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Promotive actions of lncRNA EBLN3P involved in cervical cancer progression via interacting with miR-29c-3p and TAF15 to modify RCC2
CONCLUSION: Altogether, lncRNA EBLN3P positively regulates RCC2 expression via competitively binding to miR-29c-3p and interacting with TAF15, thereby boosting proliferation, migration, and invasion of cervical cancer cells.PMID:38555043 | DOI:10.1016/j.abb.2024.109980 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - March 30, 2024 Category: Biochemistry Authors: Ting Zou Yan Gao Mingrong Qie Source Type: research

Wogonin inhibits the migration and invasion of fibroblast-like synoviocytes by targeting PI3K/AKT/NF- κB pathway in rheumatoid arthritis
CONCLUSION: Wogonin effectively inhibits migration, invasion and pro-inflammatory cytokine production of RA fibroblast-like synoviocytes through the PI3K/AKT/NF-κB pathway, and thus wogonin, as a natural flavonoid, has great potential for treating RA.PMID:38552763 | DOI:10.1016/j.abb.2024.109965 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - March 29, 2024 Category: Biochemistry Authors: Haixin Yang Cuizhen Liu Xiujuan Lin Xing Li Shan Zeng Zhaohui Gong Qiang Xu Detang Li Nan Li Source Type: research

Building on a theme: The redox hierarchy of pyridine nucleotide-disulfide oxidoreductases
Arch Biochem Biophys. 2024 Mar 26;755:109966. doi: 10.1016/j.abb.2024.109966. Online ahead of print.ABSTRACTFlavin disulfide reductases (FDRs) are FAD-dependent enzymes that transmit electrons from NAD(P)H to reduce specific oxidant substrate disulfides. These enzymes have been studied extensively, most particularly the paradigm examples: glutathione reductase and thioredoxin reductase. The common, though not universal, traits of the family include a tyrosine- or phenylalanine-gated binding pocket for NAD(P) nicotinamides adjacent to the FAD isoalloxazine re-face, and a disulfide stacked against the si-face of the isoallox...
Source: Archives of Biochemistry and Biophysics - March 27, 2024 Category: Biochemistry Authors: Madison M Smith Graham R Moran Source Type: research

Building on a theme: The redox hierarchy of pyridine nucleotide-disulfide oxidoreductases
Arch Biochem Biophys. 2024 Mar 25:109966. doi: 10.1016/j.abb.2024.109966. Online ahead of print.ABSTRACTFlavin disulfide reductases (FDRs) are FAD-dependent enzymes that transmit electrons from NAD(P)H to reduce specific oxidant substrate disulfides. These enzymes have been studied extensively, most particularly the paradigm examples: glutathione reductase and thioredoxin reductase. The common, though not universal, traits of the family include a tyrosine- or phenylalanine-gated binding pocket for NAD(P) nicotinamides adjacent to the FAD isoalloxazine re-face, and a disulfide stacked against the si-face of the isoalloxazin...
Source: Archives of Biochemistry and Biophysics - March 27, 2024 Category: Biochemistry Authors: Madison M Smith Graham R Moran Source Type: research

Capsaicin induces ATP-dependent thermogenesis via the activation of TRPV1/ β3-AR/α1-AR in 3T3-L1 adipocytes and mouse model
In this study, we employed qRT-PCR, immunoblot, staining method, and assay kit to investigate the role of CAP on ATP-dependent thermogenesis and its modulatory roles on the TRPV1, β3-adrenergic receptor (β3-AR), and α1-AR using in vitro and in vivo models. The studies showed that CAP treatment in high-fat diet-induced obese mice resulted in lower body weight gain and elevated ATP-dependent thermogenic effectors' protein and gene expression through ATP-consuming calcium and creatine futile cycles. In both in vitro and in vivo experiments, CAP treatment elevated the protein and gene expressions of sarcoendoplasmic/endopla...
Source: Archives of Biochemistry and Biophysics - March 26, 2024 Category: Biochemistry Authors: Abdillah Alfin Mohammad Jong Won Yun Source Type: research

