Implementation of Web-based Education for Patients with Chronic Skin Disease.
Abstract is missing (Short communication). PMID: 26864897 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 11, 2016 Category: Dermatology Authors: van Cranenburgh OD, Ter Stege JA, de Rie MA, Smets EM, Sprangers MA, de Korte J Tags: Acta Derm Venereol Source Type: research

Glial Cells are Involved in Itch Processing.
Abstract Recent discoveries in itch neurophysiology include itch-selective neuronal pathways, the clinically relevant non-histaminergic pathway, and elucidation of the notable similarities and differences between itch and pain. Potential involvement of glial cells in itch processing and the possibility of glial modulation of chronic itch have been identified recently, similarly to the established glial modulation of pain. This review outlines the similarities and differences between itch and pain, and how different types of central and peripheral glial cells may be differentially involved in the development of chr...
Source: Acta Dermato-Venereologica - February 11, 2016 Category: Dermatology Authors: Andersen HH, Arendt-Nielsen L, Gazerani P Tags: Acta Derm Venereol Source Type: research

Cutaneous Manifestations of Thymoma-associated Multi-organ Autoimmunity: A Fatal Sign.
Abstract is missing (Short communication). PMID: 26865095 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 11, 2016 Category: Dermatology Authors: Muramatsu K, Fujita Y, Inokuma D, Tsukinaga I, Ito K, Nishiura Y, Shimizu H Tags: Acta Derm Venereol Source Type: research

Acute Generalized Exanthematous Pustulosis Secondary to Acyclovir Confirmed by Positive Patch Testing.
Abstract is missing (Short communication). PMID: 26831480 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 2, 2016 Category: Dermatology Authors: Kubin ME, Jackson P, Riekki R Tags: Acta Derm Venereol Source Type: research

Decreased Number of Circulating Endothelial Progenitor Cells (CD133+/KDR+) in Patients with Psoriatic Arthritis.
Abstract Cardiovascular diseases are a major cause of mortality in patients with psoriatic arthritis (PsA), but the precise mechanism of increased cardiovascular risk is unknown. Endothelial dysfunction plays a crucial role in the development of atherosclerosis. Circulating endothelial progenitor cells (CEPCs) contribute to endothelial regeneration, and their level may be affected by chronic inflammation. The aim of this study was to evaluate the number of CEPCs in patients with PsA (n = 24) compared with controls (n = 26). CEPCs were identified as CD133+/ KDR+ cells in peripheral blood...
Source: Acta Dermato-Venereologica - February 2, 2016 Category: Dermatology Authors: Batycka-Baran A, Paprocka M, Baran W, Szepietowski JC Tags: Acta Derm Venereol Source Type: research

Serotonergic Markers in Atopic Dermatitis.
Abstract Stress and anxiety may worsen atopic dermatitis (AD) through the serotonin system. Serotonergic expression was measured in 28 patients with AD in relation to extent of the disease (SCORing of Atopic Dermatitis; SCORAD), pruritus intensity (visual analogue scale; VAS), anxiety traits (Swedish Universities Scales of Personality; SSP) and depression (Montgomery-Åsberg Depression Rating Scale-Self assessment; MADRS-S). Biopsies were taken from lesional and non-lesional AD skin, and investigated for expression of serotonin, its receptors 5-HT1A and 5-HT2, and serotonin transporter protein (SERT), using i...
Source: Acta Dermato-Venereologica - February 2, 2016 Category: Dermatology Authors: Rasul A, El-Nour H, Lonne-Rahm SB, Fransson O, Johansson C, Johansson B, Zubeidi M, Seeberg E, Radu Djurfeldt D, Azmitia EC, Nordlind K Tags: Acta Derm Venereol Source Type: research

Unilateral Erythematous Lesions with Wax-like Scaling and Limb Abnormalities: A Quiz.
Abstract is missing (Quiz). PMID: 26832123 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 2, 2016 Category: Dermatology Authors: Lelonek E, Matusiak Ł, Bieniek A, Szepietowski JC Tags: Acta Derm Venereol Source Type: research

