American Journal of Respiratory Cell and Molecular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Modelling the Human Alveolar Epithelium: Promises and Challenges
Am J Respir Cell Mol Biol. 2024 Feb 14. doi: 10.1165/rcmb.2023-0471ED. Online ahead of print.NO ABSTRACTPMID:38353673 | DOI:10.1165/rcmb.2023-0471ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 14, 2024 Category: Molecular Biology Authors: Vitalii Kryvenko Istv án Vadász Source Type: research

Tamping Down the Fire: Taming Pyroptosis through RNA Methylation in Acute Lung Injury
Am J Respir Cell Mol Biol. 2024 Feb 14. doi: 10.1165/rcmb.2024-0001ED. Online ahead of print.NO ABSTRACTPMID:38353587 | DOI:10.1165/rcmb.2024-0001ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 14, 2024 Category: Molecular Biology Authors: Kun Woo D Shin Robert B Hamanaka Source Type: research

TRPV4 Regulates the Macrophage Metabolic Response to Limit Sepsis-induced Lung Injury
Am J Respir Cell Mol Biol. 2024 Feb 12. doi: 10.1165/rcmb.2023-0456OC. Online ahead of print.ABSTRACTSepsis is a systemic inflammatory response that requires effective macrophage metabolic functions to resolve ongoing inflammation. Previous work showed that the mechanosensitive cation channel, transient receptor potential vanilloid 4 (TRPV4), mediates macrophage phagocytosis and cytokine production in response to lung infection. Here, we show that TRPV4 regulates glycolysis in a stiffness dependent manner by augmenting macrophage glucose uptake by GLUT1. In addition, TRPV4 is required for lipopolysaccharide (LPS)-induced p...
Source: American Journal of Respiratory Cell and Molecular Biology - February 12, 2024 Category: Molecular Biology Authors: Erica M Orsini Sanjoy Roychowdhury Mahesha Gangadhariah Emily Cross Susamma Abraham Amanda Reinhardt Megan E Grund Julie Y Zhou Olivia Stuehr Bishnu Pant Mitchell A Olman Vidula Vachharajani Rachel G Scheraga Source Type: research

Lung Interstitial Macrophages Can Present Soluble Antigens and Induce Foxp3+ Regulatory T Cells
Am J Respir Cell Mol Biol. 2024 Feb 8. doi: 10.1165/rcmb.2023-0254OC. Online ahead of print.ABSTRACTLung macrophages constitute a sophisticated surveillance and defense system that contributes to tissue homeostasis, host defense, and allows the host to cope with the myriad of insults and antigens to which the lung mucosa is exposed. As opposed to alveolar macrophages, lung interstitial macrophages express high levels of type 2 major histocompatibility complex (MHC-II), a hallmark of antigen-presenting cells. Here, we showed that lung IMs, like dendritic cells (DCs), possess the machinery to present soluble antigens in an M...
Source: American Journal of Respiratory Cell and Molecular Biology - February 8, 2024 Category: Molecular Biology Authors: C éline Legrand Domien Vanneste Alexandre Hego Catherine Sabatel Kir éna Mollers Joey Schyns Pauline Mar échal Joan Abinet Amandine Tytgat Maude Li égeois Barbara Polese Margot Meunier Coraline Radermecker Laurence Fi évez Fabrice Bureau Thomas Maric Source Type: research

Alternative Splicing Is a Major Factor Shaping Transcriptome Diversity in Mild and Severe COPD
In conclusion, we observed large and significant differences in alternative splicing between bronchial samples of COPD and control individuals, with more events observed in severe than in mild-to-moderate COPD. The changes in the expression of several splicing factors correlated with prevalence of alternative splicing in severe COPD. Alternative splicing can indirectly impact gene expression by changing the relative abundance of protein-coding isoforms potentially influencing pathophysiological changes. The presented results provide a better understanding of COPD-related alternative splicing changes.PMID:38315810 | DOI:10....
Source: American Journal of Respiratory Cell and Molecular Biology - February 5, 2024 Category: Molecular Biology Authors: Dmitry Khalenkow Corry-Anke Brandsma Wim Timens David F Choy Michele A Grimbaldeston Carrie M Rosenberger Dirk-Jan Slebos Huib A M Kerstjens Alen Faiz Gerard H Koppelman Martijn C Nawijn Maarten van den Berge Victor Guryev Source Type: research

Breath Markers of Oxidative Stress in Children with Severe Viral Lower Respiratory Tract Infection
Am J Respir Cell Mol Biol. 2024 Feb 5. doi: 10.1165/rcmb.2023-0349OC. Online ahead of print.ABSTRACTSevere viral lower respiratory tract infection (LRTI), resulting in both acute and long-term pulmonary disease, constitutes a substantial burden among young children. Viral LRTI triggers local oxidative stress pathways by infection and inflammation, and supportive care in the pediatric intensive care unit may further aggravate oxidative injury. The main goal of this exploratory study was to identify and monitor breath markers linked to oxidative stress in children over the disease course of severe viral LRTI. Exhaled breath ...
Source: American Journal of Respiratory Cell and Molecular Biology - February 5, 2024 Category: Molecular Biology Authors: Thijs A Lilien Paul Brinkman Dominic W Fenn Job B M van Woensel Lieuwe D J Bos Reinout A Bem Source Type: research

