Lack of S1PR2 in Macrophage Ameliorates Sepsis-associated Lung Injury through Inducing IL-33-mediated Type 2 Immunity
In conclusion, a lack of S1PR2 modulates type 2 immune response by upregulating IL-33 release from macrophages and alleviates sepsis-induced lung injury. Targeting S1PR2 may have a potential therapeutic value for sepsis treatment.PMID:38061028 | DOI:10.1165/rcmb.2023-0075OC (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 7, 2023 Category: Molecular Biology Authors: Chenchen Gong Yue Jin Xi Wang Jiali Mao Dongdong Wang Xiangyang Yu Shiyu Chen Yang Wang Daqing Ma Xiangming Fang Kai Zhang Qiang Shu Source Type: research

Mutual Regulation of Transcriptomes Between Murine Pneumocytes and Fibroblasts Mediates Alveolar Regeneration in Air-Liquid Interface Cultures
Am J Respir Cell Mol Biol. 2023 Dec 5. doi: 10.1165/rcmb.2023-0078OC. Online ahead of print.ABSTRACTAlveolar type 2 (AT2) and club cells are part of the stem cell niche of the lung and their differentiation is required for pulmonary homeostasis and tissue regeneration. A disturbed crosstalk between fibroblasts and epithelial cells contributes to the loss of lung structure in chronic lung diseases. Therefore, it is important to understand how fibroblasts and lung epithelial cells interact during regeneration. Here we analyzed the interaction of fibroblasts and the alveolar epithelium modelled in air-liquid interface culture...
Source: American Journal of Respiratory Cell and Molecular Biology - December 5, 2023 Category: Molecular Biology Authors: Yiwen Yao Sarah Miethe Kathrin Kattler Bet ül Colakoglu J örn Walter Nicole Schneider-Daum Christian Herr Holger Garn Felix Ritzmann Robert Bals Christoph Beisswenger Source Type: research

Mutual Regulation of Transcriptomes Between Murine Pneumocytes and Fibroblasts Mediates Alveolar Regeneration in Air-Liquid Interface Cultures
Am J Respir Cell Mol Biol. 2023 Dec 5. doi: 10.1165/rcmb.2023-0078OC. Online ahead of print.ABSTRACTAlveolar type 2 (AT2) and club cells are part of the stem cell niche of the lung and their differentiation is required for pulmonary homeostasis and tissue regeneration. A disturbed crosstalk between fibroblasts and epithelial cells contributes to the loss of lung structure in chronic lung diseases. Therefore, it is important to understand how fibroblasts and lung epithelial cells interact during regeneration. Here we analyzed the interaction of fibroblasts and the alveolar epithelium modelled in air-liquid interface culture...
Source: American Journal of Respiratory Cell and Molecular Biology - December 5, 2023 Category: Molecular Biology Authors: Yiwen Yao Sarah Miethe Kathrin Kattler Bet ül Colakoglu J örn Walter Nicole Schneider-Daum Christian Herr Holger Garn Felix Ritzmann Robert Bals Christoph Beisswenger Source Type: research

December Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2023 Dec;69(6):iii. doi: 10.1165/rcmb.69i6RedAlert.NO ABSTRACTPMID:38038397 | DOI:10.1165/rcmb.69i6RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Source Type: research

Single-Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells
Am J Respir Cell Mol Biol. 2023 Dec;69(6):698-701. doi: 10.1165/rcmb.2023-0292LE.NO ABSTRACTPMID:38038398 | DOI:10.1165/rcmb.2023-0292LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Authors: Manalee V Surve Brian Lin Jennifer L Reedy Arianne J Crossen Anthony Xu Bruce S Klein Jatin M Vyas Jayaraj Rajagopal Source Type: research

December Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2023 Dec;69(6):iii. doi: 10.1165/rcmb.69i6RedAlert.NO ABSTRACTPMID:38038397 | DOI:10.1165/rcmb.69i6RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Source Type: research

Single-Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells
Am J Respir Cell Mol Biol. 2023 Dec;69(6):698-701. doi: 10.1165/rcmb.2023-0292LE.NO ABSTRACTPMID:38038398 | DOI:10.1165/rcmb.2023-0292LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Authors: Manalee V Surve Brian Lin Jennifer L Reedy Arianne J Crossen Anthony Xu Bruce S Klein Jatin M Vyas Jayaraj Rajagopal Source Type: research

December Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2023 Dec;69(6):iii. doi: 10.1165/rcmb.69i6RedAlert.NO ABSTRACTPMID:38038397 | DOI:10.1165/rcmb.69i6RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Source Type: research

Single-Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells
Am J Respir Cell Mol Biol. 2023 Dec;69(6):698-701. doi: 10.1165/rcmb.2023-0292LE.NO ABSTRACTPMID:38038398 | DOI:10.1165/rcmb.2023-0292LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Authors: Manalee V Surve Brian Lin Jennifer L Reedy Arianne J Crossen Anthony Xu Bruce S Klein Jatin M Vyas Jayaraj Rajagopal Source Type: research

