This Month in AJP
Am J Pathol. 2024 Mar;194(3):323. doi: 10.1016/j.ajpath.2024.01.001. Epub 2024 Jan 11.NO ABSTRACTPMID:38365345 | DOI:10.1016/j.ajpath.2024.01.001 (Source: Am J Pathol)
Source: Am J Pathol - February 16, 2024 Category: Pathology Source Type: research
Correction
Am J Pathol. 2024 Mar;194(3):471. doi: 10.1016/j.ajpath.2023.12.004. Epub 2024 Jan 2.NO ABSTRACTPMID:38365346 | DOI:10.1016/j.ajpath.2023.12.004 (Source: Am J Pathol)
Source: Am J Pathol - February 16, 2024 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2024 Feb 10:S0002-9440(24)00048-8. doi: 10.1016/j.ajpath.2024.02.001. Online ahead of print.NO ABSTRACTPMID:38342225 | DOI:10.1016/j.ajpath.2024.02.001 (Source: Am J Pathol)
Source: Am J Pathol - February 11, 2024 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2024 Feb 10:S0002-9440(24)00048-8. doi: 10.1016/j.ajpath.2024.02.001. Online ahead of print.NO ABSTRACTPMID:38342225 | DOI:10.1016/j.ajpath.2024.02.001 (Source: Am J Pathol)
Source: Am J Pathol - February 11, 2024 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2024 Feb 10:S0002-9440(24)00048-8. doi: 10.1016/j.ajpath.2024.02.001. Online ahead of print.NO ABSTRACTPMID:38342225 | DOI:10.1016/j.ajpath.2024.02.001 (Source: Am J Pathol)
Source: Am J Pathol - February 11, 2024 Category: Pathology Source Type: research
Ninjurin 2 Modulates Tumorigenesis, Inflammation, and Metabolism via Pyroptosis
Am J Pathol. 2024 Feb 5:S0002-9440(24)00044-0. doi: 10.1016/j.ajpath.2024.01.013. Online ahead of print.ABSTRACTThe nerve injury induced protein 2 (NINJ2) belongs to a family of homophilic adhesion molecules and was initially found to be involved in nerve regeneration. However, the role of NINJ2 in other cellular process are not well studied. Here, by generating a Ninj2-deficient mouse model, we showed that mice deficient in Ninj2 have a short lifespan and are prone to spontaneous tumors, systemic inflammation and metabolic defects. To better understand the metabolic traits that contributes to these phenotypes, we performe...
Source: Am J Pathol - February 7, 2024 Category: Pathology Authors: Jin Zhang Xiangmudong Kong Hee Jung Yang Weici Zhang Mingyi Chen Xinbin Chen Source Type: research
Computational Pathology for Prediction of Isocitrate Dehydrogenase Gene Mutation from Whole Slide Images in Adult Patients with Diffuse Glioma
Am J Pathol. 2024 Feb 5:S0002-9440(24)00039-7. doi: 10.1016/j.ajpath.2024.01.009. Online ahead of print.ABSTRACTIsocitrate dehydrogenase gene (IDH) mutation is one of the most important molecular markers of glioma. Accurate detection of IDH status is a crucial step for integrated diagnosis of adult-type diffuse gliomas. A clustering-based hybrid of a convolutional neural network and a vision transformer deep learning model was developed to detect IDH mutation status from annotation-free hematoxylin and eosin-stained whole slide pathologic images of 2275 adult patients with diffuse gliomas. For comparison, we also assessed ...
