American Journal of Respiratory Cell and Molecular Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.December Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2023 Dec;69(6):iii. doi: 10.1165/rcmb.69i6RedAlert.NO ABSTRACTPMID:38038397 | DOI:10.1165/rcmb.69i6RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Source Type: research
Single-Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells
Am J Respir Cell Mol Biol. 2023 Dec;69(6):698-701. doi: 10.1165/rcmb.2023-0292LE.NO ABSTRACTPMID:38038398 | DOI:10.1165/rcmb.2023-0292LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Authors: Manalee V Surve Brian Lin Jennifer L Reedy Arianne J Crossen Anthony Xu Bruce S Klein Jatin M Vyas Jayaraj Rajagopal Source Type: research
December Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2023 Dec;69(6):iii. doi: 10.1165/rcmb.69i6RedAlert.NO ABSTRACTPMID:38038397 | DOI:10.1165/rcmb.69i6RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Source Type: research
Single-Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells
Am J Respir Cell Mol Biol. 2023 Dec;69(6):698-701. doi: 10.1165/rcmb.2023-0292LE.NO ABSTRACTPMID:38038398 | DOI:10.1165/rcmb.2023-0292LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Authors: Manalee V Surve Brian Lin Jennifer L Reedy Arianne J Crossen Anthony Xu Bruce S Klein Jatin M Vyas Jayaraj Rajagopal Source Type: research
Rieske Iron-Sulfur Protein Mediates Pulmonary Hypertension Following Nicotine/Hypoxia Co-Exposure
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0181OC. Online ahead of print.ABSTRACTThe high mortality of chronic obstructive pulmonary disease (COPD) patients may occur due to pulmonary hypertension (PH). These diseases are highly associated with cigarette smoke (CS) and its key component nicotine use. Here, we created a novel animal model of PH using nicotine (or CS) and hypoxia (N/H) co-exposure. This never-reported model showed a significant early-onset pulmonary vasoremodeling and PH. Using newly-generated complementary smooth muscle (SM)-specific Rieske iron-sulfur protein (RISP) gene knockout (KO) a...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Lillian N Truong Ed Wilson Santos Yun-Min Zheng Yong-Xiao Wang Source Type: research
GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0151OC. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a lethal progressive disease with elusive molecular mechanisms and limited therapeutic methods. Aberrant activation of fibroblasts is a central hallmark of lung fibrosis. Here we report that Golgi membrane protein 1 (GOLM1, also known as GP73 or GOLPH2), was elevated in both lungs of patients with pulmonary fibrosis and bleomycin (BLM)-induced pulmonary fibrotic mice. Loss of GOLM1 inhibited proliferation, differentiation, and extracellular matrix (ECM) deposition of fibroblasts, while...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Yani Wang Danjing Hu Linyan Wan Shuhui Yang Song Liu Zixi Wang Jie Li Jia Li Zhoude Zheng Chongsheng Cheng Yanan Wang Hanghang Wang Xinlun Tian Wenhui Chen Shanqing Li Ji Zhang Xiaojun Zha Jingyu Chen Hongbing Zhang Kai-Feng Xu Source Type: research
Rieske Iron-Sulfur Protein Mediates Pulmonary Hypertension Following Nicotine/Hypoxia Co-Exposure
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0181OC. Online ahead of print.ABSTRACTThe high mortality of chronic obstructive pulmonary disease (COPD) patients may occur due to pulmonary hypertension (PH). These diseases are highly associated with cigarette smoke (CS) and its key component nicotine use. Here, we created a novel animal model of PH using nicotine (or CS) and hypoxia (N/H) co-exposure. This never-reported model showed a significant early-onset pulmonary vasoremodeling and PH. Using newly-generated complementary smooth muscle (SM)-specific Rieske iron-sulfur protein (RISP) gene knockout (KO) a...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Lillian N Truong Ed Wilson Santos Yun-Min Zheng Yong-Xiao Wang Source Type: research
GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0151OC. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a lethal progressive disease with elusive molecular mechanisms and limited therapeutic methods. Aberrant activation of fibroblasts is a central hallmark of lung fibrosis. Here we report that Golgi membrane protein 1 (GOLM1, also known as GP73 or GOLPH2), was elevated in both lungs of patients with pulmonary fibrosis and bleomycin (BLM)-induced pulmonary fibrotic mice. Loss of GOLM1 inhibited proliferation, differentiation, and extracellular matrix (ECM) deposition of fibroblasts, while...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Yani Wang Danjing Hu Linyan Wan Shuhui Yang Song Liu Zixi Wang Jie Li Jia Li Zhoude Zheng Chongsheng Cheng Yanan Wang Hanghang Wang Xinlun Tian Wenhui Chen Shanqing Li Ji Zhang Xiaojun Zha Jingyu Chen Hongbing Zhang Kai-Feng Xu Source Type: research
Rieske Iron-Sulfur Protein Mediates Pulmonary Hypertension Following Nicotine/Hypoxia Co-Exposure
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0181OC. Online ahead of print.ABSTRACTThe high mortality of chronic obstructive pulmonary disease (COPD) patients may occur due to pulmonary hypertension (PH). These diseases are highly associated with cigarette smoke (CS) and its key component nicotine use. Here, we created a novel animal model of PH using nicotine (or CS) and hypoxia (N/H) co-exposure. This never-reported model showed a significant early-onset pulmonary vasoremodeling and PH. Using newly-generated complementary smooth muscle (SM)-specific Rieske iron-sulfur protein (RISP) gene knockout (KO) a...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Lillian N Truong Ed Wilson Santos Yun-Min Zheng Yong-Xiao Wang Source Type: research
GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0151OC. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a lethal progressive disease with elusive molecular mechanisms and limited therapeutic methods. Aberrant activation of fibroblasts is a central hallmark of lung fibrosis. Here we report that Golgi membrane protein 1 (GOLM1, also known as GP73 or GOLPH2), was elevated in both lungs of patients with pulmonary fibrosis and bleomycin (BLM)-induced pulmonary fibrotic mice. Loss of GOLM1 inhibited proliferation, differentiation, and extracellular matrix (ECM) deposition of fibroblasts, while...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Yani Wang Danjing Hu Linyan Wan Shuhui Yang Song Liu Zixi Wang Jie Li Jia Li Zhoude Zheng Chongsheng Cheng Yanan Wang Hanghang Wang Xinlun Tian Wenhui Chen Shanqing Li Ji Zhang Xiaojun Zha Jingyu Chen Hongbing Zhang Kai-Feng Xu Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: American Journal of Respiratory Cell and Molecular Biology - November 17, 2023 Category: Molecular Biology Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: American Journal of Respiratory Cell and Molecular Biology - November 17, 2023 Category: Molecular Biology Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: American Journal of Respiratory Cell and Molecular Biology - November 17, 2023 Category: Molecular Biology Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: American Journal of Respiratory Cell and Molecular Biology - November 17, 2023 Category: Molecular Biology Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
Epigenetic Reprogramming Drives Epithelial Disruption in COPD
In this study, we sought to determine if epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the CDH1 gene, disrupts epithelial integrity, and by reducing these epigenetic marks, we can restore epithelial integrity and rescue alveolar airspace destruction. We used differentiated normal and COPD-derived primary human airway epithelial cells, genetically manipulated mouse tracheal epithelial cells, and mouse and human precision-cut lung slices to assess the effects of epigenetic reprogramming. We show that the loss of CDH1 in COPD is due to increased DNA methylation site at the CDH1 enhancer D ...
Source: American Journal of Respiratory Cell and Molecular Biology - November 17, 2023 Category: Molecular Biology Authors: Bonnie H Yeung-Luk Ara Wally Carter Swaby Sofia Jauregui Esther Lee Rachel Zhang Daniel Chen Sean H Luk Nisha Upadya Ethan Tieng Kai Wilmsen Ethan Sherman Dheeksha Sudhakar Matthew Luk Abhishek Kumar Shrivastav Shuo Cao Baishakhi Ghosh Stephanie A Christe Source Type: research
