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Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGF β1- Smad1/5 signaling pathway
CONCLUSIONS: Our findings suggest that Lrg1 silencing can be applied as a potential therapeutic target to inhibit the TGFβ1-Smad1/5 pathway, thereby enhancing autophagy and decreasing apoptosis in patients with acute kidney injury.PMID:38246328 | DOI:10.1016/j.abb.2024.109892 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - January 21, 2024 Category: Biochemistry Authors: Jianhui Chen Zuoman Zhang Ling Feng Weihua Liu Xin Wang Haishan Chen Hequn Zou Source Type: research

Ferulic acid protects against gamma-radiation induced liver injury via regulating JAK/STAT/Nrf2 pathways
In conclusion, the current study suggests the potential complex mechanisms underlying the mitigating impact of FA in IR-induced ferroptotic liver damage.PMID:38244663 | DOI:10.1016/j.abb.2024.109895 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - January 20, 2024 Category: Biochemistry Authors: Rania A Gawish Esraa M Samy Maha M Aziz Source Type: research

Characterization of haloacid dehalogenase superfamily acid phosphatase from Staphylococcus lugdunensis
Arch Biochem Biophys. 2024 Jan 15;753:109888. doi: 10.1016/j.abb.2024.109888. Online ahead of print.ABSTRACTThe haloacid dehalogenase superfamily implicated in bacterial pathogenesis comprises different enzymes having roles in many metabolic pathways. Staphylococcus lugdunensis, a Gram-positive bacterium, is an opportunistic human pathogen causing infections in the central nervous system, urinary tract, bones, peritoneum, systemic conditions and cutaneous infection. The haloacid dehalogenase superfamily proteins play a significant role in the pathogenicity of certain bacteria, facilitating invasion, survival, and prolifera...
Source: Archives of Biochemistry and Biophysics - January 17, 2024 Category: Biochemistry Authors: Harry Kaur Surabhi Rode Sandra Kp Jai Krishna Mahto Md Shahid Alam Deena Nath Gupta Bibekananda Kar Jitin Singla Pravindra Kumar Ashwani Kumar Sharma Source Type: research

A multifactorial study of in situ antioxidant activity of modified GrO in myocardial reperfusion injury using the Langerdorff model
In this study, the cardioprotective and antioxidant potential of modified GrO as a pre-treatment in rats was evaluated for the first time. In Langendorff isolated rat heart I/R model, the left ventricle developed pressure (LVDP), the end-diastolic pressure (EDP), the maximal (dP/dtmax) and minimal (dP/dtmin) value of the first derivative of LVDP, and heart rate (HR) were measured. The oxidative-nitrosative markers, in particular, the rate of O2*- and H2O2 generation, the content of malonic dialdehyde, diene conjugates, and leukotriene as well as cNOS and iNOS activity were estimated. Obtained results show a significant res...
Source: Archives of Biochemistry and Biophysics - January 17, 2024 Category: Biochemistry Authors: Kateryna V Sencha-Hlevatska Yury I Sementsov Sergey V Zhuravskyi Lidia A Mys Yulia P Korkach Hristo Kolev Vadym F Sagach Yulia V Goshovska Source Type: research

Functional regulation of the protein phosphatase PPM1M by phosphorylation at multiple sites with Ser/Thr-Pro motifs
In this study, we show that PPM1M is regulated in different ways by multiple phosphorylation. PPM1M has four Ser/Thr-Pro motifs (Ser27, Ser43, Ser60, and Thr254) that are recognized by proline-directed kinases, and Ser60 was found to be phosphorylated by cyclin-dependent kinase 5 (CDK5) in the cell. The phospho-mimetic mutation of Ser27 and Ser43 in the N-terminal domain suppresses the nuclear localization of PPM1M and promotes its accumulation in the cytoplasm. The phospho-mimetic mutation of Ser60 decreases PPM1M activity; conversely, the phospho-mimetic mutation of Thr254 increases PPM1M activity. These results suggest ...
Source: Archives of Biochemistry and Biophysics - January 15, 2024 Category: Biochemistry Authors: Jin Osawa Masataka Karakawa Aoi Taniguchi Yuiko Inui Chika Usuki Atsuhiko Ishida Isamu Kameshita Noriyuki Sueyoshi Source Type: research

FKBP38 suppresses endometrial cancer cell proliferation and metastasis by inhibiting the mTOR pathway
Arch Biochem Biophys. 2024 Feb;752:109891. doi: 10.1016/j.abb.2024.109891. Epub 2024 Jan 11.ABSTRACTEndometrial cancer (EC) is a common gynecological malignancy, and advanced-stage or recurrent EC is associated with a high mortality rate owing to the ineffectiveness of currently available treatments. FK506-binding protein 38 (FKBP38) is a member of the immunophilin family and inhibits melanoma and breast cancer cell metastasis. However, the functions of FKBP38 and its potential mechanism in EC remain unclear. Herein, we analyzed the expression levels of FKBP38 in EC cells and found that the FKBP38 expression was high in Is...
Source: Archives of Biochemistry and Biophysics - January 13, 2024 Category: Biochemistry Authors: Yunjing Yan Shuai Wang Zongmeng Zhang Minyi Tang Allan Z Zhao Zhuang Li Xiaoli Wu Fanghong Li Source Type: research

