A Randomized, Double-blind, Placebo-controlled Clinical Study to Investigate the efficacy of Herring Roe Oil for treatment of Psoriasis.
N, Bjørndal B Abstract The effect of omega-3 polyunsaturated fatty acid supplements in patients with Psoriasis vulgaris has previously been investigated, but interventions varied in source, composition, dose, administration route and duration of treatment. The observed beneficial effects in patients with Psoriasis vulgaris using as a dietary supplement prompted this investigation. This randomised, double blind and placebo controlled study was designed and performed to explore the efficacy and safety of herring roe oil supplementation in 64 patients with plaque psoriasis (ClinicalTrials.gov: NCT03359577). T...
Source: Acta Dermato-Venereologica - May 7, 2020 Category: Dermatology Authors: Tveit KS, Brokstad KA, Berge RK, Sæbø PC, Hallaråker H, Brekke S, Meland N, Bjørndal B Tags: Acta Derm Venereol Source Type: research

Annular Sarcoidosis with Geographic Appearance in a Patient with Systemic Sarcoidosis.
PMID: 32378725 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 7, 2020 Category: Dermatology Authors: Takama H, Ohshima Y, Ando Y, Yanagishita T, Takahashi E, Tsuzuki T, Uchida K, Eishi Y, Akiyama M, Watanabe D Tags: Acta Derm Venereol Source Type: research

Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716.
Abstract To evaluate cellular response to oncostatin M (OSM) in comparison to interleukin (IL)-31, we analyzed monocyte chemoattractant protein 1 (MCP-1) as a readout for OSM responses with and without IL-4, IL-13, anti-OSM receptor β monoclonal antibody KPL-716, and anti-IL-31 receptor α antibody in human epidermal keratinocytes and human dermal fibroblasts in vitro. In human epidermal keratinocytes, OSM significantly induced STAT3 or STAT1 phosphorylation and synergized with IL-13 or IL-4 in elevating MCP-1. In human dermal fibroblasts, OSM results were similar, and leukemia inhibitory factor or IL-31...
Source: Acta Dermato-Venereologica - May 6, 2020 Category: Dermatology Authors: Richards CD, Gandhi R, Botelho F, Ho L, Paolini JF Tags: Acta Derm Venereol Source Type: research

Cutaneous Manifestations of Granulomatosis with Polyangiitis: A Case Series Study.
ago S Abstract The aim of this study was to determine the prevalence and type of cutaneous manifestations which occur in patients with granulomatosis with polyangiitis and to explore the potential association between cutaneous and systemic involvement in these patients. A retrospective case series study was designed, including all granulomatosis with polyangiitis cases diagnosed between 2010 and 2018 at the Hospital Universitario Virgen de las Nieves. Thirty-nine patients with granulomatosis with polyangiitis were identified, of which 53.85% presented cutaneous manifestations. In decreasing order of frequency, the...
Source: Acta Dermato-Venereologica - May 6, 2020 Category: Dermatology Authors: Montero-Vilchez T, Martinez-Lopez A, Salvador-Rodriguez L, Del Carmen Ramírez-Barberena M, Tercedor-Sanchez J, Molina-Leyva A, Arias-Santiago S Tags: Acta Derm Venereol Source Type: research

Update of the Management of Cutaneous Squamous-cell Carcinoma.
Abstract For all primary cutaneous squamous cell carcinomas (cSCCs), physical examination should include full skin examination, recording of tumour diameter and regional lymph-node-basin status. Surgery is the treatment of choice, with a minimal 5-mm margin. For elderly patients with well-differentiated tumours, other surgical modalities can be explored. Surgery for organ-transplant recipients should not be delayed. The issue with cSCC is identifying high-risk tumours with staging, as this may alter treatment and follow-up schedules. Adjuvant radiation therapy should be considered for incomplete resection, when re...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Maubec E Tags: Acta Derm Venereol Source Type: research

Cutaneous Melanoma - A Review of Systemic Therapies.
Abstract Cutaneous malignant melanoma is a rare and aggressive cancer of the melanocytes of the skin. The majority of cutaneous melanomas are cured surgically, but a significant proportion are either metastatic at presentation or recur following resection. Historically, outcomes for patients with advanced melanoma were poor due to a paucity of effective treatment options. However, the past decade has seen the introduction of targeted therapies and immunotherapies which have revolutionised the treatment of advanced melanoma. This review will cover the systemic treatment of melanoma, with a description of available ...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Lee KA, Nathan P Tags: Acta Derm Venereol Source Type: research