Source: Am J Pathol - February 7, 2024 Category: Pathology Authors: Yuanshen Zhao Weiwei Wang Yuchen Ji Yang Guo Jingxian Duan Xianzhi Liu Dongming Yan Dong Liang Wencai Li Zhenyu Zhang Zhi-Cheng Li Source Type: research
WSB1, a Hypoxia-Inducible E3 Ligase, Promotes Myofibroblast Accumulation and Attenuates Alveolar Epithelial Regeneration in Mouse Lung Fibrosis
In this study, we explored the expression, cellular distribution and function of WSB1 in bleomycin (BLM)-induced mouse lung injury and fibrosis. WSB1 expression was highly induced by BLM injury and correlated with the progression of lung fibrosis. Significantly, conditional deletion of Wsb1 in adult mice ameliorated BLM-induced pulmonary fibrosis. Phenotypically, Wsb1-deficient mice exhibited reduced lipofibroblast (LIF) to MYF transition, but enhanced alveolar type 2 (AT2) proliferation and differentiation into AT1 following BLM injury. Proteomic analysis of mouse lung tissues identified Caveolin 2 as a potential downstre...
Source: Am J Pathol - February 7, 2024 Category: Pathology Authors: Lei Chong Lihui Zou Liyan Xiang Xinyue Song Wanqi Miao Xihua Yan Ming Xu Gongxia Ling Elie El Agha Saverio Bellusci Zhenkun Lou Hailin Zhang Jin-San Zhang Source Type: research
TRPV1 channels facilitate axonal degeneration of corneal sensory nerves in dry eye
Am J Pathol. 2024 Feb 5:S0002-9440(24)00047-6. doi: 10.1016/j.ajpath.2024.01.015. Online ahead of print.ABSTRACTCorneal nerve impairment contributes significantly to dry eye disease (DED) symptoms and is thought to be secondary to corneal epithelial damage. Transient receptor potential vanilloid-1 (TRPV1) channels abound in corneal nerve fibers and respond to inflammation-derived ligands, which increase in DED. TRPV1 overactivation promotes axonal degeneration in vitro but whether it participates in DED-associated corneal nerve dysfunction is unknown. To explore this, DED was surgically induced in wild-type and TRPV1-knock...
Source: Am J Pathol - February 7, 2024 Category: Pathology Authors: Manuela Pizzano Alexia Vereertbrugghen Agostina Cernutto Florencia Sabbione Irene A Keitelman Carolina M Shiromizu Douglas Vera Aguilar Federico Fuentes Mirta N Giordano Anal ía S Trevani Jerem ías G Galletti Source Type: research
IL-6 upregulates expression of LMO4 in psoriatic keratinocytes through activation of the MEK/ERK/NF- κB pathway
In this study, human immortalized keratinocyte (HaCaT) cells, clinical biopsy specimens, and an animal model of psoriasis induced by imiquimod cream were used to investigate the role of IL-6 in the regulation of keratinocyte proliferation and differentiation. We found that IL-6 and LMO4 were abnormally expressed in the psoriatic epidermis. IL-6 up-regulates the expression of LMO4 and promotes keratinocyte proliferation and differentiation. Furthermore, in vitro and in vivo studies showed that IL-6 upregulates LMO4 expression by activating the MEK/ERK/NF-κB signaling pathway. These results suggest that IL-6 can activate th...
Source: Am J Pathol - February 6, 2024 Category: Pathology Authors: Zhenzhen Tu Wei Wei Fanjun Zeng Wenwen Wang Yuyan Zhang Yintao Zhang Fusheng Zhou Chunlin Cai Siping Zhang Haisheng Zhou Source Type: research
BTF3L4 enhances malignant phenotypes through modulating tumor cell function and immune microenvironment in glioma
Am J Pathol. 2024 Feb 4:S0002-9440(24)00042-7. doi: 10.1016/j.ajpath.2024.01.011. Online ahead of print.ABSTRACTRecent investigations into the tumor microenvironment have provided insights into the limited response of glioma progression to immunotherapy. However, the specific involvement of Basic Transcription Factor 3 Like 4 (BTF3L4) in glioma progression and its correlation with immune cell infiltration remained areas of uncertainty that require further exploration. In the present study, BTF3L4 expression was delineated using gene-expression-profiling-interactive-analysis and multiplex-immunohistological staining of tiss...
