Pravastatin attenuates isoprenaline induced cardiac fibrosis in a mouse model
Biotech Histochem. 2023 Oct 10:1-11. doi: 10.1080/10520295.2023.2260303. Online ahead of print.ABSTRACTWe investigated the effects of pravastatin (PRAVA) on isoprenaline (ISP) induced cardiac fibrosis using four groups of mice: untreated control, PRAVA, ISP, ISP + PRAVA groups. ISP, 20 mg/kg, was administered subcutaneously daily for 14 days. PRAVA, 20 mg/kg, was administered orally daily for 14 days. Mice were sacrificed on day15 and heart and blood samples were collected to investigate cardiac injury markers. The mean body weight for the ISP group on day 15 was decreased significantly compared to day 0; PRAVA increased t...
Source: Biotechnic and Histochemistry - October 10, 2023 Category: Research Authors: Abhinav Rana Thakur Uttam Singh Meemansha Sharma Manju Gari Tarun Kumar Subhashree Parida Madhu Cholenahalli Lingaraju Asok Kumar Mariappan Akhilesh Kumar Dinesh Kumar Source Type: research
Pravastatin attenuates isoprenaline induced cardiac fibrosis in a mouse model
Biotech Histochem. 2023 Oct 10:1-11. doi: 10.1080/10520295.2023.2260303. Online ahead of print.ABSTRACTWe investigated the effects of pravastatin (PRAVA) on isoprenaline (ISP) induced cardiac fibrosis using four groups of mice: untreated control, PRAVA, ISP, ISP + PRAVA groups. ISP, 20 mg/kg, was administered subcutaneously daily for 14 days. PRAVA, 20 mg/kg, was administered orally daily for 14 days. Mice were sacrificed on day15 and heart and blood samples were collected to investigate cardiac injury markers. The mean body weight for the ISP group on day 15 was decreased significantly compared to day 0; PRAVA increased t...
Source: Biotechnic and Histochemistry - October 10, 2023 Category: Research Authors: Abhinav Rana Thakur Uttam Singh Meemansha Sharma Manju Gari Tarun Kumar Subhashree Parida Madhu Cholenahalli Lingaraju Asok Kumar Mariappan Akhilesh Kumar Dinesh Kumar Source Type: research
Immunohistochemical evaluation of hormones secreted by pancreatic endocrine tumors
Biotech Histochem. 2023 Oct 3:1-6. doi: 10.1080/10520295.2023.2260307. Online ahead of print.ABSTRACTThe endocrine component of the pancreas is located primarily in the islets of Langerhans, but is also found as single cells among the acinar cells and duct epithelium. It currently is thought that endocrine tumors of the pancreas (PETs) arise from pluripotent stem cells located within the ductal epithelium rather than from existing endocrine cells. Islet cell components include alpha, beta, PP, delta and epsilon cells, which secrete glucagon, insulin, pancreatic polypeptide, somatostatin and ghrelin, respectively. We invest...
Source: Biotechnic and Histochemistry - October 3, 2023 Category: Research Authors: Anne Mones Sheila Criswell Source Type: research
Immunohistochemical evaluation of hormones secreted by pancreatic endocrine tumors
Biotech Histochem. 2023 Oct 3:1-6. doi: 10.1080/10520295.2023.2260307. Online ahead of print.ABSTRACTThe endocrine component of the pancreas is located primarily in the islets of Langerhans, but is also found as single cells among the acinar cells and duct epithelium. It currently is thought that endocrine tumors of the pancreas (PETs) arise from pluripotent stem cells located within the ductal epithelium rather than from existing endocrine cells. Islet cell components include alpha, beta, PP, delta and epsilon cells, which secrete glucagon, insulin, pancreatic polypeptide, somatostatin and ghrelin, respectively. We invest...
Source: Biotechnic and Histochemistry - October 3, 2023 Category: Research Authors: Anne Mones Sheila Criswell Source Type: research
Immunohistochemical evaluation of hormones secreted by pancreatic endocrine tumors
Biotech Histochem. 2023 Oct 3:1-6. doi: 10.1080/10520295.2023.2260307. Online ahead of print.ABSTRACTThe endocrine component of the pancreas is located primarily in the islets of Langerhans, but is also found as single cells among the acinar cells and duct epithelium. It currently is thought that endocrine tumors of the pancreas (PETs) arise from pluripotent stem cells located within the ductal epithelium rather than from existing endocrine cells. Islet cell components include alpha, beta, PP, delta and epsilon cells, which secrete glucagon, insulin, pancreatic polypeptide, somatostatin and ghrelin, respectively. We invest...
