The Importance of Achieving Clear or Almost Clear Skin for Patients: Results from the Nordic Countries of the Global Clear about Psoriasis Patient Survey.
This report highlights stigmatization among Nordic patients with psoriasis and the potential to improve physician-patient communication. PMID: 30250961 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 24, 2018 Category: Dermatology Authors: Rasmussen MK, Enger M, Dahlborn AK, Juvik S, Fagerhed L, Dodge R, Enerbäck C Tags: Acta Derm Venereol Source Type: research

Daylight-photodynamic Therapy in Combination with Corticosteroid and Brimonidine Tartrate for Multiple Actinic Keratoses: A Randomized Clinical Trial.
PMID: 30250962 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 24, 2018 Category: Dermatology Authors: Wiegell SR, Johansen UB, Wulf HC Tags: Acta Derm Venereol Source Type: research

Increase in Vitamin D but not Regulatory T Cells following Ultraviolet B Phototherapy of Patients with Atopic Dermatitis.
This study investigated serum 25-hydroxyvitamin D (25(OH)D) concentrations and circulating regulatory T cells in patients with atopic dermatitis receiving narrow-band ultraviolet B (nbUVB) phototherapy. Thirty adult patients with atopic dermatitis were included. Blood samples were collected at baseline and at weeks 2 and 4 of nbUVB phototherapy. Skin biopsies were taken at baseline and at week 4. Serum 25(OH)D concentrations increased significantly following nbUVB phototherapy (estimate of change from baseline to week 2: 32.00 nmol/l, confidence interval (CI) 20.48-43.52, p 
Source: Acta Dermato-Venereologica - September 24, 2018 Category: Dermatology Authors: Simonsen S, Bonefeld CM, Thyssen JP, Geisler C, Skov L Tags: Acta Derm Venereol Source Type: research

Evaluation of Single Nucleotide Variants in Ethiopian Patients with Atopic Dermatitis.
Bradley M PMID: 30251743 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 24, 2018 Category: Dermatology Authors: Asad S, Tapia-Páez I, Montes AM, Wahlgren CF, Wahlgren CF, Bilcha KD, Nordenskjöld M, Bradley M Tags: Acta Derm Venereol Source Type: research

Fast-growing Painful Leg Ulcers in a 26-year-old Woman with Systemic Lupus Erythematosus: A Quiz.
PMID: 30229266 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 18, 2018 Category: Dermatology Authors: Hartmann J, Haenssle HH, Enk AH, Toberer F Tags: Acta Derm Venereol Source Type: research

Occurrence, Chronicity and Intensity of Itch in a Clinical Consecutive Sample of Patients with Skin Diseases: a Multi-centre Study in 13 European Countries.
fer J Abstract Itch is an unpleasant symptom, affecting many dermatological patients. Studies investigating the occurrence and intensity of itch in dermatological patients often focus on a single skin disease and omit a control group with healthy skin. The aim of this multi-centre study was to assess the occurrence, chronicity and intensity (visual analogue scale 0-10) of itch in patients with different skin diseases and healthy-skin controls. Out of 3,530 dermatological patients, 54.3% reported itch (mean ± standard deviation itch intensity 5.5 ± 2.5), while out of 1,094 ...
Source: Acta Dermato-Venereologica - September 18, 2018 Category: Dermatology Authors: Schut C, Dalgard FJ, Halvorsen JA, Gieler U, Lien L, Tomas Aragones L, Poot F, Jemec GB, Misery L, Kemény L, Sampogna F, van Middendorp H, Balieva F, Linder D, Szepietowski JC, Lvov A, Marron SE, Altunay IK, Finlay AY, Salek S, Kupfer J Tags: Acta Derm Venereol Source Type: research

Cytophagic Histiocytic Panniculitis Associated with Myelodysplastic Syndrome.
PMID: 30226527 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 18, 2018 Category: Dermatology Authors: Kimura R, Sugita K, Goto H, Yamamoto O Tags: Acta Derm Venereol Source Type: research

