Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
CONCLUSION: In this study, we established and validated reliable, highly sensitive, and accurate nucleic acid-based testing methods for a broad spectrum of canine pathogens.PMID:38097939 | PMC:PMC10720183 | DOI:10.1186/s12575-023-00226-x (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 15, 2023 Category: Molecular Biology Authors: Emese Pekker Katalin Priskin Éva Szabó-Kriston Bernadett Cs ányi Orsolya Buz ás-Bereczki Lili Adorj án Val éria Szukacsov Lajos Pint ér Mikl ós Rusvai Paul Cooper Endre Kiss-T óth Lajos Haracska Source Type: research
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
CONCLUSION: In this study, we established and validated reliable, highly sensitive, and accurate nucleic acid-based testing methods for a broad spectrum of canine pathogens.PMID:38097939 | PMC:PMC10720183 | DOI:10.1186/s12575-023-00226-x (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 15, 2023 Category: Molecular Biology Authors: Emese Pekker Katalin Priskin Éva Szabó-Kriston Bernadett Cs ányi Orsolya Buz ás-Bereczki Lili Adorj án Val éria Szukacsov Lajos Pint ér Mikl ós Rusvai Paul Cooper Endre Kiss-T óth Lajos Haracska Source Type: research
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
CONCLUSION: In this study, we established and validated reliable, highly sensitive, and accurate nucleic acid-based testing methods for a broad spectrum of canine pathogens.PMID:38097939 | PMC:PMC10720183 | DOI:10.1186/s12575-023-00226-x (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 15, 2023 Category: Molecular Biology Authors: Emese Pekker Katalin Priskin Éva Szabó-Kriston Bernadett Cs ányi Orsolya Buz ás-Bereczki Lili Adorj án Val éria Szukacsov Lajos Pint ér Mikl ós Rusvai Paul Cooper Endre Kiss-T óth Lajos Haracska Source Type: research
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
CONCLUSION: In this study, we established and validated reliable, highly sensitive, and accurate nucleic acid-based testing methods for a broad spectrum of canine pathogens.PMID:38097939 | PMC:PMC10720183 | DOI:10.1186/s12575-023-00226-x (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 15, 2023 Category: Molecular Biology Authors: Emese Pekker Katalin Priskin Éva Szabó-Kriston Bernadett Cs ányi Orsolya Buz ás-Bereczki Lili Adorj án Val éria Szukacsov Lajos Pint ér Mikl ós Rusvai Paul Cooper Endre Kiss-T óth Lajos Haracska Source Type: research
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
CONCLUSION: In this study, we established and validated reliable, highly sensitive, and accurate nucleic acid-based testing methods for a broad spectrum of canine pathogens.PMID:38097939 | PMC:PMC10720183 | DOI:10.1186/s12575-023-00226-x (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 15, 2023 Category: Molecular Biology Authors: Emese Pekker Katalin Priskin Éva Szabó-Kriston Bernadett Cs ányi Orsolya Buz ás-Bereczki Lili Adorj án Val éria Szukacsov Lajos Pint ér Mikl ós Rusvai Paul Cooper Endre Kiss-T óth Lajos Haracska Source Type: research
Development of a Large-Scale Pathogen Screening Test for the Biosafety Evaluation of Canine Mesenchymal Stem Cells
CONCLUSION: In this study, we established and validated reliable, highly sensitive, and accurate nucleic acid-based testing methods for a broad spectrum of canine pathogens.PMID:38097939 | DOI:10.1186/s12575-023-00226-x (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 15, 2023 Category: Molecular Biology Authors: Emese Pekker Katalin Priskin Éva Szabó-Kriston Bernadett Cs ányi Orsolya Buz ás-Bereczki Lili Adorj án Val éria Szukacsov Lajos Pint ér Mikl ós Rusvai Paul Cooper Endre Kiss-T óth Lajos Haracska Source Type: research
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
