Immunohistochemical evaluation of hormones secreted by pancreatic endocrine tumors

Biotech Histochem. 2023 Oct 3:1-6. doi: 10.1080/10520295.2023.2260307. Online ahead of print.ABSTRACTThe endocrine component of the pancreas is located primarily in the islets of Langerhans, but is also found as single cells among the acinar cells and duct epithelium. It currently is thought that endocrine tumors of the pancreas (PETs) arise from pluripotent stem cells located within the ductal epithelium rather than from existing endocrine cells. Islet cell components include alpha, beta, PP, delta and epsilon cells, which secrete glucagon, insulin, pancreatic polypeptide, somatostatin and ghrelin, respectively. We investigated immunohistochemical labeling of 24 formalin fixed paraffin embedded PETs to identify which hormones were produced most frequently. Glucagon was the most frequently secreted hormone (83%) in PETS followed by insulin, ghrelin, pancreatic polypeptide and somatostatin.PMID:37787578 | DOI:10.1080/10520295.2023.2260307
Source: Biotechnic and Histochemistry - Category: Research Authors: Source Type: research