Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats
Biotech Histochem. 2023 Jul 19:1-13. doi: 10.1080/10520295.2023.2233417. Online ahead of print.ABSTRACTCitalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected in...
Source: Biotechnic and Histochemistry - July 19, 2023 Category: Research Authors: Gozde Akturk Serap Cilaker Micili Ozlem Gursoy Doruk Nil Hocaoglu Pinar Akan Bekir Ugur Ergur Samar Ahmed Sule Kalkan Source Type: research
Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats
Biotech Histochem. 2023 Jul 19:1-13. doi: 10.1080/10520295.2023.2233417. Online ahead of print.ABSTRACTCitalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected in...
Source: Biotechnic and Histochemistry - July 19, 2023 Category: Research Authors: Gozde Akturk Serap Cilaker Micili Ozlem Gursoy Doruk Nil Hocaoglu Pinar Akan Bekir Ugur Ergur Samar Ahmed Sule Kalkan Source Type: research
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Biotech Histochem. 2023 Nov;98(6):445. doi: 10.1080/10520295.2023.2184029. Epub 2023 Mar 1.NO ABSTRACTPMID:37461912 | DOI:10.1080/10520295.2023.2184029 (Source: Biotechnic and Histochemistry)
Source: Biotechnic and Histochemistry - July 18, 2023 Category: Research Source Type: research
An immunohistochemical study of the vasculature and stem cells and carbonic anhydrase IV in the ducts of irradiated and normal human submandibular salivary glands
Biotech Histochem. 2023 Nov;98(6):373-381. doi: 10.1080/10520295.2023.2229232. Epub 2023 Jul 7.ABSTRACTTherapeutic irradiation for cancers of the head and neck causes serious and irreversible damage to the salivary glands; the resulting adverse effects on salivary quality and quantity produce detrimental effects on teeth and oral mucosa. The salivary effects have been related mostly to loss of serous acini; damage to the ducts is relatively minor. Other radiation effects include fibrosis, adiposis and vascular damage. Stem cells in the salivary gland ducts have the potential to generate acinar cells in vitro and in vivo. I...
Source: Biotechnic and Histochemistry - July 7, 2023 Category: Research Authors: Robert S Redman Source Type: research
An immunohistochemical study of the vasculature and stem cells and carbonic anhydrase IV in the ducts of irradiated and normal human submandibular salivary glands
Biotech Histochem. 2023 Jul 7:1-9. doi: 10.1080/10520295.2023.2229232. Online ahead of print.ABSTRACTTherapeutic irradiation for cancers of the head and neck causes serious and irreversible damage to the salivary glands; the resulting adverse effects on salivary quality and quantity produce detrimental effects on teeth and oral mucosa. The salivary effects have been related mostly to loss of serous acini; damage to the ducts is relatively minor. Other radiation effects include fibrosis, adiposis and vascular damage. Stem cells in the salivary gland ducts have the potential to generate acinar cells in vitro and in vivo. I i...
Source: Biotechnic and Histochemistry - July 7, 2023 Category: Research Authors: Robert S Redman Source Type: research
An immunohistochemical study of the vasculature and stem cells and carbonic anhydrase IV in the ducts of irradiated and normal human submandibular salivary glands
Biotech Histochem. 2023 Jul 7:1-9. doi: 10.1080/10520295.2023.2229232. Online ahead of print.ABSTRACTTherapeutic irradiation for cancers of the head and neck causes serious and irreversible damage to the salivary glands; the resulting adverse effects on salivary quality and quantity produce detrimental effects on teeth and oral mucosa. The salivary effects have been related mostly to loss of serous acini; damage to the ducts is relatively minor. Other radiation effects include fibrosis, adiposis and vascular damage. Stem cells in the salivary gland ducts have the potential to generate acinar cells in vitro and in vivo. I i...
