DOCK2 promotes atherosclerosis by mediating the endothelial cell inflammatory response
This study aims to explore the role of dedicator of cytokinesis 2 (DOCK2) in the pathogenesis of atherosclerosis. Low-density lipoprotein receptor (LDLR)-deficient mice with DOCK2 deficiency (LDLR-/-DOCK2-/-) and control (LDLR-/-) mice were fed with a high-fat diet (HFD) to induce atherosclerosis. The aortas and aortic roots were collected for atherosclerosis analysis. DOCK2 expression was induced in atherosclerotic lesions with increased expression of ICAM-1 and VCAM-1 after HFD for 4 weeks in LDLR-/- mice. LDLR-/-DOCK2-/- mice exhibited significantly decreased Oil-Red O (ORO) staining in both aortic roots and aortas comp...
Source: Am J Pathol - October 14, 2023 Category: Pathology Authors: Guoqing Qian Oluwaseun Adeyanju Dunpeng Cai Torry A Tucker Steven Idell Shi-You Chen Xia Guo Source Type: research
Introducing the Ocular Pathobiology Topic Category in The American Journal of Pathology
Am J Pathol. 2023 Nov;193(11):1620-1621. doi: 10.1016/j.ajpath.2023.09.002.NO ABSTRACTPMID:37838454 | DOI:10.1016/j.ajpath.2023.09.002 (Source: Am J Pathol)
Source: Am J Pathol - October 14, 2023 Category: Pathology Authors: Patricia A D'Amore Source Type: research
Defining the functional influence of endothelial cell-expressed oncogenic activating mutations on vascular morphogenesis and capillary assembly
Am J Pathol. 2023 Oct 12:S0002-9440(23)00375-9. doi: 10.1016/j.ajpath.2023.08.017. Online ahead of print.ABSTRACTWe sought to define key molecules and signals controlling major steps in vascular morphogenesis, and how these signals regulate pericyte recruitment and pericyte-induced basement membrane deposition. The morphogenic impact of EC expression of activating mutants of kRas, Mek1, PIK3CA, Akt1, Rheb, Jak2, or Stat3 expression vs. controls was evaluated, along with EC signaling events, pharmacological inhibitor assays, and siRNA suppression experiments. We observe that primary stimulators of EC lumen formation include...
Source: Am J Pathol - October 14, 2023 Category: Pathology Authors: Prisca K Lin Zheying Sun George E Davis Source Type: research
DOCK2 promotes atherosclerosis by mediating the endothelial cell inflammatory response
This study aims to explore the role of dedicator of cytokinesis 2 (DOCK2) in the pathogenesis of atherosclerosis. Low-density lipoprotein receptor (LDLR)-deficient mice with DOCK2 deficiency (LDLR-/-DOCK2-/-) and control (LDLR-/-) mice were fed with a high-fat diet (HFD) to induce atherosclerosis. The aortas and aortic roots were collected for atherosclerosis analysis. DOCK2 expression was induced in atherosclerotic lesions with increased expression of ICAM-1 and VCAM-1 after HFD for 4 weeks in LDLR-/- mice. LDLR-/-DOCK2-/- mice exhibited significantly decreased Oil-Red O (ORO) staining in both aortic roots and aortas comp...
Source: Am J Pathol - October 14, 2023 Category: Pathology Authors: Guoqing Qian Oluwaseun Adeyanju Dunpeng Cai Torry A Tucker Steven Idell Shi-You Chen Xia Guo Source Type: research
Introducing the Ocular Pathobiology Topic Category in The American Journal of Pathology
Am J Pathol. 2023 Nov;193(11):1620-1621. doi: 10.1016/j.ajpath.2023.09.002.NO ABSTRACTPMID:37838454 | DOI:10.1016/j.ajpath.2023.09.002 (Source: Am J Pathol)
Source: Am J Pathol - October 14, 2023 Category: Pathology Authors: Patricia A D'Amore Source Type: research
Defining the functional influence of endothelial cell-expressed oncogenic activating mutations on vascular morphogenesis and capillary assembly
Am J Pathol. 2023 Oct 12:S0002-9440(23)00375-9. doi: 10.1016/j.ajpath.2023.08.017. Online ahead of print.ABSTRACTWe sought to define key molecules and signals controlling major steps in vascular morphogenesis, and how these signals regulate pericyte recruitment and pericyte-induced basement membrane deposition. The morphogenic impact of EC expression of activating mutants of kRas, Mek1, PIK3CA, Akt1, Rheb, Jak2, or Stat3 expression vs. controls was evaluated, along with EC signaling events, pharmacological inhibitor assays, and siRNA suppression experiments. We observe that primary stimulators of EC lumen formation include...
