Archives of Biochemistry and Biophysics 
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1
Arch Biochem Biophys. 2024 Feb 8:109921. doi: 10.1016/j.abb.2024.109921. Online ahead of print.ABSTRACTZinc finger protein 131 (ZNF131), a member of BTB-ZF transcription factors, has been previously reported as an oncogene in several human cancers. However, the function and underlying mechanism of ZNF131 in hepatocellular carcinoma (HCC) are still unclear. In our study, the upregulated expression of ZNF131 mRNA was confirmed in HCC tissues by analyzing the TCGA and GEO datasets. The immunohistochemical staining data also revealed the overexpression of ZNF131 protein in HCC samples. High expression of ZNF131 predicted poor ...
Source: Archives of Biochemistry and Biophysics - February 10, 2024 Category: Biochemistry Authors: Guozhi Yin Siying Jia Youju Zhang Yao Xian Yong Guo Qingguang Liu Source Type: research
Cinnamaldehyde attenuates TNF- α induced skeletal muscle loss in C2C12 myotubes via regulation of protein synthesis, proteolysis, oxidative stress and inflammation
Arch Biochem Biophys. 2024 Feb 8:109922. doi: 10.1016/j.abb.2024.109922. Online ahead of print.ABSTRACTInflammation is the primary driver of skeletal muscle wasting, with oxidative stress serving as both a major consequence and a contributor to its deleterious effects. In this regard, regulation of both can efficiently prevent atrophy and thus will increase the rate of survival (Meng and Yu, 2010) [1]. With this idea, we hypothesize that preincubation of Cinnamaldehyde (CNA), a known compound with anti-oxidative and anti-inflammatory properties, may be able to prevent skeletal muscle loss. To examine the same, C2C12 post-d...
Source: Archives of Biochemistry and Biophysics - February 10, 2024 Category: Biochemistry Authors: Nirmaljeet Kaur Prachi Gupta Vikas Dutt Onkar Sharma Sanjeev Gupta Anita Dua Elisha Injeti Ashwani Mittal Source Type: research
TRIM34 suppresses non-small-cell lung carcinoma via inducing mTORC1-dependent glucose utilization and promoting cellular death
This study aimed to examine the underlying regulatory effects of TRIM34 in NSCLC. TRIM34 exhibited lower expression in NSCLC. TRIM34 facilitated mitochondrial damage and apoptosis in NSCLC. TRIM34 induced the increased activity of mTORC1 and accelerated glycolysis in NSCLC. Enhanced mitochondrial damage induced by TRIM34 overexpression was reversed after rapamycin (mTORC1 inhibitor) treatment in NSCLC. The strengthened cell apoptosis stimulated by TRIM34 overexpression was rescued after rapamycin treatment. TRIM34 activated mTORC1 to suppress NSCLC progression in vivo. TRIM34 suppressed NSCLC via inducing mTORC1-dependent ...
Source: Archives of Biochemistry and Biophysics - February 9, 2024 Category: Biochemistry Authors: Pengfei Zhang Zhida Chen Juan Li Hui Mao Yi Hu Source Type: research
PTEN hinders the formation of scars by regulating the levels of proteins in the extracellular matrix and promoting the apoptosis of dermal fibroblasts through Bcl-xL
The objective of this study was to investigate the influence of PTEN on hypertrophic scars(HS) and its function in the regulation of scar formation, with the aim of identifying a pivotal molecular target for scar treatment. Our results demonstrate that the overexpression of PTEN (AdPTEN) significantly suppressed the expression of type I collagen (Col I), type III collagen (Col III), and alpha smooth muscle actin (α-SMA) in HSFs. Furthermore, it was observed that the introduction of AdPTEN resulted in the suppression of Bcl-xL expression, which consequently led to an increase in the apoptosis of HSFs. Similarly, in the inh...
Source: Archives of Biochemistry and Biophysics - February 7, 2024 Category: Biochemistry Authors: Shaohui Li Yunwei Wang Yang Chen Hao Zhang Peng Cao Kuo Shen Hao Guan Source Type: research
GDNF facilitates the differentiation of ADSCs to Schwann cells and enhances nerve regeneration through GDNF/MTA1/Hes1 axis
Arch Biochem Biophys. 2024 Feb 1;753:109893. doi: 10.1016/j.abb.2024.109893. Online ahead of print.ABSTRACTAdipose tissue-derived stem cells (ADSCs) are a kind of stem cells with multi-directional differentiation potential, which mainly restore tissue repair function and promote cell regeneration. It can be directionally differentiated into Schwann-like cells to promote the repair of peripheral nerve injury. Glial cell line-derived neurotrophic factor (GDNF) plays an important role in the repair of nerve injury, but the underlying mechanism remains unclear, which seriously limits its further application.The study aimed to ...
