Suppression of overactive IGF-1 attenuates trauma-induced heterotopic ossification in mice
In conclusion, our results indicated that IGF-1 mediated the progression of traumatic HO through PI3K/Akt/mTOR signaling, and suppressing IGF-1 signaling cascades attenuated HO formation, providing a promising therapeutic strategy targeting HO.PMID:38101566 | DOI:10.1016/j.ajpath.2023.11.012 (Source: Am J Pathol)
Source: Am J Pathol - December 15, 2023 Category: Pathology Authors: Dong Mao Kai Wang Hong Jiang Jingyi Mi Xiaoyun Pan Gang Zhao Yongjun Rui Source Type: research
IL-22 binding protein controls IL-22 driven bleomycin-induced lung injury
Am J Pathol. 2023 Dec 13:S0002-9440(23)00456-X. doi: 10.1016/j.ajpath.2023.11.011. Online ahead of print.ABSTRACTThe high mortality rates of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) challenge the field to identify biomarkers and factors that can be exploited for therapeutic approaches. IL-22 is a cytokine that has antibacterial and reparative properties in the lung. However, it can also exacerbate inflammation and requires tight control by the extracellular inhibitory protein known as IL-22 binding protein (IL-22BP) (Il22ra2). Here we demonstrate the necessity of IL-22BP in controlling and pre...
Source: Am J Pathol - December 15, 2023 Category: Pathology Authors: Zhe Zhang Mazvita B Chakawa Joshua A Frydman Michaela J Allen Michelle Galeas Pena MaryJane Jones Derek Pociask Source Type: research
Suppression of overactive IGF-1 attenuates trauma-induced heterotopic ossification in mice
In conclusion, our results indicated that IGF-1 mediated the progression of traumatic HO through PI3K/Akt/mTOR signaling, and suppressing IGF-1 signaling cascades attenuated HO formation, providing a promising therapeutic strategy targeting HO.PMID:38101566 | DOI:10.1016/j.ajpath.2023.11.012 (Source: Am J Pathol)
Source: Am J Pathol - December 15, 2023 Category: Pathology Authors: Dong Mao Kai Wang Hong Jiang Jingyi Mi Xiaoyun Pan Gang Zhao Yongjun Rui Source Type: research
IL-22 binding protein controls IL-22 driven bleomycin-induced lung injury
Am J Pathol. 2023 Dec 13:S0002-9440(23)00456-X. doi: 10.1016/j.ajpath.2023.11.011. Online ahead of print.ABSTRACTThe high mortality rates of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) challenge the field to identify biomarkers and factors that can be exploited for therapeutic approaches. IL-22 is a cytokine that has antibacterial and reparative properties in the lung. However, it can also exacerbate inflammation and requires tight control by the extracellular inhibitory protein known as IL-22 binding protein (IL-22BP) (Il22ra2). Here we demonstrate the necessity of IL-22BP in controlling and pre...
Source: Am J Pathol - December 15, 2023 Category: Pathology Authors: Zhe Zhang Mazvita B Chakawa Joshua A Frydman Michaela J Allen Michelle Galeas Pena MaryJane Jones Derek Pociask Source Type: research
A complex interplay between Notch effectors and β-catenin signaling in morular differentiation of endometrial carcinoma cells
Am J Pathol. 2023 Dec 12:S0002-9440(23)00459-5. doi: 10.1016/j.ajpath.2023.11.014. Online ahead of print.ABSTRACTNotch signaling contributes to tissue development and homeostasis, but little is known about its roles in morular differentiation of endometrial carcinoma (Em Ca) cells. The current study focused on crosstalk between Notch and β-catenin signaling in Em Ca with morules. Promoters of hairy and enhancer of split 1 (Hes1) and mastermind-like 2 (MAML2) were activated by Notch intracellular domain 1 (NICD1) but not β-catenin; we also observed a positive feedback loop between Hes1 and MAML2. Immunoreactivities for nu...
Source: Am J Pathol - December 14, 2023 Category: Pathology Authors: Ako Yokoi Akari Murayama Miki Hashimura Yasuko Oguri Yohei Harada Naomi Fukagawa Misato Hayashi Mototsugu Ono Kensuke Ohhigata Makoto Saegusa Source Type: research
Vision transformers for breast cancer human epidermal growth factor receptor 2 (HER2) expression staging without immunohistochemical (IHC) staining
This article argues for the effectiveness of customized vision transformers in staging HER2 expression in breast cancer using only H&E-stained images. This work introduces a spatial transformer network (STN) for weakly localizing critical image features before utilizing a vision transformer-based deep learning architecture. An ordinal loss function is employed to precisely characterize HER2 expression stages. The proposed algorithm comprises three modules: a localization module for weak feature identification using spatial transformers, an attention module for global learning via vision transformers, and a loss module ...
Source: Am J Pathol - December 14, 2023 Category: Pathology Authors: Gelan Ayana Eonjin Lee Se-Woon Choe Source Type: research
A complex interplay between Notch effectors and β-catenin signaling in morular differentiation of endometrial carcinoma cells
Am J Pathol. 2023 Dec 12:S0002-9440(23)00459-5. doi: 10.1016/j.ajpath.2023.11.014. Online ahead of print.ABSTRACTNotch signaling contributes to tissue development and homeostasis, but little is known about its roles in morular differentiation of endometrial carcinoma (Em Ca) cells. The current study focused on crosstalk between Notch and β-catenin signaling in Em Ca with morules. Promoters of hairy and enhancer of split 1 (Hes1) and mastermind-like 2 (MAML2) were activated by Notch intracellular domain 1 (NICD1) but not β-catenin; we also observed a positive feedback loop between Hes1 and MAML2. Immunoreactivities for nu...
