Developmental dopaminergic signaling modulates neural circuit formation and contributes to autism spectrum disorder (ASD)-related phenotypes

In this study, human brain RNA-seq transcriptome analysis revealed a significant correlation between changes in dopaminergic signaling pathways and neural developmental signaling in ASD patients. In the zebrafish model, disrupted developmental dopaminergic signaling led to neural circuit abnormalities and behavior reminiscent of autism. Dopaminergic signaling may impact neuronal specification by potentially modulating integrins. These findings shed light on the mechanisms underlying the link between disrupted developmental dopamine signaling and ASD, and they point to the possibility of targeting dopaminergic signaling in early development for ASD treatment.PMID:38492733 | DOI:10.1016/j.ajpath.2024.02.014

Source: Am J Pathol - March 16, 2024 Category: Pathology Authors: Xiaojuan Lu Yixing Song Jiaqi Wang Yunyun Cai Siwan Peng Jiaqi Lin Biqin Lai Junjie Sun Tianqing Liu Gang Chen Lingyan Xing Source Type: research