Suppression of overactive IGF-1 attenuates trauma-induced heterotopic ossification in mice

In conclusion, our results indicated that IGF-1 mediated the progression of traumatic HO through PI3K/Akt/mTOR signaling, and suppressing IGF-1 signaling cascades attenuated HO formation, providing a promising therapeutic strategy targeting HO.PMID:38101566 | DOI:10.1016/j.ajpath.2023.11.012

Source: Am J Pathol - December 15, 2023 Category: Pathology Authors: Dong Mao Kai Wang Hong Jiang Jingyi Mi Xiaoyun Pan Gang Zhao Yongjun Rui Source Type: research