Unusual Congenital Multiple Clustered Dermatofibroma: First Reported Case on the Face.
PMID: 30543382 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 13, 2018 Category: Dermatology Authors: Higaki-Mori H, Yoshida Y, Hisaoka M, Nishigori C, Shindo M, Yamamoto O Tags: Acta Derm Venereol Source Type: research

Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study.
Abstract Keratinocyte cancer (KC) is the most common malignancy in Caucasians. The incidence of KC has increased over the past 40 years. This case-control study investigated the environmental and host risk-factors responsible for development of KC in Australia's high-risk population. Cases were immune-competent adults from Townsville, Australia (19.3°S) who had a new basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) histologically-confirmed during 2004 to 2009. Cases were age-matched (±5 years) to immuno-competent, community-based controls from Townsville with no prior history of KC. Binary lo...
Source: Acta Dermato-Venereologica - December 13, 2018 Category: Dermatology Authors: Serna-Higuita LM, Harrison SL, Buttner P, Glasby M, Raasch BA, Iftner A, Garbe C, Martus P, Iftner T Tags: Acta Derm Venereol Source Type: research

Measurement of Nocturnal Scratching in Patients with Pruritus Using a Smartwatch: Initial Clinical Studies with the Itch Tracker App.
Abstract Three clinical studies were conducted to test a newly-developed app for smartwatches, which included an algorithm to measure nocturnal scratching using acceleration data. The first study in 5 patients with atopic dermatitis demonstrated high reliability of the app for measurement of scratching compared with video monitoring (positive predictive value 90.2 ± 6.6%, sensitivity 84.6 ± 10.2%, correlation of scratching duration per h r = 0.851-0.901, p 
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: Ikoma A, Ebata T, Chantalat L, Takemura K, Mizzi F, Poncet M, LeClercq D Tags: Acta Derm Venereol Source Type: research

Painless Horny Keratotic Spines on the Palms: A Quiz.
PMID: 30521054 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: de Lorenzi C, Kaya G, Quenan S Tags: Acta Derm Venereol Source Type: research

Massive Localized Lymphedema, an Emerging Problem and a Challenging Pseudosarcomatous Condition Mimicking Liposarcoma.
PMID: 30521055 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: Florek AG, Lutfi R, Wind K, Liu W, Krunic AL Tags: Acta Derm Venereol Source Type: research

Use of Systemic Treatment in Patients with Chronic Pruritus: A Survey of Dermatologists in the Netherlands.
Abstract Treatment of chronic pruritus can be a challenge for clinicians. Several systemic treatments have been suggested to reduce itch, such as gabapentinoids and antidepressants. The aim of this study was to assess the current practice of dermatologists regarding systemic treatment in patients with chronic pruritus, and to identify possible barriers in the prescription of these treatments. An online survey was sent to all dermatologists and dermatology residents in the Netherlands between July 2017 and April 2018. A total of 193 physi-cians completed the questionnaire (response rate 27.0%). Overall, 61.7% presc...
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: Kouwenhoven TA, van der Kerkhof PCM, Kamsteeg M Tags: Acta Derm Venereol Source Type: research

Nail Psoriasis: An Updated Review and Expert Opinion on Available Treatments, Including Biologics.
Abstract Nail psoriasis affects 50-79% of patients with skin psoriasis and up to 80% of patients with psoriatic arthritis, and can also represent a negative prognostic factor in individuals with plaque psoriasis. Treatments for nail psoriasis are limited, as nails are often difficult to treat with topical therapies alone, and relapse is common. Among different systemic agents, secukinumab, a fully human monoclonal antibody targeting interleukin (IL)-17A, is the only antibody supported by a trial specifically conducted in patients with nail psoriasis (the TRANSFIGURE trial) and has the longest follow-up available t...
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: Bardazzi F, Starace M, Bruni F, Magnano M, Piraccini BM, Alessandrini A Tags: Acta Derm Venereol Source Type: research

