American Journal of Respiratory Cell and Molecular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

P300/CBP Regulates HIF-1 Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia
Am J Respir Cell Mol Biol. 2023 Oct 24. doi: 10.1165/rcmb.2022-0481OC. Online ahead of print.ABSTRACTObstructive sleep apnea (OSA), a widespread breathing disorder, leads to intermittent hypoxia (IH). OSA patients and IH-treated rodents exhibit heightened sympathetic nerve activity and hypertension. Previous studies reported transcriptional activation of NADPH oxidases (Nox) by hypoxia-inducible factor-1 (HIF-1) contribute to autonomic dysfunction in IH treated rodents. Lysine acetylation, regulated by lysine acetyltransferase (KATs) and lysine deacetylase (KDACs), activates gene transcription and play an important role in...
Source: American Journal of Respiratory Cell and Molecular Biology - October 24, 2023 Category: Molecular Biology Authors: Ning Wang Xiaoyu Su David Sams Nanduri R Prabhakar Jayasri Nanduri Source Type: research

Cellular Senescence Contributes to the Progression of Hyperoxic Bronchopulmonary Dysplasia
Am J Respir Cell Mol Biol. 2023 Oct 24. doi: 10.1165/rcmb.2023-0038OC. Online ahead of print.ABSTRACTOxidative stress (OS), inflammation, and endoplasmic reticulum (ER) stress sequentially occur in bronchopulmonary dysplasia (BPD), and all result in DNA damage. When DNA damage becomes irreparable, tumor suppressors increase, followed by apoptosis or senescence. Although cellular senescence contributes to wound healing, its persistence inhibits growth. Therefore, we hypothesized that cellular senescence contributes to BPD progression. Human autopsy lungs were obtained. Sprague-Dawley rat pups exposed to 95% oxygen between p...
Source: American Journal of Respiratory Cell and Molecular Biology - October 24, 2023 Category: Molecular Biology Authors: Xigang Jing Shuang Jia Maggie Teng Billy W Day Adeleye J Afolayan Jason A Jarzembowski Chien-Wei Lin Martin J Hessner Kirkwood A Pritchard Stephen Naylor G Ganesh Konduri Ru-Jeng Teng Source Type: research

Pleural Fibrosis: Now That's What mTORC(ing) About
Am J Respir Cell Mol Biol. 2023 Oct 3. doi: 10.1165/rcmb.2023-0327ED. Online ahead of print.NO ABSTRACTPMID:37788451 | DOI:10.1165/rcmb.2023-0327ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - October 3, 2023 Category: Molecular Biology Authors: Steven E Mutsaers Vera P Krymskaya Source Type: research