β-Glucan ameliorates cisplatin-induced oxidative and histological damage in kidney and liver of rats
Biotech Histochem. 2024 Feb;99(2):92-100. doi: 10.1080/10520295.2024.2320626. Epub 2024 Mar 6.ABSTRACTWe investigated the effects of β-glucan (βg) on kidney and liver damage caused by cisplatin (CP), an antineoplastic agent widely used to treat many types of cancer, in a rat model. The side effects of CP in many tissues and organs limit its usage. βg is a natural polysaccharide that is an effective free radical scavenger. A total of 28 rats were randomly divided into four groups. Group 1 was a non-intervention control, only feed and water were given. Group 2 was administered 7 mg/kg CP in a single dose. Group 3 was admi...
Source: Biotechnic and Histochemistry - March 6, 2024 Category: Research Authors: K ürşat Kaya O Ciftci N Basak Turkmen A Ta şlıdere C C G ül Source Type: research
Diazoxide attenuates DOX-induced cardiotoxicity in cultured rat myocytes
Biotech Histochem. 2024 Mar 5:1-12. doi: 10.1080/10520295.2024.2324368. Online ahead of print.ABSTRACTDoxorubicin (DOX)-induced cardiotoxicity is a well known clinical problem, and many investigations have been made of its possible amelioration. We have investigated whether diazoxide (DIA), an agonist at mitochondrial ATP-sensitive potassium channels (mitoKATP), could reverse DOX-induced apoptotic myocardial cell loss, in cultured rat cardiomyocytes. The role of certain proteins in this pathway was also studied. The rat cardiomyocyte cell line (H9c2) was treated with DOX, and also co-treated with DOX and DIA, for 24 h. Dis...
Source: Biotechnic and Histochemistry - March 5, 2024 Category: Research Authors: Celal Guven Eylem Taskin Özgül Aydın Salih Tun ç Kaya Yusuf Sevgiler Source Type: research
Diazoxide attenuates DOX-induced cardiotoxicity in cultured rat myocytes
Biotech Histochem. 2024 Mar 5:1-12. doi: 10.1080/10520295.2024.2324368. Online ahead of print.ABSTRACTDoxorubicin (DOX)-induced cardiotoxicity is a well known clinical problem, and many investigations have been made of its possible amelioration. We have investigated whether diazoxide (DIA), an agonist at mitochondrial ATP-sensitive potassium channels (mitoKATP), could reverse DOX-induced apoptotic myocardial cell loss, in cultured rat cardiomyocytes. The role of certain proteins in this pathway was also studied. The rat cardiomyocyte cell line (H9c2) was treated with DOX, and also co-treated with DOX and DIA, for 24 h. Dis...
Source: Biotechnic and Histochemistry - March 5, 2024 Category: Research Authors: Celal Guven Eylem Taskin Özgül Aydın Salih Tun ç Kaya Yusuf Sevgiler Source Type: research
Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are decreased in metastatic lesions in a murine breast carcinoma model
Biotech Histochem. 2024 Jan 31:1-8. doi: 10.1080/10520295.2024.2305114. Online ahead of print.ABSTRACTThree genes are associated with cerebral cavernous malformations (CCMs): CCM1, CCM2 and CCM3. These genes participate in microvascular angiogenesis, cell-to-cell junctions, migration and apoptosis. We evaluated the expression in vivo of CCM genes in primary tumors and metastastases in a murine model of metastatic breast carcinoma. We used cell lines obtained from metastasis of 4T1, 4TLM and 4THM breast cancer to liver and heart. These cells were injected into the mammary ridge of Balb/C female mice. After 27 days, the prim...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: Mansur Cici Sayra Dilmac Gunes Aytac Gamze Tanriover Source Type: research
Relation of Langerhans cell size to buccal carcinoma
Biotech Histochem. 2024 Jan 31:1-8. doi: 10.1080/10520295.2024.2305499. Online ahead of print.ABSTRACTOral cancer decreases quality of life despite timely medical management. The carcinogens in tobacco products and their role in tumorigenesis are well documented. Langerhans cells (LCs) are a subset of antigen-presenting cells (APCs) that monitor the tumor microenvironment and engulf carcinogens and foreign bodies. We investigated the distribution and size of LCs and their relation to the mode of tobacco consumption and clinical outcome in patients with buccal carcinoma. We recruited patients with oral cancer who were sched...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: John Kandam Kulathu Mathew Pranay Gaikwad Rajadoss M K Pandian Grace Rebekah Suganthy Rabi Source Type: research
Effects of an energy drink on myonectin in the liver, kidney and skeletal muscle of exercised rats