A Case of Syndromic X-linked Ichthyosis with Léri-Weill Dyschondrosteosis.
A Case of Syndromic X-linked Ichthyosis with Léri-Weill Dyschondrosteosis. Acta Derm Venereol. 2016 Feb 2; Authors: Abasq-Thomas C, Schmitt S, Brenaut E, Metz C, Chiesa J, Misery L Abstract is missing (Short communication). PMID: 26832328 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 2, 2016 Category: Dermatology Authors: Abasq-Thomas C, Schmitt S, Brenaut E, Metz C, Chiesa J, Misery L Tags: Acta Derm Venereol Source Type: research

Skin Patterns Associated with Upper Airway Infantile Haemangiomas: A Retrospective Multicentre Study.
We report here the largest cohort of airway haemangioma. A third of patients do not completely fit with the definition of the high-risk area of airway haemangioma. Segmental lower lip and neck involvement also seem to be very suggestive areas. Clinicians must be able to recognize these areas. PMID: 26832659 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 2, 2016 Category: Dermatology Authors: Uthurriague C, Boccara O, Catteau B, Fayoux P, Léauté-Labrèze C, Chiaverini C, Maruani A, Pondaven-Letourmy S, Alaidarous A, Puzenat E, Hubiche T, Mallet S, Dreyfus I, Mazereeuw-Hautier J Tags: Acta Derm Venereol Source Type: research

Cold Contact Urticaria Following Vaccination: Four Cases.
Abstract is missing (Short communication). PMID: 26832889 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 2, 2016 Category: Dermatology Authors: Raison-Peyron N, Philibert C, Bernard N, Du-Thanh A, Barbaud A, Bessis D Tags: Acta Derm Venereol Source Type: research

Upregulation of PI3K/AKT/mTOR, FABP5 and PPARβ/δ in Human Psoriasis and Imiquimod-induced Murine Psoriasiform Dermatitis Model.
Upregulation of PI3K/AKT/mTOR, FABP5 and PPARβ/δ in Human Psoriasis and Imiquimod-induced Murine Psoriasiform Dermatitis Model. Acta Derm Venereol. 2016 Feb 2; Authors: Chamcheu JC, Chaves-Rodriquez MI, Adhami VM, Siddiqui IA, Wood GS, Longley BJ, Mukhtar H Abstract is missing (Short communication). PMID: 26833029 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 2, 2016 Category: Dermatology Authors: Chamcheu JC, Chaves-Rodriquez MI, Adhami VM, Siddiqui IA, Wood GS, Longley BJ, Mukhtar H Tags: Acta Derm Venereol Source Type: research

Effects of Apremilast on Pruritus and Skin Discomfort/Pain Correlate With Improvements in Quality of Life in Patients With Moderate to Severe Plaque Psoriasis.
Abstract Pruritus and skin discomfort/pain negatively impact health-related quality of life (HRQoL). The effects of apremilast, an oral phosphodiesterase inhibitor, on pruritus, skin discomfort/pain, and patient global assessment of psoriasis disease activity (PgAPDA) were assessed in moderate/severe chronic plaque psoriasis patients in the phase 3 ESTEEM trials. Significant improvements in pruritus and skin discomfort/pain observed at Week 2 with apremilast versus placebo (both studies, p 
Source: Acta Dermato-Venereologica - February 2, 2016 Category: Dermatology Authors: Sobell JM, Foley P, Toth D, Mrowietz U, Girolomoni G, Goncalves J, Day RM, Chen R, Yosipovitch G Tags: Acta Derm Venereol Source Type: research

Squamous Cell Carcinoma Following Photodynamic Therapy for Cutaneous Bowen's Disease in a Series of 105 Patients.
Abstract Photodynamic therapy (PDT) is an alternative to surgery for Bowen's disease. This monocentric retrospective study included 105 patients with Bowen's disease, treated with PDT between 2007 and 2013, who received a total of 151 different PDT fields. Comparison of immunocompromised and non-immunocompromised patients revealed that the former often had a previous history of squamous cell carcinoma (SCC; p = 0.004) and received more PDT fields (p = 0.007) than the latter. At least 1 SCC occurred post-PDT in 16 out of 105 patients in a PDT field. However, many of the patients were at ...
Source: Acta Dermato-Venereologica - December 30, 2015 Category: Dermatology Authors: Ratour-Bigot C, Chemidling M, Montlahuc C, Abirached G, Madjlessi N, Bullier C, Battistella M, Bagot M, Lebbe C, Basset-Seguin N Tags: Acta Derm Venereol Source Type: research

