Deletion of MyD88 in T-cells Improves Anti-Tumor Activity in Melanoma
Am J Pathol. 2024 Mar 3:S0002-9440(24)00083-X. doi: 10.1016/j.ajpath.2024.02.012. Online ahead of print.ABSTRACTCytotoxic CD8+ T-cells are central to the anti-tumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88 (myeloid differentiation response 88). However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. We recently...
Source: Am J Pathol - March 5, 2024 Category: Pathology Authors: Abraham L Bayer Darwing Padilla-Rolon Sasha Smolgovsky Philip Hinds Pilar Alcaide Source Type: research
Ficolin-A/2 aggravated severe lung injury through NETs mediated by GSDMD-induced pyroptosis
In conclusion, these results suggested that Ficolin-A/2 exacerbated NET formation and LPS-induced lung injury via the GSDMD-mediated pyroptosis.PMID:38442803 | DOI:10.1016/j.ajpath.2024.02.011 (Source: Am J Pathol)
Source: Am J Pathol - March 5, 2024 Category: Pathology Authors: Li Huang Xiaowu Tan Weixia Xuan Qing Luo Li Xie Yunzhu Xi Rong Li Li Li Feifan Li Meiyun Zhao Yongliang Jiang Xu Wu Source Type: research
Deletion of MyD88 in T-cells Improves Anti-Tumor Activity in Melanoma
Am J Pathol. 2024 Mar 3:S0002-9440(24)00083-X. doi: 10.1016/j.ajpath.2024.02.012. Online ahead of print.ABSTRACTCytotoxic CD8+ T-cells are central to the anti-tumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88 (myeloid differentiation response 88). However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. We recently...
Source: Am J Pathol - March 5, 2024 Category: Pathology Authors: Abraham L Bayer Darwing Padilla-Rolon Sasha Smolgovsky Philip Hinds Pilar Alcaide Source Type: research
Ficolin-A/2 aggravated severe lung injury through NETs mediated by GSDMD-induced pyroptosis
In conclusion, these results suggested that Ficolin-A/2 exacerbated NET formation and LPS-induced lung injury via the GSDMD-mediated pyroptosis.PMID:38442803 | DOI:10.1016/j.ajpath.2024.02.011 (Source: Am J Pathol)
Source: Am J Pathol - March 5, 2024 Category: Pathology Authors: Li Huang Xiaowu Tan Weixia Xuan Qing Luo Li Xie Yunzhu Xi Rong Li Li Li Feifan Li Meiyun Zhao Yongliang Jiang Xu Wu Source Type: research
Deletion of MyD88 in T-cells Improves Anti-Tumor Activity in Melanoma
Am J Pathol. 2024 Mar 3:S0002-9440(24)00083-X. doi: 10.1016/j.ajpath.2024.02.012. Online ahead of print.ABSTRACTCytotoxic CD8+ T-cells are central to the anti-tumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88 (myeloid differentiation response 88). However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. We recently...
Source: Am J Pathol - March 5, 2024 Category: Pathology Authors: Abraham L Bayer Darwing Padilla-Rolon Sasha Smolgovsky Philip Hinds Pilar Alcaide Source Type: research
Ficolin-A/2 aggravated severe lung injury through NETs mediated by GSDMD-induced pyroptosis
In conclusion, these results suggested that Ficolin-A/2 exacerbated NET formation and LPS-induced lung injury via the GSDMD-mediated pyroptosis.PMID:38442803 | DOI:10.1016/j.ajpath.2024.02.011 (Source: Am J Pathol)
Source: Am J Pathol - March 5, 2024 Category: Pathology Authors: Li Huang Xiaowu Tan Weixia Xuan Qing Luo Li Xie Yunzhu Xi Rong Li Li Li Feifan Li Meiyun Zhao Yongliang Jiang Xu Wu Source Type: research
Deletion of MyD88 in T-cells Improves Anti-Tumor Activity in Melanoma
Am J Pathol. 2024 Mar 3:S0002-9440(24)00083-X. doi: 10.1016/j.ajpath.2024.02.012. Online ahead of print.ABSTRACTCytotoxic CD8+ T-cells are central to the anti-tumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88 (myeloid differentiation response 88). However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. We recently...