Biotech Histochem. 2024 Jan 31:1-7. doi: 10.1080/10520295.2024.2305113. Online ahead of print.ABSTRACTMyonectin is a hormone that is produced mainly by skeletal muscle. We investigated the effects of exercise and energy drink (ED) administration on myonectin expression in skeletal muscle, liver and kidney tissue in rats; myonectin is produced by all three tissues. We used 28 male albino rats in four groups: untreated control (C), exercise (E), energy drink (ED) and exercise + energy drink (E + ED). The E and E + ED groups were exercised using a treadmill for 4 weeks. We also administered 3.5 ml/kg/day ED during week 1, 7 m...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: Emsal Cagla Avcu Vedat Çınar Yavuz Yasul Taner Akbulut Zarife Pancar I Sa Aydemir Suna Aydin Mehmet Hanifi Yalcin Suleyman Aydin Source Type: research
Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are decreased in metastatic lesions in a murine breast carcinoma model
Biotech Histochem. 2024 Jan 31:1-8. doi: 10.1080/10520295.2024.2305114. Online ahead of print.ABSTRACTThree genes are associated with cerebral cavernous malformations (CCMs): CCM1, CCM2 and CCM3. These genes participate in microvascular angiogenesis, cell-to-cell junctions, migration and apoptosis. We evaluated the expression in vivo of CCM genes in primary tumors and metastastases in a murine model of metastatic breast carcinoma. We used cell lines obtained from metastasis of 4T1, 4TLM and 4THM breast cancer to liver and heart. These cells were injected into the mammary ridge of Balb/C female mice. After 27 days, the prim...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: Mansur Cici Sayra Dilmac Gunes Aytac Gamze Tanriover Source Type: research
Relation of Langerhans cell size to buccal carcinoma
Biotech Histochem. 2024 Jan 31:1-8. doi: 10.1080/10520295.2024.2305499. Online ahead of print.ABSTRACTOral cancer decreases quality of life despite timely medical management. The carcinogens in tobacco products and their role in tumorigenesis are well documented. Langerhans cells (LCs) are a subset of antigen-presenting cells (APCs) that monitor the tumor microenvironment and engulf carcinogens and foreign bodies. We investigated the distribution and size of LCs and their relation to the mode of tobacco consumption and clinical outcome in patients with buccal carcinoma. We recruited patients with oral cancer who were sched...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: John Kandam Kulathu Mathew Pranay Gaikwad Rajadoss M K Pandian Grace Rebekah Suganthy Rabi Source Type: research
Effects of an energy drink on myonectin in the liver, kidney and skeletal muscle of exercised rats
Biotech Histochem. 2024 Jan 31:1-7. doi: 10.1080/10520295.2024.2305113. Online ahead of print.ABSTRACTMyonectin is a hormone that is produced mainly by skeletal muscle. We investigated the effects of exercise and energy drink (ED) administration on myonectin expression in skeletal muscle, liver and kidney tissue in rats; myonectin is produced by all three tissues. We used 28 male albino rats in four groups: untreated control (C), exercise (E), energy drink (ED) and exercise + energy drink (E + ED). The E and E + ED groups were exercised using a treadmill for 4 weeks. We also administered 3.5 ml/kg/day ED during week 1, 7 m...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: Emsal Cagla Avcu Vedat Çınar Yavuz Yasul Taner Akbulut Zarife Pancar I Sa Aydemir Suna Aydin Mehmet Hanifi Yalcin Suleyman Aydin Source Type: research
Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are decreased in metastatic lesions in a murine breast carcinoma model
Biotech Histochem. 2024 Jan 31:1-8. doi: 10.1080/10520295.2024.2305114. Online ahead of print.ABSTRACTThree genes are associated with cerebral cavernous malformations (CCMs): CCM1, CCM2 and CCM3. These genes participate in microvascular angiogenesis, cell-to-cell junctions, migration and apoptosis. We evaluated the expression in vivo of CCM genes in primary tumors and metastastases in a murine model of metastatic breast carcinoma. We used cell lines obtained from metastasis of 4T1, 4TLM and 4THM breast cancer to liver and heart. These cells were injected into the mammary ridge of Balb/C female mice. After 27 days, the prim...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: Mansur Cici Sayra Dilmac Gunes Aytac Gamze Tanriover Source Type: research
Relation of Langerhans cell size to buccal carcinoma