Source: Biotechnic and Histochemistry - October 3, 2023 Category: Research Authors: Anne Mones Sheila Criswell Source Type: research
Immunohistochemical evaluation of hormones secreted by pancreatic endocrine tumors
Biotech Histochem. 2023 Oct 3:1-6. doi: 10.1080/10520295.2023.2260307. Online ahead of print.ABSTRACTThe endocrine component of the pancreas is located primarily in the islets of Langerhans, but is also found as single cells among the acinar cells and duct epithelium. It currently is thought that endocrine tumors of the pancreas (PETs) arise from pluripotent stem cells located within the ductal epithelium rather than from existing endocrine cells. Islet cell components include alpha, beta, PP, delta and epsilon cells, which secrete glucagon, insulin, pancreatic polypeptide, somatostatin and ghrelin, respectively. We invest...
Source: Biotechnic and Histochemistry - October 3, 2023 Category: Research Authors: Anne Mones Sheila Criswell Source Type: research
Immunohistochemical evaluation of hormones secreted by pancreatic endocrine tumors
Biotech Histochem. 2023 Oct 3:1-6. doi: 10.1080/10520295.2023.2260307. Online ahead of print.ABSTRACTThe endocrine component of the pancreas is located primarily in the islets of Langerhans, but is also found as single cells among the acinar cells and duct epithelium. It currently is thought that endocrine tumors of the pancreas (PETs) arise from pluripotent stem cells located within the ductal epithelium rather than from existing endocrine cells. Islet cell components include alpha, beta, PP, delta and epsilon cells, which secrete glucagon, insulin, pancreatic polypeptide, somatostatin and ghrelin, respectively. We invest...
Source: Biotechnic and Histochemistry - October 3, 2023 Category: Research Authors: Anne Mones Sheila Criswell Source Type: research
Role of canagliflozin in ameliorating isoprenaline induced cardiomyocyte oxidative stress via the heme oxygenase-1 mediated pathway
Biotech Histochem. 2023 Oct 2:1-13. doi: 10.1080/10520295.2023.2262390. Online ahead of print.ABSTRACTCanagliflozin (CZ) is commonly prescribed for management of type-2 diabetes mellitus (T2DM); it also can reduce the risk of myocardial infarction. We used 80 albino Wistar rats to investigate the cardioprotective potential of CZ against oxidative stress caused by administration of isoprenaline (ISO). We found that ISO stimulates production of reactive oxygen species and that CZ administration caused up-regulation of antioxidants and down-regulation of oxidants due to nuclear factor erythroid-2 related factor-2, as well as ...
Source: Biotechnic and Histochemistry - October 2, 2023 Category: Research Authors: Ahmed Ahmed Dina Abdel-Rahman Ehab M Hantash Source Type: research
Disulfiram ameliorates bleomycin induced pulmonary inflammation and fibrosis in rats
Biotech Histochem. 2023 Oct 2:1-9. doi: 10.1080/10520295.2023.2261367. Online ahead of print.ABSTRACTBleomycin (BL) is a widely used anticancer drug that can cause pulmonary fibrosis due to increased fibroblast proliferation and increased secretion of extracellular matrix. RASSF1A is a tumor suppressor gene that is down-regulated by DNA methylation during fibrosis. Disulfiram (DSF), a noncytosine DNA methyltransferase inhibitor, can revert epigenetic biomarkers and re-express silenced genes. We investigated anti-inflammatory and anti-fibrotic effects of DSF on regulation of epigenetic molecules and histopathology in a rat ...
Source: Biotechnic and Histochemistry - October 2, 2023 Category: Research Authors: Negar Hamidi Farideh Feizi Abbas Azadmehr Ebrahim Zabihi Soraya Khafri Zeinab Zarei-Behjani Zahra Babazadeh Source Type: research
Role of canagliflozin in ameliorating isoprenaline induced cardiomyocyte oxidative stress via the heme oxygenase-1 mediated pathway
Biotech Histochem. 2023 Oct 2:1-13. doi: 10.1080/10520295.2023.2262390. Online ahead of print.ABSTRACTCanagliflozin (CZ) is commonly prescribed for management of type-2 diabetes mellitus (T2DM); it also can reduce the risk of myocardial infarction. We used 80 albino Wistar rats to investigate the cardioprotective potential of CZ against oxidative stress caused by administration of isoprenaline (ISO). We found that ISO stimulates production of reactive oxygen species and that CZ administration caused up-regulation of antioxidants and down-regulation of oxidants due to nuclear factor erythroid-2 related factor-2, as well as ...
Source: Biotechnic and Histochemistry - October 2, 2023 Category: Research Authors: Ahmed Ahmed Dina Abdel-Rahman Ehab M Hantash Source Type: research
Disulfiram ameliorates bleomycin induced pulmonary inflammation and fibrosis in rats
Biotech Histochem. 2023 Oct 2:1-9. doi: 10.1080/10520295.2023.2261367. Online ahead of print.ABSTRACTBleomycin (BL) is a widely used anticancer drug that can cause pulmonary fibrosis due to increased fibroblast proliferation and increased secretion of extracellular matrix. RASSF1A is a tumor suppressor gene that is down-regulated by DNA methylation during fibrosis. Disulfiram (DSF), a noncytosine DNA methyltransferase inhibitor, can revert epigenetic biomarkers and re-express silenced genes. We investigated anti-inflammatory and anti-fibrotic effects of DSF on regulation of epigenetic molecules and histopathology in a rat ...
