Correction: Circ ‑ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA‑128‑3p/ZEB1 axis
Biol Proced Online. 2023 Aug 4;25(1):23. doi: 10.1186/s12575-023-00216-z.NO ABSTRACTPMID:37542238 | DOI:10.1186/s12575-023-00216-z (Source: Biological Procedures Online)
Source: Biological Procedures Online - August 4, 2023 Category: Molecular Biology Authors: Wei Feng Dongya Zhang Ruitao Zhang Source Type: research
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
CONCLUSION: A BSL-2 compatible assay system that is equivalent to the infectious SARS-CoV-2 is a promising tool for high-throughput screening of large compound libraries for viral entry inhibitors against SARS-CoV-2 along with toxicity and effects on syncytia. Studies using clinical isolates of SARS-CoV-2 are warranted to confirm the antiviral potency of the leads and the utility of the screening system.PMID:37495994 | PMC:PMC10373420 | DOI:10.1186/s12575-023-00214-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 26, 2023 Category: Molecular Biology Authors: Shine Varghese Jancy Santhik Subhasingh Lupitha Aneesh Chandrasekharan Shankara Narayanan Varadarajan Shijulal Nelson-Sathi Roshny Prasad Sara Jones Sreekumar Easwaran Pramod Darvin Aswathy Sivasailam Thankayyan Retnabai Santhoshkumar Source Type: research
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
CONCLUSION: A BSL-2 compatible assay system that is equivalent to the infectious SARS-CoV-2 is a promising tool for high-throughput screening of large compound libraries for viral entry inhibitors against SARS-CoV-2 along with toxicity and effects on syncytia. Studies using clinical isolates of SARS-CoV-2 are warranted to confirm the antiviral potency of the leads and the utility of the screening system.PMID:37495994 | PMC:PMC10373420 | DOI:10.1186/s12575-023-00214-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 26, 2023 Category: Molecular Biology Authors: Shine Varghese Jancy Santhik Subhasingh Lupitha Aneesh Chandrasekharan Shankara Narayanan Varadarajan Shijulal Nelson-Sathi Roshny Prasad Sara Jones Sreekumar Easwaran Pramod Darvin Aswathy Sivasailam Thankayyan Retnabai Santhoshkumar Source Type: research
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
CONCLUSION: A BSL-2 compatible assay system that is equivalent to the infectious SARS-CoV-2 is a promising tool for high-throughput screening of large compound libraries for viral entry inhibitors against SARS-CoV-2 along with toxicity and effects on syncytia. Studies using clinical isolates of SARS-CoV-2 are warranted to confirm the antiviral potency of the leads and the utility of the screening system.PMID:37495994 | PMC:PMC10373420 | DOI:10.1186/s12575-023-00214-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 26, 2023 Category: Molecular Biology Authors: Shine Varghese Jancy Santhik Subhasingh Lupitha Aneesh Chandrasekharan Shankara Narayanan Varadarajan Shijulal Nelson-Sathi Roshny Prasad Sara Jones Sreekumar Easwaran Pramod Darvin Aswathy Sivasailam Thankayyan Retnabai Santhoshkumar Source Type: research
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
CONCLUSION: A BSL-2 compatible assay system that is equivalent to the infectious SARS-CoV-2 is a promising tool for high-throughput screening of large compound libraries for viral entry inhibitors against SARS-CoV-2 along with toxicity and effects on syncytia. Studies using clinical isolates of SARS-CoV-2 are warranted to confirm the antiviral potency of the leads and the utility of the screening system.PMID:37495994 | PMC:PMC10373420 | DOI:10.1186/s12575-023-00214-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 26, 2023 Category: Molecular Biology Authors: Shine Varghese Jancy Santhik Subhasingh Lupitha Aneesh Chandrasekharan Shankara Narayanan Varadarajan Shijulal Nelson-Sathi Roshny Prasad Sara Jones Sreekumar Easwaran Pramod Darvin Aswathy Sivasailam Thankayyan Retnabai Santhoshkumar Source Type: research
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
CONCLUSION: A BSL-2 compatible assay system that is equivalent to the infectious SARS-CoV-2 is a promising tool for high-throughput screening of large compound libraries for viral entry inhibitors against SARS-CoV-2 along with toxicity and effects on syncytia. Studies using clinical isolates of SARS-CoV-2 are warranted to confirm the antiviral potency of the leads and the utility of the screening system.PMID:37495994 | PMC:PMC10373420 | DOI:10.1186/s12575-023-00214-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 26, 2023 Category: Molecular Biology Authors: Shine Varghese Jancy Santhik Subhasingh Lupitha Aneesh Chandrasekharan Shankara Narayanan Varadarajan Shijulal Nelson-Sathi Roshny Prasad Sara Jones Sreekumar Easwaran Pramod Darvin Aswathy Sivasailam Thankayyan Retnabai Santhoshkumar Source Type: research
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