Extracellular vesicles promote silica nanoparticle aggregation that inhibits silica-induced cytotoxicity
Arch Biochem Biophys. 2024 Mar 23:109964. doi: 10.1016/j.abb.2024.109964. Online ahead of print.ABSTRACTAmorphous silica has been approved as a food and pharmaceutical additive. However, its potential to enhance the carcinogenicity of epithelial cells is incontrovertible. With their expanded surface area per unit mass and distinctive cellular incorporation, nano-sized silica particles (nSPs) exhibit heightened cytotoxicity compared to micrometer-sized counterparts. The precise effect of nSPs on the generation of small extracellular vesicles (sEVs) within endosomes after cellular uptake remains unclear. In the present study...
Source: Archives of Biochemistry and Biophysics - March 25, 2024 Category: Biochemistry Authors: Takeshi Yoshida Kenji Goto Akihito Kodama Dilireba Bolidong Takafumi Seto Rikinari Hanayama Source Type: research

A novel approach of using Maca root as a radioprotector in a rat testicular damage model focusing on GRP78/CHOP/Caspase-3 pathway
CONCLUSION: Our findings show for the first time that Maca has a protective effect on male reproductive damage induced by radiotherapy. Maca root reveals anti-apoptotic effect and protection against testicular damage via GRP78/CHOP/caspase-3 pathway.PMID:38518815 | DOI:10.1016/j.abb.2024.109963 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - March 22, 2024 Category: Biochemistry Authors: Mai H Mekkawy Fatma Y Abdou Maha M Ali Amira Abd-ElRaouf Source Type: research

Exosomes derived from diabetic serum accelerate the progression of osteoarthritis
Arch Biochem Biophys. 2024 Mar 19;755:109960. doi: 10.1016/j.abb.2024.109960. Online ahead of print.ABSTRACTDiabetes mellitus (DM) has been demonstrated to accelerate the progression of osteoarthritis (OA) by largely unknown mechanisms. Studies have shown that DM dysfunctional adipocyte-derived exosomes play a crucial role in the pathogenesis of remote organ functions. The present study aimed to clarify whether and how diabetic adipocyte-derived exosomes mediate the pathological regulation of OA. We found that intraarticular injection of DM serum exosomes in the non-diabetic mice significantly exacerbated OA injury as evid...
Source: Archives of Biochemistry and Biophysics - March 21, 2024 Category: Biochemistry Authors: Tao Jin Lei Wu Jizu Wang Xingbo Wang Zongru He Wenfei Di Qingshan Yang Xiaodong Wei Source Type: research

Exosomes derived from diabetic serum accelerate the progression of osteoarthritis
Arch Biochem Biophys. 2024 Mar 19:109960. doi: 10.1016/j.abb.2024.109960. Online ahead of print.ABSTRACTDiabetes mellitus (DM) has been demonstrated to accelerate the progression of osteoarthritis (OA) by largely unknown mechanisms. Studies have shown that DM dysfunctional adipocyte-derived exosomes play a crucial role in the pathogenesis of remote organ functions. The present study aimed to clarify whether and how diabetic adipocyte-derived exosomes mediate the pathological regulation of OA. We found that intraarticular injection of DM serum exosomes in the non-diabetic mice significantly exacerbated OA injury as evidence...
Source: Archives of Biochemistry and Biophysics - March 21, 2024 Category: Biochemistry Authors: Tao Jin Lei Wu Jizu Wang Xingbo Wang Zongru He Wenfei Di Qingshan Yang Xiaodong Wei Source Type: research

Identifying novel aryl hydrocarbon receptor (AhR) modulators from clinically approved drugs: In silico screening and In vitro validation
Arch Biochem Biophys. 2024 Mar 16:109958. doi: 10.1016/j.abb.2024.109958. Online ahead of print.ABSTRACTThe aryl hydrocarbon receptor (AhR) functions as a vital ligand-activated transcription factor, governing both physiological and pathophysiological processes. Notably, it responds to xenobiotics, leading to a diverse array of outcomes. In the context of drug repurposing, we present here a combined approach of utilizing structure-based virtual screening and molecular dynamics simulations. This approach aims to identify potential AhR modulators from Drugbank repository of clinically approved drugs. By focusing on the AhR P...
Source: Archives of Biochemistry and Biophysics - March 18, 2024 Category: Biochemistry Authors: Farag E S Mosa Mohammed A Alqahtani Mahmoud A El-Ghiaty Khaled Barakat Ayman O S El-Kadi Source Type: research