Release of miR-29 target laminin C2 improves skin repair
Am J Pathol. 2023 Nov 17:S0002-9440(23)00422-4. doi: 10.1016/j.ajpath.2023.11.002. Online ahead of print.ABSTRACTMicroRNAs (miRs) are small non-coding RNAs that regulate mRNA targets in a cell-specific manner. miR-29 is expressed in mouse and human skin where it may regulate functions important for skin repair. Cutaneous wound healing model in miR29ab1 knockout (KO) mice was used to identify miR-29 targets in the wound matrix, where angiogenesis and maturation of provisional granulation tissue was enhanced in response to genetic deletion of miR-29. Consistently, antisense-mediated inhibition of miR-29 promoted angiogenesis...
Source: Am J Pathol - November 19, 2023 Category: Pathology Authors: Connor James Robinson Lalitha Thiagarajan Rebecca Maynard Maneesha Aruketty Jeremy Herrera Lewis Dingle Adam Reid Jason Wong Heng Cao James Dooley Adrian Liston Daniela M üllhaupt Paul Hiebert Hayley Hiebert Svitlana Kurinna Source Type: research
Insight into the role of gut microbiota in Duchenne muscular dystrophy: an age-related study in mdx mice
This study highlights a specific gut microbiota composition and points out inter-organ interactions in mdx physiopathology with gut microbiota as potential central metabolic organ.PMID:37981219 | DOI:10.1016/j.ajpath.2023.10.010 (Source: Am J Pathol)
Source: Am J Pathol - November 19, 2023 Category: Pathology Authors: Maxence Jollet Mahendra Mariadassou Olivier Ru é Laurence Pessemesse Vincent Ollendorff Sofiane Ramdani Barbara Vernus Anne Bonnieu Christelle Bertrand-Gaday B énédicte Goustard Christelle Koechlin-Ramonatxo Source Type: research
FOXO3-activated HOTTIP Sequesters MiR-615-3p Away from COL2A1 to Mitigate Intervertebral Disc Degeneration
Am J Pathol. 2023 Nov 17:S0002-9440(23)00421-2. doi: 10.1016/j.ajpath.2023.10.011. Online ahead of print.ABSTRACTKnockout of FOXO3 was found to impair IVD maturation and homeostasis in postnatal mice as well as facilitating extracellular matrix (ECM) degradation. RNA sequencing can uncover disease-related gene expression and investigate disease pathophysiology. High-throughput transcriptome sequencing and experimental validations were used to identify the essential gene and mechanism involved in intervertebral disc degeneration (IDD). Nucleus pulposus (NP) tissue samples were collected from the mice with conditional knocko...
Source: Am J Pathol - November 19, 2023 Category: Pathology Authors: Yingjie Hao Guangduo Zhu Lei Yu Zhinan Ren Weiwei Zhou Panke Zhang Xu Lian Source Type: research
Release of miR-29 target laminin C2 improves skin repair
Am J Pathol. 2023 Nov 17:S0002-9440(23)00422-4. doi: 10.1016/j.ajpath.2023.11.002. Online ahead of print.ABSTRACTMicroRNAs (miRs) are small non-coding RNAs that regulate mRNA targets in a cell-specific manner. miR-29 is expressed in mouse and human skin where it may regulate functions important for skin repair. Cutaneous wound healing model in miR29ab1 knockout (KO) mice was used to identify miR-29 targets in the wound matrix, where angiogenesis and maturation of provisional granulation tissue was enhanced in response to genetic deletion of miR-29. Consistently, antisense-mediated inhibition of miR-29 promoted angiogenesis...
Source: Am J Pathol - November 19, 2023 Category: Pathology Authors: Connor James Robinson Lalitha Thiagarajan Rebecca Maynard Maneesha Aruketty Jeremy Herrera Lewis Dingle Adam Reid Jason Wong Heng Cao James Dooley Adrian Liston Daniela M üllhaupt Paul Hiebert Hayley Hiebert Svitlana Kurinna Source Type: research
Insight into the role of gut microbiota in Duchenne muscular dystrophy: an age-related study in mdx mice
This study highlights a specific gut microbiota composition and points out inter-organ interactions in mdx physiopathology with gut microbiota as potential central metabolic organ.PMID:37981219 | DOI:10.1016/j.ajpath.2023.10.010 (Source: Am J Pathol)
Source: Am J Pathol - November 19, 2023 Category: Pathology Authors: Maxence Jollet Mahendra Mariadassou Olivier Ru é Laurence Pessemesse Vincent Ollendorff Sofiane Ramdani Barbara Vernus Anne Bonnieu Christelle Bertrand-Gaday B énédicte Goustard Christelle Koechlin-Ramonatxo Source Type: research
FOXO3-activated HOTTIP Sequesters MiR-615-3p Away from COL2A1 to Mitigate Intervertebral Disc Degeneration
Am J Pathol. 2023 Nov 17:S0002-9440(23)00421-2. doi: 10.1016/j.ajpath.2023.10.011. Online ahead of print.ABSTRACTKnockout of FOXO3 was found to impair IVD maturation and homeostasis in postnatal mice as well as facilitating extracellular matrix (ECM) degradation. RNA sequencing can uncover disease-related gene expression and investigate disease pathophysiology. High-throughput transcriptome sequencing and experimental validations were used to identify the essential gene and mechanism involved in intervertebral disc degeneration (IDD). Nucleus pulposus (NP) tissue samples were collected from the mice with conditional knocko...