Cost-utility Analysis of Supported Self-management with Motiva-tional Interviewing for Patients with Psoriasis.
Abstract There are few studies evaluating the cost-effectiveness of self-management interventions for patients with psoriasis. Motivational interviewing (MI) as a telephone follow-up after climate-heliotherapy was effective on several clinical parameters, but its cost-effectiveness is unknown. A cost-utility analysis was conducted alongside a randomized controlled trial (RCT) comparing MI with usual care. A total of 169 Norwegian patients were included. A within-trial analysis compared the costs and quality-adjusted life years (QALYs). Utilities were measured with the 15D instrument, supplemented with Dermatologic...
Source: Acta Dermato-Venereologica - December 30, 2015 Category: Dermatology Authors: Larsen MH, Wahl AK, Krogstad AL, Aas E Tags: Acta Derm Venereol Source Type: research

Malignant Peripheral Nerve Sheath Tumour Arising From Solitary Sclerotic Neurofibroma.
Abstract is missing (Short communication). PMID: 26714581 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 30, 2015 Category: Dermatology Authors: Moriya S, Hirose J, Yoshida Y, Yamamoto O Tags: Acta Derm Venereol Source Type: research

Different Responses to Ustekinumab of Two HLA-Cw6-positive Homozygous Twins with Psoriasis.
Abstract is missing (Short communication). PMID: 26714660 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 30, 2015 Category: Dermatology Authors: Burlando M, Cozzani E, Campisi C, Di Costanzo A, Parodi A Tags: Acta Derm Venereol Source Type: research

Photoallergic Drug Eruption Caused by Certolizumab Pegol.
Abstract is missing (Short communication). PMID: 26714785 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 30, 2015 Category: Dermatology Authors: Inoue A, Sawada Y, Ohmori S, Omoto D, Haruyama S, Kabashima-Kubo R, Yoshioka M, Nisio D, Nakamura M Tags: Acta Derm Venereol Source Type: research

Facial Erythema of Rosacea - Aetiology, Different Pathophysiologies and Treatment Options.
Abstract Rosacea is a common chronic skin condition that displays a broad diversity of clinical manifestations. Although the pathophysiological mechanisms of the four subtypes are not completely elucidated, the key elements often present are augmented immune responses of the innate and adaptive immune system, and neurovascular dysregulation. The most common primary feature of all cutaneous subtypes of rosacea is transient or persistent facial erythema. Perilesional erythema of papules or pustules is based on the sustained vasodilation and plasma extravasation induced by the inflammatory infiltrates. In contrast, t...
Source: Acta Dermato-Venereologica - December 30, 2015 Category: Dermatology Authors: Steinhoff M, Schmelz M, Schauber J Tags: Acta Derm Venereol Source Type: research

Itch Perception and Skin Reactions as Modulated by Verbal Suggestions: Role of Participant's and Investigator's Sex.
This study investigated sex-specific differences in itch perception and skin reactions, as modulated by verbal suggestions, and the role of the investigator's sex. Healthy volunteers (50 males, 50 females), divided into 4 groups, were tested by male and female investigators. Itch was induced via prick testing with sodium chloride and histamine in 4 runs; 2 control conditions (with no exaggerated verbal comments about expected itch) and 2 experimental conditions (with exaggerated verbal comments). After 5 min, wheal and flare reactions were measured and itch intensity was rated by subjects on a numerical rating scale. Exagg...
Source: Acta Dermato-Venereologica - December 30, 2015 Category: Dermatology Authors: Stumpf A, Zerey V, Heuft G, Ständer S, Pfleiderer B, Schneider G Tags: Acta Derm Venereol Source Type: research

Economic Burden of Psoriasis and Potential Cost Offsets with Biologic Treatment: A Swedish Register Analysis.
ring;hle M Abstract Estimates of direct and indirect costs of psoriasis are limited. The aim of this study was to estimate: (i) costs in patients with psoriasis compared with controls; and (ii) impact on costs from initiating biologics. The study extracted data from Swedish administrative registers and compared 31,043 patients with 111,645 sex-, age- and residency-matched referents. Mean direct and indirect costs were estimated as US dollars (USD) 1,365 (62%) and USD 3,319 (50%) higher in patients compared with referents, respectively. The study also included 352 patients treated with biologics who had at least 1-...
Source: Acta Dermato-Venereologica - December 30, 2015 Category: Dermatology Authors: Svedbom A, Dahlén J, Mamolo C, Cappelleri JC, Mallbris L, Petersson IF, Ståhle M Tags: Acta Derm Venereol Source Type: research