Computer-made peptide RQ18 acts as a dual antifungal and antibiofilm peptide though membrane-associated mechanisms of action
Arch Biochem Biophys. 2024 Jan 11;753:109884. doi: 10.1016/j.abb.2024.109884. Online ahead of print.ABSTRACTThe spread of fungi resistant to conventional drugs has become a threatening problem. In this context, antimicrobial peptides (AMPs) have been considered as one of the main alternatives for controlling fungal infections. Here, we report the antifungal and antibiofilm activity and some clues about peptide RQ18's mechanism of action against Candida and Cryptococcus. This peptide inhibited yeast growth from 2.5 μM and killed all Candida tropicalis cells within 2 h incubation. Moreover, it showed a synergistic effect wi...
Source: Archives of Biochemistry and Biophysics - January 13, 2024 Category: Biochemistry Authors: Claudiane Vilharroel Almeida Caio Fernando Ramalho de Oliveira Lu ís Henrique de Oliveira Almeida Suellen Rodrigues Ramalho Camila de Oliveira Gutierrez Janaina de Cassia Orlandi Sardi Oct ávio Luiz Franco Marlon Henrique Cardoso Maria Ligia Rodrigues M Source Type: research

Hemin competitively inhibits HSPA8 ATPase activity mitigating its foldase function
Arch Biochem Biophys. 2024 Feb;752:109889. doi: 10.1016/j.abb.2024.109889. Epub 2024 Jan 10.ABSTRACTHemolysis in red blood cells followed by hemoglobin degradation results in high hemin levels in the systemic circulation. Such a level of hemin is disastrous for cells and tissues and is considerably responsible for the pathologies of diseases like severe malaria. Hemin's hydrophobic chemical nature and structure allow it to bind several proteins leading to their functional modification. Such modifications in physiologically relevant proteins can have a high impact on various cellular processes. HSPA8 is a chaperone that has...
Source: Archives of Biochemistry and Biophysics - January 12, 2024 Category: Biochemistry Authors: Alok Kumar Pandey Vishal Trivedi Source Type: research

Echinacoside stimulates myogenesis and ATP-dependent thermogenesis in the skeletal muscle via the activation of D1-like dopaminergic receptors
In this study, we investigated the effect of echinacoside (ECH), a caffeic acid glycoside from the phenylpropanoid class, on myogenesis and ATP-dependent thermogenesis in the skeletal muscle and its interaction with the dopaminergic receptors 1 and 5 (DRD1 and DRD5). We applied RT-PCR, immunoblot analysis, a staining method, and an assay kit to determine the effects of ECH on diverse target genes and proteins involved in skeletal muscle myogenesis and ATP-consuming futile processes. Our study demonstrated that ECH enhanced myogenic differentiation, glucose, and fatty acid uptake, as well as lipid catabolism, and induced AT...
Source: Archives of Biochemistry and Biophysics - January 12, 2024 Category: Biochemistry Authors: Kiros Haddish Jong Won Yun Source Type: research

The presence of free palmitic acid modulates the effects of lutein on structural and dynamic properties of lipid membranes
We presented the simplified model membrane that could be a suitable representation of the physiological process of de-esterification of PA from LUT appearing in natural biomembranes in humans.PMID:38211638 | DOI:10.1016/j.abb.2024.109883 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - January 11, 2024 Category: Biochemistry Authors: Emilia Reszczy ńska Anna Wi śniewska-Becker Mariusz Duda Alicja S ęk Wies ław I Gruszecki Agnieszka Hanaka Source Type: research

G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β < sub > 1 < /sub > -adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells
Arch Biochem Biophys. 2024 Feb;752:109882. doi: 10.1016/j.abb.2024.109882. Epub 2024 Jan 10.ABSTRACTG protein-coupled receptor 30 (GPR30), also named G protein-coupled estrogen receptor (GPER), and the β1-adrenergic receptor (β1AR) are G protein-coupled receptors (GPCR) that are implicated in breast cancer progression. Both receptors contain PSD-95/Discs-large/ZO-1 homology (PDZ) motifs in their C-terminal tails through which they interact in the plasma membrane with membrane-associated guanylate kinase (MAGUK) scaffold proteins, and in turn protein kinase A anchoring protein (AKAP) 5. GPR30 constitutively and PDZ-depend...
Source: Archives of Biochemistry and Biophysics - January 11, 2024 Category: Biochemistry Authors: Julia Tutzauer D Stephen Serafin Tobias Schmidt Bj örn Olde Kathleen M Caron L M Fredrik Leeb-Lundberg Source Type: research

