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Structure-activity relationship and cytotoxicity of the new thiosemicarbazide derivatives and their Cu(II) complexes against prostate and melanoma cancer cells
In this study, eighteen new ligands (B1-B18) containing a thiosemicarbazide core were synthesized and characterized in terms of physicochemical properties, molecular docking and in vitro biological activity. The structures of eleven ligands were investigated using X-Ray diffraction and Hirschfeld Surface analysis. To study the structure-activity relationship, the organic ligands contained pyridin-2-ylmethyl, pyridin-3-ylmethyl or pyridin-4-ylmethyl moieties and various substituents. Their pharmakokinetic profiles and molecular docking results suggest high potential as new drug candidates. The complexing ability of the sele...
Source: Archives of Biochemistry and Biophysics - March 9, 2024 Category: Biochemistry Authors: Bart łomiej Rogalewicz Monika Pitucha Marcin Świątkowski Ewelina Humeniuk Grzegorz Adamczuk Monika Dr ózd Zbigniew Karczmarzyk El żbieta Kuśmierek Krzysztof Strzelec Anita Raducka Waldemar Wysocki Alina Olender Anna Kozub Dorota Kowalczuk Ewa Polesz Source Type: research

Oxidized phospholipid-protein adducts: The future targets of interest
Arch Biochem Biophys. 2024 Mar 6:109956. doi: 10.1016/j.abb.2024.109956. Online ahead of print.ABSTRACTPhospholipids are key biomolecules with important roles as components of membranes, lipoproteins and as signalling molecules. However, phospholipids are quite prone to oxidation. Upon oxidation they generate several types of oxidation products including long chain oxidation products, as hydroperoxyl and hydroxy derivatives, and highly reactive oxidation products, like small aldehydes and truncated oxidized phospholipids. The formation of protein adducts with small electrophilic aldehydes (like malondialdehyde) is now well...
Source: Archives of Biochemistry and Biophysics - March 8, 2024 Category: Biochemistry Authors: Helena Beatriz Ferreira M Ros ário Domingues Source Type: research

The crucial role of NRF2 in erythropoiesis and anemia: Mechanisms and therapeutic opportunities
Arch Biochem Biophys. 2024 Mar 5:109948. doi: 10.1016/j.abb.2024.109948. Online ahead of print.ABSTRACTThe nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor crucial in cellular defense against oxidative and electrophilic stresses. Recent research has highlighted the significance of NRF2 in normal erythropoiesis and anemia. NRF2 regulates genes involved in vital aspects of erythroid development, including hemoglobin catabolism, inflammation, and iron homeostasis in erythrocytes. Disrupted NRF2 activity has been implicated in various pathologies involving abnormal erythropoiesis. In this review, we...
Source: Archives of Biochemistry and Biophysics - March 7, 2024 Category: Biochemistry Authors: Lei Yang Yong Chen Sheng He Duonan Yu Source Type: research

Peculiarities of ion homeostasis in neurons containing calcium-permeable AMPA receptors
Arch Biochem Biophys. 2024 Mar 5:109951. doi: 10.1016/j.abb.2024.109951. Online ahead of print.ABSTRACTGlutamate excitotoxicity accompanies numerous brain pathologies, including traumatic brain injury, ischemic stroke, and epilepsy. Disturbances of the ion homeostasis, mitochondria dysfunction, and further cell death are considered the main detrimental consequences of excitotoxicity. It is well known that neurons demonstrate different vulnerability to pathological exposures. In this regard, neurons containing calcium-permeable AMPA receptors (CP-AMPARs) may show higher susceptibility to excitotoxicity due to an additional ...
Source: Archives of Biochemistry and Biophysics - March 7, 2024 Category: Biochemistry Authors: Sergei A Maiorov Bakhytzhan K Kairat Alexey V Berezhnov Valery P Zinchenko Sergei G Gaidin Artem M Kosenkov Source Type: research