Source: Am J Pathol - October 14, 2023 Category: Pathology Authors: Prisca K Lin Zheying Sun George E Davis Source Type: research
DOCK2 promotes atherosclerosis by mediating the endothelial cell inflammatory response
This study aims to explore the role of dedicator of cytokinesis 2 (DOCK2) in the pathogenesis of atherosclerosis. Low-density lipoprotein receptor (LDLR)-deficient mice with DOCK2 deficiency (LDLR-/-DOCK2-/-) and control (LDLR-/-) mice were fed with a high-fat diet (HFD) to induce atherosclerosis. The aortas and aortic roots were collected for atherosclerosis analysis. DOCK2 expression was induced in atherosclerotic lesions with increased expression of ICAM-1 and VCAM-1 after HFD for 4 weeks in LDLR-/- mice. LDLR-/-DOCK2-/- mice exhibited significantly decreased Oil-Red O (ORO) staining in both aortic roots and aortas comp...
Source: Am J Pathol - October 14, 2023 Category: Pathology Authors: Guoqing Qian Oluwaseun Adeyanju Dunpeng Cai Torry A Tucker Steven Idell Shi-You Chen Xia Guo Source Type: research
Introducing the Ocular Pathobiology Topic Category in The American Journal of Pathology
Am J Pathol. 2023 Nov;193(11):1620-1621. doi: 10.1016/j.ajpath.2023.09.002.NO ABSTRACTPMID:37838454 | DOI:10.1016/j.ajpath.2023.09.002 (Source: Am J Pathol)
Source: Am J Pathol - October 14, 2023 Category: Pathology Authors: Patricia A D'Amore Source Type: research
Elucidating the Role of PIK3CA in Early-Stage Bladder Tumorigenesis: New Insights from a Novel Transgenic Mouse Model
Am J Pathol. 2023 Oct 11:S0002-9440(23)00378-4. doi: 10.1016/j.ajpath.2023.10.001. Online ahead of print.NO ABSTRACTPMID:37832869 | DOI:10.1016/j.ajpath.2023.10.001 (Source: Am J Pathol)
Source: Am J Pathol - October 13, 2023 Category: Pathology Authors: Bishoy M Faltas Source Type: research
Exogenous TGF β1 and its mimic HpTGM attenuate the heart's inflammatory response to ischaemic injury and reduce mature scar size
Am J Pathol. 2023 Oct 11:S0002-9440(23)00376-0. doi: 10.1016/j.ajpath.2023.09.014. Online ahead of print.ABSTRACTSuccessful and timely coronary reperfusion following acute ST-elevation myocardial infarction (STEMI) is standard therapy to salvage ischaemic heart muscle. However, subsequent inflammatory responses within the infarct leads to further loss of viable myocardium. TGFβ1 is a potent anti-inflammatory cytokine released endogenously in response to infection or tissue injury and the goal of this study was to investigate its protective effects when given exogenously following MI. In STEMI patients, we observe a signif...
