Larval therapy vs conventional silver dressings for full-thickness burns: a randomized controlled trial
This is the first clinical trial to investigate the effectiveness of maggot debridement therapy (MDT) for full-thickness burn injuries in comparison to conventional silver dressings. (Source: BMC Medicine)
Source: BMC Medicine - September 19, 2023 Category: Internal Medicine Authors: Jasem Gaffari, Kamran Akbarzadeh, Mozhgan Baniardalani, Reza Hosseini, Safdar Masoumi, Zahra Sadat Amiri, Razieh Shabani Kordshouli, Javad Rafinejad and Mostafa Dahmardehei Tags: Research article Source Type: research

Evidencing general acceptability of open-label placebo use for tackling overtreatment in primary care: a mixed methods study
This study presents the first account for examining the feasibility of placebo use for red... (Source: BMC Medicine)
Source: BMC Medicine - September 19, 2023 Category: Internal Medicine Authors: E. M. Krockow, T. Emerson, E. Youssef, S. Scott and S. Tromans Tags: Research article Source Type: research

Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study
Major depressive disorder (MDD) has a significant impact on global burden of disease. Complications in clinical management can occur when response to pharmacological modalities is considered inadequate and sym... (Source: BMC Medicine)
Source: BMC Medicine - September 14, 2023 Category: Internal Medicine Authors: Vasilios Karageorgiou, Francesco Casanova, Jessica O ’Loughlin, Harry Green, Trevelyan J. McKinley, Jack Bowden and Jessica Tyrrell Tags: Research article Source Type: research

Financial hardship associated with catastrophic out-of-pocket spending tied to primary care services in low- and lower-middle-income countries: findings from a modeling study
Financial risk protection (FRP) is a key component of universal health coverage (UHC): all individuals must be able to obtain the health services they need without experiencing financial hardship. In many low-... (Source: BMC Medicine)
Source: BMC Medicine - September 14, 2023 Category: Internal Medicine Authors: Sarah Bolongaita, Yeeun Lee, Kjell Arne Johansson, Øystein A. Haaland, Mieraf Taddesse Tolla, Jongwook Lee and Stéphane Verguet Tags: Research article Source Type: research

Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses
Despite epidemiological evidence associating gallstone disease (GSD) with cardiovascular disease (CVD), a dilemma remains on the role of cholecystectomy in modifying the risk of CVD. We aimed to characterize t... (Source: BMC Medicine)
Source: BMC Medicine - September 13, 2023 Category: Internal Medicine Authors: Li Zhang, Wenqiang Zhang, Lin He, Huijie Cui, Yutong Wang, Xueyao Wu, Xunying Zhao, Peijing Yan, Chao Yang, Changfeng Xiao, Mingshuang Tang, Lin Chen, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Yanfang Yang & hellip; Tags: Research article Source Type: research

A roadmap for sex- and gender-disaggregated health research
Sex and gender are fundamental aspects of health and wellbeing. Yet many research studies fail to consider sex or gender differences, and even when they do this is often limited to merely cataloguing such diff... (Source: BMC Medicine)
Source: BMC Medicine - September 13, 2023 Category: Internal Medicine Authors: Sanne A. E. Peters and Mark Woodward Tags: Research article Source Type: research

Importance of accurate and accessible recording of healthcare contacts in mental health
(Source: BMC Medicine)
Source: BMC Medicine - September 12, 2023 Category: Internal Medicine Authors: Ruth H. Jack, Carol A. C. Coupland, Rebecca M. Joseph, Chris Hollis, Richard Morriss, Roger David Knaggs, Andrea Cipriani, Samuele Cortese and Julia Hippisley-Cox Tags: Correspondence Source Type: research

Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysis
Few studies have investigated associations between adiposity and reproductive factors using causal methods, both of which have a number of consequences on women ’s health. Here we assess whether adiposity at di... (Source: BMC Medicine)
Source: BMC Medicine - September 12, 2023 Category: Internal Medicine Authors: Claire Prince, Laura D. Howe, Gemma C. Sharp, Abigail Fraser and Rebecca C. Richmond Tags: Research article Source Type: research