Source: Biotechnic and Histochemistry - October 2, 2023 Category: Research Authors: Negar Hamidi Farideh Feizi Abbas Azadmehr Ebrahim Zabihi Soraya Khafri Zeinab Zarei-Behjani Zahra Babazadeh Source Type: research
Selenium protection from DNA damage and regulation of apoptosis signaling following cyclophosphamide induced cardiotoxicity in rats
Biotech Histochem. 2023 Nov;98(7):534-542. doi: 10.1080/10520295.2023.2253424. Epub 2023 Sep 11.ABSTRACTWe investigated the mechanism of the cardioprotective effect of selenium (Se) against cyclophosphamide (CPA) induced cardiotoxicity in rats. We divided 24 female Wistar albino rats into four groups. The control group was injected intraperitoneally (i.p.) with normal saline. The CPA group was injected i.p. with 200 mg/kg CPA. The Se group was injected i.p. with 1 mg/kg Se. The CPA + Se group was injected i.p. with 200 mg/kg CPA and 1 mg/kg Se. Rats were euthanized 24 h after injection and heart tissues were harvested. His...
Source: Biotechnic and Histochemistry - September 11, 2023 Category: Research Authors: Emrah İpek Mehmet Hesap çıoğlu Mehmet Karabo ğa Hamdi Avc ı Source Type: research
Selenium protection from DNA damage and regulation of apoptosis signaling following cyclophosphamide induced cardiotoxicity in rats
Biotech Histochem. 2023 Nov;98(7):534-542. doi: 10.1080/10520295.2023.2253424. Epub 2023 Sep 11.ABSTRACTWe investigated the mechanism of the cardioprotective effect of selenium (Se) against cyclophosphamide (CPA) induced cardiotoxicity in rats. We divided 24 female Wistar albino rats into four groups. The control group was injected intraperitoneally (i.p.) with normal saline. The CPA group was injected i.p. with 200 mg/kg CPA. The Se group was injected i.p. with 1 mg/kg Se. The CPA + Se group was injected i.p. with 200 mg/kg CPA and 1 mg/kg Se. Rats were euthanized 24 h after injection and heart tissues were harvested. His...
Source: Biotechnic and Histochemistry - September 11, 2023 Category: Research Authors: Emrah İpek Mehmet Hesap çıoğlu Mehmet Karabo ğa Hamdi Avc ı Source Type: research
Selenium protection from DNA damage and regulation of apoptosis signaling following cyclophosphamide induced cardiotoxicity in rats
Biotech Histochem. 2023 Nov;98(7):534-542. doi: 10.1080/10520295.2023.2253424. Epub 2023 Sep 11.ABSTRACTWe investigated the mechanism of the cardioprotective effect of selenium (Se) against cyclophosphamide (CPA) induced cardiotoxicity in rats. We divided 24 female Wistar albino rats into four groups. The control group was injected intraperitoneally (i.p.) with normal saline. The CPA group was injected i.p. with 200 mg/kg CPA. The Se group was injected i.p. with 1 mg/kg Se. The CPA + Se group was injected i.p. with 200 mg/kg CPA and 1 mg/kg Se. Rats were euthanized 24 h after injection and heart tissues were harvested. His...
Source: Biotechnic and Histochemistry - September 11, 2023 Category: Research Authors: Emrah İpek Mehmet Hesap çıoğlu Mehmet Karabo ğa Hamdi Avc ı Source Type: research
Selenium protection from DNA damage and regulation of apoptosis signaling following cyclophosphamide induced cardiotoxicity in rats
Biotech Histochem. 2023 Nov;98(7):534-542. doi: 10.1080/10520295.2023.2253424. Epub 2023 Sep 11.ABSTRACTWe investigated the mechanism of the cardioprotective effect of selenium (Se) against cyclophosphamide (CPA) induced cardiotoxicity in rats. We divided 24 female Wistar albino rats into four groups. The control group was injected intraperitoneally (i.p.) with normal saline. The CPA group was injected i.p. with 200 mg/kg CPA. The Se group was injected i.p. with 1 mg/kg Se. The CPA + Se group was injected i.p. with 200 mg/kg CPA and 1 mg/kg Se. Rats were euthanized 24 h after injection and heart tissues were harvested. His...
Source: Biotechnic and Histochemistry - September 11, 2023 Category: Research Authors: Emrah İpek Mehmet Hesap çıoğlu Mehmet Karabo ğa Hamdi Avc ı Source Type: research
