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Prediction of MET Overexpression in Lung Adenocarcinoma from Hematoxylin and Eosin Images
Am J Pathol. 2024 Mar 15:S0002-9440(24)00088-9. doi: 10.1016/j.ajpath.2024.02.015. Online ahead of print.ABSTRACTMET protein overexpression is a targetable event in non-small cell lung cancer (NSCLC) and is the subject of active drug development. Challenges in identifying patients for these therapies include lack of access to validated testing, such as standardized immunohistochemistry (IHC) assessment, and consumption of valuable tissue for a single gene/protein assay. Development of pre-screening algorithms using routinely available digitized hematoxylin and eosin (H&E)-stained slides to predict MET overexpression co...
Source: Am J Pathol - March 17, 2024 Category: Pathology Authors: Kshitij Ingale Sun Hae Hong Josh S K Bell Abbas Rizvi Amy Welch Lingdao Sha Irvin Ho Kunal Nagpal A ïcha Bentaieb Rohan P Joshi Martin C Stumpe Source Type: research

Sortilin in biliary epithelial cells promotes ductular reaction and fibrosis during cholestatic injury
In conclusion, sortilin-governed engagement of LIF signaling in BEC promotes ductular reaction and morphogenesis during cholestatic injury. Moreover, BEC sortilin is pivotal for the development of fibrosis.PMID:38493927 | DOI:10.1016/j.ajpath.2024.01.023 (Source: Am J Pathol)
Source: Am J Pathol - March 17, 2024 Category: Pathology Authors: Einav Hubel Anat Neuman Sigal Fishman Ortal Schaffer Noam Erez Bander Abu Shrkihe Yuval Shteingard Tamar Gross Oren Shibolet Chen Varol Isabel Zvibel Source Type: research

Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes
In this study, human brain RNA-seq transcriptome analysis revealed a significant correlation between changes in dopaminergic signaling pathways and neural developmental signaling in ASD patients. In the zebrafish model, disrupted developmental dopaminergic signaling led to neural circuit abnormalities and behavior reminiscent of autism. Dopaminergic signaling may impact neuronal specification by potentially modulating integrins. These findings shed light on the mechanisms underlying the link between disrupted developmental dopamine signaling and ASD, and they point to the possibility of targeting dopaminergic signaling in ...
Source: Am J Pathol - March 16, 2024 Category: Pathology Authors: Xiaojuan Lu Yixing Song Jiaqi Wang Yunyun Cai Siwan Peng Jiaqi Lin Biqin Lai Junjie Sun Tianqing Liu Gang Chen Lingyan Xing Source Type: research

This Month in AJP
Am J Pathol. 2024 Mar 9:S0002-9440(24)00085-3. doi: 10.1016/j.ajpath.2024.03.001. Online ahead of print.NO ABSTRACTPMID:38467190 | DOI:10.1016/j.ajpath.2024.03.001 (Source: Am J Pathol)
Source: Am J Pathol - March 11, 2024 Category: Pathology Source Type: research

Ficolin-A/2 aggravated severe lung injury through NETs mediated by GSDMD-induced pyroptosis
In conclusion, these results suggested that Ficolin-A/2 exacerbated NET formation and LPS-induced lung injury via the GSDMD-mediated pyroptosis.PMID:38442803 | DOI:10.1016/j.ajpath.2024.02.011 (Source: Am J Pathol)
Source: Am J Pathol - March 5, 2024 Category: Pathology Authors: Li Huang Xiaowu Tan Weixia Xuan Qing Luo Li Xie Yunzhu Xi Rong Li Li Li Feifan Li Meiyun Zhao Yongliang Jiang Xu Wu Source Type: research

Deletion of MyD88 in T-cells Improves Anti-Tumor Activity in Melanoma
Am J Pathol. 2024 Mar 3:S0002-9440(24)00083-X. doi: 10.1016/j.ajpath.2024.02.012. Online ahead of print.ABSTRACTCytotoxic CD8+ T-cells are central to the anti-tumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88 (myeloid differentiation response 88). However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. We recently...
Source: Am J Pathol - March 5, 2024 Category: Pathology Authors: Abraham L Bayer Darwing Padilla-Rolon Sasha Smolgovsky Philip Hinds Pilar Alcaide Source Type: research