American Journal of Respiratory Cell and Molecular Biology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Alveolar Epithelial Cell Dysfunction in IPF Linked to Lipid Alterations: Therapeutic Implications
Am J Respir Cell Mol Biol. 2024 Jan 25. doi: 10.1165/rcmb.2023-0432ED. Online ahead of print.NO ABSTRACTPMID:38271680 | DOI:10.1165/rcmb.2023-0432ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - January 25, 2024 Category: Molecular Biology Authors: Francesca Polverino Ana Mora Source Type: research

FTO Deficiency Alleviate LPS-induced ALI by TXNIP/NLPR3-mediated Alveolar Epithelial Cell Pyroptosis
This study aimed to examine the role and mechanism of the m6A demethylase FTO in lipopolysaccharide (LPS)-induced ALI. Lung epithelial FTO knockout mice and FTO knockdown/overexpression A549 cell lines were constructed to evaluate the effects of FTO on ALI. Bioinformatics analysis and a series of in vivo and in vitro assays were used to examine the mechanism of FTO regulation. Rescue assays were conducted to examine whether the impact of FTO on ALI depended on the TXNIP/NLRP3 pathway. In LPS-induced ALI, RNA m6A modification levels were upregulated, and FTO expression was downregulated. In vivo, lung epithelial FTO knockou...
Source: American Journal of Respiratory Cell and Molecular Biology - January 25, 2024 Category: Molecular Biology Authors: Wei-Ming Xie Wei Su Xin-Yu Liu Junhao Zhou Min Wang Yuchang Wang Wei Wang Xiangjun Bai Zhanfei Li Tianyu Li Source Type: research

Drebrin Is Required for Myosin-facilitated Actin Cytoskeletal Remodeling During Pulmonary Alveolar Development
Am J Respir Cell Mol Biol. 2024 Jan 25. doi: 10.1165/rcmb.2023-0229OC. Online ahead of print.ABSTRACTAlveolar septation increases gas-exchange surface area and requires coordinated cytoskeletal rearrangement in lung fibroblasts (LF), to balance the demands of contraction and cell migration. We hypothesized that drebrin (DBN), a modulator of the actin cytoskeleton in neuronal dendrites, regulates the remodeling of the LF-cytoskeleton. Using mice bearing a transgelin-Cre (TGCre) targeted deletion of Dbn in pulmonary fibroblasts and pericytes, we examined alterations in alveolar septal outgrowth, LF spreading and migration, a...
Source: American Journal of Respiratory Cell and Molecular Biology - January 25, 2024 Category: Molecular Biology Authors: Stephen E McGowan Nikolas Gilfanov Mohanish K Chandurka Jonathan A Stiber Sangyoon J Han Source Type: research

Getting the Timing Right: Controlling BCL-2 Inhibition as an Anti-Fibrotic Therapy
Am J Respir Cell Mol Biol. 2024 Jan 23. doi: 10.1165/rcmb.2023-0436ED. Online ahead of print.NO ABSTRACTPMID:38259233 | DOI:10.1165/rcmb.2023-0436ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - January 23, 2024 Category: Molecular Biology Authors: Joseph C Cooley Elizabeth F Redente Source Type: research

S1PR2: A Fulcrum in the Balance of Type 1 and Type 2 Responses During Sepsis-induced Acute Lung Injury
Am J Respir Cell Mol Biol. 2024 Jan 16. doi: 10.1165/rcmb.2023-0433ED. Online ahead of print.NO ABSTRACTPMID:38226863 | DOI:10.1165/rcmb.2023-0433ED (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - January 16, 2024 Category: Molecular Biology Authors: Philip A Verhoef Source Type: research

Antenatal Endotoxin Induces Dysanapsis in Experimental Bronchopulmonary Dysplasia
Am J Respir Cell Mol Biol. 2024 Jan 11. doi: 10.1165/rcmb.2023-0157OC. Online ahead of print.ABSTRACTBronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, is characterized by impaired lung development with sustained functional abnormalities due to alterations of airways and the distal lung. Although clinical studies have shown striking associations between antenatal stress and BPD, little is known about underlying pathogenetic mechanisms. Whether dysanapsis, the concept of discordant growth of airways and parenchyma, contributes to late respiratory disease due to antenatal stress is unknown. We hypothe...
Source: American Journal of Respiratory Cell and Molecular Biology - January 11, 2024 Category: Molecular Biology Authors: Elizabeth A McGinn Elisa Bye Tania Gonzalez Alexander Sosa Jill Bilodeaux Gregory Seedorf Bradford J Smith Steven H Abman Erica W Mandell Source Type: research

Characterization of Commercially Available Human Primary Alveolar Epithelial Cells
Am J Respir Cell Mol Biol. 2024 Jan 11. doi: 10.1165/rcmb.2023-0320MA. Online ahead of print.ABSTRACTIn vitro lung research requires appropriate cell culture models that adequately mimic in vivo structure and function. Previously, researchers have extensively utilized commercially available and easily expandable A549 and NCI-H441 cells which replicate some yet not all features of alveolar epithelial cells. Specifically, these cells are often restricted by terminally altered expression while lacking important alveolar epithelial characteristics. Of late, human primary alveolar epithelial cells (hPAEpC) have become commercia...
Source: American Journal of Respiratory Cell and Molecular Biology - January 11, 2024 Category: Molecular Biology Authors: Christopher J Herbst Elena Lopez-Rodriguez Vladimir Gluhovic Sabrina Schulz Raphael Brandt Sara Timm Jubilant Abledu Juliana Falivene Peter Pennitz Holger Kirsten Geraldine Nouailles Martin Witzenrath Matthias Ochs Wolfgang M Kuebler Source Type: research