Melanoma Genomics.
Abstract The incidence of cutaneous melanoma continues to increase in pale skinned peoples in Europe and elsewhere. Epidemiological studies identified genetically determined phenotypes such as pale skin, freckles and red hair, and sunburn as risk factors for this cancer. The development of many melanocytic naevi is also genetically determined and a strong melanoma risk phenotype. Not surprisingly then, genome wide association studies have identified pigmentation genes as common risk genes, and to a lesser extent, genes associated with melanocytic naevi. More unexpectedly, genes associated with telomere length have...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Newton-Bishop J, Bishop DT, Harland M Tags: Acta Derm Venereol Source Type: research

Melanoma Risk and Melanocyte Biology.
Abstract Cutaneous melanoma arises from melanocytes following genetic, epigenetic and allogenetic (i.e. other than epi/genetic) modifications. An estimated 10% of cutaneous melanoma cases are due to inherited variants or de novo mutations in approximately 20 genes, found using linkage, next-generation sequencing and association studies. Based on these studies, 3 classes of predisposing melanoma genes have been defined based on the frequency of the variants in the general population and lifetime risk of developing a melanoma: (i) ultra-rare variants with a high risk, (ii) rare with a moderate risk, and (iii) freque...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Bertrand JU, Steingrimsson E, Jouenne F, PBressac-de Aillerets B, Larue L Tags: Acta Derm Venereol Source Type: research

Biomarkers Predicting for Response and Relapse with Melanoma Systemic Therapy.
Abstract Introduction of new systemic therapies in the last 10 years has radically improved outcomes for melanoma patients. Even so, not all patients benefit. These two major drug classes, small molecule BRAF targeted kinase inhibitors and immune checkpoint inhibitors, both come at significant cost, with sometimes serious side effects as well as high expense for health services. Almost half of melanomas harbour a BRAFV600 mutation and virtually all patients receiving BRAF targeted therapy will experience some amount of response. However, duration of response with these agents is uncertain, due to acquired resistan...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Welsh SJ, Corrie PG Tags: Acta Derm Venereol Source Type: research

It's Not All Sunshine: Non-sun-related Melanoma Risk-factors.
Abstract There is increasing evidence that the behaviour of naevi and melanoma is under significant genetic and/or epigenetic control. Melanoma tumours behaves similarly all over the world. Many genes have now been implicated in melanoma risk and naevi number. Embryogenesis has also been important in the discovery of links between several neurological diseases and melanoma susceptibility. Telomere biology, which regulates cell senescence, is increasingly relevant in melanoma. Melanoma is often found in the context of family cancer syndromes and the identification of these families is important as screening for can...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Bataille V Tags: Acta Derm Venereol Source Type: research

Update in the Management of Basal Cell Carcinoma.
Abstract Basal cell carcinomas are the most frequent skin cancers in the fair-skinned adult population over 50 years of age. Their incidence is increasing throughout the world. Ultraviolet (UV) exposure is the major carcinogenic factor. Some genodermatosis can predispose to formation of basal cell carcinomas at an earlier age. Basal cell carcinomas are heterogeneous, from superficial or nodular lesions of good prognosis to very extensive difficult-to-treat lesions that must be discussed in multidisciplinary committees. Recent guidelines have updated the management of basal cell carcinoma. The prognosis is linked t...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Basset-Seguin N, Herms F Tags: Acta Derm Venereol Source Type: research

Melanoma Epidemiology and Sun Exposure.
Abstract The worldwide incidence of melanoma has increased rapidly over the last 50 years. Melanoma is the most common cancer found in the young adult population, and its incidence is very high among geriatric populations. The incidence of melanoma varies by sex, and this factor is also associated with differences in the anatomical site melanoma. Adolescent and young adult women have a higher incidence than men. This may be, in part, due to the greater use of sunbeds, as well as intentional sun exposure among girls and, in general, risky behaviours in seeking to suntan, due to socially-determined aesthetic needs. ...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Raimondi S, Suppa M, Gandini S Tags: Acta Derm Venereol Source Type: research

