Long-term Cu exposure alters CYP450s activity and induces jejunum injury and apoptosis in broilers
Biometals. 2023 Nov 22. doi: 10.1007/s10534-023-00559-w. Online ahead of print.ABSTRACTCopper (Cu) is an essential trace element that plays a crucial role in numerous physiopathological processes related to human and animal health. In the poultry industry, Cu is used to promote growth as a feed supplement, but excessive use can lead to toxicity on animals. Cytochrome P450 enzymes (CYP450s) are a superfamily of proteins that require heme as a cofactor and are essential for the metabolism of xenobiotic compounds. The purpose of this study was to explore the influence of exposure to Cu on CYP450s activity and apoptosis in the...
Source: Biometals - November 22, 2023 Category: Biochemistry Authors: Lei Li Gaolong Zhong Yuanxu Li Tingyu Li Yihui Huo Feiyang Ma Ying Li Hui Zhang Jiaqiang Pan Lianmei Hu Jianzhao Liao Zhaoxin Tang Source Type: research
Long-term Cu exposure alters CYP450s activity and induces jejunum injury and apoptosis in broilers
Biometals. 2023 Nov 22. doi: 10.1007/s10534-023-00559-w. Online ahead of print.ABSTRACTCopper (Cu) is an essential trace element that plays a crucial role in numerous physiopathological processes related to human and animal health. In the poultry industry, Cu is used to promote growth as a feed supplement, but excessive use can lead to toxicity on animals. Cytochrome P450 enzymes (CYP450s) are a superfamily of proteins that require heme as a cofactor and are essential for the metabolism of xenobiotic compounds. The purpose of this study was to explore the influence of exposure to Cu on CYP450s activity and apoptosis in the...
Source: Biometals - November 22, 2023 Category: Biochemistry Authors: Lei Li Gaolong Zhong Yuanxu Li Tingyu Li Yihui Huo Feiyang Ma Ying Li Hui Zhang Jiaqiang Pan Lianmei Hu Jianzhao Liao Zhaoxin Tang Source Type: research
Long-term Cu exposure alters CYP450s activity and induces jejunum injury and apoptosis in broilers
Biometals. 2023 Nov 22. doi: 10.1007/s10534-023-00559-w. Online ahead of print.ABSTRACTCopper (Cu) is an essential trace element that plays a crucial role in numerous physiopathological processes related to human and animal health. In the poultry industry, Cu is used to promote growth as a feed supplement, but excessive use can lead to toxicity on animals. Cytochrome P450 enzymes (CYP450s) are a superfamily of proteins that require heme as a cofactor and are essential for the metabolism of xenobiotic compounds. The purpose of this study was to explore the influence of exposure to Cu on CYP450s activity and apoptosis in the...
Source: Biometals - November 22, 2023 Category: Biochemistry Authors: Lei Li Gaolong Zhong Yuanxu Li Tingyu Li Yihui Huo Feiyang Ma Ying Li Hui Zhang Jiaqiang Pan Lianmei Hu Jianzhao Liao Zhaoxin Tang Source Type: research
Long-term Cu exposure alters CYP450s activity and induces jejunum injury and apoptosis in broilers
Biometals. 2023 Nov 22. doi: 10.1007/s10534-023-00559-w. Online ahead of print.ABSTRACTCopper (Cu) is an essential trace element that plays a crucial role in numerous physiopathological processes related to human and animal health. In the poultry industry, Cu is used to promote growth as a feed supplement, but excessive use can lead to toxicity on animals. Cytochrome P450 enzymes (CYP450s) are a superfamily of proteins that require heme as a cofactor and are essential for the metabolism of xenobiotic compounds. The purpose of this study was to explore the influence of exposure to Cu on CYP450s activity and apoptosis in the...
Source: Biometals - November 22, 2023 Category: Biochemistry Authors: Lei Li Gaolong Zhong Yuanxu Li Tingyu Li Yihui Huo Feiyang Ma Ying Li Hui Zhang Jiaqiang Pan Lianmei Hu Jianzhao Liao Zhaoxin Tang Source Type: research
Reductions in plasma and urine mercury concentrations following N,N'bis-(2-mercaptoethyl) isophthalamide (NBMI) therapy: a post hoc analysis of data from a randomized human clinical trial
This study supports the dose-dependent ability of NBMI therapy to significantly reduce mercury concentrations, particularly in the urine, in an acutely mercury exposed human population. NBMI therapy should be evaluated in other mercury exposed populations.PMID:37987955 | DOI:10.1007/s10534-023-00560-3 (Source: Biometals)
Source: Biometals - November 21, 2023 Category: Biochemistry Authors: David A Geier Mark R Geier Source Type: research
Cadmium and copper-induced metabolic and proteomic changes in the root tip during early maize growth
In this study, the metabolic adjustments performed by maize (Zea mays L.) seminal roots exposed to 25 µM Cd2+ or 25 µM Cu2+ at pre-emergence are compared, focusing on the proteomic changes after metal exposure. Root width was increased, and root length was decreased after 72 h of metal treatment. Both metals induced H2O2 accumulation and lipid peroxidation in the root tip. These changes were accompanied by increases in lipoxygenase activity and 4-hydroxy-2-nonenal content. NMR spectroscopy revealed that the abundance of 38 water-soluble metabolites was significantly modified by Cd and Cu exposure; this set of metabolites...