Myopathy-causing mutation R91P in the TPM3 gene drastically impairs structural and functional properties of slow skeletal muscle tropomyosin γβ-heterodimer
Arch Biochem Biophys. 2024 Feb;752:109881. doi: 10.1016/j.abb.2023.109881. Epub 2024 Jan 6.ABSTRACTTropomyosin (Tpm) is a regulatory actin-binding protein involved in Ca2+ activation of contraction of striated muscle. In human slow skeletal muscles, two distinct Tpm isoforms, γ and β, are present. They interact to form three types of dimeric Tpm molecules: γγ-homodimers, γβ-heterodimers, or ββ-homodimers, and a majority of the molecules are present as γβ-Tpm heterodimers. Point mutation R91P within the TPM3 gene encoding γ-Tpm is linked to the condition known as congenital fiber-type disproportion (CFTD), which ...
Source: Archives of Biochemistry and Biophysics - January 7, 2024 Category: Biochemistry Authors: Anastasiia D Gonchar Natalia A Koubassova Galina V Kopylova Anastasia M Kochurova Victoria V Nefedova Daria S Yampolskaya Daniil V Shchepkin Sergey Y Bershitsky Andrey K Tsaturyan Alexander M Matyushenko Dmitrii I Levitsky Source Type: research

Myopathy-causing mutation R91P in the TPM3 gene drastically impairs structural and functional properties of slow skeletal muscle tropomyosin γβ-heterodimer
Arch Biochem Biophys. 2024 Jan 5:109881. doi: 10.1016/j.abb.2023.109881. Online ahead of print.ABSTRACTTropomyosin (Tpm) is a regulatory actin-binding protein involved in Ca2+ activation of contraction of striated muscle. In human slow skeletal muscles, two distinct Tpm isoforms, γ and β, are present. They interact to form three types of dimeric Tpm molecules: γγ-homodimers, γβ-heterodimers, or ββ-homodimers, and a majority of the molecules are present as γβ-Tpm heterodimers. Point mutation R91P within the TPM3 gene encoding γ-Tpm is linked to the condition known as congenital fiber-type disproportion (CFTD), wh...
Source: Archives of Biochemistry and Biophysics - January 7, 2024 Category: Biochemistry Authors: Anastasiia D Gonchar Natalia A Koubassova Galina V Kopylova Anastasia M Kochurova Victoria V Nefedova Daria S Yampolskaya Daniil V Shchepkin Sergey Y Bershitsky Andrey K Tsaturyan Alexander M Matyushenko Dmitrii I Levitsky Source Type: research

Myopathy-causing mutation R91P in the TPM3 gene drastically impairs structural and functional properties of slow skeletal muscle tropomyosin γβ-heterodimer
Arch Biochem Biophys. 2024 Jan 5:109881. doi: 10.1016/j.abb.2023.109881. Online ahead of print.ABSTRACTTropomyosin (Tpm) is a regulatory actin-binding protein involved in Ca2+ activation of contraction of striated muscle. In human slow skeletal muscles, two distinct Tpm isoforms, γ and β, are present. They interact to form three types of dimeric Tpm molecules: γγ-homodimers, γβ-heterodimers, or ββ-homodimers, and a majority of the molecules are present as γβ-Tpm heterodimers. Point mutation R91P within the TPM3 gene encoding γ-Tpm is linked to the condition known as congenital fiber-type disproportion (CFTD), wh...
Source: Archives of Biochemistry and Biophysics - January 7, 2024 Category: Biochemistry Authors: Anastasiia D Gonchar Natalia A Koubassova Galina V Kopylova Anastasia M Kochurova Victoria V Nefedova Daria S Yampolskaya Daniil V Shchepkin Sergey Y Bershitsky Andrey K Tsaturyan Alexander M Matyushenko Dmitrii I Levitsky Source Type: research

Middle-age abolishes cardioprotection conferred by thioredoxin-1 in mice
This study aimed to evaluate if combining two cardioprotective strategies, such as Trx1 overexpression and PostC, could exert a synergistic effect in reducing infarct size in middle-aged mice. Young or middle-aged wild-type mice (Wt), transgenic mice overexpressing Trx1, and dominant negative (DN-Trx1) mutant of Trx1 mice were used. Mice hearts were subjected to I/R or PostC protocol. Infarct size, hydrogen peroxide (H2O2) production, protein nitration, Trx1 activity, mitochondrial function, and Trx1, pAkt and pGSK3β expression were measured. PostC could not reduce infarct size even in the presence of Trx1 overexpression ...
Source: Archives of Biochemistry and Biophysics - January 3, 2024 Category: Biochemistry Authors: V Perez T Zaobornyj T Vico V Vanasco T Marchini E Godoy S Alvarez P Evelson M Donato R J Gelpi V D'Annunzio Source Type: research