CONCLUSION: A BSL-2 compatible assay system that is equivalent to the infectious SARS-CoV-2 is a promising tool for high-throughput screening of large compound libraries for viral entry inhibitors against SARS-CoV-2 along with toxicity and effects on syncytia. Studies using clinical isolates of SARS-CoV-2 are warranted to confirm the antiviral potency of the leads and the utility of the screening system.PMID:37495994 | PMC:PMC10373420 | DOI:10.1186/s12575-023-00214-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 26, 2023 Category: Molecular Biology Authors: Shine Varghese Jancy Santhik Subhasingh Lupitha Aneesh Chandrasekharan Shankara Narayanan Varadarajan Shijulal Nelson-Sathi Roshny Prasad Sara Jones Sreekumar Easwaran Pramod Darvin Aswathy Sivasailam Thankayyan Retnabai Santhoshkumar Source Type: research
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
CONCLUSION: A BSL-2 compatible assay system that is equivalent to the infectious SARS-CoV-2 is a promising tool for high-throughput screening of large compound libraries for viral entry inhibitors against SARS-CoV-2 along with toxicity and effects on syncytia. Studies using clinical isolates of SARS-CoV-2 are warranted to confirm the antiviral potency of the leads and the utility of the screening system.PMID:37495994 | PMC:PMC10373420 | DOI:10.1186/s12575-023-00214-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 26, 2023 Category: Molecular Biology Authors: Shine Varghese Jancy Santhik Subhasingh Lupitha Aneesh Chandrasekharan Shankara Narayanan Varadarajan Shijulal Nelson-Sathi Roshny Prasad Sara Jones Sreekumar Easwaran Pramod Darvin Aswathy Sivasailam Thankayyan Retnabai Santhoshkumar Source Type: research
A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity
CONCLUSION: A BSL-2 compatible assay system that is equivalent to the infectious SARS-CoV-2 is a promising tool for high-throughput screening of large compound libraries for viral entry inhibitors against SARS-CoV-2 along with toxicity and effects on syncytia. Studies using clinical isolates of SARS-CoV-2 are warranted to confirm the antiviral potency of the leads and the utility of the screening system.PMID:37495994 | DOI:10.1186/s12575-023-00214-1 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 26, 2023 Category: Molecular Biology Authors: Shine Varghese Jancy Santhik Subhasingh Lupitha Aneesh Chandrasekharan Shankara Narayanan Varadarajan Shijulal Nelson-Sathi Roshny Prasad Sara Jones Sreekumar Easwaran Pramod Darvin Aswathy Sivasailam Thankayyan Retnabai Santhoshkumar Source Type: research
Full spectrum flow cytometry-powered comprehensive analysis of PBMC as biomarkers for immunotherapy in NSCLC with EGFR-TKI resistance
CONCLUSIONS: Some EGFR-TKI-resistant NSCLC patients could indeed benefit from ICI plus chemotherapy, but most patients are primary resistant to immunotherapy. Comprehensive analysis of peripheral immune cells using full spectrum flow cytometry showed that compared to the proportion of cell subsets, the expression type and level of ICPs on immune cells, especially CD25, were significantly correlated with the efficacy of immunotherapy.PMID:37488517 | PMC:PMC10364374 | DOI:10.1186/s12575-023-00215-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 24, 2023 Category: Molecular Biology Authors: Juan Zhou Xiangling Chu Jing Zhao Mengqing Xie Jing Wu Xin Yu Yujia Fang Yazhou Li Xiyan Li Chunxia Su Source Type: research
Full spectrum flow cytometry-powered comprehensive analysis of PBMC as biomarkers for immunotherapy in NSCLC with EGFR-TKI resistance
CONCLUSIONS: Some EGFR-TKI-resistant NSCLC patients could indeed benefit from ICI plus chemotherapy, but most patients are primary resistant to immunotherapy. Comprehensive analysis of peripheral immune cells using full spectrum flow cytometry showed that compared to the proportion of cell subsets, the expression type and level of ICPs on immune cells, especially CD25, were significantly correlated with the efficacy of immunotherapy.PMID:37488517 | DOI:10.1186/s12575-023-00215-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 24, 2023 Category: Molecular Biology Authors: Juan Zhou Xiangling Chu Jing Zhao Mengqing Xie Jing Wu Xin Yu Yujia Fang Yazhou Li Xiyan Li Chunxia Su Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
LINC00853 contributes to tumor stemness of gastric cancer through FOXP3-mediated transcription of PDZK1IP1
CONCLUSIONS: Taken together, these findings revealed the tumor-promoting activity of LINC00853 in GC, expanding our understanding of lncRNAs regulation on GC pathogenesis.PMID:37403034 | PMC:PMC10318836 | DOI:10.1186/s12575-023-00213-2 (Source: Biological Procedures Online)
Source: Biological Procedures Online - July 4, 2023 Category: Molecular Biology Authors: Xia Hu Maoyuan Zhao Shuangyuan Hu Qingsong Liu Wenhao Liao Lina Wan Feng Wei Fangting Su Yu Guo Jinhao Zeng Source Type: research
