Sortilin in biliary epithelial cells promotes ductular reaction and fibrosis during cholestatic injury

In conclusion, sortilin-governed engagement of LIF signaling in BEC promotes ductular reaction and morphogenesis during cholestatic injury. Moreover, BEC sortilin is pivotal for the development of fibrosis.PMID:38493927 | DOI:10.1016/j.ajpath.2024.01.023

Source: Am J Pathol - March 17, 2024 Category: Pathology Authors: Einav Hubel Anat Neuman Sigal Fishman Ortal Schaffer Noam Erez Bander Abu Shrkihe Yuval Shteingard Tamar Gross Oren Shibolet Chen Varol Isabel Zvibel Source Type: research