Source: Archives of Biochemistry and Biophysics - February 3, 2024 Category: Biochemistry Authors: Weixia Cai Yang Liu Ting Zhang Peng Ji Chenyang Tian Jiaqi Liu Zhao Zheng Source Type: research
A time-resolved F örster resonance energy transfer assay to investigate drug and inhibitor binding to ABCG2
Arch Biochem Biophys. 2024 Feb 1;753:109915. doi: 10.1016/j.abb.2024.109915. Online ahead of print.ABSTRACTThe human ATP-binding cassette (ABC) transporter, ABCG2, is responsible for multidrug resistance in some tumours. Detailed knowledge of its activity is crucial for understanding drug transport and resistance in cancer, and has implications for wider pharmacokinetics. The binding of substrates and inhibitors is a key stage in the transport cycle of ABCG2. Here, we describe a novel binding assay using a high affinity fluorescent inhibitor based on Ko143 and time-resolved Förster resonance energy transfer (TR-FRET) to m...
Source: Archives of Biochemistry and Biophysics - February 2, 2024 Category: Biochemistry Authors: James I Mitchell-White Deborah A Briggs Sarah J Mistry Hannah A Mbiwan Barrie Kellam Nicholas D Holliday Stephen J Briddon Ian D Kerr Source Type: research
Biomolecular fingerprints of the effect of zoledronic acid on prostate cancer stem cells: Comparison of 2D and 3D cell culture models
Arch Biochem Biophys. 2024 Feb 1;753:109920. doi: 10.1016/j.abb.2024.109920. Online ahead of print.ABSTRACTRevealing the potential of candidate drugs against different cancer types without disrupting normal cells depends on the drug mode of action. In the current study, the drug response of prostate cancer stem cells (PCSCs) to zoledronic acid (ZOL) grown in two-dimensional (2D) and three-dimensional (3D) culture systems was compared using Fourier transform-infrared (FT-IR) spectroscopy which is a vibrational spectroscopic technique, supporting by biochemical assays and imaging techniques. Based on our data, in 2D cell cul...
Source: Archives of Biochemistry and Biophysics - February 2, 2024 Category: Biochemistry Authors: G ünnur Güler Eda Acikgoz G ünel Mukhtarova Gulperi Oktem Source Type: research
Interaction of the antifungal ketoconazole and its diphenylphosphine derivatives with lipid bilayers: Insights into their antifungal action
Arch Biochem Biophys. 2024 Feb 1;753:109919. doi: 10.1016/j.abb.2024.109919. Online ahead of print.ABSTRACTKetoconazole (Ke) is an important antifungal drug, and two of its diphenylphosphinemethyl derivatives (KeP: Ph2PCH2-Ke and KeOP: Ph2P(O)CH2-Ke) have shown improved antifungal activity, namely against a yeast strain lacking ergosterol, suggesting alternative modes of action for azole compounds. In this context, the interactions of these compounds with a model of the cell membrane were investigated, using POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) large unilamellar vesicles and taking advantage of the intri...
Source: Archives of Biochemistry and Biophysics - February 2, 2024 Category: Biochemistry Authors: Andreia Bento-Oliveira Rados ław Starosta Rodrigo F M de Almeida Source Type: research
UCP2 overexpression activates SIRT3 to regulate oxidative stress and mitochondrial dynamics induced by myocardial injury
CONCLUSIONS: Our findings revealed that UCP2 and SIRT3 were important targets of anti-myocardial injury by inhibiting cellular oxidative stress and stabilizing mitochondrial dynamics.PMID:38301949 | DOI:10.1016/j.abb.2024.109918 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - February 1, 2024 Category: Biochemistry Authors: Zhengguang Geng Wenbo Chen Qinju Lu Bao Fu Xiaoyun Fu Source Type: research
Anti-glycating and anti-cytotoxic effect of silibinin on albumin at early glycation: A physiochemical study
Arch Biochem Biophys. 2024 Jan 29:109916. doi: 10.1016/j.abb.2024.109916. Online ahead of print.ABSTRACTDuring persistent hyperglycaemia, albumin, one of the major blood proteins, can undergo fast glycation. It can be expected that timely inhibition of protein glycation might be add quality years to diabetic patients' life. Therefore, this study was designed to analyse the role of silibinin to reduced or delay amadori adduct formation at early glycation and its beneficial effect to improve the glycated albumin structure and conformation. We also analysed cytotoxic effect of amadori-albumin in the presence of silibinin on m...
