LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
CONCLUSIONS: Our data indicated that SKBR3-pool2-derived tumors were highly sensitive to lapatinib treatment, whereas BT474-HR20 tumors exhibited resistance to lapatinib. It seemed that the inefficacy of lapatinib against BT474-HR20 tumors in vivo was attributed to lapatinib-induced upregulation of IRS1 and activation of Akt. Thus, the tumor xenograft models-derived from SKBR3-pool2 and BT474-HR20 cells serve as an excellent in vivo system to test the efficacy of other HER2-targeted therapies and novel agents to overcome trastuzumab resistance against HER2-positive breast cancer.PMID:37370010 | PMC:PMC10294508 | DOI:10.118...
Source: Biological Procedures Online - June 27, 2023 Category: Molecular Biology Authors: Hao Liu Sanbao Ruan Margaret E Larsen Congcong Tan Bolin Liu Hui Lyu Source Type: research
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
CONCLUSIONS: Our data indicated that SKBR3-pool2-derived tumors were highly sensitive to lapatinib treatment, whereas BT474-HR20 tumors exhibited resistance to lapatinib. It seemed that the inefficacy of lapatinib against BT474-HR20 tumors in vivo was attributed to lapatinib-induced upregulation of IRS1 and activation of Akt. Thus, the tumor xenograft models-derived from SKBR3-pool2 and BT474-HR20 cells serve as an excellent in vivo system to test the efficacy of other HER2-targeted therapies and novel agents to overcome trastuzumab resistance against HER2-positive breast cancer.PMID:37370010 | PMC:PMC10294508 | DOI:10.118...
Source: Biological Procedures Online - June 27, 2023 Category: Molecular Biology Authors: Hao Liu Sanbao Ruan Margaret E Larsen Congcong Tan Bolin Liu Hui Lyu Source Type: research
Trastuzumab-resistant breast cancer cells-derived tumor xenograft models exhibit distinct sensitivity to lapatinib treatment in vivo
CONCLUSIONS: Our data indicated that SKBR3-pool2-derived tumors were highly sensitive to lapatinib treatment, whereas BT474-HR20 tumors exhibited resistance to lapatinib. It seemed that the inefficacy of lapatinib against BT474-HR20 tumors in vivo was attributed to lapatinib-induced upregulation of IRS1 and activation of Akt. Thus, the tumor xenograft models-derived from SKBR3-pool2 and BT474-HR20 cells serve as an excellent in vivo system to test the efficacy of other HER2-targeted therapies and novel agents to overcome trastuzumab resistance against HER2-positive breast cancer.PMID:37370010 | PMC:PMC10294508 | DOI:10.118...
Source: Biological Procedures Online - June 27, 2023 Category: Molecular Biology Authors: Hao Liu Sanbao Ruan Margaret E Larsen Congcong Tan Bolin Liu Hui Lyu Source Type: research