Source: Am J Pathol - November 19, 2023 Category: Pathology Authors: Yingjie Hao Guangduo Zhu Lei Yu Zhinan Ren Weiwei Zhou Panke Zhang Xu Lian Source Type: research
Release of miR-29 target laminin C2 improves skin repair
Am J Pathol. 2023 Nov 17:S0002-9440(23)00422-4. doi: 10.1016/j.ajpath.2023.11.002. Online ahead of print.ABSTRACTMicroRNAs (miRs) are small non-coding RNAs that regulate mRNA targets in a cell-specific manner. miR-29 is expressed in mouse and human skin where it may regulate functions important for skin repair. Cutaneous wound healing model in miR29ab1 knockout (KO) mice was used to identify miR-29 targets in the wound matrix, where angiogenesis and maturation of provisional granulation tissue was enhanced in response to genetic deletion of miR-29. Consistently, antisense-mediated inhibition of miR-29 promoted angiogenesis...
Source: Am J Pathol - November 19, 2023 Category: Pathology Authors: Connor James Robinson Lalitha Thiagarajan Rebecca Maynard Maneesha Aruketty Jeremy Herrera Lewis Dingle Adam Reid Jason Wong Heng Cao James Dooley Adrian Liston Daniela M üllhaupt Paul Hiebert Hayley Hiebert Svitlana Kurinna Source Type: research
Correction
Am J Pathol. 2023 Dec;193(12):2218. doi: 10.1016/j.ajpath.2023.10.002. Epub 2023 Oct 16.NO ABSTRACTPMID:37980071 | DOI:10.1016/j.ajpath.2023.10.002 (Source: Am J Pathol)
Source: Am J Pathol - November 18, 2023 Category: Pathology Source Type: research
Correction
Am J Pathol. 2023 Dec;193(12):2218. doi: 10.1016/j.ajpath.2023.10.002. Epub 2023 Oct 16.NO ABSTRACTPMID:37980071 | DOI:10.1016/j.ajpath.2023.10.002 (Source: Am J Pathol)
Source: Am J Pathol - November 18, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Nov 10:S0002-9440(23)00417-0. doi: 10.1016/j.ajpath.2023.11.001. Online ahead of print.NO ABSTRACTPMID:37956969 | DOI:10.1016/j.ajpath.2023.11.001 (Source: Am J Pathol)
Source: Am J Pathol - November 13, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Nov 10:S0002-9440(23)00417-0. doi: 10.1016/j.ajpath.2023.11.001. Online ahead of print.NO ABSTRACTPMID:37956969 | DOI:10.1016/j.ajpath.2023.11.001 (Source: Am J Pathol)
Source: Am J Pathol - November 13, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Nov 10:S0002-9440(23)00417-0. doi: 10.1016/j.ajpath.2023.11.001. Online ahead of print.NO ABSTRACTPMID:37956969 | DOI:10.1016/j.ajpath.2023.11.001 (Source: Am J Pathol)
Source: Am J Pathol - November 13, 2023 Category: Pathology Source Type: research
This Month in AJP
Am J Pathol. 2023 Nov 10:S0002-9440(23)00417-0. doi: 10.1016/j.ajpath.2023.11.001. Online ahead of print.NO ABSTRACTPMID:37956969 | DOI:10.1016/j.ajpath.2023.11.001 (Source: Am J Pathol)
Source: Am J Pathol - November 13, 2023 Category: Pathology Source Type: research
Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease
Am J Pathol. 2023 Nov 3:S0002-9440(23)00410-8. doi: 10.1016/j.ajpath.2023.09.016. Online ahead of print.ABSTRACTAlcohol-associated liver disease (ALD) is a serious public health problem with limited pharmacologic options. The goal of the current study was to investigate the efficacy of pharmacologic inhibition of soluble epoxide hydrolase (sEH), an enzyme involved in lipid metabolism, in experimental ALD and to examine the underlying mechanisms. C57BL/6J male mice underwent acute-on-chronic ethanol (EtOH) feeding with or without the sEH inhibitor 4-[[trans-4-[[[[4-Trifluoromethoxy phenyl] amino] carbonyl]-amino] cyclohexyl...
Source: Am J Pathol - November 4, 2023 Category: Pathology Authors: Jeffrey B Warner Josiah E Hardesty Ying L Song Alison T Floyd Zhongbin Deng Audriy Jebet Liqing He Xiang Zhang Craig J McClain Bruce D Hammock Dennis R Warner Irina A Kirpich Source Type: research
Hepatic Transcriptome and Its Regulation Following Soluble Epoxide Hydrolase Inhibition in Alcohol-Associated Liver Disease
Am J Pathol. 2023 Nov 3:S0002-9440(23)00410-8. doi: 10.1016/j.ajpath.2023.09.016. Online ahead of print.ABSTRACTAlcohol-associated liver disease (ALD) is a serious public health problem with limited pharmacologic options. The goal of the current study was to investigate the efficacy of pharmacologic inhibition of soluble epoxide hydrolase (sEH), an enzyme involved in lipid metabolism, in experimental ALD and to examine the underlying mechanisms. C57BL/6J male mice underwent acute-on-chronic ethanol (EtOH) feeding with or without the sEH inhibitor 4-[[trans-4-[[[[4-Trifluoromethoxy phenyl] amino] carbonyl]-amino] cyclohexyl...
Source: Am J Pathol - November 4, 2023 Category: Pathology Authors: Jeffrey B Warner Josiah E Hardesty Ying L Song Alison T Floyd Zhongbin Deng Audriy Jebet Liqing He Xiang Zhang Craig J McClain Bruce D Hammock Dennis R Warner Irina A Kirpich Source Type: research