Psychophysiological Processing of Itch in Patients with Chronic Post-burn Itch: An Exploratory Study.
This study aimed to explore psychophysiological processes of chronic post-burn itch by comparing 15 patients with long-term itch due to burn injury with 15 matched healthy controls. Exploratory results indicated tendencies for higher itch sensitivity in patients than in controls, for mechanical stimuli and histamine, but not for electrical stimulation. Results further suggest that the efficacy of itch modulation by an itch- or pain-conditioning stimulus or directing attention towards itch stimuli do not differ between these patients and controls. Further elucidation of the processes underlying post-burn itch may improve th...
Source: Acta Dermato-Venereologica - December 22, 2015 Category: Dermatology Authors: van Laarhoven AI, Ulrich DJ, Wilder-Smith OH, van Loey NE, Nieuwenhuis M, van der Wee NJ, Evers AW Tags: Acta Derm Venereol Source Type: research

Dangerous Leg Cramps: Severe Pustular Exanthema Caused by an Over-the-Counter Drug.
Abstract is missing (Short communication). PMID: 26694860 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 22, 2015 Category: Dermatology Authors: Stolze I, Trautmann A, Goebeler M, Stoevesandt J Tags: Acta Derm Venereol Source Type: research

Multidisciplinary Management of Mastocytosis: Nordic Expert Group Consensus.
We present here consensus recommendations from a Nordic expert group for the diagnosis and general management of patients with mastocytosis. PMID: 26694951 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 22, 2015 Category: Dermatology Authors: Broesby-Olsen S, Dybedal I, Gülen T, Kielsgaard Kristensen T, Boe Møller M, Ackermann L, Sääf M, Karlsson MA, Agertoft L, Brixen K, Hermann P, Stylianou E, Mortz CG, Torfing T, Havelund T, Sander B, Bergström A, Bendix M, Garvey LH, Weis Bjerrum O, V Tags: Acta Derm Venereol Source Type: research

Highly Concordant Results Between Immunohistochemistry and Molecular Testing of Mutated V600E BRAF in Primary and Metastatic Melanoma.
This study tested the sensitivity and specificity of VE1 antibody raised against BRAFV600E protein, on 189 melanoma samples, compared with molecular testing. In addition, the therapeutic response to BRAF inhibitors was analysed in 27 patients, according to staining intensity (scored from weak to strong) and pattern (homogeneous or heterogeneous). BRAFV600E status during melanoma progression was evaluated in a cohort of 54 patients with at least paired-samples. High sensitivity (98.6%) and specificity (97.7%) of VE1 were confirmed. During melanoma progression different samples showed concordant phenotypes. Heterogeneous VE1...
Source: Acta Dermato-Venereologica - December 22, 2015 Category: Dermatology Authors: Manfredi L, Meyer N, Tournier E, Grand D, Uro-Coste E, Rochaix P, Brousset P, Lamant L Tags: Acta Derm Venereol Source Type: research

Comment: Clinical Pathology Correlation: Clinical First, then Pathology, and Lastly Immunochemistry.
Abstract is missing (Correspondence). PMID: 26695222 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 22, 2015 Category: Dermatology Authors: Wu K Tags: Acta Derm Venereol Source Type: research

Non-invasive Imaging of Localised Scleroderma for Assessment of Skin Blood Flow and Structure.
Abstract Extensive morphoea causes major morbidity, disability and disfigurement; pathophysiology is poorly understood. The aim of this study was to investigate, with non-invasive imaging, the relationship between localised abnormalities of skin structure and perfusion, which characterise morphoea. Thirty-two patients with morphoea underwent imaging at affected and unaffected sites. Skin thickness was imaged with optical coherence tomography (OCT) and high-frequency ultrasound (HFUS). Perfusion was imaged with dual-wavelength laser Doppler imaging (LDI) and thermography. Epidermal thickness showed a small increase...
Source: Acta Dermato-Venereologica - December 22, 2015 Category: Dermatology Authors: Murray A, Moore T, Manning J, Dinsdale G, Wilkinson J, Bhushan M, Griffiths C, Herrick A Tags: Acta Derm Venereol Source Type: research