Association of Vulvar Melanoma with Lichen Sclerosus.
e K PMID: 30521058 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: Hieta N, Kurki S, Rintala M, Söderlund J, Hietanen S, Orte K Tags: Acta Derm Venereol Source Type: research

Anetoderma and Systemic Lupus Erythematosus: Case Report and Literature Review.
rez C, Flórez Á PMID: 30521059 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: Iglesias-Puzas Á, Batalla A, Peón G, Álvarez C, Flórez Á Tags: Acta Derm Venereol Source Type: research

Out-of-pocket Costs for Individuals with Atopic Eczema: A Cross-sectional Study in Nine European Countries.
Abstract Atopic eczema (AE) is one of the most common non-communicable inflammatory skin diseases, and has a huge socioeconomic impact. Studies on the everyday economic impact of AE on patients, however, are limited. To estimate the annual extra out-of-pocket spending due to AE among patients in Europe, a cross-sectional study using computer-assisted phone interviewing of patients with AE was performed in 9 European countries. A total of 1,189 patients (56% women) with AE, who were either eligible for, or on, systemic treatment, participated in the study between October 2017 and March 2018. Mean extra spending on ...
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: Zink A, Arents B, Fink-Wagner A, Seitz IA, Mensing U, Wettemann N, de Carlo G, Ring J Tags: Acta Derm Venereol Source Type: research

The Prevalence of Atopic Dermatitis and Chronic Spontaneous Urticaria are Associated with Parental Socioeconomic Status in Adolescents in China.
Abstract The association of atopic dermatitis and chronic spontaneous urticaria with socioeconomic status has been little studied. The aim of this study was to investigate the prevalence of skin diseases and their association with socioeconomic status in adolescents in China. A cross-sectional study was conducted at a comprehensive university. All newly enrolled students underwent dermatological examination and completed a survey. Socioeconomic status was measured in terms of parental education level and income. Two-level logistic regression models were used. A total of 8,226 students consented to participate. On ...
Source: Acta Dermato-Venereologica - December 6, 2018 Category: Dermatology Authors: Xiao Y, Huang X, Jing D, Huang Y, Chen L, Zhang X, Zhao S, Zhang M, Luo Z, Su J, Kuang Y, Li J, Zhu W, Zhang J, Chen X, Shen M Tags: Acta Derm Venereol Source Type: research

Allogeneic Haematopoietic Cell Transplantation for Epidermolysis Bullosa: the Dutch Experience.
PMID: 30484854 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 28, 2018 Category: Dermatology Authors: Gostyńska KB, Yenamandra VK, Lindemans C, Duipmans J, Gostyński A, Jonkman MF, Boelens JJ Tags: Acta Derm Venereol Source Type: research

Combination of Surgery and Nd:YAG Laser Therapy for Recalcitrant Viral Warts: A Successful Therapeutic Approach for Immunosuppressed Patients.
PMID: 30460366 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Baczako A, Krautheim V, Biedermann T, Volz T Tags: Acta Derm Venereol Source Type: research

A Case of Aplasia Cutis Congenita with Widespread Multifocal Skin Defects Without Extracutaneous Abnormalities.
PMID: 30460367 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Kim J, Kim J, Lee M, Huh ER, Lim J, Park KI, Oh SH Tags: Acta Derm Venereol Source Type: research

Use of Anti-transcriptional Intermediary Factor-1 Gamma Autoantibody in Identifying Adult Dermatomyositis Patients with Cancer: A Systematic Review and Meta-analysis.
Abstract Anti-transcriptional intermediary factor-1γ (TIF-1γ) autoantibody may be associated with cancer in adult patients with dermatomyositis. The aim of this study was to evaluate the risk of cancer in the presence of anti-TIF-1γ autoantibody in adult dermatomyositis. A comprehensive database search of EMBASE, MEDLINE and the Cochrane Library up to May 2018 was performed using the main key words "dermatomyositis", ""myositis", "inflammatory myopathies" and "anti-TIF-1". Eighteen studies, with a total of 1,962 dermatomyositis, were included in the me...
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Best M, Molinari N, Chasset F, Vincent T, Cordel N, Bessis D Tags: Acta Derm Venereol Source Type: research