Source: Am J Pathol - October 13, 2023 Category: Pathology Authors: Rachael E Redgrave Esha Singh Simon Tual-Chalot Catherine Park Darroch Hall Karim Bennaceur Danielle J Smyth Rick M Maizels Ioakim Spyridopoulos Helen M Arthur Source Type: research
Elucidating the Role of PIK3CA in Early-Stage Bladder Tumorigenesis: New Insights from a Novel Transgenic Mouse Model
Am J Pathol. 2023 Oct 11:S0002-9440(23)00378-4. doi: 10.1016/j.ajpath.2023.10.001. Online ahead of print.NO ABSTRACTPMID:37832869 | DOI:10.1016/j.ajpath.2023.10.001 (Source: Am J Pathol)
Source: Am J Pathol - October 13, 2023 Category: Pathology Authors: Bishoy M Faltas Source Type: research
Exogenous TGF β1 and its mimic HpTGM attenuate the heart's inflammatory response to ischaemic injury and reduce mature scar size
Am J Pathol. 2023 Oct 11:S0002-9440(23)00376-0. doi: 10.1016/j.ajpath.2023.09.014. Online ahead of print.ABSTRACTSuccessful and timely coronary reperfusion following acute ST-elevation myocardial infarction (STEMI) is standard therapy to salvage ischaemic heart muscle. However, subsequent inflammatory responses within the infarct leads to further loss of viable myocardium. TGFβ1 is a potent anti-inflammatory cytokine released endogenously in response to infection or tissue injury and the goal of this study was to investigate its protective effects when given exogenously following MI. In STEMI patients, we observe a signif...
Source: Am J Pathol - October 13, 2023 Category: Pathology Authors: Rachael E Redgrave Esha Singh Simon Tual-Chalot Catherine Park Darroch Hall Karim Bennaceur Danielle J Smyth Rick M Maizels Ioakim Spyridopoulos Helen M Arthur Source Type: research
The Role of Endothelial Cells in Atherosclerosis: Insights from Genetic Association Studies
Am J Pathol. 2023 Oct 10:S0002-9440(23)00373-5. doi: 10.1016/j.ajpath.2023.09.012. Online ahead of print.ABSTRACTEndothelial cells (ECs) mediate several biological functions that are relevant to atherosclerosis and coronary artery disease (CAD), regulating an array of vital processes including vascular tone, wound healing, reactive oxygen species, shear stress response, and inflammation. Although it is not yet known which of these functions is causally linked with CAD development and/or progression, genome-wide association studies (GWASs) have implicated over 400 loci associated with CAD risk, among which several have demo...
Source: Am J Pathol - October 12, 2023 Category: Pathology Authors: Mark E Pepin Rajat Gupta Source Type: research
Overexpression of Corin Ameliorates Kidney fibrosis through Inhibition of Wnt/ β-Catenin Signaling in Mice
Am J Pathol. 2023 Oct 10:S0002-9440(23)00364-4. doi: 10.1016/j.ajpath.2023.09.008. Online ahead of print.ABSTRACTThe Wnt/β-catenin pathway represents a promising therapeutic target for mitigating kidney fibrosis. Corin possesses the homologous ligand binding site (Frizzled-cysteine rich domain, Fz-CRD) similar to Frizzled proteins, which act as receptors for Wnt. The Fz-CRD has been found in eight different proteins, all of which, except for corin, are known to bind Wnt and regulate its signal transmission. It is hypothesized that corin may inhibit the Wnt/β-catenin signaling pathway and thereby reduce fibrogenesis. Redu...
Source: Am J Pathol - October 12, 2023 Category: Pathology Authors: Xiaole Su Sijia Li Yanru Zhang Xuan Tie Rongrong Feng Xiaojiao Guo Xi Qiao Lihua Wang Source Type: research
Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplification of Androgen-Independent Epithelial Cell Populations Sensitive to Antioxidant Therapy
Am J Pathol. 2023 Oct 10:S0002-9440(23)00366-8. doi: 10.1016/j.ajpath.2023.09.010. Online ahead of print.ABSTRACTBenign prostate hyperplasia (BPH) is caused by the non-malignant enlargement of the transition zone of the prostate gland, leading to lower urinary tract symptoms (LUTS). While current medical treatments are unsatisfactory in many patients, the limited understanding of the mechanisms driving disease progression prevents the development of alternative therapeutic strategies. The probasin-prolactin (Pb-PRL) transgenic mouse recapitulates many histopathological features of human BPH. We here show that these alterat...
Source: Am J Pathol - October 12, 2023 Category: Pathology Authors: Le ïla Dos Santos Francesco Carbone Emeline Pacreau Sekou Diarra Marine Luka Natascha Pigat Manon Baures Emilie Navarro Julien Anract Nicolas Barry Delongchamps Nicolas Cagnard Fr édéric Bost Ivan Nemazanyy Olivier Petitjean Ahmed Hama ï Micka ël Men Source Type: research