December Highlights/Papers by Junior Investigators/NIH News
Am J Respir Cell Mol Biol. 2023 Dec;69(6):iii. doi: 10.1165/rcmb.69i6RedAlert.NO ABSTRACTPMID:38038397 | DOI:10.1165/rcmb.69i6RedAlert (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Source Type: research

Single-Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells
Am J Respir Cell Mol Biol. 2023 Dec;69(6):698-701. doi: 10.1165/rcmb.2023-0292LE.NO ABSTRACTPMID:38038398 | DOI:10.1165/rcmb.2023-0292LE (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - December 1, 2023 Category: Molecular Biology Authors: Manalee V Surve Brian Lin Jennifer L Reedy Arianne J Crossen Anthony Xu Bruce S Klein Jatin M Vyas Jayaraj Rajagopal Source Type: research

Rieske Iron-Sulfur Protein Mediates Pulmonary Hypertension Following Nicotine/Hypoxia Co-Exposure
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0181OC. Online ahead of print.ABSTRACTThe high mortality of chronic obstructive pulmonary disease (COPD) patients may occur due to pulmonary hypertension (PH). These diseases are highly associated with cigarette smoke (CS) and its key component nicotine use. Here, we created a novel animal model of PH using nicotine (or CS) and hypoxia (N/H) co-exposure. This never-reported model showed a significant early-onset pulmonary vasoremodeling and PH. Using newly-generated complementary smooth muscle (SM)-specific Rieske iron-sulfur protein (RISP) gene knockout (KO) a...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Lillian N Truong Ed Wilson Santos Yun-Min Zheng Yong-Xiao Wang Source Type: research

GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0151OC. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a lethal progressive disease with elusive molecular mechanisms and limited therapeutic methods. Aberrant activation of fibroblasts is a central hallmark of lung fibrosis. Here we report that Golgi membrane protein 1 (GOLM1, also known as GP73 or GOLPH2), was elevated in both lungs of patients with pulmonary fibrosis and bleomycin (BLM)-induced pulmonary fibrotic mice. Loss of GOLM1 inhibited proliferation, differentiation, and extracellular matrix (ECM) deposition of fibroblasts, while...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Yani Wang Danjing Hu Linyan Wan Shuhui Yang Song Liu Zixi Wang Jie Li Jia Li Zhoude Zheng Chongsheng Cheng Yanan Wang Hanghang Wang Xinlun Tian Wenhui Chen Shanqing Li Ji Zhang Xiaojun Zha Jingyu Chen Hongbing Zhang Kai-Feng Xu Source Type: research

Rieske Iron-Sulfur Protein Mediates Pulmonary Hypertension Following Nicotine/Hypoxia Co-Exposure
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0181OC. Online ahead of print.ABSTRACTThe high mortality of chronic obstructive pulmonary disease (COPD) patients may occur due to pulmonary hypertension (PH). These diseases are highly associated with cigarette smoke (CS) and its key component nicotine use. Here, we created a novel animal model of PH using nicotine (or CS) and hypoxia (N/H) co-exposure. This never-reported model showed a significant early-onset pulmonary vasoremodeling and PH. Using newly-generated complementary smooth muscle (SM)-specific Rieske iron-sulfur protein (RISP) gene knockout (KO) a...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Lillian N Truong Ed Wilson Santos Yun-Min Zheng Yong-Xiao Wang Source Type: research

GOLM1 Promotes Pulmonary Fibrosis through Upregulation of NEAT1
Am J Respir Cell Mol Biol. 2023 Nov 29. doi: 10.1165/rcmb.2023-0151OC. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a lethal progressive disease with elusive molecular mechanisms and limited therapeutic methods. Aberrant activation of fibroblasts is a central hallmark of lung fibrosis. Here we report that Golgi membrane protein 1 (GOLM1, also known as GP73 or GOLPH2), was elevated in both lungs of patients with pulmonary fibrosis and bleomycin (BLM)-induced pulmonary fibrotic mice. Loss of GOLM1 inhibited proliferation, differentiation, and extracellular matrix (ECM) deposition of fibroblasts, while...
Source: American Journal of Respiratory Cell and Molecular Biology - November 29, 2023 Category: Molecular Biology Authors: Yani Wang Danjing Hu Linyan Wan Shuhui Yang Song Liu Zixi Wang Jie Li Jia Li Zhoude Zheng Chongsheng Cheng Yanan Wang Hanghang Wang Xinlun Tian Wenhui Chen Shanqing Li Ji Zhang Xiaojun Zha Jingyu Chen Hongbing Zhang Kai-Feng Xu Source Type: research