Effects of PKC ε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo
Biotech Histochem. 2023 Jul 28:1-7. doi: 10.1080/10520295.2023.2240226. Online ahead of print.ABSTRACTGlioma is the most common type of primary brain tumor; it exhibits great invasive capacity, morbidity and mortality. Protein kinase Cε (PKCε), a serine/threonine kinase, contributes to the development and progression of many cancers. We investigated whether knockdown of PKCε could affect the mitochondrial membrane potential of human glioma cell lines, U251 and U87, and the growth of U251 cell-derived tumors in nude mice. We found that the expression of PKCε was greater in human glioma tissues than in human normal brain...
Source: Biotechnic and Histochemistry - July 28, 2023 Category: Research Authors: Yaming Xu Jie Tao Yafei Hou Shuzhang Zhang Source Type: research
Effects of PKC ε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo
Biotech Histochem. 2023 Jul 28:1-7. doi: 10.1080/10520295.2023.2240226. Online ahead of print.ABSTRACTGlioma is the most common type of primary brain tumor; it exhibits great invasive capacity, morbidity and mortality. Protein kinase Cε (PKCε), a serine/threonine kinase, contributes to the development and progression of many cancers. We investigated whether knockdown of PKCε could affect the mitochondrial membrane potential of human glioma cell lines, U251 and U87, and the growth of U251 cell-derived tumors in nude mice. We found that the expression of PKCε was greater in human glioma tissues than in human normal brain...
Source: Biotechnic and Histochemistry - July 28, 2023 Category: Research Authors: Yaming Xu Jie Tao Yafei Hou Shuzhang Zhang Source Type: research
Effects of PKC ε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo
Biotech Histochem. 2023 Jul 28:1-7. doi: 10.1080/10520295.2023.2240226. Online ahead of print.ABSTRACTGlioma is the most common type of primary brain tumor; it exhibits great invasive capacity, morbidity and mortality. Protein kinase Cε (PKCε), a serine/threonine kinase, contributes to the development and progression of many cancers. We investigated whether knockdown of PKCε could affect the mitochondrial membrane potential of human glioma cell lines, U251 and U87, and the growth of U251 cell-derived tumors in nude mice. We found that the expression of PKCε was greater in human glioma tissues than in human normal brain...
Source: Biotechnic and Histochemistry - July 28, 2023 Category: Research Authors: Yaming Xu Jie Tao Yafei Hou Shuzhang Zhang Source Type: research
Effects of PKC ε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo
Biotech Histochem. 2023 Jul 28:1-7. doi: 10.1080/10520295.2023.2240226. Online ahead of print.ABSTRACTGlioma is the most common type of primary brain tumor; it exhibits great invasive capacity, morbidity and mortality. Protein kinase Cε (PKCε), a serine/threonine kinase, contributes to the development and progression of many cancers. We investigated whether knockdown of PKCε could affect the mitochondrial membrane potential of human glioma cell lines, U251 and U87, and the growth of U251 cell-derived tumors in nude mice. We found that the expression of PKCε was greater in human glioma tissues than in human normal brain...
Source: Biotechnic and Histochemistry - July 28, 2023 Category: Research Authors: Yaming Xu Jie Tao Yafei Hou Shuzhang Zhang Source Type: research
Effects of PKC ε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo
Biotech Histochem. 2023 Jul 28:1-7. doi: 10.1080/10520295.2023.2240226. Online ahead of print.ABSTRACTGlioma is the most common type of primary brain tumor; it exhibits great invasive capacity, morbidity and mortality. Protein kinase Cε (PKCε), a serine/threonine kinase, contributes to the development and progression of many cancers. We investigated whether knockdown of PKCε could affect the mitochondrial membrane potential of human glioma cell lines, U251 and U87, and the growth of U251 cell-derived tumors in nude mice. We found that the expression of PKCε was greater in human glioma tissues than in human normal brain...