Diagnostic Indicators of Rosacea and Demodicosis.
Abstract Papulopustular rosacea and demodicosis are characterized by non-specific symptoms, which can make clinical diagnosis difficult. This retrospective study of 844 patients assessed the diagnostic importance of clinical signs and symptoms that are poorly recognized as being associated with these conditions. In addition to well-known signs (vascular signs (present in 80% of patients), papules (39%), pustules (22%) and ocular involvement (21%)), other signs and symptoms (discreet follicular scales (93%), scalp symptoms (pruritus, dandruff or folliculitis; 38%) and pruritus (15%)) may also suggest a diagnosis no...
Source: Acta Dermato-Venereologica - September 18, 2018 Category: Dermatology Authors: Forton FMN, De Maertelaer V Tags: Acta Derm Venereol Source Type: research

Novel Compound Heterozygous Mutations in RAG1 in a Patient with Cutaneous Lymphoproliferative Disease.
PMID: 30226529 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 18, 2018 Category: Dermatology Authors: Xu CC, Chen ZM, Xiong JS, Chen H, Sun JF Tags: Acta Derm Venereol Source Type: research

Perception of Dermatology and Dermatologists Among Medical Students.
PMID: 30226530 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 18, 2018 Category: Dermatology Authors: Ludriksone L, Tittelbach J, Elsner P Tags: Acta Derm Venereol Source Type: research

Phenotypic Features of Epidermolysis Bullosa Simplex due to KLHL24 Mutations in 3 Italian Cases.
PMID: 30226531 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 18, 2018 Category: Dermatology Authors: El Hachem M, Barresi S, Diociaiuti A, Boldrini R, Condorelli AG, Capoluongo E, Proto V, Scuvera G, Has C, Tartaglia M, Castiglia D Tags: Acta Derm Venereol Source Type: research

Progressive Nodular Histiocytosis with Large Nodules and a Bulky Mass.
PMID: 30226532 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 18, 2018 Category: Dermatology Authors: Kiyohara T, Makimura K, Miyamoto M, Shijimaya T, Nagano N, Nakamaru S, Tanimura H Tags: Acta Derm Venereol Source Type: research

Adverse Sexual Effects of Treatment with Finasteride or Dutasteride for Male Androgenetic Alopecia: A Systematic Review and Meta-analysis.
Abstract Treatment of male androgenetic alopecia with 5α-reductase inhibitors is efficacious. However, the risk of adverse sexual effects remains controversial. This systematic review and meta-analysis investigated the risk of adverse sexual effects due to treatment of androgenetic alopecia in male patients with finasteride, 1 mg/day, or dutasteride, 0.5 mg/day. Fifteen randomized double-blinded placebo-controlled trials (4,495 subjects) were meta-analysed. Use of 5α-reductase inhibitors carried a 1.57-fold risk of sexual dysfunction (95% confidence interval (95% CI) 1.19-2.08). The relative risk was 1...
Source: Acta Dermato-Venereologica - September 12, 2018 Category: Dermatology Authors: Lee S, Lee YB, Choe SJ, Lee WS Tags: Acta Derm Venereol Source Type: research

Bizarre Pigmented Lesion on the Scalp: A Quiz.
bba F PMID: 30206636 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 12, 2018 Category: Dermatology Authors: Micali G, Verzì AE, D'Agata E, Lacarrubba F Tags: Acta Derm Venereol Source Type: research

Predatory Journals in Dermatology: A Hidden Danger.
PMID: 30206637 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 12, 2018 Category: Dermatology Authors: Shalom G Tags: Acta Derm Venereol Source Type: research

Nail Involvement as a Predictor of Disease Severity in Paediatric Psoriasis: Follow-up Data from the Dutch ChildCAPTURE Registry.
Abstract Little is known about the relationship between nail psoriasis and psoriasis severity in children, and there has been no longitudinal assessment of psoriasis severity related to nail psoriasis. The aim of this study was to assess whether nail psoriasis could serve as a predictor for a more severe disease course. De-identified data were obtained from the Child-CAPTURE registry, a daily clinical practice cohort of children with psoriasis, from September 2008 to November 2015. Cross-sectional analyses were performed at baseline. Longitudinal data until 2-year follow-up were analysed by linear mixed models. Na...
Source: Acta Dermato-Venereologica - September 12, 2018 Category: Dermatology Authors: Bronckers IMGJ, Bruins FM, van Geel MJ, Groenewoud HMM, Kievit W, van de Kerkhof PCM, Pasch MC, de Jong EMGJ, Seyger MMB Tags: Acta Derm Venereol Source Type: research