Interstitial Macrophages Mediate Efferocytosis of Alveolar Epithelium During Influenza Infection
Am J Respir Cell Mol Biol. 2024 Jan 11. doi: 10.1165/rcmb.2023-0217MA. Online ahead of print.ABSTRACTEfferocytosis is a process where apoptotic cells are cleared to maintain tissue homeostasis. In the lungs, efferocytosis has been implicated in several acute and chronic inflammatory diseases. A longstanding method to study efferocytosis in vivo is to instill apoptotic cells into the lungs to evaluate macrophage uptake. However, this approach provides non-physiologic levels of cells to the airspaces where there is preferential access to the alveolar macrophages (AMs). To circumvent this limitation, we developed a new method...
Source: American Journal of Respiratory Cell and Molecular Biology - January 11, 2024 Category: Molecular Biology Authors: Marilia Sanchez Santos Rizzo Zuttion Tanyalak Parimon Changfu Yao Barry R Stripp Ying Wang Christopher M Soto Zackary Ortega Xiao Li William J Janssen Peter Chen Source Type: research

MLKL Protects Pulmonary Endothelial Cells in Acute Lung Injury
Am J Respir Cell Mol Biol. 2024 Jan 11. doi: 10.1165/rcmb.2023-0207OC. Online ahead of print.ABSTRACTThe role of autophagy in pulmonary microvascular endothelial cell (PMVEC) are controversial in lipopolysaccharide (LPS)-induced ALI. Mixed lineage kinase domain like pseudokinase (MLKL) has been recently reported to keep cell survival by facilitating autophagic flux in response to starvation, rather than its well-recognized role in necroptosis. Using mouse PMVEC and LPS-induced ALI model, we showed that in PMVEC, MLKL was phosphorylated (p-MLKL) and autophagic flux was accelerated at the early stage of LPS stimulation (1-3 ...
Source: American Journal of Respiratory Cell and Molecular Biology - January 11, 2024 Category: Molecular Biology Authors: Ying Li Yingxiang Liu Xueya Yao Ling Zhu Liqun Yang Qionghui Zhan Source Type: research

COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging
Am J Respir Cell Mol Biol. 2023 Nov;69(5):592-595. doi: 10.1165/rcmb.2023-0177LE.NO ABSTRACTPMID:38195114 | PMC:PMC10633845 | DOI:10.1165/rcmb.2023-0177LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - January 9, 2024 Category: Molecular Biology Authors: Kadambari Vijaykumar Hui Min Leung Amilcar Barrios Courtney M Fernandez-Petty George M Solomon Heather Y Hathorne Justin D Wade Kathryn Monroe Katie Brand Slaten Qian Li Sixto M Leal Derek B Moates Hannah M Pierce Kristian R Olson Paul Currier Sam Foster Source Type: research

COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging
Am J Respir Cell Mol Biol. 2023 Nov;69(5):592-595. doi: 10.1165/rcmb.2023-0177LE.NO ABSTRACTPMID:38195114 | DOI:10.1165/rcmb.2023-0177LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - January 9, 2024 Category: Molecular Biology Authors: Kadambari Vijaykumar Hui Min Leung Amilcar Barrios Courtney M Fernandez-Petty George M Solomon Heather Y Hathorne Justin D Wade Kathryn Monroe Katie Brand Slaten Qian Li Sixto M Leal Derek B Moates Hannah M Pierce Kristian R Olson Paul Currier Sam Foster Source Type: research

Extracellular Matrix as a Driver of Chronic Lung Diseases
Am J Respir Cell Mol Biol. 2024 Jan 8. doi: 10.1165/rcmb.2023-0176PS. Online ahead of print.ABSTRACTThe extracellular matrix (ECM) is not just a 3 dimensional scaffold that provides stable support for all cells in the lungs but is also an important component of chronic fibrotic airways, vascular, and interstitial diseases. It is a bioactive entity that is dynamically modulated during tissue homeostasis and disease, which controls structural and immune cell functions, drug responses, and which can release fragments that have biological activity and that can be used to monitor disease activity. There is a growing recognition...
Source: American Journal of Respiratory Cell and Molecular Biology - January 8, 2024 Category: Molecular Biology Authors: Janette K Burgess Daniel J Weiss Gunilla Westergren-Thorsson Jenny Wigen Charlotte H Dean Sharon Mumby Andrew Bush Ian M Adcock Source Type: research

DNA Methylation Profiling of Heterogeneous Sporadic LAM and Matched Lung Tissue
Am J Respir Cell Mol Biol. 2024 Jan;70(1):81-84. doi: 10.1165/rcmb.2023-0300LE.NO ABSTRACTPMID:38156802 | DOI:10.1165/rcmb.2023-0300LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 29, 2023 Category: Molecular Biology Authors: Ryan M Powell Ji ří C Moravec Greg T Jones Basharat Bhat Susan M Lin Joseph D Planer Vera P Krymskaya Edward Cantu Sharon Pattison Ian M Morison Bronwyn Gray Michael R Eccles Erin C Macaulay Source Type: research

Homozygous, Intragenic Tandem Duplication of < em > SFTPB < /em > Causes Neonatal Respiratory Failure
Am J Respir Cell Mol Biol. 2024 Jan;70(1):78-80. doi: 10.1165/rcmb.2023-0156LE.NO ABSTRACTPMID:38156804 | PMC:PMC10768837 | DOI:10.1165/rcmb.2023-0156LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 29, 2023 Category: Molecular Biology Authors: Jennifer A Wambach Daniel J Wegner Joseph Kitzmiller Frances V White Hillary B Heins Ping Yang Alexander J Paul Jorge L Granadillo Pirooz Eghtesady Cadence Kuklinski Tiffany Turner Korre Fairman Kristyne Stone Theodore Wilson Amy Breman Janice Smith Molly Source Type: research