The Role of Auditory Itch Contagion in Psoriasis.
Abstract Itch and associated scratching is a common and distressing symptom of psoriasis. Here, we tested whether people with psoriasis, relative to healthy controls, show an increased vulnerability to auditory itch contagion (a deleterious influence) when presented with sounds of itch-associated actions of scratching and rubbing. We were also interested in whether manipulating the high frequency volume of these sounds alters itch perception. Results show that both groups rated scratching sounds as more itch-inducing than rubbing sounds, and the amount of induced itch increased as a function of high frequency volu...
Source: Acta Dermato-Venereologica - December 17, 2015 Category: Dermatology Authors: Swithenbank S, Cowdell F, Holle H Tags: Acta Derm Venereol Source Type: research

The Role of Neuromediators and Innervation in Cutaneous Wound Healing.
Abstract The skin is densely innervated with an intricate network of cutaneous nerves, neuromediators and specific receptors which influence a variety of physiological and disease processes. There is emerging evidence that cutaneous innervation may play an important role in mediating wound healing. This review aims to comprehensively examine the evidence that signifies the role of innervation during the overlapping stages of cutaneous wound healing. Numerous neuropeptides that are secreted by the sensory and autonomic nerve fibres play an essential part during the distinct phases of wound healing. Delayed wound he...
Source: Acta Dermato-Venereologica - December 17, 2015 Category: Dermatology Authors: Ashrafi M, Baguneid M, Bayat A Tags: Acta Derm Venereol Source Type: research

Eczema Trials: Quality of Life Instruments Used and Their Relation to Patient-reported Outcomes. A Systematic Review.
In conclusion, only about one fifth of eczema trials include a quality of life measure as outcome. Many different instruments are used, limiting the possibilities of comparing and synthesising individual trials' findings. PMID: 26676847 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 17, 2015 Category: Dermatology Authors: Heinl D, Chalmers J, Nankervis H, Apfelbacher CJ Tags: Acta Derm Venereol Source Type: research

Cadherin 11 Involved in Basement Membrane Damage and Dermal Changes in Melasma.
Abstract Basement membrane (BM) disruption and dermal changes (elastosis, collagenolysis, vascular ectasia) have been reported in melasma. Although ultraviolet (UV) irradiation can induce these changes, UV is not always necessary for melasma development. Cadherin 11 (CDH11), which is upregulated in some melasma patients, has previously been shown to stimulate melanogenesis. Because CDH11 action requires cell-cell adhesion between fibroblasts and melanocytes, BM disruption in vivo should facilitate this. The aim of this study was to examine whether CDH11 overexpression leads to BM disruption and dermal changes, ind...
Source: Acta Dermato-Venereologica - December 15, 2015 Category: Dermatology Authors: Kim NH, Choi SH, Lee TR, Lee CH, Lee AY Tags: Acta Derm Venereol Source Type: research

Itch and Pain Characteristics in Skin Carcinomas.
Abstract is missing (Short communication). PMID: 26671517 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 15, 2015 Category: Dermatology Authors: Poulaliou A, Legoupil D, Schoenlaub P, Herault M, Fonclare AL, Dupuy-De Poulaliou M, Misery L, Brenaut E Tags: Acta Derm Venereol Source Type: research

Alexithymia in Uraemic Pruritus.
Abstract is missing (Short communication). PMID: 26671621 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 15, 2015 Category: Dermatology Authors: Heisig M, Reich A, Szepietowski JC Tags: Acta Derm Venereol Source Type: research

Possible Antipruritic Mechanism of Cyclosporine A in Atopic Dermatitis.
Abstract Cyclosporine A is an immunosuppressive agent that suppresses pruritus and is currently used in the treatment of patients with severe atopic dermatitis. The aim of this study was to elucidate the antipruritic mechanism of cyclosporine A using a mouse model of atopic dermatitis. Intraperitoneal injection of cyclosporine A (5 mg/kg) significantly reduced epidermal nerve density, number of scratching bouts, dermatitis scores, and transepidermal water loss, as well as decreasing the numbers of inflammatory cells in the dermis and decreasing epidermal thickness. Intraperitoneal injection of cyclosporine A dose-...
Source: Acta Dermato-Venereologica - December 15, 2015 Category: Dermatology Authors: Ko KC, Tominaga M, Kamata Y, Umehara Y, Matsuda H, Takahashi N, Kina K, Ogawa M, Ogawa H, Takamori K Tags: Acta Derm Venereol Source Type: research

