Alcoholism: Clinical and Experimental Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Latent classes of neurodevelopmental profiles and needs in children and adolescents with prenatal alcohol exposure
CONCLUSIONS: Four relatively distinct subgroups were present in a large heterogeneous sample of children and adolescents with PAE assessed for FASD in Canada. These findings may inform clinical services by guiding clinicians to identify distinct service pathways for these subgroups, potentially increasing access to a more personalized treatment approach and improving outcomes.PMID:36799306 | DOI:10.1111/acer.15028 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Kaitlyn McLachlan Meenu Minhas Chantel Ritter Kathleen Kennedy Vannesa Joly Martina Faitakis Jocelynn Cook Kathy Unsworth James MacKillop Jacqueline Pei Source Type: research

Alcohol-induced changes in mesostriatal resting-state functional connectivity are linked to sensation seeking in young adults
CONCLUSION: These findings provide novel information about how acute alcohol impacts resting-state connectivity, an effect that may be driven by the complex pre and postsynaptic effects of alcohol on various neurotransmitters including dopamine. Further, alcohol-induced differences in VTA connectivity represent a plausible mechanistic substrate underlying sensation seeking.PMID:36799331 | DOI:10.1111/acer.15032 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Angelica M Morales Sydney Gilbert Elijah Hart Scott A Jones Stephen J Boyd Suzanne H Mitchell Bonnie J Nagel Source Type: research

Chronic ethanol exposure induces mitochondrial dysfunction and alters gene expression and metabolism in human cardiac spheroids
CONCLUSION: Chronic ethanol treatment of hiPSC-CMs resulted in overall decreased mitochondrial function, increased glycolysis, disrupted fatty acid oxidation, and impaired cardiac structural development.PMID:36799338 | DOI:10.1111/acer.15026 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Hyun Hwang Rui Liu Ronald Eldridge Xin Hu Parvin Forghani Dean P Jones Chunhui Xu Source Type: research

Pretreatment changes in drinking: A test of a tailored treatment approach
CONCLUSIONS: In the substantial change arm, results suggest that offering a less intensive initial treatment, like RPT, may lower costs and conserve clinical resources. In the Minimal Change arm, results indicate the need to continue searching for a treatment or treatment enhancements to improve alcohol outcomes.PMID:36799772 | DOI:10.1111/acer.15022 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Paul R Stasiewicz Clara M Bradizza Joseph F Lucke Junru Zhao Kurt H Dermen Braden K Linn Kim S Slosman Charles LaBarre Source Type: research

Advancing screening for FASD: Commentary on "validation of the FASD-Tree as a screening tool for fetal alcohol spectrum disorders"
Alcohol Clin Exp Res. 2023 Feb 17. doi: 10.1111/acer.15033. Online ahead of print.NO ABSTRACTPMID:36799086 | DOI:10.1111/acer.15033 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Michelle Kuhn Source Type: research

Interleukin-22 alleviates alcohol-associated hepatic fibrosis, inhibits autophagy, and suppresses the PI3K/AKT/mTOR pathway in mice
CONCLUSIONS: IL-22 exerts a marked protective effect against alcohol-associated hepatic fibrosis. Its effect may be partly related to the alteration of autophagy-related gene expression and inhibition of the PI3K/AKT/mTOR pathway in the liver.PMID:36799106 | DOI:10.1111/acer.15021 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Yu-Xi Meng Rui Zhao Li-Juan Huo Source Type: research

Indomethacin restores loss of hippocampal neurogenesis and cholinergic innervation and reduces innate immune expression and reversal learning deficits in adult male and female rats following adolescent ethanol exposure
CONCLUSIONS: These data suggest that in males and females, (1) AIE persistent neuroimmune induction mediates both the loss of adult hippocampal DCX and loss of basal forebrain cholinergic neurons and their innervation to hippocampal targets, and (2) anti-inflammatory indomethacin treatment following AIE that restores these persistent molecular pathologies also restores spatial reversal learning deficits.PMID:36799290 | DOI:10.1111/acer.15019 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Victoria Macht Ryan Vetreno Natalie Elchert Rachael Fisher Fulton Crews Source Type: research

Impact of alcohol use disorder severity on human immunodeficiency virus (HIV) viral suppression and CD4 count in three international cohorts of people with HIV
CONCLUSIONS: In three cohorts of PWH, AUD severity was not associated with HIV viral suppression or CD4 count. PWH with AUD in the current era of antiretroviral therapy can achieve virologic control.PMID:36799302 | DOI:10.1111/acer.15031 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Nicolas Bertholet Richard Saitz Judith A Hahn Timothy C Heeren Nneka I Emenyonu Matthew Freiberg Michael R Winter Theresa W Kim Kara Magane Christine Lloyd-Travaglini Robin Fatch Kendall Bryant Leah S Forman Lindsey Rateau Elena Blokhina Winnie R Muyindik Source Type: research

Chronic alcohol intake regulates expression of SARS-CoV2 infection-relevant genes in an organ-specific manner
CONCLUSIONS: We conclude that alcohol-induced upregulation of Ace2 gene expression can lead to an elevated stochastic probability of virus entry into cells and may thus confer a molecular risk for SARS-CoV2 infection.PMID:36774629 | DOI:10.1111/acer.14981 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 12, 2023 Category: Addiction Authors: Marion M Friske Francesco Giannone Mona Senger Robin Seitz Anita C Hansson Rainer Spanagel Source Type: research