Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
CONCLUSIONS: Our data indicated that SKBR3-pool2-derived tumors were highly sensitive to lapatinib treatment, whereas BT474-HR20 tumors exhibited resistance to lapatinib. It seemed that the inefficacy of lapatinib against BT474-HR20 tumors in vivo was attributed to lapatinib-induced upregulation of IRS1 and activation of Akt. Thus, the tumor xenograft models-derived from SKBR3-pool2 and BT474-HR20 cells serve as an excellent in vivo system to test the efficacy of other HER2-targeted therapies and novel agents to overcome trastuzumab resistance against HER2-positive breast cancer.PMID:37370010 | PMC:PMC10294508 | DOI:10.118...
Source: Biological Procedures Online - June 27, 2023 Category: Molecular Biology Authors: Hao Liu Sanbao Ruan Margaret E Larsen Congcong Tan Bolin Liu Hui Lyu Source Type: research
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
CONCLUSIONS: Our data indicated that SKBR3-pool2-derived tumors were highly sensitive to lapatinib treatment, whereas BT474-HR20 tumors exhibited resistance to lapatinib. It seemed that the inefficacy of lapatinib against BT474-HR20 tumors in vivo was attributed to lapatinib-induced upregulation of IRS1 and activation of Akt. Thus, the tumor xenograft models-derived from SKBR3-pool2 and BT474-HR20 cells serve as an excellent in vivo system to test the efficacy of other HER2-targeted therapies and novel agents to overcome trastuzumab resistance against HER2-positive breast cancer.PMID:37370010 | PMC:PMC10294508 | DOI:10.118...
Source: Biological Procedures Online - June 27, 2023 Category: Molecular Biology Authors: Hao Liu Sanbao Ruan Margaret E Larsen Congcong Tan Bolin Liu Hui Lyu Source Type: research
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
CONCLUSIONS: Our data indicated that SKBR3-pool2-derived tumors were highly sensitive to lapatinib treatment, whereas BT474-HR20 tumors exhibited resistance to lapatinib. It seemed that the inefficacy of lapatinib against BT474-HR20 tumors in vivo was attributed to lapatinib-induced upregulation of IRS1 and activation of Akt. Thus, the tumor xenograft models-derived from SKBR3-pool2 and BT474-HR20 cells serve as an excellent in vivo system to test the efficacy of other HER2-targeted therapies and novel agents to overcome trastuzumab resistance against HER2-positive breast cancer.PMID:37370010 | DOI:10.1186/s12575-023-00212...
Source: Biological Procedures Online - June 27, 2023 Category: Molecular Biology Authors: Hao Liu Sanbao Ruan Margaret E Larsen Congcong Tan Bolin Liu Hui Lyu Source Type: research
Integrating Omics and CRISPR Technology for Identification and Verification of Genomic Safe Harbor Loci in the Chicken Genome
CONCLUSIONS: cHIPP and cROSA loci introduced in this study can be reliably exploited for consistent bio-manufacturing of recombinant proteins in the genetically-engineered chickens. Also, results showed that the genomic context dictates the expression of transgene controlled by ΔCMV in GSH loci.PMID:37355580 | PMC:PMC10290409 | DOI:10.1186/s12575-023-00210-5 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 24, 2023 Category: Molecular Biology Authors: Nima Dehdilani Lena Goshayeshi Sara Yousefi Taemeh Ahmad Reza Bahrami Sylvie Rival Gervier Bertrand Pain Hesam Dehghani Source Type: research
Integrating Omics and CRISPR Technology for Identification and Verification of Genomic Safe Harbor Loci in the Chicken Genome
CONCLUSIONS: cHIPP and cROSA loci introduced in this study can be reliably exploited for consistent bio-manufacturing of recombinant proteins in the genetically-engineered chickens. Also, results showed that the genomic context dictates the expression of transgene controlled by ΔCMV in GSH loci.PMID:37355580 | PMC:PMC10290409 | DOI:10.1186/s12575-023-00210-5 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 24, 2023 Category: Molecular Biology Authors: Nima Dehdilani Lena Goshayeshi Sara Yousefi Taemeh Ahmad Reza Bahrami Sylvie Rival Gervier Bertrand Pain Hesam Dehghani Source Type: research
Integrating Omics and CRISPR Technology for Identification and Verification of Genomic Safe Harbor Loci in the Chicken Genome
CONCLUSIONS: cHIPP and cROSA loci introduced in this study can be reliably exploited for consistent bio-manufacturing of recombinant proteins in the genetically-engineered chickens. Also, results showed that the genomic context dictates the expression of transgene controlled by ΔCMV in GSH loci.PMID:37355580 | DOI:10.1186/s12575-023-00210-5 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 24, 2023 Category: Molecular Biology Authors: Nima Dehdilani Lena Goshayeshi Sara Yousefi Taemeh Ahmad Reza Bahrami Sylvie Rival Gervier Bertrand Pain Hesam Dehghani Source Type: research
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
CONCLUSION: Taken together, R1-MVs exert significant protective effects against H2O2-induced oxidative stress in keratinocytes and have the potential to be applied in radiation-induced oxidative stress models.PMID:37328878 | PMC:PMC10273539 | DOI:10.1186/s12575-023-00211-4 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 16, 2023 Category: Molecular Biology Authors: Jeong Moo Han Ha-Yeon Song Jong-Hyun Jung Sangyong Lim Ho Seong Seo Woo Sik Kim Seung-Taik Lim Eui-Baek Byun Source Type: research
