American Journal of Respiratory Cell and Molecular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Application of Metabolomics Across the Spectrum of Pulmonary and Critical Care Medicine
We present several examples of metabolomics applied to pulmonary and critical care medicine in order to illustrate the potential of this avenue of research to deepen our understanding of pathophysiology. We conclude by reviewing recent advances in the field and future research directions that stand to further the goal of personalizing medicine in order to improve patient care.PMID:38547373 | DOI:10.1165/rcmb.2024-0080PS (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - March 28, 2024 Category: Molecular Biology Authors: Catherine E Simpson Julie G Ledford Gang Liu Source Type: research

Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: American Journal of Respiratory Cell and Molecular Biology - March 28, 2024 Category: Molecular Biology Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research

Akt-driven TGF- β and DKK1 Secretion Impairs F508del CF Airway Epithelium Polarity
Am J Respir Cell Mol Biol. 2024 Mar 26. doi: 10.1165/rcmb.2023-0408OC. Online ahead of print.ABSTRACTEpithelial polarity is fundamental in maintaining barrier integrity and tissue protection. In cystic fibrosis (CF), apicobasal polarity of the airway epithelium is altered, resulting in increased apical fibronectin deposition and enhanced susceptibility to bacterial infections. Here, we evaluated the effect of highly effective modulator treatment (HEMT) on fibronectin apical deposition and investigated the intracellular mechanisms triggering the defect in polarity of the CF airway epithelium. To this end, primary cultures o...
Source: American Journal of Respiratory Cell and Molecular Biology - March 26, 2024 Category: Molecular Biology Authors: Tahir Idris Michael Bachmann Marc Bacchetta Bernhard Wehrle-Haller Marc Chanson Mehdi Badaoui Source Type: research

Kisspeptin/KISS1R Signaling Modulates Human Airway Smooth Muscle Cell Migration
Am J Respir Cell Mol Biol. 2024 Mar 21. doi: 10.1165/rcmb.2023-0469OC. Online ahead of print.ABSTRACTAirway remodeling is a cardinal feature of asthma, associated with increased airway smooth muscle cell (ASM) mass and up-regulation of extracellular matrix deposition. Exaggerated ASM cell migration contributes to excessive ASM mass. Previously, we demonstrated the alleviating role of kisspeptin (Kp) receptor (KISS1R) activation by Kp-10 in mitogen (PDGF)-induced human ASM cell proliferation in vitro and airway remodeling in vivo in a mouse model of asthma. Here, we examined the mechanisms by which KISS1R activation regulat...
Source: American Journal of Respiratory Cell and Molecular Biology - March 21, 2024 Category: Molecular Biology Authors: Premanand Balraj Nilesh Sudhakar Ambhore Yogaraj S Ramakrishnan Niyati A Borkar Priyanka Banerjee Mohammad Irshad Reza Subashini Varadharajan Ashish Kumar Christina M Pabelick Y S Prakash Sathish Venkatachalem Source Type: research

"When the Going Gets Tough": Novel Roles for TRPV4 in Stiffness-induced Phagolysosome Maturation
Am J Respir Cell Mol Biol. 2024 Mar 19. doi: 10.1165/rcmb.2024-0070ED. Online ahead of print.NO ABSTRACTPMID:38502902 | DOI:10.1165/rcmb.2024-0070ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - March 19, 2024 Category: Molecular Biology Authors: Adriana Estrada-Bernal Lokesh Sharma Faraaz Ali Shah Source Type: research

Cell-Corpse Clearance after Lung Damage: The Essential Role of MerTK-mediated Alveolar Macrophage Efferocytosis
Am J Respir Cell Mol Biol. 2024 Mar 19. doi: 10.1165/rcmb.2024-0108ED. Online ahead of print.NO ABSTRACTPMID:38502903 | DOI:10.1165/rcmb.2024-0108ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - March 19, 2024 Category: Molecular Biology Authors: Angela Haczku Source Type: research