Source: Biometals - November 21, 2023 Category: Biochemistry Authors: Carolina Lucila Matayoshi Odalis Maholi Jim énez Guaman Marcos Leopoldo Esteso Micaela Pavoni Mart ín Arán Liliana Beatriz Pena Susana Mabel Gallego Source Type: research
Genomic insights into the adaptation of Acinetobacter johnsonii RB2-047 to the heavy metal-contaminated subsurface mine environment
Biometals. 2023 Nov 16. doi: 10.1007/s10534-023-00555-0. Online ahead of print.ABSTRACTThe subsurface mine environments characterized by high levels of toxic metals and low nutrient availability represent an extreme threat to bacterial persistence. In recent study, the genomic analysis of the Acinetobacter johnsonii strain RB2-047 isolated from the Rozália Gold Mine in Slovakia was performed. As expected, the studied isolate showed a high level of heavy metal tolerance (minimum inhibitory concentrations were 500 mg/L for copper and nickel, 1,500 mg/L for lead, and 250 mg/L for zinc). The RB2-047 strain also showed noticea...
Source: Biometals - November 16, 2023 Category: Biochemistry Authors: Ivana Timkov á Lenka Malini čová Lea Nos áľová Mariana Koles árová Zuzana Lorkov á Nikola Petrov á Peter Prista š Jana Kiskov á Source Type: research
Intestinal microbiota protects against methylmercury-induced neurotoxicity
Biometals. 2023 Nov 16. doi: 10.1007/s10534-023-00554-1. Online ahead of print.ABSTRACTMethylmercury (MeHg) remains a global public health issue because of its frequent presence in human food sources obtained from the water. The excretion of MeHg in humans occurs slowly with a biological half-time of 32-47 days. Short-term MeHg exposure may cause long-lasting neurotoxicity. The excretion through feces is a major route in the demethylation of MeHg. Accumulating evidence suggests that the intestinal microbiota plays an important role in the demethylation of MeHg, thereby protecting the host from neurotoxic effects. Here, we ...
Source: Biometals - November 16, 2023 Category: Biochemistry Authors: Tao Ke Andr é Rajoo Alexey A Tinkov Anatoly V Skalny Yousef Tizabi Joao B T Rocha Aaron B Bowman Michael Aschner Source Type: research
Genomic insights into the adaptation of Acinetobacter johnsonii RB2-047 to the heavy metal-contaminated subsurface mine environment
Biometals. 2023 Nov 16. doi: 10.1007/s10534-023-00555-0. Online ahead of print.ABSTRACTThe subsurface mine environments characterized by high levels of toxic metals and low nutrient availability represent an extreme threat to bacterial persistence. In recent study, the genomic analysis of the Acinetobacter johnsonii strain RB2-047 isolated from the Rozália Gold Mine in Slovakia was performed. As expected, the studied isolate showed a high level of heavy metal tolerance (minimum inhibitory concentrations were 500 mg/L for copper and nickel, 1,500 mg/L for lead, and 250 mg/L for zinc). The RB2-047 strain also showed noticea...
Source: Biometals - November 16, 2023 Category: Biochemistry Authors: Ivana Timkov á Lenka Malini čová Lea Nos áľová Mariana Koles árová Zuzana Lorkov á Nikola Petrov á Peter Prista š Jana Kiskov á Source Type: research
Intestinal microbiota protects against methylmercury-induced neurotoxicity
Biometals. 2023 Nov 16. doi: 10.1007/s10534-023-00554-1. Online ahead of print.ABSTRACTMethylmercury (MeHg) remains a global public health issue because of its frequent presence in human food sources obtained from the water. The excretion of MeHg in humans occurs slowly with a biological half-time of 32-47 days. Short-term MeHg exposure may cause long-lasting neurotoxicity. The excretion through feces is a major route in the demethylation of MeHg. Accumulating evidence suggests that the intestinal microbiota plays an important role in the demethylation of MeHg, thereby protecting the host from neurotoxic effects. Here, we ...