Biotech Histochem. 2024 Jan 31:1-8. doi: 10.1080/10520295.2024.2305499. Online ahead of print.ABSTRACTOral cancer decreases quality of life despite timely medical management. The carcinogens in tobacco products and their role in tumorigenesis are well documented. Langerhans cells (LCs) are a subset of antigen-presenting cells (APCs) that monitor the tumor microenvironment and engulf carcinogens and foreign bodies. We investigated the distribution and size of LCs and their relation to the mode of tobacco consumption and clinical outcome in patients with buccal carcinoma. We recruited patients with oral cancer who were sched...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: John Kandam Kulathu Mathew Pranay Gaikwad Rajadoss M K Pandian Grace Rebekah Suganthy Rabi Source Type: research
Effects of an energy drink on myonectin in the liver, kidney and skeletal muscle of exercised rats
Biotech Histochem. 2024 Jan 31:1-7. doi: 10.1080/10520295.2024.2305113. Online ahead of print.ABSTRACTMyonectin is a hormone that is produced mainly by skeletal muscle. We investigated the effects of exercise and energy drink (ED) administration on myonectin expression in skeletal muscle, liver and kidney tissue in rats; myonectin is produced by all three tissues. We used 28 male albino rats in four groups: untreated control (C), exercise (E), energy drink (ED) and exercise + energy drink (E + ED). The E and E + ED groups were exercised using a treadmill for 4 weeks. We also administered 3.5 ml/kg/day ED during week 1, 7 m...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: Emsal Cagla Avcu Vedat Çınar Yavuz Yasul Taner Akbulut Zarife Pancar I Sa Aydemir Suna Aydin Mehmet Hanifi Yalcin Suleyman Aydin Source Type: research
Cerebral cavernous malformation proteins, CCM1, CCM2 and CCM3, are decreased in metastatic lesions in a murine breast carcinoma model
Biotech Histochem. 2024 Jan 31:1-8. doi: 10.1080/10520295.2024.2305114. Online ahead of print.ABSTRACTThree genes are associated with cerebral cavernous malformations (CCMs): CCM1, CCM2 and CCM3. These genes participate in microvascular angiogenesis, cell-to-cell junctions, migration and apoptosis. We evaluated the expression in vivo of CCM genes in primary tumors and metastastases in a murine model of metastatic breast carcinoma. We used cell lines obtained from metastasis of 4T1, 4TLM and 4THM breast cancer to liver and heart. These cells were injected into the mammary ridge of Balb/C female mice. After 27 days, the prim...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: Mansur Cici Sayra Dilmac Gunes Aytac Gamze Tanriover Source Type: research
Relation of Langerhans cell size to buccal carcinoma
Biotech Histochem. 2024 Jan 31:1-8. doi: 10.1080/10520295.2024.2305499. Online ahead of print.ABSTRACTOral cancer decreases quality of life despite timely medical management. The carcinogens in tobacco products and their role in tumorigenesis are well documented. Langerhans cells (LCs) are a subset of antigen-presenting cells (APCs) that monitor the tumor microenvironment and engulf carcinogens and foreign bodies. We investigated the distribution and size of LCs and their relation to the mode of tobacco consumption and clinical outcome in patients with buccal carcinoma. We recruited patients with oral cancer who were sched...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: John Kandam Kulathu Mathew Pranay Gaikwad Rajadoss M K Pandian Grace Rebekah Suganthy Rabi Source Type: research
Effects of an energy drink on myonectin in the liver, kidney and skeletal muscle of exercised rats
Biotech Histochem. 2024 Jan 31:1-7. doi: 10.1080/10520295.2024.2305113. Online ahead of print.ABSTRACTMyonectin is a hormone that is produced mainly by skeletal muscle. We investigated the effects of exercise and energy drink (ED) administration on myonectin expression in skeletal muscle, liver and kidney tissue in rats; myonectin is produced by all three tissues. We used 28 male albino rats in four groups: untreated control (C), exercise (E), energy drink (ED) and exercise + energy drink (E + ED). The E and E + ED groups were exercised using a treadmill for 4 weeks. We also administered 3.5 ml/kg/day ED during week 1, 7 m...
Source: Biotechnic and Histochemistry - January 31, 2024 Category: Research Authors: Emsal Cagla Avcu Vedat Çınar Yavuz Yasul Taner Akbulut Zarife Pancar I Sa Aydemir Suna Aydin Mehmet Hanifi Yalcin Suleyman Aydin Source Type: research