Sutton Naevi as Melanoma Simulators: Can Confocal Microscopy Help in the Diagnosis?
This study retrospectively characterized lesions that had been excised in order to avoid the possibility of melanoma, which were subsequently diagnosed histologically as Sutton naevi (n = 21, 37%); plus typical white halo Sutton naevi monitored for 1 year (n = 13, 23%); and proven thin melanomas with histological regression features (n = 23, 40%). On dermoscopy, atypical Sutton naevi and melanomas were indistinguishable. Reflectance confocal microscopy demonstrated significant differences at the dermo-epidermal junction: marked dermo-epidermal junction thickening and non-edged pap...
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Brugués A, Ribero S, Martins de Silva V, Aguilera P, Garcia AP, Alós L, Malvehy J, Puig S, Carrera C Tags: Acta Derm Venereol Source Type: research

Evaluating the Efficacy of Crisaborole Using the Atopic Dermatitis Severity Index and Percentage of Affected Body Surface Area.
Abstract Crisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis pools results from 2 phase 3 studies (ClinicalTrials.gov, NCT02118766 [AD-301]; NCT02118792 [AD-302]) to evaluate crisaborole efficacy in patients ≥ 2 years with mild-to-moderate atopic dermatitis (per Investigator's Static Global Assessment) using the Atopic Dermatitis Severity Index (ADSI) and percentage of treatable body surface area (%BSA). Patients were randomly assigned 2:1 to receive crisaborole (n = 1,016) or vehicle (n&th...
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Silverberg JI, Tallman AM, Ports WC, Gerber RA, Tan H, Zielinski MA Tags: Acta Derm Venereol Source Type: research

Actinic Keratosis Diagnosis and Increased Risk of Developing Skin Cancer: A 10-year Cohort Study of 17,651 Patients in Sweden.
In conclusion, a diagnosis of actinic keratosis, even in the absence of documentation of other features of chronic sun exposure, is a marker of increased risk of skin cancer, which should be addressed with individually directed preventive advice. PMID: 32314794 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Guorgis G, Anderson CD, Lyth J, Falk M Tags: Acta Derm Venereol Source Type: research

Allergic Rhinitis and Asthma Among Adolescents with Psoriasis: A Population-based Cross-sectional Study.
In conclusion, amongst adolescents, psoriasis was found to be associated with allergic rhinitis and asthma. PMID: 32314795 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Galili E, Barzilai A, Twig G, Caspi T, Daniely D, Shreberk-Hassidim R, Astman N Tags: Acta Derm Venereol Source Type: research

Cutaneous Clinico-Pathological Findings in three COVID-19-Positive Patients Observed in the Metropolitan Area of Milan, Italy.
PMID: 32315073 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Gianotti R, Veraldi S, Recalcati S, Cusini M, Ghislanzoni M, Boggio F, Fox LP Tags: Acta Derm Venereol Source Type: research

Psychiatric Comorbidities in Non-psychogenic Chronic Itch, a US-based Study.
Abstract Research suggests that itch and psychiatric diseases are intimately related. In efforts to examine the prevalence of psychiatric diagnoses in patients with chronic itch not due to psychogenic causes, we conducted a retrospective chart review of 502 adult patients diagnosed with chronic itch in an outpatient dermatology clinic specializing in itch and assessed these patients for a co-existing psychiatric disease. Psychiatric disease was identified and recorded based on ICD-10 codes made at any point in time which were recorded in the patient's electronic medical chart, which includes all medical department...
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Golpanian RS, Lipman Z, Fourzali K, Fowler E, Yosipovitch G Tags: Acta Derm Venereol Source Type: research

Unexpected Hair Regrowth in a Patient with Longstanding Alopecia Universalis During Treatment of Recalcitrant Dermatomyositis with the Janus Kinase Inhibitor Ruxolitinib.
PMID: 32285135 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 8, 2020 Category: Dermatology Authors: Fetter T, Cuevas Rios G, Niebel D, Bieber T, Wenzel J Tags: Acta Derm Venereol Source Type: research

