Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: American Journal of Respiratory Cell and Molecular Biology - November 7, 2023 Category: Molecular Biology Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research

Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: American Journal of Respiratory Cell and Molecular Biology - November 7, 2023 Category: Molecular Biology Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research

Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: American Journal of Respiratory Cell and Molecular Biology - November 7, 2023 Category: Molecular Biology Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research

Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: American Journal of Respiratory Cell and Molecular Biology - November 7, 2023 Category: Molecular Biology Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research

Augmentation of Endothelial S1PR1 Attenuates Post-Viral Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2023 Nov 7. doi: 10.1165/rcmb.2023-0286OC. Online ahead of print.ABSTRACTRespiratory viral infections are frequent causes of acute respiratory distress syndrome (ARDS), a disabling condition with a mortality of up to 46%. The pulmonary endothelium plays an important role in the development of ARDS as well as the pathogenesis of pulmonary fibrosis; however, the therapeutic potential to modulate endothelial-dependent signaling to prevent deleterious consequences has not been well explored. Here we use a clinically relevant influenza A virus infection model, endothelial cell-specific transgenic gain...
Source: American Journal of Respiratory Cell and Molecular Biology - November 7, 2023 Category: Molecular Biology Authors: Patricia L Brazee Andreane Cartier Andrew Kuo Alexis M Haring Trong Nguyen Lida P Hariri Jason W Griffith Timothy Hla Benjamin D Medoff Rachel S Knipe Source Type: research

Standardized Digital Method for Histological Evaluation of Experimental Acute Lung Injury
Am J Respir Cell Mol Biol. 2023 Nov;69(5):596-598. doi: 10.1165/rcmb.2023-0182LE.NO ABSTRACTPMID:37909696 | DOI:10.1165/rcmb.2023-0182LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Authors: Camilla Predella Daniela Iezza Michael L Miller Theresa Swayne Anjali Saqi N Valerio Dorrello Source Type: research

Erratum: Growth Factor Receptor Bound Protein 2-Associated Binder 2, a Scaffolding Adaptor Protein, Negatively Regulates Host Immunity against Tuberculosis
Am J Respir Cell Mol Biol. 2023 Nov;69(5):599-600. doi: 10.1165/rcmb.695Erratum.NO ABSTRACTPMID:37909697 | DOI:10.1165/rcmb.695Erratum (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Source Type: research

November Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2023 Nov;69(5):iii-iv. doi: 10.1165/rcmb.69i5RedAlert.NO ABSTRACTPMID:37909695 | DOI:10.1165/rcmb.69i5RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Source Type: research

Standardized Digital Method for Histological Evaluation of Experimental Acute Lung Injury
Am J Respir Cell Mol Biol. 2023 Nov;69(5):596-598. doi: 10.1165/rcmb.2023-0182LE.NO ABSTRACTPMID:37909696 | DOI:10.1165/rcmb.2023-0182LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Authors: Camilla Predella Daniela Iezza Michael L Miller Theresa Swayne Anjali Saqi N Valerio Dorrello Source Type: research

Erratum: Growth Factor Receptor Bound Protein 2-Associated Binder 2, a Scaffolding Adaptor Protein, Negatively Regulates Host Immunity against Tuberculosis
Am J Respir Cell Mol Biol. 2023 Nov;69(5):599-600. doi: 10.1165/rcmb.695Erratum.NO ABSTRACTPMID:37909697 | DOI:10.1165/rcmb.695Erratum (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Source Type: research

November Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2023 Nov;69(5):iii-iv. doi: 10.1165/rcmb.69i5RedAlert.NO ABSTRACTPMID:37909695 | DOI:10.1165/rcmb.69i5RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Source Type: research

Standardized Digital Method for Histological Evaluation of Experimental Acute Lung Injury
Am J Respir Cell Mol Biol. 2023 Nov;69(5):596-598. doi: 10.1165/rcmb.2023-0182LE.NO ABSTRACTPMID:37909696 | DOI:10.1165/rcmb.2023-0182LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Authors: Camilla Predella Daniela Iezza Michael L Miller Theresa Swayne Anjali Saqi N Valerio Dorrello Source Type: research

Erratum: Growth Factor Receptor Bound Protein 2-Associated Binder 2, a Scaffolding Adaptor Protein, Negatively Regulates Host Immunity against Tuberculosis
Am J Respir Cell Mol Biol. 2023 Nov;69(5):599-600. doi: 10.1165/rcmb.695Erratum.NO ABSTRACTPMID:37909697 | DOI:10.1165/rcmb.695Erratum (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Source Type: research

November Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2023 Nov;69(5):iii-iv. doi: 10.1165/rcmb.69i5RedAlert.NO ABSTRACTPMID:37909695 | DOI:10.1165/rcmb.69i5RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Source Type: research

Standardized Digital Method for Histological Evaluation of Experimental Acute Lung Injury
Am J Respir Cell Mol Biol. 2023 Nov;69(5):596-598. doi: 10.1165/rcmb.2023-0182LE.NO ABSTRACTPMID:37909696 | DOI:10.1165/rcmb.2023-0182LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - November 1, 2023 Category: Molecular Biology Authors: Camilla Predella Daniela Iezza Michael L Miller Theresa Swayne Anjali Saqi N Valerio Dorrello Source Type: research