Knowledge and Influence of Predatory Journals in Dermatology: A Pan-Austrian Survey.
g E Abstract The aim of this study was to assess the knowledge and influence of predatory journals in the field of dermatology in Austria. A total of 286 physicians (50.5% men) completed a questionnaire. The vast majority of subjects read scientific articles (n = 281, 98.3%) and took them into consideration in their clinical decision-making (n = 271, 98.5% of participants that regularly read scientific literature). Open access was known by 161 (56.3%), predatory journals by 84 (29.4%), and the Beall's list by 19 physicians (6.7%). A total of 117 participants (40.9%) had been challenged ...
Source: Acta Dermato-Venereologica - September 12, 2018 Category: Dermatology Authors: Richtig G, Richtig M, Hoetzenecker W, Saxinger W, Lange-Asschenfeldt B, Steiner A, Strohal R, Posch C, Bauer JW, Müllegger RR, Deinlein T, Sepp N, Volc-Platzer B, Nguyen VA, Schmuth M, Hoeller C, Muehlbacher E, Pregartner G, Richtig E Tags: Acta Derm Venereol Source Type: research

Langerhans Cell Histiocytosis with Lymph Node Involvment Presenting as Erythroderma.
PMID: 30182134 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 5, 2018 Category: Dermatology Authors: Zhu H, Ma Y, Sun L, Zhang R, Lv L, Wang A Tags: Acta Derm Venereol Source Type: research

Two Novel Mutations in the ERCC8 Gene in a Patient with Ultraviolet-sensitive Syndrome.
PMID: 30182135 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 5, 2018 Category: Dermatology Authors: Li Y, Zheng L, Chen F, Yao Z, Li M Tags: Acta Derm Venereol Source Type: research

Expression of n-MYC, NAMPT and SIRT1 in Basal Cell Carcinomas and their Cells of Origin.
Abstract Deregulated Hedgehog signalling is a driver of basal cell carcinomas. One effector of the Hedgehog pathway is n-MYC. c/n-MYC proteins, NAMPT and DBC1 are linked to SIRT1 in a positive feedback loop that may contribute to tumorigenesis of basal cell carcinoma. In 5 basal cell carcinoma types immunohistochemistry revealed n-MYC, NAMPT and SIRT1 expression. DBC1 was homogenously expressed in all epithelial cells. NAMPT, SIRT1 and c-MYC were expressed in the stratum basale of human and murine skin. In hair follicles NAMPT and SIRT1 were expressed together with c-MYC and n-MYC, except for the matrix, where n-M...
Source: Acta Dermato-Venereologica - September 5, 2018 Category: Dermatology Authors: Brandl L, Hartmann D, Kirchner T, Menssen A Tags: Acta Derm Venereol Source Type: research

Intergluteal Contour Deformity in Hidradenitis Suppurativa.
PMID: 30183056 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 5, 2018 Category: Dermatology Authors: Musumeci ML, Capuzzo G, Cammisuli B, Pesce A, Micali G Tags: Acta Derm Venereol Source Type: research

Acquired Partial Lipodystrophy Associated with Anti- Antibody-positive Adult-onset Dermatomyositis.
PMID: 30182133 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Shiraishi K, Tohyama M, Sayama K Tags: Acta Derm Venereol Source Type: research