Source: Biotechnic and Histochemistry - July 7, 2023 Category: Research Authors: Robert S Redman Source Type: research
An immunohistochemical study of the vasculature and stem cells and carbonic anhydrase IV in the ducts of irradiated and normal human submandibular salivary glands
Biotech Histochem. 2023 Jul 7:1-9. doi: 10.1080/10520295.2023.2229232. Online ahead of print.ABSTRACTTherapeutic irradiation for cancers of the head and neck causes serious and irreversible damage to the salivary glands; the resulting adverse effects on salivary quality and quantity produce detrimental effects on teeth and oral mucosa. The salivary effects have been related mostly to loss of serous acini; damage to the ducts is relatively minor. Other radiation effects include fibrosis, adiposis and vascular damage. Stem cells in the salivary gland ducts have the potential to generate acinar cells in vitro and in vivo. I i...
Source: Biotechnic and Histochemistry - July 7, 2023 Category: Research Authors: Robert S Redman Source Type: research
An immunohistochemical study of the vasculature and stem cells and carbonic anhydrase IV in the ducts of irradiated and normal human submandibular salivary glands
Biotech Histochem. 2023 Jul 7:1-9. doi: 10.1080/10520295.2023.2229232. Online ahead of print.ABSTRACTTherapeutic irradiation for cancers of the head and neck causes serious and irreversible damage to the salivary glands; the resulting adverse effects on salivary quality and quantity produce detrimental effects on teeth and oral mucosa. The salivary effects have been related mostly to loss of serous acini; damage to the ducts is relatively minor. Other radiation effects include fibrosis, adiposis and vascular damage. Stem cells in the salivary gland ducts have the potential to generate acinar cells in vitro and in vivo. I i...
Source: Biotechnic and Histochemistry - July 7, 2023 Category: Research Authors: Robert S Redman Source Type: research
An immunohistochemical study of the vasculature and stem cells and carbonic anhydrase IV in the ducts of irradiated and normal human submandibular salivary glands
Biotech Histochem. 2023 Jul 7:1-9. doi: 10.1080/10520295.2023.2229232. Online ahead of print.ABSTRACTTherapeutic irradiation for cancers of the head and neck causes serious and irreversible damage to the salivary glands; the resulting adverse effects on salivary quality and quantity produce detrimental effects on teeth and oral mucosa. The salivary effects have been related mostly to loss of serous acini; damage to the ducts is relatively minor. Other radiation effects include fibrosis, adiposis and vascular damage. Stem cells in the salivary gland ducts have the potential to generate acinar cells in vitro and in vivo. I i...
Source: Biotechnic and Histochemistry - July 7, 2023 Category: Research Authors: Robert S Redman Source Type: research
An immunohistochemical study of the vasculature and stem cells and carbonic anhydrase IV in the ducts of irradiated and normal human submandibular salivary glands
Biotech Histochem. 2023 Jul 7:1-9. doi: 10.1080/10520295.2023.2229232. Online ahead of print.ABSTRACTTherapeutic irradiation for cancers of the head and neck causes serious and irreversible damage to the salivary glands; the resulting adverse effects on salivary quality and quantity produce detrimental effects on teeth and oral mucosa. The salivary effects have been related mostly to loss of serous acini; damage to the ducts is relatively minor. Other radiation effects include fibrosis, adiposis and vascular damage. Stem cells in the salivary gland ducts have the potential to generate acinar cells in vitro and in vivo. I i...
Source: Biotechnic and Histochemistry - July 7, 2023 Category: Research Authors: Robert S Redman Source Type: research
An immunohistochemical study of the vasculature and stem cells and carbonic anhydrase IV in the ducts of irradiated and normal human submandibular salivary glands
Biotech Histochem. 2023 Jul 7:1-9. doi: 10.1080/10520295.2023.2229232. Online ahead of print.ABSTRACTTherapeutic irradiation for cancers of the head and neck causes serious and irreversible damage to the salivary glands; the resulting adverse effects on salivary quality and quantity produce detrimental effects on teeth and oral mucosa. The salivary effects have been related mostly to loss of serous acini; damage to the ducts is relatively minor. Other radiation effects include fibrosis, adiposis and vascular damage. Stem cells in the salivary gland ducts have the potential to generate acinar cells in vitro and in vivo. I i...
