, Zugen Chen, Minzhao Li, Wei Wang, Riwei Yang, Zuomin Wang, Yuxiang Ma, Yulong Xu, Shan Ao, Leqi Liang, Chao Cai, Changning Wang, Tuo Deng, Di Gu, Hongqing Zhou & hellip; Tags: Research article Source Type: research
A 10-year update to the principles for clinical trial data sharing by pharmaceutical companies: perspectives based on a decade of literature and policies
Data sharing is essential for promoting scientific discoveries and informed decision-making in clinical practice. In 2013, PhRMA/EFPIA recognised the importance of data sharing and supported initiatives to enh... (Source: BMC Medicine)
Source: BMC Medicine - October 23, 2023 Category: Internal Medicine Authors: Natansh D. Modi, Ganessan Kichenadasse, Tammy C. Hoffmann, Mark Haseloff, Jessica M. Logan, Areti A. Veroniki, Rebecca L. Venchiarutti, Amelia K. Smit, Haitham Tuffaha, Harindra Jayasekara, Arkady Manning-Bennet, Erin Morton, Ross A. McKinnon, Andrew Rowl Tags: Correspondence Source Type: research
Correction: Understanding the impact of tuberous sclerosis complex: development and validation of the TSC-PROM
(Source: BMC Medicine)
Source: BMC Medicine - October 23, 2023 Category: Internal Medicine Authors: Annelieke R. M üller, Michiel A. J. Luijten, Lotte Haverman, Wendela L. de Ranitz-Greven, Peter Janssens, André B. Rietman, Leontine W.ten Hoopen, Laura C. G. de Graaff, Marie-Claire de Wit, Anna C. Jansen, Tanjala Gipson, Jamie K. Capal, Petrus J. de V Tags: Correction Source Type: research
Racial differences in healthcare expenditures for prevalent multimorbidity combinations in the USA: a cross-sectional study
We aimed to model total charges for the most prevalent multimorbidity combinations in the USA and assess model accuracy across Asian/Pacific Islander, African American, Biracial, Caucasian, Hispanic, and Nativ... (Source: BMC Medicine)
Source: BMC Medicine - October 23, 2023 Category: Internal Medicine Authors: Manal Alshakhs, Patricia J. Goedecke, James E. Bailey and Charisse Madlock-Brown Tags: Research article Source Type: research
Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly defined condition encompassing hepatic steatosis and metabolic dysfunction. However, the relationship between MAFLD and multi-system dise... (Source: BMC Medicine)
Source: BMC Medicine - October 20, 2023 Category: Internal Medicine Authors: Yu Jia, Dongze Li, Yi You, Jing Yu, Wenli Jiang, Yi Liu, Rui Zeng, Zhi Wan, Yi Lei and Xiaoyang Liao Tags: Research article Source Type: research
Cardiovascular outcomes between COVID-19 and non-COVID-19 pneumonia: a nationwide cohort study
Previous studies that assessed the risk of cardiovascular outcomes in survivors of coronavirus disease 2019 (COVID-19) were likely limited by lack of generalizability and selection of controls nonrepresentativ... (Source: BMC Medicine)
Source: BMC Medicine - October 20, 2023 Category: Internal Medicine Authors: Min-Taek Lee, Moon Seong Baek, Tae Wan Kim, Sun-Young Jung and Won-Young Kim Tags: Research article Source Type: research
Combination of GT90001 and nivolumab in patients with advanced hepatocellular carcinoma: a multicenter, single-arm, phase 1b/2 study
GT90001 (also known as PF-03446962) is an anti-ALK-1 monoclonal antibody and has shown activity in hepatocellular carcinoma (HCC). This phase 1b/2 study was designed to determine the recommended phase 2 dose (... (Source: BMC Medicine)
Source: BMC Medicine - October 20, 2023 Category: Internal Medicine Authors: Chiun Hsu, Yi-Fang Chang, Chia-Jui Yen, Yu-Wei Xu, Min Dong and You-Zhi Tong Tags: Research article Source Type: research
Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection
Thoracic aortic dissection (TAD) is a life-threatening disease caused by an intimal tear in the aorta. The histological characteristics differ significantly between the tear area (TA) and the distant area. Pre... (Source: BMC Medicine)
Source: BMC Medicine - October 20, 2023 Category: Internal Medicine Authors: Yixuan Sheng, Liying Wu, Yuan Chang, Wendao Liu, Menghao Tao, Xiao Chen, Xiong Zhang, Bin Li, Ningning Zhang, Dongting Ye, Chunxi Zhang, Daliang Zhu, Haisen Zhao, Aijun Chen, Haisheng Chen and Jiangping Song Tags: Research article Source Type: research
Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo
Single low-dose primaquine (SLDPQ) effectively blocks the transmission of Plasmodium falciparum malaria, but anxiety remains regarding its haemolytic potential in patients with glucose-6-phopshate dehydrogenase (... (Source: BMC Medicine)
Source: BMC Medicine - October 20, 2023 Category: Internal Medicine Authors: Marie A. Onyamboko, Peter Olupot-Olupot, Winifred Were, Cate Namayanja, Peter Onyas, Harriet Titin, Joy Baseke, Rita Muhindo, Daddy K. Kayembe, Pauline O. Ndjowo, Benjamin B. Basara, Charles B. Okalebo, Thomas N. Williams, Sophie Uyoga, Chiraporn Taya, Ad Tags: Research article Source Type: research
What is the impact of one ’s chronic illness on his or her spouse’s future chronic illness: a community-based prospective cohort study
Integrating a joint approach to chronic disease management within the context of a couple has immense potential as a valuable strategy for both prevention and treatment. Although spousal concordance has been r... (Source: BMC Medicine)
Source: BMC Medicine - October 16, 2023 Category: Internal Medicine Authors: Hoyoung An, Hee Won Yang, Dae Jong Oh, Eunji Lim, Jin Shin, Dong Gyu Moon, Seung Wan Suh, Seonjeong Byun, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu & hellip; Tags: Research article Source Type: research
Association of breastfeeding with mental disorders in mother and child: a systematic review and meta-analysis
Breastfeeding has long been associated with numerous benefits for both mothers and infants. While some observational studies have explored the relationship between breastfeeding and mental health outcomes in m... (Source: BMC Medicine)
Source: BMC Medicine - October 16, 2023 Category: Internal Medicine Authors: Polina Bugaeva, Inna Arkusha, Rinat Bikaev, Igor Kamenskiy, Aleksandra Pokrovskaya, Yasmin El-Taravi, Valeria Caso, Alla Avedisova, Derek K. Chu, Jon Genuneit, Gabriel Torbahn, Timothy R. Nicholson, Dina Baimukhambetova, Aigun Mursalova, Anastasia Kolotil Tags: Research article Source Type: research
Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with C... (Source: BMC Medicine)
Source: BMC Medicine - October 13, 2023 Category: Internal Medicine Authors: Sangeetha Shyam, Jes ús Francisco García-Gavilán, Indira Paz-Graniel, José J. Gaforio, Miguel Ángel Martínez-González, Dolores Corella, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Mira Tags: Research article Source Type: research
Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer
Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus p... (Source: BMC Medicine)
Source: BMC Medicine - October 13, 2023 Category: Internal Medicine Authors: Katharina Nimptsch, Krasimira Aleksandrova, Thu Thi Pham, Nikos Papadimitriou, J ürgen Janke, Sofia Christakoudi, Alicia Heath, Anja Olsen, Anne Tjønneland, Matthias B. Schulze, Verena Katzke, Rudolf Kaaks, Bethany van Guelpen, Justin Harbs, Domenico Pa Tags: Research article Source Type: research
Causal association between inflammatory bowel disease and 32 site-specific extracolonic cancers: a Mendelian randomization study
The risk of extracolonic cancer is increased in inflammatory bowel disease (IBD) patients, but it is not clear whether there is a causal relationship. We aimed to systematically estimate the causal relationshi... (Source: BMC Medicine)
Source: BMC Medicine - October 10, 2023 Category: Internal Medicine Authors: Hui Gao, Shuhao Zheng, Xin Yuan, Jiarong Xie and Lei Xu Tags: Research article Source Type: research
Fotagliptin monotherapy with alogliptin as an active comparator in patients with uncontrolled type 2 diabetes mellitus: a randomized, multicenter, double-blind, placebo-controlled, phase 3 trial
Dipeptidyl peptidase-4 inhibitors (DPP-4i) have become firmly established in treatment algorithms and national guidelines for improving glycemic control in type 2 diabetes mellitus (T2DM).To report the finding... (Source: BMC Medicine)
Source: BMC Medicine - October 9, 2023 Category: Internal Medicine Authors: Mingtong Xu, Kan Sun, Wenjie Xu, Chuan Wang, Dewen Yan, Shu Li, Li Cong, Yinzhen Pi, Weihong Song, Qingyuan Sun, Rijun Xiao, Weixia Peng, Jianping Wang, Hui Peng, Yawei Zhang, Peng Duan & hellip; Tags: Research article Source Type: research