Diagnostic Accuracy of Non-melanocytic Pink Flat Skin Lesions on the Legs: Dermoscopic and Reflectance Confocal Microscopy Evaluation.
M, Segura S Abstract Pink flat skin lesions on the legs in elderly people represent a diagnostic challenge due to the paucity of clinical and dermoscopic evidence. A prospective study of 114 pink flat lesions on the legs of 85 elderly patients was performed to describe the utility of reflectance confocal microscopy in this clinical context. Evaluation of clinical, dermoscopic and confocal parameters and calculation of diagnostic accuracy/sensitivity/specificity of each technique were carried out. Thirty-four benign and 80 malignant neoplasms were analysed. A correct clinical diagnosis was established in 49.1% of c...
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Gómez-Martín I, Moreno S, Duran X, Pujol RM, Segura S Tags: Acta Derm Venereol Source Type: research

The Number of FoxP3-positive Cells and Their Contacts with Tryptase-positive Mast Cells Increase in Tape-stripped Skin that Does not Develop the Isomorphic Psoriatic Reaction.
PMID: 30176038 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Suttle MM, Ritanen RL, Harvima IT Tags: Acta Derm Venereol Source Type: research

Direct Immunofluorescence of Mechanobullous Epidermolysis Bullosa Acquisita, Porphyria Cutanea Tarda and Pseudoporphyria.
Abstract Mechanobullous epidermolysis bullosa acquisita (mEBA) can have a clinical presentation that is very similar to other blistering diseases, such as porphyria cutanea tarda (PCT) and pseudoporphyria. Direct immunofluorescence is an important feature in the diagnosis of mEBA, although features that overlap with PCT and pseudoporphyria have been reported. This retrospective observational study investigated whether direct immunofluorescence can discriminate mEBA from PCT and pseudoporphyria. Biopsies of 13 patients with mEBA, 10 with PCT and 10 with pseudoporphyria were included. In 7 cases of PCT and 4 of pseu...
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: de Groot HJ, Jonkman MF, Pas HH, Diercks GFH Tags: Acta Derm Venereol Source Type: research

A Myxoid Fibrotic Reaction Pattern is Associated with Metastatic Risk in Cutaneous Squamous Cell Carcinoma.
This study aimed to examine the different stromal fibrotic patterns as markers of metastatic risk. We performed a multicenter retrospective study that included 102 cutaneous squamous cell carcinomas (52 non-metastatic and 50 metastatic carcinomas). Clinical and histopathological data were registered. The fibrotic reaction pattern was classified as mature, intermediate or immature depending on the presence of keloid-like collagen and myxoid stroma. The immature pattern (areas characterized by myxoid changes with no inflammation) was observed in 18 samples and its presence was significantly associated with immuno-suppression...
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Hernández-Ruiz E, Hernández-Muñoz I, Masferrer E, Ferrándiz-Pulido C, Andrades E, Gimeno J, Duran X, García-Patos V, Pujol RM, Toll A Tags: Acta Derm Venereol Source Type: research

Disseminated Erythematous Papules and Pustules: A Quiz.
PMID: 30176041 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Fujita Y, Shiiya C, Inamura-Takashima Y, Nomura T, Shibaki A, Shimizu H Tags: Acta Derm Venereol Source Type: research

Two Cases of Acute Febrile Neutrophilic Dermatosis Thought to be Caused by Topical Clindamycin.
PMID: 30176042 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Nitta K, Kano Y, Ushigome Y, Hayakawa J, Shiohara T Tags: Acta Derm Venereol Source Type: research

Clinical Experience of Overnight use of a Temperature-controlled Airflow Device in a Teenager with Severe Atopic Dermatitis.
ing; PMID: 30176043 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Theodosiou G, Svensson Å Tags: Acta Derm Venereol Source Type: research

Identification of a Single Nucleotide Polymorphism in NFKBIA with Different Effects on Psoriatic Arthritis and Cutaneous Psoriasis in China.
This study genotyped 12 single nucleotide polymorphisms in 379 patients with psoriatic arthritis, 376 with cutaneous psoriasis, and 760 healthy controls using Sequenom's Mass ARRAY system. The aim of the study was to expand the database for psoriatic arthritis and cutaneous psoriasis, and develop a genetic prediction system for the early diagnosis of psoriatic arthritis in the Chinese population. One variant in NFKBIA, rs12883343, had a significantly different association with psoriatic arthritis than with cutaneous psoriasis (p = 4.93×10-10, odds ratio 2.371). This suggests that there are differences i...
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Zhao Q, Sun Y, Fu X, Wang Z, Yu G, Yue Z, Wang Y, Zhang H, Wang C, Liu H, Yang Q, Zhang F Tags: Acta Derm Venereol Source Type: research