Patch-testing with Main Sensitizers Does Not Detect All Cases of Contact Allergy to Oxidized Lavender Oil.
on J Abstract Lavender oil is an essential oil obtained from lavender (Lavendula angustifolia). The main components linalool and linalyl acetate have been shown to autoxidize in contact with oxygen in the air, forming sensitizing hydroperoxides. Patients with suspected allergic contact dermatitis were consecutively patch-tested with oxidized lavender oil 6% pet., oxidized linalyl acetate 6% pet., and oxidized linalool 6% pet. to investigate the frequency of contact allergy to oxidized lavender oil, and the pattern of concomitant reactions to oxidized linalool and oxidized linalyl acetate. Positive reactions to oxi...
Source: Acta Dermato-Venereologica - December 15, 2015 Category: Dermatology Authors: Hagvall L, Bråred Christensson J Tags: Acta Derm Venereol Source Type: research

Hormonal Factors and Risk of Psoriasis in Women: A Cohort Study.
Abstract Previous studies suggest that hormonal factors modulate the natural course of psoriasis in women. However, the association of hormonal factors with psoriasis risk has not been assessed using prospective data. We carried out a thorough prospective analysis on the topic in 163,763 women in the Nurses' Health Study I and II. Participants provided information on age at menarche, parity, menopause status, and exogenous hormone use (oral contraceptive and postmenopausal hormone therapy) over the follow-up. We ascertained 1,253 incident psoriasis cases over 2 million person-years. Psoriasis risk appeared to be h...
Source: Acta Dermato-Venereologica - December 11, 2015 Category: Dermatology Authors: Wu S, Cho E, Li W, Grodstein F, Qureshi AA Tags: Acta Derm Venereol Source Type: research

Urethritis-associated Pathogens in Urine from Men with Non-gonococcal Urethritis: A Case-control Study.
Jensen J Abstract The aetiology of non-gonococcal urethritis (NGU) remains unexplained in 30-40% of patients. Urine samples from men attending Swedish sexually transmitted disease clinics were examined by species-specific quantitative PCRs for Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, Ureaplasma urealyticum, U. parvum, adenovirus, herpes simplex virus, Neisseria meningitidis, Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae. A total of 187 men with acute NGU (symptoms ≤ 30 days) and 24 with chronic NGU (symptoms> 30 days) were cases, and 73 ...
Source: Acta Dermato-Venereologica - December 11, 2015 Category: Dermatology Authors: Frølund M, Lidbrink P, Wikström A, Cowan S, Ahrens P, Skov Jensen J Tags: Acta Derm Venereol Source Type: research

Is Oil a Balsam for Baby Skin?
e;n L Abstract is missing (Commentary). PMID: 26661909 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 11, 2015 Category: Dermatology Authors: Norlén L Tags: Acta Derm Venereol Source Type: research

Pain in Hidradenitis Suppurativa: A Pilot Study.
ec GB Abstract is missing (Short communication). PMID: 26631388 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 3, 2015 Category: Dermatology Authors: Ring HC, Sørensen H, Miller IM, List EK, Saunte DM, Jemec GB Tags: Acta Derm Venereol Source Type: research

CD30-positive Cutaneous Pseudolymphoma Caused by Tocilizumab in a Patient with Rheumatoid Arthritis: Case Report and Literature Review.
Abstract is missing (Short communication). PMID: 26631390 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 3, 2015 Category: Dermatology Authors: Inoue A, Sawada Y, Ohmori S, Omoto D, Haruyama S, Yoshioka M, Nishio D, Nakamura M Tags: Acta Derm Venereol Source Type: research

Squamous Cell Carcinoma of the Skin has More Than Doubled Over the Last Decade in the UK.
Abstract is missing (Short communication). PMID: 26631391 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 3, 2015 Category: Dermatology Authors: Goon PK, Greenberg DC, Igali L, Levell NJ Tags: Acta Derm Venereol Source Type: research

