Some remarks on the biological application of gold(III) complexes
Biometals. 2023 Oct 19. doi: 10.1007/s10534-023-00545-2. Online ahead of print.ABSTRACTGold(III) complexes are widely studied as antitumor agents and show good results. The interaction with biologically active thiols (thiomalate, cysteine, glutathione (GSH) and human serum albumin) of a number of gold(III) complexes with N-containing polydentate ligands in aqueous solution with pH 7.4 and 0.2 M NaCl was studied. Complexes with 1,10-phenanthroline and 2,2'-bipyridyl, Au(phen)(OH)2+ and Au(bipy)(OH)2+, react fast with an excess of any of these thiols and in less than a few seconds transform into gold(I) bis-thiolate complexe...
Source: Biometals - October 19, 2023 Category: Biochemistry Authors: Igor V Mironov Viktoria Yu Kharlamova Eugenia V Makotchenko Source Type: research
Buffer-free CAS assay using a diluted growth medium efficiently detects siderophore production and microbial growth
Biometals. 2023 Oct 17. doi: 10.1007/s10534-023-00544-3. Online ahead of print.ABSTRACTSiderophores are iron chelators and low-molecular-weight compounds secreted by various microorganisms under low-iron conditions. Many microorganisms produce siderophores in the natural environment as iron is an essential element for many of them. CAS assays are widely used to detect siderophores in cultures of various microorganisms; however, it is necessary to improve their sensitivity for the efficient application to fastidious microorganisms. We developed a simple, high-throughput CAS assay employing a buffer-free CAS reagent and dilu...
Source: Biometals - October 17, 2023 Category: Biochemistry Authors: Chiho Murakami Arowu R Tanaka Yuichiro Sato Kinjiro Morimoto Source Type: research
Buffer-free CAS assay using a diluted growth medium efficiently detects siderophore production and microbial growth
Biometals. 2023 Oct 17. doi: 10.1007/s10534-023-00544-3. Online ahead of print.ABSTRACTSiderophores are iron chelators and low-molecular-weight compounds secreted by various microorganisms under low-iron conditions. Many microorganisms produce siderophores in the natural environment as iron is an essential element for many of them. CAS assays are widely used to detect siderophores in cultures of various microorganisms; however, it is necessary to improve their sensitivity for the efficient application to fastidious microorganisms. We developed a simple, high-throughput CAS assay employing a buffer-free CAS reagent and dilu...
Source: Biometals - October 17, 2023 Category: Biochemistry Authors: Chiho Murakami Arowu R Tanaka Yuichiro Sato Kinjiro Morimoto Source Type: research
Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset
Biometals. 2023 Oct 10. doi: 10.1007/s10534-023-00537-2. Online ahead of print.ABSTRACTThe quantification of arsenic, mercury, cadmium and lead in the human bloodstream is routinely used today to assess exposure to these toxic metal(loid)s, but the interpretation of the obtained data in terms of their cumulative health relevance remains problematic. Seemingly unrelated to this, epidemiological studies strongly suggest that the simultaneous chronic exposure to these environmental pollutants is associated with the etiology of autism, type 2 diabetes, irritable bowel disease and other diseases. This from a public health point...
Source: Biometals - October 10, 2023 Category: Biochemistry Authors: Maryam Doroudian Negar Pourzadi Astha Gautam J ürgen Gailer Source Type: research
Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset
Biometals. 2023 Oct 10. doi: 10.1007/s10534-023-00537-2. Online ahead of print.ABSTRACTThe quantification of arsenic, mercury, cadmium and lead in the human bloodstream is routinely used today to assess exposure to these toxic metal(loid)s, but the interpretation of the obtained data in terms of their cumulative health relevance remains problematic. Seemingly unrelated to this, epidemiological studies strongly suggest that the simultaneous chronic exposure to these environmental pollutants is associated with the etiology of autism, type 2 diabetes, irritable bowel disease and other diseases. This from a public health point...
Source: Biometals - October 10, 2023 Category: Biochemistry Authors: Maryam Doroudian Negar Pourzadi Astha Gautam J ürgen Gailer Source Type: research
Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset
Biometals. 2023 Oct 10. doi: 10.1007/s10534-023-00537-2. Online ahead of print.ABSTRACTThe quantification of arsenic, mercury, cadmium and lead in the human bloodstream is routinely used today to assess exposure to these toxic metal(loid)s, but the interpretation of the obtained data in terms of their cumulative health relevance remains problematic. Seemingly unrelated to this, epidemiological studies strongly suggest that the simultaneous chronic exposure to these environmental pollutants is associated with the etiology of autism, type 2 diabetes, irritable bowel disease and other diseases. This from a public health point...