Source: Biotechnic and Histochemistry - July 7, 2023 Category: Research Authors: Robert S Redman Source Type: research
Protective effect of < em > Arum maculatum < /em > against dextran sulfate sodium induced colitis in rats
Biotech Histochem. 2023 Jul 3:1-10. doi: 10.1080/10520295.2023.2225226. Online ahead of print.ABSTRACTUlcerative colitis (UC) is an inflammatory disease of the large intestine that is characterized by diarrhea, bloody stools, abdominal pain and mucosal ulceration. UC is treated with nonsteroidal anti-inflammatory drugs, corticosteroids or immunosuppressants, but long-term use of these drugs can cause adverse effects. Arum maculatum is used as a traditional treatment for digestive system disorders, but its use for treatment of UC has not been investigated rigorously. We investigated the possible protective effect of a metha...
Source: Biotechnic and Histochemistry - July 3, 2023 Category: Research Authors: G ülsüm Toparlı Doğan Remziye Aysun Kepek çi Nuray Bostanc ıeri Mehmet Tarak çıoğlu Source Type: research
Protective effect of < em > Arum maculatum < /em > against dextran sulfate sodium induced colitis in rats
Biotech Histochem. 2023 Jul 3:1-10. doi: 10.1080/10520295.2023.2225226. Online ahead of print.ABSTRACTUlcerative colitis (UC) is an inflammatory disease of the large intestine that is characterized by diarrhea, bloody stools, abdominal pain and mucosal ulceration. UC is treated with nonsteroidal anti-inflammatory drugs, corticosteroids or immunosuppressants, but long-term use of these drugs can cause adverse effects. Arum maculatum is used as a traditional treatment for digestive system disorders, but its use for treatment of UC has not been investigated rigorously. We investigated the possible protective effect of a metha...
Source: Biotechnic and Histochemistry - July 3, 2023 Category: Research Authors: G ülsüm Toparlı Doğan Remziye Aysun Kepek çi Nuray Bostanc ıeri Mehmet Tarak çıoğlu Source Type: research
Protective effect of < em > Arum maculatum < /em > against dextran sulfate sodium induced colitis in rats
Biotech Histochem. 2023 Jul 3:1-10. doi: 10.1080/10520295.2023.2225226. Online ahead of print.ABSTRACTUlcerative colitis (UC) is an inflammatory disease of the large intestine that is characterized by diarrhea, bloody stools, abdominal pain and mucosal ulceration. UC is treated with nonsteroidal anti-inflammatory drugs, corticosteroids or immunosuppressants, but long-term use of these drugs can cause adverse effects. Arum maculatum is used as a traditional treatment for digestive system disorders, but its use for treatment of UC has not been investigated rigorously. We investigated the possible protective effect of a metha...
Source: Biotechnic and Histochemistry - July 3, 2023 Category: Research Authors: G ülsüm Toparlı Doğan Remziye Aysun Kepek çi Nuray Bostanc ıeri Mehmet Tarak çıoğlu Source Type: research
Protective effect of < em > Arum maculatum < /em > against dextran sulfate sodium induced colitis in rats
Biotech Histochem. 2023 Jul 3:1-10. doi: 10.1080/10520295.2023.2225226. Online ahead of print.ABSTRACTUlcerative colitis (UC) is an inflammatory disease of the large intestine that is characterized by diarrhea, bloody stools, abdominal pain and mucosal ulceration. UC is treated with nonsteroidal anti-inflammatory drugs, corticosteroids or immunosuppressants, but long-term use of these drugs can cause adverse effects. Arum maculatum is used as a traditional treatment for digestive system disorders, but its use for treatment of UC has not been investigated rigorously. We investigated the possible protective effect of a metha...
Source: Biotechnic and Histochemistry - July 3, 2023 Category: Research Authors: G ülsüm Toparlı Doğan Remziye Aysun Kepek çi Nuray Bostanc ıeri Mehmet Tarak çıoğlu Source Type: research