Unresectable Non-metastatic Primary Melanoma: Complete Remission Following Treatment with Anti-Programmed-cell-death-receptor 1.
, Guégan S PMID: 30176045 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Lheure C, Hoffmann C, Kramkimel N, Plée J, Franck N, Vanhaecke C, Goldman-Lévy G, Bataillon G, Damotte D, Dupin N, Aractingi S, Grange F, Guégan S Tags: Acta Derm Venereol Source Type: research

Congenital Nodule on the Ear in a Two-year-old Boy: A Quiz.
PMID: 30176046 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - September 3, 2018 Category: Dermatology Authors: Ikeda A, Goto H, Sugita K, Yamamoto O Tags: Acta Derm Venereol Source Type: research

Role of the Gut Microbiota in Atopic Dermatitis: A Systematic Review.
Abstract The immune mechanisms involved in atopic dermatitis (AD) are complex and little is known about the possible role of the gut microbiota in the aetiopathogenesis of AD. A systematic review of the literature was performed according to PRISMA guidelines, and included 44 of 2,199 studies (26 observational and 18 interventional studies). Detection of gut microbiota was performed by either 16s rRNA PCR, or by culture. Observational studies were diverse regarding the age of study participants and the bacterial species investigated. Overall, the results were conflicting with regard to diversity of the gut microbio...
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Pedersen EBM, Skov L, Thyssen JP, Jensen P Tags: Acta Derm Venereol Source Type: research

Dipeptidyl Peptidase-4 Inhibitor-associated Bullous Pemphigoid: Recurrence with Epitope Spreading.
PMID: 30085319 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Takama H, Yoshida M, Izumi K, Yanagishita T, Muto J, Ohshima Y, Nishie W, Shimizu H, Akiyama M, Watanabe D Tags: Acta Derm Venereol Source Type: research

Carvone Contact Allergy in Southern Sweden: A 21-year Retrospective Study.
Abstract Carvone (l-carvone), a mint flavour in spearmint oil, is considered a mild skin sensitizer. Carvone-sensitization may be linked to oral/perioral signs and oral lichen, but studies are sparse. The prevalence of patch test reactions to carvone and relevant findings from the positive group were investigated. Records for patch tested patients at the Malmö clinic, for the period 1996 to 2016, were studied. Carvone-positive and carvone-negative patients were compared regarding patch test data from baseline series and dental series. Dental series-tested carvone-positive patients were also compared with a ma...
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Kroona L, Isaksson M, Ahlgren C, Dahlin J, Bruze M, Warfvinge G Tags: Acta Derm Venereol Source Type: research

Treatment of Early Folliculotropic Mycosis Fungoides with Special Focus on Psoralen plus Ultraviolet A.
Abstract Data on the treatment of early folliculotropic mycosis fungoides, a recently defined clinicopathological subgroup of folliculotropic mycosis fungoides with an indolent course, is limited. Treatment outcomes were studied in a retrospective cohort of 47 adults with early folliculotropic mycosis fungoides, with a focus on psoralen plus ultraviolet A (PUVA) monotherapy, including dosimetric data, and the findings were compared with data for PUVA in 18 adults with early-classic mycosis fungoides. PUVA was given to 27 patients with early folliculotropic mycosis fungoides: 70% achieved complete response and 26% ...
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Amitay-Laish I, Prag-Naveh H, Dalal A, Pavlovsky L, Feinmesser M, Hodak E Tags: Acta Derm Venereol Source Type: research

