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Comparison of two protocols for the generation of iPSC-derived human astrocytes
CONCLUSIONS: Overall, our analyses highlight the need to consider the advantages and disadvantages of a given differentiation protocol, when designing functional or drug discovery studies involving iPSC-derived astrocytes.PMID:37730545 | PMC:PMC10512486 | DOI:10.1186/s12575-023-00218-x (Source: Biological Procedures Online)
Source: Biological Procedures Online - September 20, 2023 Category: Molecular Biology Authors: Patrycja Mulica Carmen Venegas Zied Landoulsi Katja Badanjak Sylvie Delcambre Maria Tziortziou Soraya Hezzaz Jenny Ghelfi Semra Smajic Jens Schwamborn Rejko Kr üger Paul Antony Patrick May Enrico Glaab Anne Gr ünewald Sandro L Pereira Source Type: research

A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
CONCLUSIONS: Collectively, our study highlights the utility of the dual-reporter system for real-time monitoring and quantitative analysis of protein secretion through conventional ER-Golgi and unconventional exosome pathways. Moreover, our findings unveil distinct features of exosome-mediated protein secretion, shedding light on its differential capacity, dynamics, and regulatory mechanisms compared to ER-Golgi-mediated proteins in human cells.PMID:37726652 | PMC:PMC10510171 | DOI:10.1186/s12575-023-00219-w (Source: Biological Procedures Online)
Source: Biological Procedures Online - September 19, 2023 Category: Molecular Biology Authors: Christopher Olson Pengyang Zhang Joy Ku Renceh Flojo Darin Boyes Biao Lu Source Type: research

A Novel Dual-Reporter System Reveals Distinct Characteristics of Exosome-Mediated Protein Secretion in Human Cells
CONCLUSIONS: Collectively, our study highlights the utility of the dual-reporter system for real-time monitoring and quantitative analysis of protein secretion through conventional ER-Golgi and unconventional exosome pathways. Moreover, our findings unveil distinct features of exosome-mediated protein secretion, shedding light on its differential capacity, dynamics, and regulatory mechanisms compared to ER-Golgi-mediated proteins in human cells.PMID:37726652 | DOI:10.1186/s12575-023-00219-w (Source: Biological Procedures Online)
Source: Biological Procedures Online - September 19, 2023 Category: Molecular Biology Authors: Christopher Olson Pengyang Zhang Joy Ku Renceh Flojo Darin Boyes Biao Lu Source Type: research

Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis
CONCLUSION: Our findings suggest that compared to other organs, the strongest immune activation effect occurs with brain RT, and ES-SCLC patients who received radioimmunotherapy (RIT) earlier achieved higher OS rates.PMID:37710179 | PMC:PMC10503112 | DOI:10.1186/s12575-023-00217-y (Source: Biological Procedures Online)
Source: Biological Procedures Online - September 14, 2023 Category: Molecular Biology Authors: Min Wu Shihao Wu Yuetong Chen Liangchao Sun Jundong Zhou Source Type: research