Source: Biometals - October 10, 2023 Category: Biochemistry Authors: Maryam Doroudian Negar Pourzadi Astha Gautam J ürgen Gailer Source Type: research
Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset
Biometals. 2023 Oct 10. doi: 10.1007/s10534-023-00537-2. Online ahead of print.ABSTRACTThe quantification of arsenic, mercury, cadmium and lead in the human bloodstream is routinely used today to assess exposure to these toxic metal(loid)s, but the interpretation of the obtained data in terms of their cumulative health relevance remains problematic. Seemingly unrelated to this, epidemiological studies strongly suggest that the simultaneous chronic exposure to these environmental pollutants is associated with the etiology of autism, type 2 diabetes, irritable bowel disease and other diseases. This from a public health point...
Source: Biometals - October 10, 2023 Category: Biochemistry Authors: Maryam Doroudian Negar Pourzadi Astha Gautam J ürgen Gailer Source Type: research
Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset
Biometals. 2023 Oct 10. doi: 10.1007/s10534-023-00537-2. Online ahead of print.ABSTRACTThe quantification of arsenic, mercury, cadmium and lead in the human bloodstream is routinely used today to assess exposure to these toxic metal(loid)s, but the interpretation of the obtained data in terms of their cumulative health relevance remains problematic. Seemingly unrelated to this, epidemiological studies strongly suggest that the simultaneous chronic exposure to these environmental pollutants is associated with the etiology of autism, type 2 diabetes, irritable bowel disease and other diseases. This from a public health point...
Source: Biometals - October 10, 2023 Category: Biochemistry Authors: Maryam Doroudian Negar Pourzadi Astha Gautam J ürgen Gailer Source Type: research
Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset
Biometals. 2023 Oct 10. doi: 10.1007/s10534-023-00537-2. Online ahead of print.ABSTRACTThe quantification of arsenic, mercury, cadmium and lead in the human bloodstream is routinely used today to assess exposure to these toxic metal(loid)s, but the interpretation of the obtained data in terms of their cumulative health relevance remains problematic. Seemingly unrelated to this, epidemiological studies strongly suggest that the simultaneous chronic exposure to these environmental pollutants is associated with the etiology of autism, type 2 diabetes, irritable bowel disease and other diseases. This from a public health point...
Source: Biometals - October 10, 2023 Category: Biochemistry Authors: Maryam Doroudian Negar Pourzadi Astha Gautam J ürgen Gailer Source Type: research
Translational toxicology of metal(loid) species: linking their bioinorganic chemistry in the bloodstream to organ damage onset
Biometals. 2023 Oct 10. doi: 10.1007/s10534-023-00537-2. Online ahead of print.ABSTRACTThe quantification of arsenic, mercury, cadmium and lead in the human bloodstream is routinely used today to assess exposure to these toxic metal(loid)s, but the interpretation of the obtained data in terms of their cumulative health relevance remains problematic. Seemingly unrelated to this, epidemiological studies strongly suggest that the simultaneous chronic exposure to these environmental pollutants is associated with the etiology of autism, type 2 diabetes, irritable bowel disease and other diseases. This from a public health point...
Source: Biometals - October 10, 2023 Category: Biochemistry Authors: Maryam Doroudian Negar Pourzadi Astha Gautam J ürgen Gailer Source Type: research
Nitric oxide and AMF-mediated regulation of soil enzymes activities, cysteine-H < sub > 2 < /sub > S system and thiol metabolites in mitigating chromium (Cr (VI)) toxicity in pigeonpea genotypes
Biometals. 2023 Oct 4. doi: 10.1007/s10534-023-00540-7. Online ahead of print.ABSTRACTCr (VI) hampers plant growth and yield by reducing essential nutrient uptake as it competes for phosphate and sulfate transporters. Nitric oxide (NO) and mycorrhization play important roles in mitigating Cr (VI) toxicity. Present study aimed to compare the potential of AMF (Arbuscular mycorrhizal fungi)-Rhizoglomus intraradices and NO (0.25 mM) in alleviating Cr (VI) stress (0, 10 and 20 mg/kg) in two differentially tolerant pigeonpea genotypes (Pusa 2001 and AL 201). Cr (VI) toxicity reduced growth, mycorrhizal colonization, nutrient upt...