Identification of Lymphangioleiomyomatosis-associated Serum MicroRNAs
Am J Respir Cell Mol Biol. 2024 Feb;70(2):146-148. doi: 10.1165/rcmb.2023-0243LE.NO ABSTRACTPMID:38299793 | DOI:10.1165/rcmb.2023-0243LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 1, 2024 Category: Molecular Biology Authors: Riccardo L Rossi Davide Elia Olga Torre Roberto Cassandro Antonella Caminati Elisabetta Bulgheroni Elena Carelli Chiara Vasco Sergio Abrignani Jens Geginat Sergio Harari Source Type: research

Loss of Pulmonary Endothelial Cells in Emphysema Impairs Support of Human Alveolar Epithelial Cell Growth
Am J Respir Cell Mol Biol. 2024 Feb;70(2):149-152. doi: 10.1165/rcmb.2023-0084LE.NO ABSTRACTPMID:38299794 | DOI:10.1165/rcmb.2023-0084LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 1, 2024 Category: Molecular Biology Authors: Abilash Ravi Li Jia Xinhui Wu Andries D van der Meer Reinoud Gosens Jan Stolk Anne M van der Does Frits Koning Pieter S Hiemstra P Padmini J S Khedoe Source Type: research

February Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2024 Feb;70(2):iii. doi: 10.1165/rcmb.70i2RedAlert.NO ABSTRACTPMID:38299795 | DOI:10.1165/rcmb.70i2RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 1, 2024 Category: Molecular Biology Source Type: research

Time Is Running Out in Pulmonary Arterial Hypertension: The Epigenetic Clock Is Clicking
Am J Respir Cell Mol Biol. 2024 Feb;70(2):140-143. doi: 10.1165/rcmb.2023-0335LE.NO ABSTRACTPMID:38299796 | DOI:10.1165/rcmb.2023-0335LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 1, 2024 Category: Molecular Biology Authors: Reem El Kabbout Nabil Azhar Sandra Breuils-Bonnet Sandra Martineau Vinod Krishna Shanker Kalyana-Sundaram Olivier Boucherat Steeve Provencher S ébastien Bonnet Fran çois Potus Source Type: research

Pulmonary Veno-Occlusive Disease and Pulmonary Fibrosis in a Family with < em > EIF2AK4 < /em > Pathogenic Variants
Am J Respir Cell Mol Biol. 2024 Feb;70(2):143-145. doi: 10.1165/rcmb.2023-0166LE.NO ABSTRACTPMID:38299797 | DOI:10.1165/rcmb.2023-0166LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 1, 2024 Category: Molecular Biology Authors: Kelly Vetel M élanie Eyries Laurent Savale Caroline Kanengiesser Raphael Borie Marc Humbert David Montani Source Type: research

Farnesoid X Receptor Protects Murine Lung Against IL-6-promoted Ferroptosis Induced by Poly(I:C)
In this study, a intratracheal instillation of poly(I:C) with or without IL-6 neutralizing antibody model combined with metabonomics, transcriptomics and so on to explore the underlying molecular mechanisms of IL-6-exacerbated lung injury. We found that poly(I:C) increased IL-6 level, and the up-regulated IL-6 further induced lung ferroptosis, especially in AT2 cells. Meanwhile, the lung regeneration was impaired. Mechanistically, metabolomics analysis showed that poly(I:C) significantly decreased glycolytic metabolites and increased bile acid intermediate metabolites that inhibited the bile acid nuclear receptor farnesoid...
Source: American Journal of Respiratory Cell and Molecular Biology - February 1, 2024 Category: Molecular Biology Authors: Dongmin Yang Hongbiao Liang Xiangrui Zhu Bochuan Li Chun Li Guizimeng Hu Xing Du Guohui Dang Yuwei Song Xiaolong Ma Peng Zhang Tianqi Chen Bo Liu Li Yan Chunshui Pan Kai Sun Xinmei Huo Yingmei Feng Xian Wang Ding Ai Jingyan Han Juan Feng Source Type: research

Lung Epithelium Releases Growth Differentiation Factor 15 in Response to Pathogen-mediated Injury
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:38301257 | DOI:10.1165/rcmb.2023-0429OC (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 1, 2024 Category: Molecular Biology Authors: Faraaz A Shah Harinath Bahudhanapati Mao Jiang Mohammadreza Tabary Rick van der Geest Nathanial J Tolman Megan Kochin Zeyu Xiong Nameer Al-Yousif Khaled Sayed Panayiotis V Benos Kristen Raffensperger John Evankovich Matthew D Neal Mark E Snyder Oliver Eic Source Type: research

Unraveling a Key Molecular Player Governing Pulmonary Alveolar Development
Am J Respir Cell Mol Biol. 2024 Feb 1. doi: 10.1165/rcmb.2024-0025ED. Online ahead of print.NO ABSTRACTPMID:38301261 | DOI:10.1165/rcmb.2024-0025ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 1, 2024 Category: Molecular Biology Authors: Shihang Ding Shinji Deguchi Taeyoon Kim Source Type: research