Source: Biotechnic and Histochemistry - July 28, 2023 Category: Research Authors: Yaming Xu Jie Tao Yafei Hou Shuzhang Zhang Source Type: research
Effects of PKC ε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo
Biotech Histochem. 2023 Jul 28:1-7. doi: 10.1080/10520295.2023.2240226. Online ahead of print.ABSTRACTGlioma is the most common type of primary brain tumor; it exhibits great invasive capacity, morbidity and mortality. Protein kinase Cε (PKCε), a serine/threonine kinase, contributes to the development and progression of many cancers. We investigated whether knockdown of PKCε could affect the mitochondrial membrane potential of human glioma cell lines, U251 and U87, and the growth of U251 cell-derived tumors in nude mice. We found that the expression of PKCε was greater in human glioma tissues than in human normal brain...
Source: Biotechnic and Histochemistry - July 28, 2023 Category: Research Authors: Yaming Xu Jie Tao Yafei Hou Shuzhang Zhang Source Type: research
Effects of PKC ε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo
Biotech Histochem. 2023 Jul 28:1-7. doi: 10.1080/10520295.2023.2240226. Online ahead of print.ABSTRACTGlioma is the most common type of primary brain tumor; it exhibits great invasive capacity, morbidity and mortality. Protein kinase Cε (PKCε), a serine/threonine kinase, contributes to the development and progression of many cancers. We investigated whether knockdown of PKCε could affect the mitochondrial membrane potential of human glioma cell lines, U251 and U87, and the growth of U251 cell-derived tumors in nude mice. We found that the expression of PKCε was greater in human glioma tissues than in human normal brain...
Source: Biotechnic and Histochemistry - July 28, 2023 Category: Research Authors: Yaming Xu Jie Tao Yafei Hou Shuzhang Zhang Source Type: research
Effects of PKC ε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo
Biotech Histochem. 2023 Jul 28:1-7. doi: 10.1080/10520295.2023.2240226. Online ahead of print.ABSTRACTGlioma is the most common type of primary brain tumor; it exhibits great invasive capacity, morbidity and mortality. Protein kinase Cε (PKCε), a serine/threonine kinase, contributes to the development and progression of many cancers. We investigated whether knockdown of PKCε could affect the mitochondrial membrane potential of human glioma cell lines, U251 and U87, and the growth of U251 cell-derived tumors in nude mice. We found that the expression of PKCε was greater in human glioma tissues than in human normal brain...
Source: Biotechnic and Histochemistry - July 28, 2023 Category: Research Authors: Yaming Xu Jie Tao Yafei Hou Shuzhang Zhang Source Type: research
Effects of PKC ε knockdown on mitochondrial membrane potential of human glioma cells in vitro and growth of U251 cell-derived tumors in vivo
Biotech Histochem. 2023 Jul 28:1-7. doi: 10.1080/10520295.2023.2240226. Online ahead of print.ABSTRACTGlioma is the most common type of primary brain tumor; it exhibits great invasive capacity, morbidity and mortality. Protein kinase Cε (PKCε), a serine/threonine kinase, contributes to the development and progression of many cancers. We investigated whether knockdown of PKCε could affect the mitochondrial membrane potential of human glioma cell lines, U251 and U87, and the growth of U251 cell-derived tumors in nude mice. We found that the expression of PKCε was greater in human glioma tissues than in human normal brain...
Source: Biotechnic and Histochemistry - July 28, 2023 Category: Research Authors: Yaming Xu Jie Tao Yafei Hou Shuzhang Zhang Source Type: research
Influence of type 2 diabetes on immunohistochemical detection of TRAF6, cFos and NFATC1 in the gingiva in cases of chronic periodontitis
Biotech Histochem. 2023 Jul 24:1-9. doi: 10.1080/10520295.2023.2236543. Online ahead of print.ABSTRACTType 2 diabetes (T2D) and chronic periodontitis (CP) are common diseases worldwide. Although T2D increases the severity of CP and alveolar bone loss, the mechanism of this is not well understood. We investigated using immunohistochemistry the expression of three osteoclast proteins, TRAF6, cFos and NFATc1, in gingival tissues. Gingival tissues were obtained from three groups: HC group, healthy controls; CP group, patients with CP; T2D + CP group, patients with both T2D and CP. Strong immunostaining for TRAF6, cFos and NFAT...
