Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation

CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | PMC:PMC10691036 | DOI:10.1186/s12575-023-00222-1

Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research