Effect of Diet in Chronic Spontaneous Urticaria: A Systematic Review.
In conclusion, there is evidence for the benefit of diets in CSU only in individual patients with clinical symptoms. However, the level of evidence is low for the benefit of systematic diets in CSU because systematic double-blind controlled trials of diet are lacking. PMID: 30085322 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Cornillier H, Giraudeau B, Samimi M, Munck S, Hacard F, Jonville-Bera AP, Jegou MH, d'Acremont G, Pham BN, Chosidow O, Maruani A Tags: Acta Derm Venereol Source Type: research

Paraproteinaemia in Primary Cutaneous Marginal Zone Lymphoma.
This study retrospectively analysed the records of 23 patients with PCMZL. During treatment and follow-up, laboratory tests, including full blood count, lactate dehydrogenase, serum protein electrophoresis and turbidimetric analyses, were conducted. Thirty-nine percent of cases showed a suspicious serum protein electrophoresis in terms of paraproteinaemia. In 44% of cases the heavy and light chain restriction in tissue samples correlated with serological findings. Altogether, 89% of the PCMZL patients with paraproteinaemia eventually experienced a relapse, in contrast to 62% of the group without paraproteinaemia. This stud...
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Frings VG, Schäfer K, Strate A, Rosenwald A, Roth S, Kneitz H, Goebeler M, Geissinger E, Wobser M Tags: Acta Derm Venereol Source Type: research

Achieving Hidradenitis Suppurativa Response Score (HiSCR) Is Associated With Significant Improvement in Clinical and Patient-Reported Outcomes: Post Hoc Analysis of Pooled Data From PIONEER I and II.
Abstract Hidradenitis Suppurativa Clinical Response (HiSCR), is a validated tool that has been used to assess the efficacy of adalimumab among patients with hidradenitis suppurativa. We evaluated the clinical meaning of HiSCR by relating it to patient-reported outcomes to give further context to its achievement in a post hoc analysis of integrated data from two phase 3 clinical trials (PIONEER I and II). Pooling placebo and active treatment arms, 39% of patients (245/629) achieved HiSCR at week 12. Irrespective of treatment, significantly (p 
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Kimball AB, Tzellos T, Calimlim BM, Teixeira HD, Geng Z, Okun MM Tags: Acta Derm Venereol Source Type: research

Diagnostic Value of T-SPOT.TB Test in Cutaneous Mycobacterial Infections.
PMID: 30085325 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Chen Y, Jiang H, Zhang W, Chen Z, Mei Y, Chen H, Shi Y, Gao W, Wang L, Chokkakula S, Wang H Tags: Acta Derm Venereol Source Type: research

A Postzygotic ATP2A2 Novel Mutation Identified by Next-generation Sequencing in Mosaic Darier Disease.
PMID: 30085326 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Guerra L, Pedicelli C, Proto V, Condorelli AG, Mazzanti C, Castiglia D Tags: Acta Derm Venereol Source Type: research

Tuberculosis Screening in Patients with Psoriasis Receiving Biologic Therapy: A Retrospective Cohort Study.
PMID: 30085327 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Snast I, Bercovici E, Avni T, Shitenberg D, Hodak E, Pavlovsky L Tags: Acta Derm Venereol Source Type: research

Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain.
S, Suárez Conde I, Pereiro-Ferreirós M Abstract Actinic cheilitis is thought to be a premalignant lesion or a superficial squamous cell carcinoma. The prevalence of actinic cheilitis in Europe is unknown. The aim of this study was to determine the prevalence of actinic cheilitis in the Galicia region (north-west Spain). Secondary objectives were the description of risk factors of actinic cheilitis. A cross-sectional multicentre study in patients ≥ 45 years of age was performed in 8 dermatology departments in Galicia region during a 1-year period. The prevalence of actinic cheilitis was 31....
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Rodríguez-Blanco I, Flórez Á, Paredes-Suárez C, Rodríguez-Lojo R, González-Vilas D, Ramírez-Santos A, Paradela S, Suárez Conde I, Pereiro-Ferreirós M Tags: Acta Derm Venereol Source Type: research