Source: Biotechnic and Histochemistry - July 24, 2023 Category: Research Authors: R Mathangi Vidyarani Shyamsundar A Meenakshi N Aravindha Babu Yaongamphi Vashum S Shila Source Type: research
Influence of type 2 diabetes on immunohistochemical detection of TRAF6, cFos and NFATC1 in the gingiva in cases of chronic periodontitis
Biotech Histochem. 2023 Jul 24:1-9. doi: 10.1080/10520295.2023.2236543. Online ahead of print.ABSTRACTType 2 diabetes (T2D) and chronic periodontitis (CP) are common diseases worldwide. Although T2D increases the severity of CP and alveolar bone loss, the mechanism of this is not well understood. We investigated using immunohistochemistry the expression of three osteoclast proteins, TRAF6, cFos and NFATc1, in gingival tissues. Gingival tissues were obtained from three groups: HC group, healthy controls; CP group, patients with CP; T2D + CP group, patients with both T2D and CP. Strong immunostaining for TRAF6, cFos and NFAT...
Source: Biotechnic and Histochemistry - July 24, 2023 Category: Research Authors: R Mathangi Vidyarani Shyamsundar A Meenakshi N Aravindha Babu Yaongamphi Vashum S Shila Source Type: research
Influence of type 2 diabetes on immunohistochemical detection of TRAF6, cFos and NFATC1 in the gingiva in cases of chronic periodontitis
Biotech Histochem. 2023 Jul 24:1-9. doi: 10.1080/10520295.2023.2236543. Online ahead of print.ABSTRACTType 2 diabetes (T2D) and chronic periodontitis (CP) are common diseases worldwide. Although T2D increases the severity of CP and alveolar bone loss, the mechanism of this is not well understood. We investigated using immunohistochemistry the expression of three osteoclast proteins, TRAF6, cFos and NFATc1, in gingival tissues. Gingival tissues were obtained from three groups: HC group, healthy controls; CP group, patients with CP; T2D + CP group, patients with both T2D and CP. Strong immunostaining for TRAF6, cFos and NFAT...
Source: Biotechnic and Histochemistry - July 24, 2023 Category: Research Authors: R Mathangi Vidyarani Shyamsundar A Meenakshi N Aravindha Babu Yaongamphi Vashum S Shila Source Type: research
Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats
Biotech Histochem. 2023 Jul 19:1-13. doi: 10.1080/10520295.2023.2233417. Online ahead of print.ABSTRACTCitalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected in...
Source: Biotechnic and Histochemistry - July 19, 2023 Category: Research Authors: Gozde Akturk Serap Cilaker Micili Ozlem Gursoy Doruk Nil Hocaoglu Pinar Akan Bekir Ugur Ergur Samar Ahmed Sule Kalkan Source Type: research
Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats
Biotech Histochem. 2023 Jul 19:1-13. doi: 10.1080/10520295.2023.2233417. Online ahead of print.ABSTRACTCitalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected in...
Source: Biotechnic and Histochemistry - July 19, 2023 Category: Research Authors: Gozde Akturk Serap Cilaker Micili Ozlem Gursoy Doruk Nil Hocaoglu Pinar Akan Bekir Ugur Ergur Samar Ahmed Sule Kalkan Source Type: research
Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats
Biotech Histochem. 2023 Jul 19:1-13. doi: 10.1080/10520295.2023.2233417. Online ahead of print.ABSTRACTCitalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected in...
Source: Biotechnic and Histochemistry - July 19, 2023 Category: Research Authors: Gozde Akturk Serap Cilaker Micili Ozlem Gursoy Doruk Nil Hocaoglu Pinar Akan Bekir Ugur Ergur Samar Ahmed Sule Kalkan Source Type: research