Source: Am J Pathol - March 5, 2024 Category: Pathology Authors: Abraham L Bayer Darwing Padilla-Rolon Sasha Smolgovsky Philip Hinds Pilar Alcaide Source Type: research
Tumor necrosis factor alpha-induced protein 8-like 1 binds to protein arginine methyltransferase 1 to suppress the methylation of signal transducer and activator of transcription 3 and cell growth in oral squamous cell carcinoma
Am J Pathol. 2024 Mar 1:S0002-9440(24)00080-4. doi: 10.1016/j.ajpath.2024.02.010. Online ahead of print.ABSTRACTTumor necrosis factor alpha-induced protein 8 (TIPE/TNFAIP8/OXi-α) family are a newly discovered series of proteins involved in immune regulation and tumorigenesis. TIPE1, as the member of TIPE/TNFAIP8/OXi-α family, has emerged as an anti-cancer drug target as it is promotes cancer cell apoptosis and inhibits cell proliferation. Here, the current study aimed to systematically reveal that TIPE1 regulates the activity of protein arginine methyltransferase 1 (PRMT1) and the subsequent methylation of signal transdu...
Source: Am J Pathol - March 3, 2024 Category: Pathology Authors: Bing Liu Wen Si Bo Wei Xuan Zhang Peng Chen Source Type: research
Decreased proteasomal function exacerbates ER stress-induced chronic inflammation in obese adipose tissue
This study employed a mouse model with decreased proteasomal function that exhibits age-related phenotypes to investigate the impact of adipocyte senescence on WAT inflammation. Transgenic mice expressing proteasomal subunit β5t with weak chymotrypsin-like activity suffer from reduced lifespan and develop age-related phenotypes. Mice fed with a high-fat diet (HFD) and suffering proteasomal dysfunction exhibited increased WAT inflammation, increased infiltration of pro-inflammatory M1-like macrophages, and increased pro-inflammatory adipocytokines like monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, ...
Source: Am J Pathol - February 29, 2024 Category: Pathology Authors: Shimpei Nakagawa Aya Fukui-Miyazaki Takuma Yoshida Yasushi Ishii Eri Murata Koji Taniguchi Akihiro Ishizu Masanori Kasahara Utano Tomaru Source Type: research
REG γ mitigates radiation-induced enteritis by preserving mucin secretion and sustaining microbiome homeostasis
Am J Pathol. 2024 Feb 27:S0002-9440(24)00077-4. doi: 10.1016/j.ajpath.2024.02.008. Online ahead of print.ABSTRACTRadiation-induced enteritis, a significant concern in abdominal radiation therapy, is closely associated with gut microbiota dysbiosis. The critical mucus layer plays a pivotal role in preventing the translocation of commensal and pathogenic microbes. While the significant expression of REGγ in intestinal epithelial cells is well established, its role in modulating mucus layer and gut microbiota remains enigmatic. Current study revealed notable changes in gut microorganisms and metabolites in irradiated mice la...
Source: Am J Pathol - February 29, 2024 Category: Pathology Authors: Xiangzhan Zhu Ya Li Xue Tian Yiming Jing Zimeng Wang Lingling Yue Jianhui Li Ling Wu Xinkui Zhou Zhidan Yu Yaodong Zhang Fangxia Guan Minglei Yang Bianhong Zhang Source Type: research
Decreased proteasomal function exacerbates ER stress-induced chronic inflammation in obese adipose tissue
This study employed a mouse model with decreased proteasomal function that exhibits age-related phenotypes to investigate the impact of adipocyte senescence on WAT inflammation. Transgenic mice expressing proteasomal subunit β5t with weak chymotrypsin-like activity suffer from reduced lifespan and develop age-related phenotypes. Mice fed with a high-fat diet (HFD) and suffering proteasomal dysfunction exhibited increased WAT inflammation, increased infiltration of pro-inflammatory M1-like macrophages, and increased pro-inflammatory adipocytokines like monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, ...