Autoantibody Profile of a Cohort of 78 Italian Patients with Mucous Membrane Pemphigoid: Correlation Between Reactivity Profile and Clinical Involvement.
Abstract Direct diagnosis of mucous membrane pemphigoid (MMP) is not easy. Circulating autoantibodies targeting bullous pemphigoid antigens of 180 kDa and 230 kDa (BP180 and BP230), α6β4 integrin, laminin 332 and type VII collagen (Col VII) are not always present. The aims of this study were to characterize the humoral immune response of a cohort of Italian patients with MMP, its association with clinical involvement and severity, and to design an algorithm for efficient serological diagnosis. Seventy-eight MMP sera were studied retrospectively by indirect immunofluorescence on salt-split skin, enzyme-l...
Source: Acta Dermato-Venereologica - December 3, 2015 Category: Dermatology Authors: Cozzani E, Di Zenzo G, Calabresi V, Carrozzo M, Burlando M, Longanesi L, Cerri A, Caproni M, Sera F, Antiga E, Quagliono P, Marzano AV, Parodi A Tags: Acta Derm Venereol Source Type: research

Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus.
Abstract Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The inflammatory status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation of cytotoxic cells. The aims of this study were to evaluate S100A8 expression in skin lesions and the in vitro effects of S100A8 on CD8+ T cells and natural killer (NK) cells in LP. Increased levels of S100A8/S100A9 expression were measured in the skin lesions and sera of subjects with LP. S100A8 expression induced a greater cytotoxic response by peripheral blood CD8+CD107a+ T cells as well as by NK CD56bright cells in patients with LP. Inc...
Source: Acta Dermato-Venereologica - December 3, 2015 Category: Dermatology Authors: de Carvalho GC, Domingues R, Almeida de Sousa Nogueira M, Calvielli Castelo Branco AC, Gomes Manfrere KC, Vieira Pereira N, Aoki V, Nacagami Sotto M, Da Silva Duarte AJ, Notomi Sato M Tags: Acta Derm Venereol Source Type: research

Erythrokeratoderma Variabilis Caused by p.Gly45Glu in Connexin 31: Importance of the First Extracellular Loop Glycine Residue for Gap Junction Function.
Abstract is missing (Short communication). PMID: 26632638 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 3, 2015 Category: Dermatology Authors: Takeichi T, Sugiura K, Hsu CK, Nomura T, Takama H, Simpson MA, Shimizu H, McGrath JA, Akiyama M Tags: Acta Derm Venereol Source Type: research

Dual CD4/CD8-positive Ichthyosiform Mycosis Fungoides with Lymph Node, Peripheral Blood and Cardiac Involvement: A Case Report.
Abstract is missing (Short communication). PMID: 26633168 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 3, 2015 Category: Dermatology Authors: Kaku Y, Otsuka A, Tanizaki H, Shibuya R, Endo Y, Nonomura Y, Hirata M, Fujimoto M, Ohmori K, Sakurai T, Kabashima K Tags: Acta Derm Venereol Source Type: research

Efficacy and Safety of Mammalian Target of Rapamycin Inhibitors in Vascular Anomalies: A Systematic Review.
Abstract Mammalian target of rapamycin (mTOR) inhibitors are a promising new treatment in vascular anomalies, but no published randomized controlled trials are available. The aim of this systematic review of all reported cases was to assess the efficacy and safety of mTOR inhibitors in all vascular anomalies, except cancers, in children and adults. In November 2014 MEDLINE, CENTRAL, LILACS and EMBASE were searched for studies of mTOR inhibitors in any vascular condition, except for malignant lesions, in humans. Fourteen publications and 9 posters, with data on 25 and 59 patients, respectively, all
Source: Acta Dermato-Venereologica - November 26, 2015 Category: Dermatology Authors: Nadal M, Giraudeau B, Tavernier E, Jonville-Bera AP, Lorette G, Maruani A Tags: Acta Derm Venereol Source Type: research