Changes in Lesional and Non-lesional Skin Microbiome During Treatment of Atopic Dermatitis.
In conclusion, a drastic increase in microbial diversity and decrease in S. aureus proportion were observed with eczema treatment. Narrowband ultraviolet B treatment did not exert additive effects on eczema improvement; however, it appeared to reduce the recurrence of eczema. PMID: 30460369 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Kwon S, Choi JY, Shin JW, Huh CH, Park KC, Du MH, Yoon S, Na JI Tags: Acta Derm Venereol Source Type: research

Psoriasis as a Predictor of Cardiometabolic Comorbidity in Women: A Study Based on the Danish National Birth Cohort.
This study investigated the association between psoriasis and cardiometabolic comorbidity, taking body mass index and smoking into account. The population comprised expectant mothers in the Danish National Birth Cohort (established 1996-2002). During pregnancy, the women were asked about physician-diagnosed psoriasis. Any association with self-reported cardiometabolic comorbidity 11 years later was assessed using logistic regression. The cohort was also followed up for hospital-diagnosed comorbidity, including cardiac death, until 31 December 2014, and the risk was assessed using Cox regression. A total of 2,435 women with...
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Blegvad C, Nybo Andersen AM, Adam A, Zachariae C, Skov L Tags: Acta Derm Venereol Source Type: research

Treatment-Induced Delusions of Infestation Associated with Increased Brain Dopamine Levels.
PMID: 30460371 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Fowler E, Maderal A, Yosipovitch G Tags: Acta Derm Venereol Source Type: research

Tazarotene 0.015% Cream as a Potential Topical Agent for Management of Ichthyosis in Dorfman-Chanarin Syndrome.
nberg A PMID: 30460372 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Niculescu L, Ruini C, Srour J, Salzer S, Schönbuchner I, von Braunmühl T, Ruzicka T, Hohenleutner U, Giehl KA, Fischer J, Wollenberg A Tags: Acta Derm Venereol Source Type: research

Prevalence and Description of Hidradenitis Suppurativa in Down Syndrome: A Cross-sectional Study of 783 Subjects.
PMID: 30460373 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Poizeau F, Sbidian E, Mircher C, Rebillat AS, Chosidow O, Wolkenstein P, Ravel A, Hotz C Tags: Acta Derm Venereol Source Type: research

Antipruritic Effects of Janus Kinase Inhibitor Tofacitinib in a Mouse Model of Psoriasis.
We presently investigated whether tofacitinib affects spontaneous itch as well as expression of itch-related cytokines and epidermal nerve fiber density (ENFD) in the imiquimod-induced mouse model of psoriasis. Psoriasis-like skin lesions were produced by daily topical application of imiquimod to the back skin. Imiquimod treatment resulted in spontaneous scratching, which was significantly inhibited by tofacitinib treatment. Imiquimod treatment significantly increased mRNA expression of Il22, Il23, and Il31, reduced peptidergic ENFD, and increased nonpeptidergic ENFD compared to naive mice. Tofacitinib significantly decrea...
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Hashimoto T, Sakai K, Sanders KM, Yosipovitch G, Akiyama T Tags: Acta Derm Venereol Source Type: research

Usefulness of Psychiatric Intervention in a Joint Consultation for the Treatment of Burning Mouth Syndrome: A Monocentric Retrospective Study.
Abstract Primary burning mouth syndrome is a term used for chronic oral mucosal pain with no identifiable organic cause. The aim of the study was to evaluate the usefulness of a psychiatric intervention for treating burning mouth syndrome based on a joint consultation with a psychiatrist and a dermatologist. The study was proposed to all patients who visited this consultation group between 2001 and 2017 for the treatment of primary burning mouth syndrome. The patients answered a questionnaire that was administered via mail. Of the 57 patients diagnosed with primary burning mouth syndrome, 38 were included. Seven p...
Source: Acta Dermato-Venereologica - November 21, 2018 Category: Dermatology Authors: Le Bris V, Chastaing M, Schollhammer M, Brenaut E, Misery L Tags: Acta Derm Venereol Source Type: research

Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000-2012.
This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14.7, 95% CI 6.5-33.4) including lichen ruber (12.0, 95% CI 3.0-48.0), indicating lichen ruber to be an important risk factor. Increased ORs were also observed for diseases of the prepuce (4.0, 95% CI 2.2-7.4), immunosuppressive drugs (5.0, 95% CI 2.5-9.8), penile surgical procedures (4.8, 95% CI 2.2-10.8), balanitis (9.2, 95...
Source: Acta Dermato-Venereologica - November 14, 2018 Category: Dermatology Authors: Kristiansen S, Svensson Å, Drevin L, Forslund O, Torbrand C, Bjartling C Tags: Acta Derm Venereol Source Type: research

A Case of Interstitial Lung Disease and Autoimmune Thyroiditis Associated with Ustekinumab.
PMID: 30426134 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 14, 2018 Category: Dermatology Authors: Lee SG, An JH, Kim DH, Yoon MS, Lee HJ Tags: Acta Derm Venereol Source Type: research

Acrokeratosis Paraneoplastica-like Findings as a Manifestation of Systemic Lupus Erythematosus.
PMID: 30426135 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 14, 2018 Category: Dermatology Authors: Huilaja L, Soronen M, Karjalainen A, Tasanen K Tags: Acta Derm Venereol Source Type: research

Socioeconomic Status and the Prevalence of Skin and Atopic Diseases in Five European Countries.
Diepgen TL Abstract The aim of this study was to investigate the association between socioeconomic status and the prevalence of self-reported skin and atopic diseases in the general population of 5 European countries. A random sample was drawn from the general population aged 18-74 years, based on electoral precincts. Socioeconomic status was estimated by combining net household income with the highest education of respondents. A total of 7,904 subjects were included in this analysis. The lifetime prevalence of "contact dermatitis" ranged from 13.1% (95% confidence interval (95% CI 11.8-14.4%) in subject...
Source: Acta Dermato-Venereologica - November 14, 2018 Category: Dermatology Authors: Ofenloch RF, Schuttelaar MLA, Svensson Å, Bruze M, Naldi L, Cazzaniga S, Elsner P, Gonçalo M, Diepgen TL Tags: Acta Derm Venereol Source Type: research

Large-scale Retrospective Cohort Study of Psychological Stress in Patients with Alopecia Areata According to the Frequency of Intralesional Steroid Injection.
PMID: 30393815 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 5, 2018 Category: Dermatology Authors: Hwang S, Shin J, Kim TG, Kim DY, Oh SH Tags: Acta Derm Venereol Source Type: research

Keratin Gel as an Adjuvant in the Treatment of Recalcitrant Pyoderma Gangrenosum Ulcers: A Case Report.
PMID: 30393816 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 5, 2018 Category: Dermatology Authors: Paulsen E, Bygum A Tags: Acta Derm Venereol Source Type: research

Early Circulating Tumour DNA Variations Predict Tumour Response in Melanoma Patients Treated with Immunotherapy.
yer N Abstract Antibodies targeting immune checkpoints were recently approved for metastatic melanoma. However, not all patients will respond to the treatment and some will experience grade III-IV immune-related adverse events. Therefore, early identification of non-responder patients would greatly aid clinical practice. Detection of circulating tumour DNA (ctDNA) is a non-invasive approach to monitor tumour response. Digital droplet PCR was used to quantify BRAF and NRAS mutations in the plasma of patients with metastatic melanoma treated with immunotherapy. In 16 patients, ctDNA variations mirrored tumour respon...
Source: Acta Dermato-Venereologica - November 5, 2018 Category: Dermatology Authors: Keller L, Guibert N, Casanova A, Brayer S, Farella M, Delaunay M, Gilhodes J, Martin E, Balagué G, Favre G, Pradines A, Meyer N Tags: Acta Derm Venereol Source Type: research