Source: Am J Pathol - February 29, 2024 Category: Pathology Authors: Shimpei Nakagawa Aya Fukui-Miyazaki Takuma Yoshida Yasushi Ishii Eri Murata Koji Taniguchi Akihiro Ishizu Masanori Kasahara Utano Tomaru Source Type: research
REG γ mitigates radiation-induced enteritis by preserving mucin secretion and sustaining microbiome homeostasis
Am J Pathol. 2024 Feb 27:S0002-9440(24)00077-4. doi: 10.1016/j.ajpath.2024.02.008. Online ahead of print.ABSTRACTRadiation-induced enteritis, a significant concern in abdominal radiation therapy, is closely associated with gut microbiota dysbiosis. The critical mucus layer plays a pivotal role in preventing the translocation of commensal and pathogenic microbes. While the significant expression of REGγ in intestinal epithelial cells is well established, its role in modulating mucus layer and gut microbiota remains enigmatic. Current study revealed notable changes in gut microorganisms and metabolites in irradiated mice la...
Source: Am J Pathol - February 29, 2024 Category: Pathology Authors: Xiangzhan Zhu Ya Li Xue Tian Yiming Jing Zimeng Wang Lingling Yue Jianhui Li Ling Wu Xinkui Zhou Zhidan Yu Yaodong Zhang Fangxia Guan Minglei Yang Bianhong Zhang Source Type: research
Decreased proteasomal function exacerbates ER stress-induced chronic inflammation in obese adipose tissue
This study employed a mouse model with decreased proteasomal function that exhibits age-related phenotypes to investigate the impact of adipocyte senescence on WAT inflammation. Transgenic mice expressing proteasomal subunit β5t with weak chymotrypsin-like activity suffer from reduced lifespan and develop age-related phenotypes. Mice fed with a high-fat diet (HFD) and suffering proteasomal dysfunction exhibited increased WAT inflammation, increased infiltration of pro-inflammatory M1-like macrophages, and increased pro-inflammatory adipocytokines like monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, ...
Source: Am J Pathol - February 29, 2024 Category: Pathology Authors: Shimpei Nakagawa Aya Fukui-Miyazaki Takuma Yoshida Yasushi Ishii Eri Murata Koji Taniguchi Akihiro Ishizu Masanori Kasahara Utano Tomaru Source Type: research
REG γ mitigates radiation-induced enteritis by preserving mucin secretion and sustaining microbiome homeostasis
Am J Pathol. 2024 Feb 27:S0002-9440(24)00077-4. doi: 10.1016/j.ajpath.2024.02.008. Online ahead of print.ABSTRACTRadiation-induced enteritis, a significant concern in abdominal radiation therapy, is closely associated with gut microbiota dysbiosis. The critical mucus layer plays a pivotal role in preventing the translocation of commensal and pathogenic microbes. While the significant expression of REGγ in intestinal epithelial cells is well established, its role in modulating mucus layer and gut microbiota remains enigmatic. Current study revealed notable changes in gut microorganisms and metabolites in irradiated mice la...
Source: Am J Pathol - February 29, 2024 Category: Pathology Authors: Xiangzhan Zhu Ya Li Xue Tian Yiming Jing Zimeng Wang Lingling Yue Jianhui Li Ling Wu Xinkui Zhou Zhidan Yu Yaodong Zhang Fangxia Guan Minglei Yang Bianhong Zhang Source Type: research
Decreased proteasomal function exacerbates ER stress-induced chronic inflammation in obese adipose tissue
This study employed a mouse model with decreased proteasomal function that exhibits age-related phenotypes to investigate the impact of adipocyte senescence on WAT inflammation. Transgenic mice expressing proteasomal subunit β5t with weak chymotrypsin-like activity suffer from reduced lifespan and develop age-related phenotypes. Mice fed with a high-fat diet (HFD) and suffering proteasomal dysfunction exhibited increased WAT inflammation, increased infiltration of pro-inflammatory M1-like macrophages, and increased pro-inflammatory adipocytokines like monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, ...
Source: Am J Pathol - February 29, 2024 Category: Pathology Authors: Shimpei Nakagawa Aya Fukui-Miyazaki Takuma Yoshida Yasushi Ishii Eri Murata Koji Taniguchi Akihiro Ishizu Masanori Kasahara Utano Tomaru Source Type: research
