A high-throughput screening system for SARS-CoV-2 entry inhibition, syncytia formation and cell toxicity

CONCLUSION: A BSL-2 compatible assay system that is equivalent to the infectious SARS-CoV-2 is a promising tool for high-throughput screening of large compound libraries for viral entry inhibitors against SARS-CoV-2 along with toxicity and effects on syncytia. Studies using clinical isolates of SARS-CoV-2 are warranted to confirm the antiviral potency of the leads and the utility of the screening system.PMID:37495994 | PMC:PMC10373420 | DOI:10.1186/s12575-023-00214-1

Source: Biological Procedures Online - July 26, 2023 Category: Molecular Biology Authors: Shine Varghese Jancy Santhik Subhasingh Lupitha Aneesh Chandrasekharan Shankara Narayanan Varadarajan Shijulal Nelson-Sathi Roshny Prasad Sara Jones Sreekumar Easwaran Pramod Darvin Aswathy Sivasailam Thankayyan Retnabai Santhoshkumar Source Type: research