Plant-based diets, genetic predisposition and risk of non-alcoholic fatty liver disease
Diets rich in plant-based foods are associated with lower risks of non-alcoholic fatty liver disease (NAFLD), while the prospective evidence is limited. We aimed to examine longitudinal associations of plant-b... (Source: BMC Medicine)
Source: BMC Medicine - September 12, 2023 Category: Internal Medicine Authors: Yanling Lv, Shuang Rong, Yan Deng, Wei Bao, Yang Xia and Liangkai Chen Tags: Research article Source Type: research

Maternal multimorbidity and preterm birth in Scotland: an observational record-linkage study
Multimorbidity is common in women across the life course. Preterm birth is the single biggest cause of neonatal mortality and morbidity. We aim to estimate the prevalence of multimorbidity in pregnant women an... (Source: BMC Medicine)
Source: BMC Medicine - September 12, 2023 Category: Internal Medicine Authors: Amaya Azcoaga-Lorenzo, Adeniyi Francis Fagbamigbe, Utkarsh Agrawal, Mairead Black, Muhammad Usman, Siang Ing Lee, Kelly-Ann Eastwood, Ngawai Moss, Rachel Plachcinski, Catherine Nelson-Piercy, Sinead Brophy, Dermot O ’Reilly, Krishnarajah Nirantharakumar Tags: Research article Source Type: research

Substantially more children receiving antidepressants see a specialist than reported by Jack et al.
We would like to draw attention to evidence of substantial bias in the article published in this journal by Jack et al. (BMC Med 18:1-12, 2020). They provide an analysis of antidepressant prescribing to childr... (Source: BMC Medicine)
Source: BMC Medicine - September 11, 2023 Category: Internal Medicine Authors: Vicky P. Taxiarchi, Carolyn A. Chew-Graham and Matthias Pierce Tags: Correspondence Source Type: research

Additional considerations before using a ctDNA-guided approach for informing adjuvant chemotherapy in colorectal cancer
The DYNAMIC trial investigated the use of circulating tumor DNA (ctDNA) to guide adjuvant treatment decisions in stage II colon cancer. Despite the DYNAMIC trial ’s assertion that a ctDNA-guided approach could ... (Source: BMC Medicine)
Source: BMC Medicine - September 8, 2023 Category: Internal Medicine Authors: Timoth ée Olivier, Alyson Haslam and Vinay Prasad Tags: Correspondence Source Type: research

Integrated epigenome, whole genome sequence and metabolome analyses identify novel multi-omics pathways in type 2 diabetes: a Middle Eastern study
T2D is of high prevalence in the middle east and thus studying its mechanisms is of a significant importance. Using 1026 Qatar BioBank samples, epigenetics, whole genome sequencing and metabolomics were combin... (Source: BMC Medicine)
Source: BMC Medicine - September 8, 2023 Category: Internal Medicine Authors: Noha A. Yousri, Omar M. E. Albagha and Steven C. Hunt Tags: Research article Source Type: research

Association of caesarean delivery with offspring health outcomes in full-cohort versus sibling-comparison studies: a comparative meta-analysis and simulation study
Full-cohort and sibling-comparison designs have yielded inconsistent results about the impacts of caesarean delivery on offspring health outcomes, with the effect estimates from the latter being more likely di... (Source: BMC Medicine)
Source: BMC Medicine - September 8, 2023 Category: Internal Medicine Authors: Hong-zhao Yu, Xiao-wei Wang, Zhen-yu Guo, Zhi Lin, Yu-bo Zhou, Hong-tian Li and Jian-meng Liu Tags: Research article Source Type: research

Integrated unbiased multiomics defines disease-independent placental clusters in common obstetrical syndromes
Placental dysfunction, a root cause of common syndromes affecting human pregnancy, such as preeclampsia (PE), fetal growth restriction (FGR), and spontaneous preterm delivery (sPTD), remains poorly defined. Th... (Source: BMC Medicine)
Source: BMC Medicine - September 8, 2023 Category: Internal Medicine Authors: Oren Barak, Tyler Lovelace, Samantha Piekos, Tianjiao Chu, Zhishen Cao, Elena Sadovsky, Jean-Francois Mouillet, Yingshi Ouyang, W. Tony Parks, Leroy Hood, Nathan D. Price, Panayiotis V. Benos and Yoel Sadovsky Tags: Research article Source Type: research