Source: Am J Pathol - February 6, 2024 Category: Pathology Authors: Bing Lu Tianyi Lu Jiawen Shi Pingping Sun Xiaojng Zhang Lei Yang Ziheng Wang Jianfei Huang Source Type: research
Histologic Evidence of Epithelial-Mesenchymal Transition and Autophagy in Human Fetal Membranes
This study documents pPROMs association with amniochorion autophagy and EMT, and confirmers OS's role in inducing dysfunctional cell fates that increase inflammation, predisposing membranes to rupture.PMID:38320630 | DOI:10.1016/j.ajpath.2023.12.011 (Source: Am J Pathol)
Source: Am J Pathol - February 6, 2024 Category: Pathology Authors: Mary Elise Severino Lauren S Richardson Marian Kacerovsky Ramkumar Menon Source Type: research
Model-Agnostic Binary Patch Grouping for Bone Marrow WSI Representation
Am J Pathol. 2024 Feb 4:S0002-9440(24)00043-9. doi: 10.1016/j.ajpath.2024.01.012. Online ahead of print.ABSTRACTHistopathology is the reference standard for pathology diagnosis, and has evolved with the digitization of glass slides, i.e. whole slide images (WSIs). Trained histopathologists can help to diagnose disease by examining WSIs visually, but this process is time-consuming and prone to variability. To address these issues, AI models are being developed to create slide-level representations of WSIs, summarizing the entire slide as a single vector. This enables various computational pathology applications, including i...
Source: Am J Pathol - February 6, 2024 Category: Pathology Authors: Youqing Mu Hamid R Tizhoosh Taher Dehkharghanian Saghir Alfasly Clinton Jv Campbell Source Type: research
Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration
Am J Pathol. 2024 Feb 5:S0002-9440(24)00040-3. doi: 10.1016/j.ajpath.2023.12.010. Online ahead of print.ABSTRACTCancer-associated fibroblasts (CAFs) in the tumor microenvironment are involved in the progression of various cancers, including esophageal squamous cell carcinoma (ESCC). CAF-like cells were generated through direct co-culture of human bone marrow-derived mesenchymal stem cells, one of CAF origins, with ESCC cells, and periostin (POSTN) was found to be highly expressed in CAF-like cells. After direct co-culture, ESCC cells showed increased malignant phenotypes, such as survival, growth, and migration, as well as...
Source: Am J Pathol - February 6, 2024 Category: Pathology Authors: Shoji Miyako Yu-Ichiro Koma Takashi Nakanishi Shuichi Tsukamoto Keitaro Yamanaka Nobuaki Ishihara Yuki Azumi Satoshi Urakami Masaki Shimizu Takayuki Kodama Mari Nishio Manabu Shigeoka Yoshihiro Kakeji Hiroshi Yokozaki Source Type: research
5-Hydroxytryptamine 4 Receptor Agonist Attenuates Diabetic Enteric Neuropathy through Inhibition of the Receptor-Interacting Protein Kinase 3 Pathway
This study aimed to explore the beneficial effects of 5-HT4R agonist on enteric neuropathy in a mouse model of diabetes and the mechanisms underlying these effects. Diabetes developed neural loss in the colon of mice. 5-HT4Rs localized in submucosal and myenteric plexuses were confirmed. Administration of 5-HT4R agonist attenuated diabetes-induced colonic hypomotility and neural loss of the colon in mice. Remarkably, RIPK3, phosphorylated RIPK3, and its downstream target mixed lineage kinase domain-like protein (MLKL), two key proteins regulating necroptosis, were significantly up-regulated in the colon of diabetic mice. T...
Source: Am J Pathol - February 4, 2024 Category: Pathology Authors: Yingying Cheng Yueting Kou Juan Wang Yue Wang Weifang Rong Hongxiu Han Guohua Zhang Source Type: research
