American Journal of Respiratory Cell and Molecular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

March Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2024 Mar;70(3):iii-iv. doi: 10.1165/rcmb.70i3RedAlert.NO ABSTRACTPMID:38426711 | DOI:10.1165/rcmb.70i3RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - March 1, 2024 Category: Molecular Biology Source Type: research

Tissue-Resident Alveolar Macrophages Reduce Ozone-induced Inflammation via MerTK Mediated Efferocytosis
Am J Respir Cell Mol Biol. 2024 Feb 22. doi: 10.1165/rcmb.2023-0390OC. Online ahead of print.ABSTRACTLung inflammation, caused by acute exposure to ozone (O3) - one of the six criteria air pollutants - is a significant source of morbidity in susceptible individuals. Alveolar macrophages (AMØs) are the most abundant immune cells in the normal lung and their number increases following O3 exposure. However, the role of AMØs in promoting or limiting O3-induced lung inflammation has not been clearly defined. Here, we used a mouse model of acute O3 exposure, lineage tracing, genetic knockouts, and data from O3-exposed human vo...
Source: American Journal of Respiratory Cell and Molecular Biology - February 22, 2024 Category: Molecular Biology Authors: Marissa A Guttenberg Aaron T Vose Anastasiya Birukova Kaitlyn Lewars R Ian Cumming Michaela C Albright Jasper I Mark Claudia J Salazar Suchitra Swaminathan Zhan Yu Yuliana V Sokolenko Elsie Bunyan Michael J Yaeger Michael B Fessler Loretta G Que Kymberly Source Type: research

Presenilin 1 Is a Therapeutic Target in Pulmonary Hypertension and Promotes Vascular Remodeling
Am J Respir Cell Mol Biol. 2024 Feb 21. doi: 10.1165/rcmb.2022-0426OC. Online ahead of print.ABSTRACTSmall muscular pulmonary artery remodeling is a dominant feature of PAH. PSEN1 affects angiogenesis, cancer and Alzheimer's disease. We aimed to determine the role of PSEN1 in the pathogenesis of vascular remodeling in PH. Haemodynamics and vascular remodeling in the Psen1-knockin and smooth muscle-specific Psen1-knockout mice were assessed. The functional partners of PSEN1 were predicted by bioinformatics analysis and biochemical experiments. The therapeutic effect of PH was evaluated by administration of the PSEN1-specifi...
Source: American Journal of Respiratory Cell and Molecular Biology - February 21, 2024 Category: Molecular Biology Authors: Tingting Shen Jiucheng Shi Xijuan Zhao Li Fu Na Wang Jiaxin Han Xiaodong Zheng Yingli Chen Minghui Li Cui Ma Pixu Liu Daling Zhu Source Type: research

Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor
Am J Respir Cell Mol Biol. 2024 Feb 20. doi: 10.1165/rcmb.2023-0253OC. Online ahead of print.ABSTRACTCigarette smoking is known to be the leading cause of chronic obstructive pulmonary disease (COPD). However, the detailed mechanisms have not been elucidated. Platelet-activating factor (PAF), a potent inflammatory mediator, is involved in the pathogenesis of various respiratory diseases, such as bronchial asthma or COPD. We focused on lysophospholipid acyltransferase 9 (LPLAT9), a biosynthetic enzyme of PAF, in the pathogenesis of COPD. LPLAT9 gene expression was observed in excised COPD lungs and single-cell RNA sequencin...
Source: American Journal of Respiratory Cell and Molecular Biology - February 20, 2024 Category: Molecular Biology Authors: Hiroaki Murano Sumito Inoue Tomomi Hashidate-Yoshida Hideo Shindou Takao Shimizu Yoichiro Otaki Yukihiro Minegishi Takumi Kitaoka Mitsuru Futakuchi Akira Igarashi Michiko Nishiwaki Takako Nemoto Masamichi Sato Maki Kobayashi Kento Sato Toshinari Hanawa Os Source Type: research

A Test to Comprehensively Capture the Known Genetic Component of Familial Pulmonary Fibrosis
This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).PMID:38363828 | DOI:10.1165/rcmb.2024-0009MA (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 16, 2024 Category: Molecular Biology Authors: Judith Villeneuve Élody Tremblay Nathalie Gaudreault Victoria Saavedra Armero Dominique K Boudreau Zhonglin Li S ébastien Renaut Genevi ève Dion Yohan Boss é Source Type: research

Pumping Iron Burns Fat in Lung Injury
Am J Respir Cell Mol Biol. 2024 Feb 16. doi: 10.1165/rcmb.2024-0033ED. Online ahead of print.NO ABSTRACTPMID:38364215 | DOI:10.1165/rcmb.2024-0033ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 16, 2024 Category: Molecular Biology Authors: Marilia Sanches Santos Rizzo Zuttion Peter Chen Source Type: research

When a DEAD-Box Protein Is the Key - A Novel Role for DDX5 in Lung Pericyte Dysfunction
Am J Respir Cell Mol Biol. 2024 Feb 16. doi: 10.1165/rcmb.2024-0031ED. Online ahead of print.NO ABSTRACTPMID:38364217 | DOI:10.1165/rcmb.2024-0031ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 16, 2024 Category: Molecular Biology Authors: Laszlo Farkas Mauricio Rojas Source Type: research

A Test to Comprehensively Capture the Known Genetic Component of Familial Pulmonary Fibrosis
The objective was to develop a laboratory developed test (LDT) based on standard Sanger sequencing in order to capture all known FPF-associated variants. Targeted DNA fragments were amplified with harmonized PCR conditions to perform the LDT in a single 96-well plate. The new genetic test was evaluated in 62 sporadic cases of idiopathic pulmonary fibrosis (IPF). As expected in this population, we observed a low yield of disease-causing mutations. More importantly, 100% of targeted variants by the LDT were successfully evaluated. Furthermore, four variants of uncertain significance with in silico-predicted deleterious score...
Source: American Journal of Respiratory Cell and Molecular Biology - February 16, 2024 Category: Molecular Biology Authors: Judith Villeneuve Élody Tremblay Nathalie Gaudreault Victoria Saavedra Armero Dominique K Boudreau Zhonglin Li S ébastien Renaut Genevi ève Dion Yohan Boss é Source Type: research