Prevalence of Indoor Tanning Among Teenagers in Norway Before and After Enforcement of Ban for Ages Under 18 Years.
;d MB PMID: 32285136 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 8, 2020 Category: Dermatology Authors: Robsahm TE, Stenehjem JS, Berge LA, Veierød MB Tags: Acta Derm Venereol Source Type: research

Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis.
Abstract Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, ca...
Source: Acta Dermato-Venereologica - April 8, 2020 Category: Dermatology Authors: Li J, Xing J, Lu F, Chang W, Liang N, Li J, Wang Y, Li X, Zhao X, Hou R, Man M, Yin G, Li X, Zhang K Tags: Acta Derm Venereol Source Type: research

Recurrent and Metastatic Cutaneous Squamous Cell Carcinomas in a Cohort of 774 Patients in Finland.
In conclusion, our study demonstrated recurrences and metastases even in the case of thin cutaneous squamous cell carcinomas and in high-risk cases close monitoring should be organised during the first years after diagnosis. PMID: 32255495 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 7, 2020 Category: Dermatology Authors: Korhonen N, Ylitalo L, Luukkaala T, Itkonen J, Häihälä H, Jernman J, Snellman E, Palve J Tags: Acta Derm Venereol Source Type: research

The Management of Scabies in the 21st Century: Past, Advances and Potentials.
Abstract Scabies is one of the most common skin diseases worldwide, affecting 150-200 million people yearly. Scabies affects young children in particular, and has the greatest impact in poor overcrowded living conditions. The burden of the disease is now well characterized, including group A Streptococcus and Staphylococcus aureus bacterial superinfections, with reports of nephritis, acute rheumatic fever, or fatal invasive sepsis secondary to scabies. Management of scabies remains largely suboptimal from diagnosis to treatment, and progress in the development of new therapeutic measures leading to cure is urgentl...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Bernigaud C, Fischer K, Chosidow O Tags: Acta Derm Venereol Source Type: research

A Hundred Years of Diagnosing Superficial Fungal Infections: Where Do We Come From, Where Are We Now and Where Would We Like To Go?
DML Abstract Superficial fungal infections have been known for hundreds of years. During the 20th century new diagnostic methods were developed and the taxonomy changed several times, which, unfortunately, resulted in many fungi having several names (synonyms). The taxonomy is important, as species-specific identification guides clinicians when choosing the most appropriate antifungal agent, and provides an indication of the source of infection (anthropophilic, zoophilic or geophilic). Traditional diagnostic tests (direct microscopy, culture and histopathology) are still widely used, but molecular-based methods, s...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Gräser Y, Saunte DML Tags: Acta Derm Venereol Source Type: research

The Changing Spectrum of Sexually Transmitted Infections in Europe.
Abstract As long as 400 years ago, syphilitic ulcers and gonococcal discharge were observed in connection with sexual intercourse. War, poverty, and lack of efficient therapeutic options led to a high incidence of venereal diseases, many of which had devastating outcomes. This situation continued until the beginning of the 20th century, when the microbial aetiology of venereal diseases was discovered. The infection rate dropped with the availability of antibiotic therapy after the Second World War. However, since the beginning of the 21st century, a steady increase in sexually transmitted infections (STIs) has bee...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Stary A Tags: Acta Derm Venereol Source Type: research

Skin Disease in the Tropics and the Lessons that can be Learned from Leprosy and Other Neglected Diseases.
Abstract Skin disease is a common illness in most tropical regions where the pattern of clinical, presentations is dominated by infections. Along with common diseases such as pyodermas and fungal infections, a group of conditions known collectively as the neglected tropical diseases of the skin or Skin NTDs, which are the targets for worldwide control or elimination are also seen in health care facilities. These diseases range from the common, such a scabies, to those that are less frequent including leprosy and mycetoma. The initiative to use skin presentations of tropical diseases as a route to diagnosis by fron...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Hay RJ Tags: Acta Derm Venereol Source Type: research

Skin Infections Caused by Staphylococcus aureus.
Abstract Staphylococcus aureus is the most common pathogen involved in skin infections worldwide, regardless of the patient's age, the climate or geographical area. The main skin clinical manifestations can be linked to a few toxins produced by the bacteria, which give rise to a rich and varied clinical spectrum. Panton Valentine leucocidin, exfoliatins, enterotoxins and toxin shock syndrome toxin 1 are the main toxins involved in most dermatological manifestations associated with S. aureus. Other less frequent cutaneous manifestations can occur in endocarditis, bacteraemia or related to a contiguity focus. Curren...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Del Giudice P Tags: Acta Derm Venereol Source Type: research

