Musashi-2 Deficiency Triggers Colorectal Cancer Ferroptosis by Downregulating the MAPK Signaling Cascade to Inhibit HSPB1 Phosphorylation
CONCLUSIONS: This study indicates that MSI2 deficiency suppresses the growth and survival of CRC cells and promotes ferroptosis by inactivating the MAPK signaling pathway to inhibit HSPB1 phosphorylation, which leads to downregulation of PCNA and Ki67 and upregulation of ACSL4 in cancer cells and subsequently induces redox imbalance, iron accumulation and mitochondrial shrinkage, ultimately triggering ferroptosis. Therefore, targeted inhibition of MSI2/MAPK/HSPB1 axis to promote ferroptosis might be a potential treatment strategy for CRC.PMID:38041016 | DOI:10.1186/s12575-023-00222-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - December 1, 2023 Category: Molecular Biology Authors: Xiaole Meng Xiao Peng Wanxin Ouyang Hui Li Risi Na Wenting Zhou Xuting You Yuhuan Li Xin Pu Ke Zhang Junjie Xia Jie Wang Guohong Zhuang Huamei Tang Zhihai Peng Source Type: research
Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
CONCLUSIONS: This study indicates that the CYP11A1-overexpressing Caki-1 cell line is useful for screening drugs against kidney cancer. The two selected compounds could be utilized as lead compounds for anticancer drug discovery, and specifically for the development of antirenal cancer medication.PMID:38036976 | DOI:10.1186/s12575-023-00225-y (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 30, 2023 Category: Molecular Biology Authors: Hien Thi My Ong Eda Ates Oh-Seung Kwon Min-Jung Kang Source Type: research
Screening of Natural Compounds for CYP11A1 Stimulation Against Cell Renal Cell Carcinoma
CONCLUSIONS: This study indicates that the CYP11A1-overexpressing Caki-1 cell line is useful for screening drugs against kidney cancer. The two selected compounds could be utilized as lead compounds for anticancer drug discovery, and specifically for the development of antirenal cancer medication.PMID:38036976 | DOI:10.1186/s12575-023-00225-y (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 30, 2023 Category: Molecular Biology Authors: Hien Thi My Ong Eda Ates Oh-Seung Kwon Min-Jung Kang Source Type: research
D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke
CONCLUSIONS: In summary, D-allose plays a crucial role in inhibiting inflammation after IS by suppressing Gal-3/TLR4/PI3K/AKT signaling pathway in vitro and in vivo.PMID:38017376 | PMC:PMC10683335 | DOI:10.1186/s12575-023-00224-z (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 28, 2023 Category: Molecular Biology Authors: Yaowen Luo Junkai Cheng Yihao Fu Min Zhang Maorong Gou Juan Li Xiaobing Li Jing Bai Yuefei Zhou Lei Zhang Dakuan Gao Source Type: research
D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke
CONCLUSIONS: In summary, D-allose plays a crucial role in inhibiting inflammation after IS by suppressing Gal-3/TLR4/PI3K/AKT signaling pathway in vitro and in vivo.PMID:38017376 | DOI:10.1186/s12575-023-00224-z (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 28, 2023 Category: Molecular Biology Authors: Yaowen Luo Junkai Cheng Yihao Fu Min Zhang Maorong Gou Juan Li Xiaobing Li Jing Bai Yuefei Zhou Lei Zhang Dakuan Gao Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
Identification of exosome protein panels as predictive biomarkers for non-small cell lung cancer
CONCLUSIONS: These findings underscore the potential of plasma exosomal biomarkers for early NSCLC diagnosis and metastasis prediction. Notably, CFHR5 stands out as a promising prognostic indicator for NSCLC patients. The clinical utility of exosomal biomarkers offers the potential to enhance the management of NSCLC.PMID:37953280 | PMC:PMC10641949 | DOI:10.1186/s12575-023-00223-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - November 12, 2023 Category: Molecular Biology Authors: Bin Luo Zujun Que Xinyi Lu Dan Qi Zhi Qiao Yun Yang Fangfang Qian Yi Jiang Yan Li Ronghu Ke Xiaoyun Shen Hua Xiao Hegen Li Erxi Wu Jianhui Tian Source Type: research