Source: Biometals - November 16, 2023 Category: Biochemistry Authors: Tao Ke Andr é Rajoo Alexey A Tinkov Anatoly V Skalny Yousef Tizabi Joao B T Rocha Aaron B Bowman Michael Aschner Source Type: research
Genomic insights into the adaptation of Acinetobacter johnsonii RB2-047 to the heavy metal-contaminated subsurface mine environment
Biometals. 2023 Nov 16. doi: 10.1007/s10534-023-00555-0. Online ahead of print.ABSTRACTThe subsurface mine environments characterized by high levels of toxic metals and low nutrient availability represent an extreme threat to bacterial persistence. In recent study, the genomic analysis of the Acinetobacter johnsonii strain RB2-047 isolated from the Rozália Gold Mine in Slovakia was performed. As expected, the studied isolate showed a high level of heavy metal tolerance (minimum inhibitory concentrations were 500 mg/L for copper and nickel, 1,500 mg/L for lead, and 250 mg/L for zinc). The RB2-047 strain also showed noticea...
Source: Biometals - November 16, 2023 Category: Biochemistry Authors: Ivana Timkov á Lenka Malini čová Lea Nos áľová Mariana Koles árová Zuzana Lorkov á Nikola Petrov á Peter Prista š Jana Kiskov á Source Type: research
Intestinal microbiota protects against methylmercury-induced neurotoxicity
Biometals. 2023 Nov 16. doi: 10.1007/s10534-023-00554-1. Online ahead of print.ABSTRACTMethylmercury (MeHg) remains a global public health issue because of its frequent presence in human food sources obtained from the water. The excretion of MeHg in humans occurs slowly with a biological half-time of 32-47 days. Short-term MeHg exposure may cause long-lasting neurotoxicity. The excretion through feces is a major route in the demethylation of MeHg. Accumulating evidence suggests that the intestinal microbiota plays an important role in the demethylation of MeHg, thereby protecting the host from neurotoxic effects. Here, we ...
Source: Biometals - November 16, 2023 Category: Biochemistry Authors: Tao Ke Andr é Rajoo Alexey A Tinkov Anatoly V Skalny Yousef Tizabi Joao B T Rocha Aaron B Bowman Michael Aschner Source Type: research
Novel vanadyl complexes synthesis, characterization and interactions with bovine serum albumin-effects on STZ- diabetes rats
Biometals. 2023 Nov 10. doi: 10.1007/s10534-023-00552-3. Online ahead of print.ABSTRACTDrug-protein interactions are essential since most administered drugs bind abundantly and reversibly to serum albumin and are delivered mainly as a complex with protein. The nature and strength of drug-protein interactions have a big impact on how a drug works biologically. The binding parameters are useful in studying the pharmacological response of drugs and the designing of dosage forms. Serum albumin is regarded as optimal model for in vitro research on drug-protein interaction since it is the main protein that binds medicines and ot...
Source: Biometals - November 9, 2023 Category: Biochemistry Authors: Ayub Shaik Vani Kondaparthy Alia Begum Ameena Husain Tejasree Chinnagalla Source Type: research
Novel vanadyl complexes synthesis, characterization and interactions with bovine serum albumin-effects on STZ- diabetes rats
Biometals. 2023 Nov 10. doi: 10.1007/s10534-023-00552-3. Online ahead of print.ABSTRACTDrug-protein interactions are essential since most administered drugs bind abundantly and reversibly to serum albumin and are delivered mainly as a complex with protein. The nature and strength of drug-protein interactions have a big impact on how a drug works biologically. The binding parameters are useful in studying the pharmacological response of drugs and the designing of dosage forms. Serum albumin is regarded as optimal model for in vitro research on drug-protein interaction since it is the main protein that binds medicines and ot...
Source: Biometals - November 9, 2023 Category: Biochemistry Authors: Ayub Shaik Vani Kondaparthy Alia Begum Ameena Husain Tejasree Chinnagalla Source Type: research
Novel vanadyl complexes synthesis, characterization and interactions with bovine serum albumin-effects on STZ- diabetes rats
Biometals. 2023 Nov 10. doi: 10.1007/s10534-023-00552-3. Online ahead of print.ABSTRACTDrug-protein interactions are essential since most administered drugs bind abundantly and reversibly to serum albumin and are delivered mainly as a complex with protein. The nature and strength of drug-protein interactions have a big impact on how a drug works biologically. The binding parameters are useful in studying the pharmacological response of drugs and the designing of dosage forms. Serum albumin is regarded as optimal model for in vitro research on drug-protein interaction since it is the main protein that binds medicines and ot...
Source: Biometals - November 9, 2023 Category: Biochemistry Authors: Ayub Shaik Vani Kondaparthy Alia Begum Ameena Husain Tejasree Chinnagalla Source Type: research