Association of a Single Nucleotide Polymorphism in a Late Cornified Envelope-like Proline-rich 1 Gene with Atopic Dermatitis.
Abstract There is some evidence that genes involved in the pathogenesis of atopic dermatitis, in addition to the filaggrin (FLG) gene, may be located at chromosome region 1q21. The aim of this study was to examine the association of single nucleotide polymorphisms in the region of the late cornified envelope-like proline-rich 1 (LELP1), hornerin (HRNR) and FLG genes with the course and risk of atopic dermatitis. Single nucleotide polymorphisms and mutations were genotyped by PCR restriction fragment length polymorphism and real-time polymerase chain reaction in a group of 152 patients with atopic dermatitis and 10...
Source: Acta Dermato-Venereologica - November 26, 2015 Category: Dermatology Authors: Trzeciak M, Wesserling M, Bandurski T, Glen J, Nowicki R, Pawelczyk T Tags: Acta Derm Venereol Source Type: research

Pemphigoid Gestationis Complicating an Egg Donation Pregnancy.
Abstract is missing (Short communication). PMID: 26608214 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 26, 2015 Category: Dermatology Authors: Guerra L, Mazzanti C, Calabresi V, De Luca N, Zambruno G, Di Zenzo G Tags: Acta Derm Venereol Source Type: research

Eight Novel Mutations Confirm the Role of AAGAB in Punctate Palmoplantar Keratoderma Type 1 (Buschke-Fischer-Brauer) and Show Broad Phenotypic Variability.
kstein GN Abstract Punctate palmoplantar keratoderma (PPKP1; Buschke-Fischer-Brauer) is a rare autosomal dominant inherited skin disease characterized by multiple hyperkeratotic papules involving the palms and soles. Mutations have been found at 2 loci, on chromosomes 15q22-15q24 and 8q24.13-8q24.21. We recently identified mutations in 3 families, in the AAGAB gene on 15q, which encodes the alpha- and gamma-adaptin-binding protein p34. The current study examined 14 additional families, comprising a total of 26 affected individuals and identified 8 novel mutations in 9 families. In 1 family a mutation that was pres...
Source: Acta Dermato-Venereologica - November 26, 2015 Category: Dermatology Authors: Giehl KA, Herzinger T, Wolff H, Sárdy M, von Braunmühl T, Dekeuleneer V, Sznajer Y, Tennstedt D, Boes P, Rapprich S, Wagner N, Betz RC, Braun-Falco M, Strom T, Ruzicka T, Eckstein GN Tags: Acta Derm Venereol Source Type: research

Usefulness of Rajka and Langeland Eczema Severity Score in Clinical Practice.
n AC, Wahlgren CF Abstract Simple, validated eczema severity scores are required for the evaluation of interventions. The Rajka and Langeland (R and L) scale is based on 3 domains (extent, course, and intensity); however, its validity is not yet confirmed. The aim of this study was to investigate the quality aspects of the R and L scale in clinical practice. In the first part of the study, experts and consumers judged the content validity of the scale. The second part of the study was performed with 87 children during a 4-month eczema school. Construct validity, internal consistency, sensitivity to change, time co...
Source: Acta Dermato-Venereologica - November 26, 2015 Category: Dermatology Authors: Gånemo A, Svensson Å, Svedman C, Grönberg BM, Öhman Johansson AC, Wahlgren CF Tags: Acta Derm Venereol Source Type: research

Anogenital Human Papillomavirus Prevalence is Unaffected by Therapeutic Tumour Necrosis Factor-alpha Inhibition.
In this study 222 patients with psoriasis or inflammatory bowel disease (IBD), who received either anti-TNF-α inhibitors or alternatives (purine-, folic acid analogues, phototherapy, fumaric ester, mesalazine) continuously for at least 6 months, were evaluated for the presence of anogenital HPV-induced lesions, mucosal HPV DNA, and serological status of mucosal low-risk HPV6 and high-risk HPV16/HPV18. Hallmarks of anogenital HPV infection were more frequently detected in patients with psoriasis than in those with IBD. HPV-induced lesions, viral DNA, and seroprevalence were not elevated in participants with psoriasis ...
Source: Acta Dermato-Venereologica - November 19, 2015 Category: Dermatology Authors: Handisurya A, Lázár S, Papay P, Primas C, Haitel A, Horvat R, Tanew A, Vogelsang H, Kirnbauer R Tags: Acta Derm Venereol Source Type: research