American Journal of Respiratory Cell and Molecular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Disrupting the TGF β/Wnt Balance to Control the Polarity of the Cystic Fibrosis Airway Epithelium
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2024-0112ED. Online ahead of print.NO ABSTRACTPMID:38574230 | DOI:10.1165/rcmb.2024-0112ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - April 4, 2024 Category: Molecular Biology Authors: Carlos M Farinha Source Type: research

Activated Clec4n < sup > hi < /sup > Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7 Dependent Manner
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2024-0017OC. Online ahead of print.ABSTRACTThe role of endothelial cells in Acute lung injury (ALI) has been widely elaborated, but little is known about the role of different subtypes of endothelial cells in ALI. ALI models were established by lipopolysaccharide. Single-cell RNA sequencing was used to identify differential molecules in endothelial subtypes and heterogeneity of lung immune cells. Specific antibodies were used to block IGFBP7 protein, and AAVshIGP7 was used to specifically knock down IGFBP7. Here, we found that Insulin-like growth factor binding prote...
Source: American Journal of Respiratory Cell and Molecular Biology - April 4, 2024 Category: Molecular Biology Authors: Linchao Yu Rui He Daoxin Wang Di Qi Source Type: research

Foxq1 Promotes Alveolar Epithelial Cell Death through Tle1-mediated Inhibition of the NF κB Signaling Pathway
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2023-0317OC. Online ahead of print.ABSTRACTAcute lung injury is a common respiratory disease characterized by diffuse alveolar injury and interstitial edema, as well as a hyperinflammatory response, lung cell damage and oxidative stress. Foxq1, a member of the FOX family of transcription factors, is expressed in various tissues, such as the lungs, liver, and kidneys, and contributes to various biological processes, such as stress, metabolism, cell cycle arrest, and aging-related apoptosis. However, the role of Foxq1 in acute lung injury is unknown. We constructed ex ...
Source: American Journal of Respiratory Cell and Molecular Biology - April 4, 2024 Category: Molecular Biology Authors: Xi Zhu Ershi Hua Qifeng Tu Mei Liu Liqin Xu Jian Feng Source Type: research

IL-10 Counteracts IFN- γ to Alleviate Acute Lung Injury in a Viral-Bacterial Superinfection Model
Am J Respir Cell Mol Biol. 2024 Apr 4. doi: 10.1165/rcmb.2023-0437OC. Online ahead of print.ABSTRACTImmune activation is essential for lung control of viral and bacterial infection, but an overwhelming inflammatory response often leads to the onset of acute respiratory distress syndrome (ARDS). Interleukin-10 (IL-10) plays a crucial role in regulating the balance between antimicrobial immunity and immunopathology. In the current study, we have investigated the role of IL-10 in acute lung injury (ALI) induced by influenza A virus (IAV) and methicillin-resistant Staphylococcus aureus (MRSA) coinfection. This unique coinfecti...
Source: American Journal of Respiratory Cell and Molecular Biology - April 4, 2024 Category: Molecular Biology Authors: Michael McKelvey Md Bashir Uddin Sunil Palani Shengjun Shao Keer Sun Source Type: research

Dissecting a Brake for Airway Smooth Muscle Cell Movement
Am J Respir Cell Mol Biol. 2024 Apr 3. doi: 10.1165/rcmb.2024-0120ED. Online ahead of print.NO ABSTRACTPMID:38568237 | DOI:10.1165/rcmb.2024-0120ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - April 3, 2024 Category: Molecular Biology Authors: Dale D Tang Source Type: research

Airway Proteotypes of E-Cigarette Users Overlap with Those Found in Asthmatics
Am J Respir Cell Mol Biol. 2024 Apr;70(4):326-328. doi: 10.1165/rcmb.2023-0381LE.NO ABSTRACTPMID:38557396 | DOI:10.1165/rcmb.2023-0381LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - April 1, 2024 Category: Molecular Biology Authors: Elise Hickman Neil E Alexis Julia E Rager Ilona Jaspers Source Type: research

April Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2024 Apr;70(4):iii-iv. doi: 10.1165/rcmb.70i4RedAlert.NO ABSTRACTPMID:38557397 | DOI:10.1165/rcmb.70i4RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - April 1, 2024 Category: Molecular Biology Source Type: research

Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: American Journal of Respiratory Cell and Molecular Biology - March 28, 2024 Category: Molecular Biology Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research