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
CONCLUSION: Taken together, R1-MVs exert significant protective effects against H2O2-induced oxidative stress in keratinocytes and have the potential to be applied in radiation-induced oxidative stress models.PMID:37328878 | PMC:PMC10273539 | DOI:10.1186/s12575-023-00211-4 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 16, 2023 Category: Molecular Biology Authors: Jeong Moo Han Ha-Yeon Song Jong-Hyun Jung Sangyong Lim Ho Seong Seo Woo Sik Kim Seung-Taik Lim Eui-Baek Byun Source Type: research
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
CONCLUSION: Taken together, R1-MVs exert significant protective effects against H2O2-induced oxidative stress in keratinocytes and have the potential to be applied in radiation-induced oxidative stress models.PMID:37328878 | PMC:PMC10273539 | DOI:10.1186/s12575-023-00211-4 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 16, 2023 Category: Molecular Biology Authors: Jeong Moo Han Ha-Yeon Song Jong-Hyun Jung Sangyong Lim Ho Seong Seo Woo Sik Kim Seung-Taik Lim Eui-Baek Byun Source Type: research
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
CONCLUSION: Taken together, R1-MVs exert significant protective effects against H2O2-induced oxidative stress in keratinocytes and have the potential to be applied in radiation-induced oxidative stress models.PMID:37328878 | PMC:PMC10273539 | DOI:10.1186/s12575-023-00211-4 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 16, 2023 Category: Molecular Biology Authors: Jeong Moo Han Ha-Yeon Song Jong-Hyun Jung Sangyong Lim Ho Seong Seo Woo Sik Kim Seung-Taik Lim Eui-Baek Byun Source Type: research
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
CONCLUSION: Taken together, R1-MVs exert significant protective effects against H2O2-induced oxidative stress in keratinocytes and have the potential to be applied in radiation-induced oxidative stress models.PMID:37328878 | PMC:PMC10273539 | DOI:10.1186/s12575-023-00211-4 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 16, 2023 Category: Molecular Biology Authors: Jeong Moo Han Ha-Yeon Song Jong-Hyun Jung Sangyong Lim Ho Seong Seo Woo Sik Kim Seung-Taik Lim Eui-Baek Byun Source Type: research
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
CONCLUSION: Taken together, R1-MVs exert significant protective effects against H2O2-induced oxidative stress in keratinocytes and have the potential to be applied in radiation-induced oxidative stress models.PMID:37328878 | PMC:PMC10273539 | DOI:10.1186/s12575-023-00211-4 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 16, 2023 Category: Molecular Biology Authors: Jeong Moo Han Ha-Yeon Song Jong-Hyun Jung Sangyong Lim Ho Seong Seo Woo Sik Kim Seung-Taik Lim Eui-Baek Byun Source Type: research
Deinococcus radiodurans-derived membrane vesicles protect HaCaT cells against H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative stress via modulation of MAPK and Nrf2/ARE pathways
CONCLUSION: Taken together, R1-MVs exert significant protective effects against H2O2-induced oxidative stress in keratinocytes and have the potential to be applied in radiation-induced oxidative stress models.PMID:37328878 | DOI:10.1186/s12575-023-00211-4 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 16, 2023 Category: Molecular Biology Authors: Jeong Moo Han Ha-Yeon Song Jong-Hyun Jung Sangyong Lim Ho Seong Seo Woo Sik Kim Seung-Taik Lim Eui-Baek Byun Source Type: research
Deep learning classification of uveal melanoma based on histopathological images and identification of a novel indicator for prognosis of patients
CONCLUSIONS: Our findings suggest that DL model can accurately predict vital status in UM patents just using histopathological images. We found out two subgroups based on histopathological DL features, which may in favor of immunotherapy and chemotherapy. Finally, a well-performing nomogram that combines DL-signature and gene-signature was constructed to give a more straightforward and reliable prognosis for UM patients in treatment and management.PMID:37268878 | PMC:PMC10239131 | DOI:10.1186/s12575-023-00207-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 2, 2023 Category: Molecular Biology Authors: Qi Wan Xiang Ren Ran Wei Shali Yue Lixiang Wang Hongbo Yin Jing Tang Ming Zhang Ke Ma Ying-Ping Deng Source Type: research
A multi-omics analysis reveals CLSPN is associated with prognosis, immune microenvironment and drug resistance in cancers
CONCLUSION: Our multi-omics analysis offers a systematic understanding of the roles of CLSPN in pan-cancer and provides a potential target for future cancer treatment.PMID:37268895 | PMC:PMC10239117 | DOI:10.1186/s12575-023-00201-6 (Source: Biological Procedures Online)
Source: Biological Procedures Online - June 2, 2023 Category: Molecular Biology Authors: Yihong Chen Haicheng Wen Yin Li Ying Han Jun Tan Cao Guo Changjing Cai Ping Liu Yinghui Peng Yihan Liu Xinwen Wang Shan Zeng Ziyang Feng Hong Shen Source Type: research
