Alternative Splicing Is a Major Factor Shaping Transcriptome Diversity in Mild and Severe COPD

In conclusion, we observed large and significant differences in alternative splicing between bronchial samples of COPD and control individuals, with more events observed in severe than in mild-to-moderate COPD. The changes in the expression of several splicing factors correlated with prevalence of alternative splicing in severe COPD. Alternative splicing can indirectly impact gene expression by changing the relative abundance of protein-coding isoforms potentially influencing pathophysiological changes. The presented results provide a better understanding of COPD-related alternative splicing changes.PMID:38315810 | DOI:10.1165/rcmb.2023-0296OC

Source: American Journal of Respiratory Cell and Molecular Biology - February 5, 2024 Category: Molecular Biology Authors: Dmitry Khalenkow Corry-Anke Brandsma Wim Timens David F Choy Michele A Grimbaldeston Carrie M Rosenberger Dirk-Jan Slebos Huib A M Kerstjens Alen Faiz Gerard H Koppelman Martijn C Nawijn Maarten van den Berge Victor Guryev Source Type: research