Source: Archives of Biochemistry and Biophysics - January 31, 2024 Category: Biochemistry Authors: Km Neelofar Jamshed Haneef Jamal Ahmad Khursheed Alam Rana Zaidi Source Type: research
Prediction and biological analysis of yeast VDAC1 phosphorylation
In conclusion, we found phosphorylation has the potential to modulate Por1, causing a marked effect on mitochondrial function. It can also impact on cell morphology and growth both in respiratory and, unpredictably, also in fermenting conditions, expanding our knowledge on the role of Por1 in cell physiology.PMID:38290597 | DOI:10.1016/j.abb.2024.109914 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - January 30, 2024 Category: Biochemistry Authors: Andr é D Sousa Ana Luisa Costa V ítor Costa Clara Pereira Source Type: research
Impact of chlorogenic acid on surface and phase properties of cholesterol-enriched phosphatidylcholine membranes
This study analyses the insertion of Chlorogenic acid (CGA) in phosphatidylcholine (PC) membranes enriched with cholesterol (Chol). While cholesterol decreases the area per lipid and increases the dipole potential, CGA increases and decreases these values, respectively. When CGA is inserted into cholesterol-containing DMPC membranes, these effects cancel out, resulting in values that overlap with those of DMPC monolayers without Chol and CGA. The presence of CGA also compensates the increase of dipole potential produced by Chol which can be explain as a consequence of the orientation of CGA molecule at the interphase oppos...
Source: Archives of Biochemistry and Biophysics - January 29, 2024 Category: Biochemistry Authors: Jimena Del P Cejas Antonio S Rosa Agust ín N González Paz Edgardo A Disalvo Mar ía de Los A Frías Source Type: research
Collagen I protects human keratinocytes HaCaT against UVB injury via restoring PINK1/parkin-mediated mitophagy
In this study, we investigated the modulatory roles of collagen I on human immortalized keratinocytes HaCaT, especially when cells were irradiated with UVB. Interestingly, the cells grown on plates coated by molecular collagen I, but not fibrillar collagen I, acquired certain resistance against UVB damages, as shown by increased survival and reduced apoptosis. The accumulation of dysfunctional mitochondria in UVB-treated cells was attenuated by molecular collagen I-coating. Interestingly, molecular collagen I rescued the loss of mitochondrial biogenesis in cells treated with UVB. Loss of PINK1/parkin-mediated mitophagy was...
Source: Archives of Biochemistry and Biophysics - January 28, 2024 Category: Biochemistry Authors: Yuying Zhu Wendie Xiang Sijun He Zhao San Weiwei Liu Jin Wu Toshihiko Hayashi Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research
Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in diabetes mellitus
Arch Biochem Biophys. 2024 Jan 26;753:109911. doi: 10.1016/j.abb.2024.109911. Online ahead of print.ABSTRACTDiabetes is a metabolic illness that increases protein glycosylation in hyperglycemic conditions, which can have an impact on almost every organ system in the body. The role of vitamin D in the etiology of diabetes under RAGE (receptor for advanced glycation end products) stress has recently received some attention on a global scale. Vitamin D's other skeletal benefits have generated a great deal of research. Vitamin D's function in the development of type 1 and type 2 diabetes is supported by the discovery of 1,25 (...
Source: Archives of Biochemistry and Biophysics - January 27, 2024 Category: Biochemistry Authors: Asma Akhter Sultan Alouffi Uzma Shahab Rihab Akasha Mohd Fazal-Ur-Rehman Mohamed E Ghoniem Naved Ahmad Kirtanjot Kaur Ramendra Pati Pandey Ahmed Alshammari Firoz Akhter Saheem Ahmad Source Type: research
A vivid outline demonstrating the benefits of exosome-mediated drug delivery in CNS-associated disease environments
Arch Biochem Biophys. 2024 Jan 23;753:109906. doi: 10.1016/j.abb.2024.109906. Online ahead of print.ABSTRACTThe efficacy of drug delivery mechanisms has been improvised with time for different therapeutic purposes. In most cases, nano-sized delivery systems have been modeled over decades for the on-target applicability of the drugs. The use of synthetic drug delivery materials has been a common practice, although research has now focussed more on using natural vehicles, to avoid the side effects of synthetic delivery systems and easy acceptance by the body. Exosome is such a natural nano-sized vehicle that exceeds the effi...
Source: Archives of Biochemistry and Biophysics - January 25, 2024 Category: Biochemistry Authors: Rachayeeta Ray Sougata Ghosh Chowdhury Parimal Karmakar Source Type: research