Correlation Between Expression of CD134, a Human Herpesvirus 6 Cellular Receptor, on CD4+ T cells and Th2-type Immune Responses in Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms.
PMID: 32201900 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 20, 2020 Category: Dermatology Authors: Miyagawa F, Nakamura-Nishimura Y, Kanatani Y, Asada H Tags: Acta Derm Venereol Source Type: research

Body Image Quality of Life in Patients with Hidradenitis Suppurativa Compared with Other Dermatological Disorders.
This study sought to describe Body Image Quality of Life (BI-QoL) in patients with hidradenitis suppurativa and to compare it with patients with other skin diseases (controls). A total of 285 participants were recruited, 141 with hidradenitis suppurativa and 144 controls, at the Department of Dermatology at Zealand University Hospital, Denmark (during 2017-18). The Danish "Body Image Quality of Life Inventory" questionnaire measured BI-QoL. Patients with hidradenitis suppurativa had significantly lower mean BI-QoL than controls: Hidradenitis suppurativa BI-QoL (standard deviation; SD) -0.87 (0.98) vs. control BI-...
Source: Acta Dermato-Venereologica - March 20, 2020 Category: Dermatology Authors: Andersen PL, Nielsen RM, Sigsgaard V, Jemec GB, Riis PT Tags: Acta Derm Venereol Source Type: research

Increasing Costs of Skin Cancer due to Increasing Incidence and Introduction of Pharmaceuticals, 2007-2017.
In conclusion, the increasing costs of skin cancer are strongly affected by the increasing incidence and introduction of expensive drugs, and future projections are for an alarming increase. PMID: 32189004 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 19, 2020 Category: Dermatology Authors: Noels E, Hollestein L, Luijkx K, Louwman M, de Uyl-de Groot C, van den Bos R, van der Veldt A, Grünhagen D, Wakkee M Tags: Acta Derm Venereol Source Type: research

Efficacy of Apremilast in Patients with Prurigo Nodularis: A Proof-of-concept Study.
PMID: 32189005 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 19, 2020 Category: Dermatology Authors: Todberg T, Skov L, Simonsen S, Kainu K, Zachariae C Tags: Acta Derm Venereol Source Type: research

Patient Satisfaction and Expectations Regarding Mobile Teledermoscopy in General Practice for Diagnosis of Non-melanoma Skin Cancer and Malignant Melanoma.
Abstract The incidence of non-melanoma skin cancer and malignant melanoma is increasing. Diagnosing these skin lesions is primarily done visually, making it suitable to use new technology, such as teledermoscopy. Before the implementation of teledermoscopy, patient satisfaction, clinician satisfaction and diagnostic accuracy, need to be evaluated. A cross-sectional quantitative survey was conducted to evaluate patient satisfaction and expectations regarding a mobile teledermoscopy service, and to identify factors influencing patient satisfaction and choice of diagnostic method. [AQ1] Almost 90% of respondents were...
Source: Acta Dermato-Venereologica - March 17, 2020 Category: Dermatology Authors: Gilling S, Mortz CG, Vestergaard T Tags: Acta Derm Venereol Source Type: research

Factors Influencing Family Burden of Paediatric Patients with Atopic Dermatitis: A Cross-sectional Study.
r J PMID: 32179930 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 17, 2020 Category: Dermatology Authors: Xu X, van Galen LS, Bajpai R, Koh MJ, Thng S, Yew YW, Järbrink K, Car J Tags: Acta Derm Venereol Source Type: research

Subjective and Objective Characteristics of Patients Seen at a Psychodermatology Unit: One-year Experience in Malm ö, Sweden.
The objective of this study was to assess morbidity in a new psychodermatology service. Information was gathered from patient records at the psychodermatology unit in Skåne University Hospital, Malmö, Sweden, from 1 February 2017 to 31 January 2018. All patients were screened with the Hospital Anxiety and Depression Scale (HADS) and the Dermatology Life Quality Index (DLQI) at baseline and after 12 months. Additional information was collated from the patient records. A total of 50 patients were treated during the 12 months, 86% were women, mean age 44 years (standard deviation (SD) 16 years). Itch was present in...
Source: Acta Dermato-Venereologica - March 17, 2020 Category: Dermatology Authors: Dalgard FJ, Sjöström K, Fhager J, Svensson Å, Wallin E, Hauksson I Tags: Acta Derm Venereol Source Type: research

