Chronic ethanol exposure induces mitochondrial dysfunction and alters gene expression and metabolism in human cardiac spheroids

CONCLUSION: Chronic ethanol treatment of hiPSC-CMs resulted in overall decreased mitochondrial function, increased glycolysis, disrupted fatty acid oxidation, and impaired cardiac structural development.PMID:36799338 | DOI:10.1111/acer.15026

Source: Alcoholism, Clinical and Experimental Research - February 17, 2023 Category: Addiction Authors: Hyun Hwang Rui Liu Ronald Eldridge Xin Hu Parvin Forghani Dean P Jones Chunhui Xu Source Type: research