Iron overload and programmed bone marrow cell death: Potential mechanistic insights
Arch Biochem Biophys. 2024 Mar 1;754:109954. doi: 10.1016/j.abb.2024.109954. Online ahead of print.ABSTRACTIron overload has detrimental effects on bone marrow mesenchymal stem cells (BMMSCs), cells crucial for bone marrow homeostasis and hematopoiesis support. Excessive iron accumulation leads to the production of reactive oxygen species (ROS), resulting in cell death, cell cycle arrest, and disruption of vital cellular pathways. Although apoptosis has been extensively studied, other programmed cell death mechanisms including autophagy, necroptosis, and ferroptosis also play significant roles in iron overload-induced bone...
Source: Archives of Biochemistry and Biophysics - March 3, 2024 Category: Biochemistry Authors: Wanat Wudhikulprapan Siriporn C Chattipakorn Nipon Chattipakorn Sirinart Kumfu Source Type: research

Beyond cyclopamine: Targeting Hedgehog signaling for cancer intervention
Arch Biochem Biophys. 2024 Mar 1:109952. doi: 10.1016/j.abb.2024.109952. Online ahead of print.ABSTRACTHedgehog (Hh) signaling plays a significant role in embryogenesis and several physiological processes, such as wound healing and organ homeostasis. In a pathological setting, it is associated with oncogenesis and is responsible for disease progression and poor clinical outcomes. Hedgehog signaling mediates downstream actions via Glioma Associated Oncogene Homolog (GLI) transcription factors. Inhibiting Hh signaling is an important oncological strategy in which inhibitors of the ligands SMO or GLI have been looked at. This...
Source: Archives of Biochemistry and Biophysics - March 3, 2024 Category: Biochemistry Authors: Beena Thazhackavayal Baby Aniruddha Murahar Kulkarni Prasanna Kumar Reddy Gayam Kuzhuvelil B Harikumar Jesil Mathew Aranjani Source Type: research

Network of extracellular vesicles surrounding senescent cells
Arch Biochem Biophys. 2024 Mar 1;754:109953. doi: 10.1016/j.abb.2024.109953. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are small lipid bilayers released from cells that contain cellular components such as proteins, nucleic acids, lipids, and metabolites. Biological information is transmitted between cells via the EV content. Cancer and senescent cells secrete more EVs than normal cells, delivering more information to the surrounding recipient cells. Cellular senescence is a state of irreversible cell cycle arrest caused by the accumulation of DNA damage. Senescent cells secrete various inflammatory protein...
Source: Archives of Biochemistry and Biophysics - March 3, 2024 Category: Biochemistry Authors: Hikaru Okawa Yoko Tanaka Akiko Takahashi Source Type: research

Network of extracellular vesicles surrounding senescent cells
Arch Biochem Biophys. 2024 Mar 1:109953. doi: 10.1016/j.abb.2024.109953. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) are small lipid bilayers released from cells that contain cellular components such as proteins, nucleic acids, lipids, and metabolites. Biological information is transmitted between cells via the EV content. Cancer and senescent cells secrete more EVs than normal cells, delivering more information to the surrounding recipient cells. Cellular senescence is a state of irreversible cell cycle arrest caused by the accumulation of DNA damage. Senescent cells secrete various inflammatory proteins kn...
Source: Archives of Biochemistry and Biophysics - March 3, 2024 Category: Biochemistry Authors: Hikaru Okawa Yoko Tanaka Akiko Takahashi Source Type: research

Iron overload and programmed bone marrow cell death: Potential mechanistic insights
Arch Biochem Biophys. 2024 Mar 1:109954. doi: 10.1016/j.abb.2024.109954. Online ahead of print.ABSTRACTIron overload has detrimental effects on bone marrow mesenchymal stem cells (BMMSCs), cells crucial for bone marrow homeostasis and hematopoiesis support. Excessive iron accumulation leads to the production of reactive oxygen species (ROS), resulting in cell death, cell cycle arrest, and disruption of vital cellular pathways. Although apoptosis has been extensively studied, other programmed cell death mechanisms including autophagy, necroptosis, and ferroptosis also play significant roles in iron overload-induced bone mar...
Source: Archives of Biochemistry and Biophysics - March 3, 2024 Category: Biochemistry Authors: Wanat Wudhikulprapan Siriporn C Chattipakorn Nipon Chattipakorn Sirinart Kumfu Source Type: research