The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis.
This study further shows, using immunofluorescence on skin biopsies, that OX40+ and OX40L+ cells are co-located within the dermis, indicating local activity of OX40/OX40L. Serum levels of sOX40 were associated with atopic diseases and, together, these results support that the OX40 system is important for chronic inflammation in AD skin. PMID: 32176307 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 16, 2020 Category: Dermatology Authors: Elsner JS, Carlsson M, Stougaard JK, Nygaard U, Buchner M, Fölster-Holst R, Hvid M, Vestergaard C, Deleuran M, Deleuran B Tags: Acta Derm Venereol Source Type: research

Erosive Lichen Planus on the Extremities During Combination Therapy with Nivolumab and Radiation: A Second Case Report.
PMID: 32176308 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 16, 2020 Category: Dermatology Authors: Katsuo K, Honda T, Komori T, Kaku Y, Kabashima K Tags: Acta Derm Venereol Source Type: research

A Systematic Review of Drug-Induced Pemphigoid.
In conclusion, 89 drugs were implicated in DABP. The strongest evidence for DABP is seen with gliptins, PD-1/PD-L1 inhibitors, loop diuretics, penicillin and derivatives. An appreciation of the medications associated with bullous pemphigoid enables clinicians to identify potential cases of DABP earlier and cease the offending medication. PMID: 32176310 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 16, 2020 Category: Dermatology Authors: Verheyden MJ, Bilgic A, Murrell DF Tags: Acta Derm Venereol Source Type: research

Direct Costs of Epidermolysis Bullosa by Disease Severity.
PMID: 32176311 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 16, 2020 Category: Dermatology Authors: Flannery D, Doyle C, Hickey S, Aherne F, Kenan A Tags: Acta Derm Venereol Source Type: research

Adverse Events Leading to Discontinuation of Phototherapy: An Observational Study.
-Rincón JM Abstract The aim of this prospective study in a phototherapy unit was to describe adverse events (AEs) associated with discontinuation of phototherapy in a clinical setting. A total of 872 included patients received 1,256 courses of phototherapy treatment: 76.9% narrow-band UVB (NBUVB); 9.6% systemic psoralen plus UVA (PUVA); 11.4% topical PUVA; and 2.1% UVA. Approximately a fifth of the treatments (n = 240, 19.1%) were associated with AEs, the most frequent of which was erythema (8.8%). Systemic PUVA had the highest rate of AEs (32.5%). Mycosis fungoides was the dermatosis with the...
Source: Acta Dermato-Venereologica - March 16, 2020 Category: Dermatology Authors: Belinchón I, Sánchez-Pujol MJ, Docampo A, Cuesta L, Schneller-Pavelescu L, Ramos-Rincón JM Tags: Acta Derm Venereol Source Type: research

Dermoscopic and Immunohistochemical Observations in Anetodermic Pilomatricoma: A Case Report.
PMID: 32162670 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 12, 2020 Category: Dermatology Authors: Chen HS, Li FG, Wang T, Huang WB, Fan YM Tags: Acta Derm Venereol Source Type: research

Itchy Erythematous Plaques after Scuba Diving: A Quiz.
PMID: 32162671 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 12, 2020 Category: Dermatology Authors: Schwob E, Marmion N, Dereure O, Du-Thanh A Tags: Acta Derm Venereol Source Type: research

Association Between Methylenetetrahydrofolate Reductase Gene Polymorphisms and Risk of Vitiligo: A Systematic Review and Meta-Analysis.
PMID: 32162672 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 12, 2020 Category: Dermatology Authors: Chang HC, Lin MH, Tsai HH Tags: Acta Derm Venereol Source Type: research

Linear Blisters in a Young Girl: A Quiz.
PMID: 32162673 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 12, 2020 Category: Dermatology Authors: Zhong W, Jian X, Dai S, Zhu X, Lin Z, Yu B Tags: Acta Derm Venereol Source Type: research