Prevalence of Psoriasis and Psoriatic Arthritis and Patient Perceptions of Severity in Sweden, Norway and Denmark: Results from the Nordic Patient Survey of Psoriasis and Psoriatic Arthritis.
kov L Abstract Optimal clinical management of psoriasis and psoriatic arthritis (PsA) requires understanding of the impact on patients. The NORdic PAtient survey of Psoriasis and PsA (NORPAPP) aimed to obtain current data on disease prevalence and patient perceptions in Sweden, Denmark and Norway. Among 22,050 individuals questioned, the reported prevalence of psoriasis and/or PsA was 9.7% (5.7% physician-diagnosed plus 4.0% self-diagnosed only); prevalence was similar in Sweden (9.4%) and Denmark (9.2%) but significantly higher in Norway (11.9%). Of those reporting a physician's diagnosis, 74.6% reported psoriasi...
Source: Acta Dermato-Venereologica - August 7, 2018 Category: Dermatology Authors: Danielsen K, Duvetorp A, Iversen L, Østergaard M, Seifert O, Steinar Tveit K, Skov L Tags: Acta Derm Venereol Source Type: research

A Case of Subcutaneous Infection with Mycobacterium mageritense Identified by Matrix-assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry.
PMID: 29978886 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - July 6, 2018 Category: Dermatology Authors: Oiwa T, Murata T, Honda T, Nakano S, Kabashima K Tags: Acta Derm Venereol Source Type: research

Changes in Androgen Receptor Expression as a Molecular Marker of Progression from Normal Epithelium to Invasive Cancer in Elderly Patients with Penile Squamous Cell Carcinoma.
odi A PMID: 29978887 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - July 6, 2018 Category: Dermatology Authors: Vellone VG, Cozzani E, Peñuela L, Russo R, Spina B, Toncini C, Terrone C, Parodi A Tags: Acta Derm Venereol Source Type: research

Efficacy of Oral Ruxolitinib in a Patient with Refractory Chronic Spontaneous Urticaria.
PMID: 29978888 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - July 6, 2018 Category: Dermatology Authors: Fukunaga A, Ito M, Nishigori C Tags: Acta Derm Venereol Source Type: research

Granular IgA Deposits in the Skin of Patients with Coeliac Disease: Is it Always Dermatitis Herpetiformis?
In conclusion, IgA deposits may be considered an immunopathological marker for coeliac disease; therefore, patients with coeliac disease showing skin manifestations with positive direct immunofluorescence should be investigated carefully in order to make a differential diagnosis between dermatitis herpetiformis and other non-dermatitis herpetiformis inflammatory skin diseases. PMID: 29972219 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - July 4, 2018 Category: Dermatology Authors: Bonciolini V, Antiga E, Bianchi B, Del Bianco E, Ninci A, Maio V, Pimpinelli N, Caproni M Tags: Acta Derm Venereol Source Type: research

Melanogenesis Inhibitors.
Abstract Abnormally high production of melanin or melanogenesis in skin melanocytes results in hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These hyperpigmentary skin disorders can significantly impact an individual's appearance, and may cause emotional and psychological distress and reduced quality of life. A large number of melanogenesis inhibitors have been developed, but most have unwanted side-effects. Further research is needed to better understand the mechanisms of hyperpigmentary skin disorders and to develop potent and safe inhibitors of melanogenesis. This review summarize...
Source: Acta Dermato-Venereologica - July 4, 2018 Category: Dermatology Authors: Kumari S, Thng STG, Verma NK, Gautam HK Tags: Acta Derm Venereol Source Type: research

Antioxidative Phytochemicals Accelerate Epidermal Terminal Differentiation via the AHR-OVOL1 Pathway: Implications for Atopic Dermatitis.
This article reviews the dynamic and multifaceted role of AHR in epidermal biology and discusses the potential use of antioxidative phytochemical ligands for AHR in inflammatory skin diseases, such as atopic dermatitis. PMID: 29972223 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - July 4, 2018 Category: Dermatology Authors: Furue M, Hashimoto-Hachiya A, Tsuji G Tags: Acta Derm Venereol Source Type: research