Source: Am J Pathol - December 14, 2023 Category: Pathology Authors: Ako Yokoi Akari Murayama Miki Hashimura Yasuko Oguri Yohei Harada Naomi Fukagawa Misato Hayashi Mototsugu Ono Kensuke Ohhigata Makoto Saegusa Source Type: research
Vision transformers for breast cancer human epidermal growth factor receptor 2 (HER2) expression staging without immunohistochemical (IHC) staining
This article argues for the effectiveness of customized vision transformers in staging HER2 expression in breast cancer using only H&E-stained images. This work introduces a spatial transformer network (STN) for weakly localizing critical image features before utilizing a vision transformer-based deep learning architecture. An ordinal loss function is employed to precisely characterize HER2 expression stages. The proposed algorithm comprises three modules: a localization module for weak feature identification using spatial transformers, an attention module for global learning via vision transformers, and a loss module ...
Source: Am J Pathol - December 14, 2023 Category: Pathology Authors: Gelan Ayana Eonjin Lee Se-Woon Choe Source Type: research
This Month in AJP
Am J Pathol. 2023 Dec 9:S0002-9440(23)00454-6. doi: 10.1016/j.ajpath.2023.12.001. Online ahead of print.NO ABSTRACTPMID:38081451 | DOI:10.1016/j.ajpath.2023.12.001 (Source: Am J Pathol)
Source: Am J Pathol - December 11, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Dec 9:S0002-9440(23)00454-6. doi: 10.1016/j.ajpath.2023.12.001. Online ahead of print.NO ABSTRACTPMID:38081451 | DOI:10.1016/j.ajpath.2023.12.001 (Source: Am J Pathol)
Source: Am J Pathol - December 11, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Dec 9:S0002-9440(23)00454-6. doi: 10.1016/j.ajpath.2023.12.001. Online ahead of print.NO ABSTRACTPMID:38081451 | DOI:10.1016/j.ajpath.2023.12.001 (Source: Am J Pathol)
Source: Am J Pathol - December 11, 2023 Category: Pathology Source Type: research
VEGF-C treatment enhances cerebrospinal fluid outflow during Toxoplasma gondii brain infection but does not improve cerebral edema
Am J Pathol. 2023 Dec 6:S0002-9440(23)00447-9. doi: 10.1016/j.ajpath.2023.11.008. Online ahead of print.ABSTRACTCerebral edema frequently develops in the setting of brain infection and can contribute to elevated intracranial pressure, a medical emergency. Currently, it is incompletely understood how excess fluid is cleared from the brain. Previous studies have shown that interstitial fluid is transported out of the brain along perivascular channels that collect into the cerebrospinal fluid (CSF)-filled subarachnoid space. CSF is then removed from the central nervous system through venous and lymphatic routes. Here, we test...
Source: Am J Pathol - December 8, 2023 Category: Pathology Authors: Michael A Kovacs Isaac W Babcock Ana Royo Marco Lydia A Sibley Abigail G Kelly Tajie H Harris Source Type: research
VEGF-C treatment enhances cerebrospinal fluid outflow during Toxoplasma gondii brain infection but does not improve cerebral edema
Am J Pathol. 2023 Dec 6:S0002-9440(23)00447-9. doi: 10.1016/j.ajpath.2023.11.008. Online ahead of print.ABSTRACTCerebral edema frequently develops in the setting of brain infection and can contribute to elevated intracranial pressure, a medical emergency. Currently, it is incompletely understood how excess fluid is cleared from the brain. Previous studies have shown that interstitial fluid is transported out of the brain along perivascular channels that collect into the cerebrospinal fluid (CSF)-filled subarachnoid space. CSF is then removed from the central nervous system through venous and lymphatic routes. Here, we test...
Source: Am J Pathol - December 8, 2023 Category: Pathology Authors: Michael A Kovacs Isaac W Babcock Ana Royo Marco Lydia A Sibley Abigail G Kelly Tajie H Harris Source Type: research
VEGF-C treatment enhances cerebrospinal fluid outflow during Toxoplasma gondii brain infection but does not improve cerebral edema
Am J Pathol. 2023 Dec 6:S0002-9440(23)00447-9. doi: 10.1016/j.ajpath.2023.11.008. Online ahead of print.ABSTRACTCerebral edema frequently develops in the setting of brain infection and can contribute to elevated intracranial pressure, a medical emergency. Currently, it is incompletely understood how excess fluid is cleared from the brain. Previous studies have shown that interstitial fluid is transported out of the brain along perivascular channels that collect into the cerebrospinal fluid (CSF)-filled subarachnoid space. CSF is then removed from the central nervous system through venous and lymphatic routes. Here, we test...
Source: Am J Pathol - December 8, 2023 Category: Pathology Authors: Michael A Kovacs Isaac W Babcock Ana Royo Marco Lydia A Sibley Abigail G Kelly Tajie H Harris Source Type: research
Understanding One Half of the Sex Difference Equation: The Modulatory Effects of Testosterone on Diabetic Cardiomyopathy
Am J Pathol. 2023 Dec 5:S0002-9440(23)00448-0. doi: 10.1016/j.ajpath.2023.11.009. Online ahead of print.ABSTRACTDiabetes is a prevalent disease, primarily characterized by high blood sugar (hyperglycemia). Significantly higher rates of myocardial dysfunction have been noted in individuals with diabetes, even in those without coronary artery disease or high blood pressure (hypertension). Numerous molecular mechanisms have been identified, through which diabetes contributes to the pathology of diabetic cardiomyopathy, which presents as cardiac hypertrophy and fibrosis. At the cellular level, oxidative stress and inflammation...
Source: Am J Pathol - December 7, 2023 Category: Pathology Authors: Mika'il Visanji Daniel E Venegas-Pino Geoff H Werstuck Source Type: research