Short-term Effect and Acceptability of Manual Lymphatic Drainage for Paediatric Limb Lymphoedema: A Prospective Study.
, Maruani A Abstract Paediatric lymphoedema (LE) is a rare condition, for which there is little data available regarding treatments. The aim of this study was to assess the short-term effect and acceptability of a 30-min session of manual lymphatic drainage (MLD) in children with well-documented LE of the lower limbs. Fifteen children were included (8 males; median age 11 years). Comparison of the sum of circumference values for the whole limb before and after MLD revealed a slight, but significant, reduction (from a median of 289.8 to 285.5 cm, p = 0.024), but the limb volumes did not decrease signi...
Source: Acta Dermato-Venereologica - March 11, 2020 Category: Dermatology Authors: El Habnouni C, Tauveron V, Leducq S, Gérémia S, Allain P, Touchard H, Benejean SA, Machet L, Maruani A Tags: Acta Derm Venereol Source Type: research

Inflammatory Vegetative Lesions of the Perineum: A Rare and Severe Clinical Presentation of Netherton Syndrome.
PMID: 32157314 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 11, 2020 Category: Dermatology Authors: Albluwi S, Maza A, Severino-Freire M, Tournier E, Mazereeuw-Hautier J Tags: Acta Derm Venereol Source Type: research

A Huge Plaque on the Back: A Quiz.
PMID: 32157315 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 11, 2020 Category: Dermatology Authors: Pi Z, Luo S, Shi Y, Chen P, Zou P, Xiao R, Zhan Y, Zhang G Tags: Acta Derm Venereol Source Type: research

Bullous Pemphigoid in Three Paediatric Patients in Finland.
PMID: 32157316 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - March 11, 2020 Category: Dermatology Authors: Pankakoski A, Panelius J, Salava A, Kluger N Tags: Acta Derm Venereol Source Type: research

Molecular Genetics of Keratinization Disorders - What's New.
Abstract The heritable forms of keratinization disorders, including various forms of ichthyosis and keratodermas, comprise a phenotypically heterogeneous group of diseases which can be divided into syndromic and non-syndromic forms. In the non-syndromic forms, the clinical manifestations are limited to the cutaneous structures while the syndromic ones are associated with a spectrum of extracutaneous manifestations. The inheritance in different families can be autosomal dominant, autosomal recessive or either X-linked dominant or recessive. Currently at least 67 distinct genes have been associated with different fo...
Source: Acta Dermato-Venereologica - March 9, 2020 Category: Dermatology Authors: Uitto J, Youssefian L, Saeidian AH, Vahidnezhad H Tags: Acta Derm Venereol Source Type: research

Ichthyosis: A Road Model for Skin Research.
auml; H Abstract The understanding of monogenetic disorders of cornification, including the group of diseases called ichthyoses, has expanded greatly in recent years. Studies of the aetiology of more than 50 types of ichthyosis have almost invariably uncovered errors in the biosynthesis of epidermal lipids or structural proteins essential for normal skin barrier function. The barrier abnormality per se may elicit epidermal inflammation, hyperproliferation and hyperkeratosis, potentially contributing to the patient's skin symptoms. Despite this and other new knowledge about pathomechanisms, treatment of ichthyosis ...
Source: Acta Dermato-Venereologica - March 9, 2020 Category: Dermatology Authors: Vahlquist A, Törmä H Tags: Acta Derm Venereol Source Type: research

Legius Syndrome and its Relationship with Neurofibromatosis Type 1.
Abstract Neurofibromatosis type 1 (NF1) is the most common disorder characterized by multiple café-au-lait macules. Most individuals with this autosomal dominant disorder also have other features, such as skinfold freckling, iris Lisch nodules and benign or malignant peripheral nerve sheath tumours. Legius syndrome is a less frequent autosomal dominant disorder with similar multiple café-au-lait macules and skinfold freckling. Legius syndrome is not characterized by an increased risk of tumours, and a correct diagnosis is important. In young children with a sporadic form of multiple café-au-la...
Source: Acta Dermato-Venereologica - March 9, 2020 Category: Dermatology Authors: Denayer E, Legius E Tags: Acta Derm Venereol Source Type: research