Source: Biometals - October 4, 2023 Category: Biochemistry Authors: Vaishali Sharma Neera Garg Source Type: research
Antibacterial effects of quercetagetin are significantly enhanced upon conjugation with chitosan engineered copper oxide nanoparticles
In this study, Chitosan copper oxide nanoparticles (CHI-CuO) were synthesized and were further loaded with Quercetagetin (QTG) to achieve the desired (CHI-CuO-QTG). Size distribution, zeta potential and morphological analysis were accomplished. Next, the developed CHI-CuO-QTG was assessed for synergistic antibacterial properties, as well as cytotoxic attributes. Bactericidal assays revealed that CHI-CuO conjugation showed remarkable effects and enhanced QTG effects against a range of Gram + ve and Gram - ve bacteria. The MIC50 of QTG against S. pyogenes was 107 µg/mL while CHI-CuO-QTG reduced it to 9 µg/mL. Similar resul...
Source: Biometals - October 4, 2023 Category: Biochemistry Authors: Adeelah Alvi Saif Alqassim Naveed Ahmed Khan Bushra Khatoon Noor Akbar Muhammad Kawish Shaheen Faizi Muhammad Raza Shah Ahmad M Alharbi Hasan Alfahemi Ruqaiyyah Siddiqui Source Type: research
Effect of exposures to multiple metals on blood pressure and hypertension in the elderly: a community-based study
According to this study, Pb and Cd were correlated with BP and HTN positively, and there was a certain joint effect. To some extent, our findings provide clues for the prevention of hypertension in the elderly.PMID:37792258 | DOI:10.1007/s10534-023-00543-4 (Source: Biometals)
Source: Biometals - October 4, 2023 Category: Biochemistry Authors: Wen-Lei Hu Wei Xiao Wen-Bin Shen Yue-Yang Wu Xue Li Qi Zhong Guo-Ao Li Huan-Huan Lu Jian-Jun Liu Zhi-Hua Zhang Fen Huang Source Type: research
Nitric oxide and AMF-mediated regulation of soil enzymes activities, cysteine-H < sub > 2 < /sub > S system and thiol metabolites in mitigating chromium (Cr (VI)) toxicity in pigeonpea genotypes
Biometals. 2023 Oct 4. doi: 10.1007/s10534-023-00540-7. Online ahead of print.ABSTRACTCr (VI) hampers plant growth and yield by reducing essential nutrient uptake as it competes for phosphate and sulfate transporters. Nitric oxide (NO) and mycorrhization play important roles in mitigating Cr (VI) toxicity. Present study aimed to compare the potential of AMF (Arbuscular mycorrhizal fungi)-Rhizoglomus intraradices and NO (0.25 mM) in alleviating Cr (VI) stress (0, 10 and 20 mg/kg) in two differentially tolerant pigeonpea genotypes (Pusa 2001 and AL 201). Cr (VI) toxicity reduced growth, mycorrhizal colonization, nutrient upt...
Source: Biometals - October 4, 2023 Category: Biochemistry Authors: Vaishali Sharma Neera Garg Source Type: research
Antibacterial effects of quercetagetin are significantly enhanced upon conjugation with chitosan engineered copper oxide nanoparticles
In this study, Chitosan copper oxide nanoparticles (CHI-CuO) were synthesized and were further loaded with Quercetagetin (QTG) to achieve the desired (CHI-CuO-QTG). Size distribution, zeta potential and morphological analysis were accomplished. Next, the developed CHI-CuO-QTG was assessed for synergistic antibacterial properties, as well as cytotoxic attributes. Bactericidal assays revealed that CHI-CuO conjugation showed remarkable effects and enhanced QTG effects against a range of Gram + ve and Gram - ve bacteria. The MIC50 of QTG against S. pyogenes was 107 µg/mL while CHI-CuO-QTG reduced it to 9 µg/mL. Similar resul...
Source: Biometals - October 4, 2023 Category: Biochemistry Authors: Adeelah Alvi Saif Alqassim Naveed Ahmed Khan Bushra Khatoon Noor Akbar Muhammad Kawish Shaheen Faizi Muhammad Raza Shah Ahmad M Alharbi Hasan Alfahemi Ruqaiyyah Siddiqui Source Type: research