Exploratory Study of Intracutaneous Histamine Stimulation in Patient Populations with Chronic Pruritus.
r S Abstract Chronic pruritus can be a diagnostic sign of an underlying disease. In the intracutaneous histamine test, histamine (one of the best-known inducers of pruritus) may cause different reaction patterns depending on the underlying disease. The aim of this study was to determine if an intracutaneous injection of histamine can differentiate between the causes of chronic pruritus and thus be used as a diagnostic test in chronic pruritus of unknown aetiology. A total of 140 subjects with chronic pruritus with various dermatological, systemic or neurological diseases were included. The intracutaneous histamine...
Source: Acta Dermato-Venereologica - November 5, 2018 Category: Dermatology Authors: Tsianakas A, Nippe N, Hamper CM, Cordes AF, Zeidler C, Schmelz M, Ständer S Tags: Acta Derm Venereol Source Type: research

Effects of Short-term Temperature Change in the Innocuous Range on Histaminergic and Non-histaminergic Acute Itch.
Abstract While temperatures in the noxious range are well-known to inhibit acute itch, the impact of temperature in the innocuous temperature range is less well understood. We investigated the effect of alternating short-term temperature changes in the innocuous range on histamine and cowhage-induced acute itch, taking into account individual differences in baseline skin temperature and sensory thresholds. Results indicate that cooling the skin to the cold threshold causes a temporary increase in the intensity of histamine-induced itch, in line with previous findings. Skin warming increased cowhage-induced itch in...
Source: Acta Dermato-Venereologica - October 25, 2018 Category: Dermatology Authors: Lewis Z, George DN, Cowdell F, Holle H Tags: Acta Derm Venereol Source Type: research

Prevalence and Clinical Characteristics of Cutaneous Manifestations Associated with Bacteraemia: A Cross-sectional Prospective Study.
ice P Abstract Bacteraemias are life-threatening conditions that require rapid care and antibiotherapy. Dermatological signs might help in deciding the most relevant treatment. The aim of this study was to determine the prevalence and clinical characteristics of cutaneous manifestations in hospitalized patients with bacteraemia. A cross-sectional study was conducted over a period of 1 year. All consecutive patients with a bacteraemia (except contaminations) were included and examined by a dermatologist within 48 h after positive blood cultures. Clinical (skin manifestations, diagnosis, origin of the bacteraemia) a...
Source: Acta Dermato-Venereologica - October 17, 2018 Category: Dermatology Authors: Taquin H, Hubiche T, Roudière L, Fribourg A, Del Giudice P Tags: Acta Derm Venereol Source Type: research

High Blood Pressure in Normal-weight Children with Psoriasis.
PMID: 30328469 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 17, 2018 Category: Dermatology Authors: Caroppo F, Ventura L, Belloni Fortina A Tags: Acta Derm Venereol Source Type: research

Staphylococcus epidermidis-induced Interleukin-1 Beta and Human Beta-defensin-2 Expression in Human Keratinocytes is Regulated by the Host Molecule A20 (TNFAIP3).
We report here that S. epidermidis induces expression of the host regulator protein A20 in human keratinocytes, thereby controlling expression and release of interleukin-1 beta. siRNA-mediated knockdown of A20 expression strongly enhanced the induction of interleukin-1 beta gene expression and protein release in keratinocytes stimulated with S. epidermidis. Furthermore, siRNA-mediated knockdown of A20 resulted in enhanced gene expression and secretion of the antimicrobial peptide human beta-defensin-2 in keratinocytes facing S. epidermidis. Mechanistically, A20 negatively controlled S. epidermidis-induced activation of the...
Source: Acta Dermato-Venereologica - October 17, 2018 Category: Dermatology Authors: Simanski M, Erkens AS, Rademacher F, Harder J Tags: Acta Derm Venereol Source Type: research

Blaschkolinear Lichen Planus Pigmentosus in the Setting of Chronic Graft-versus-host Disease.
PMID: 30328472 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 17, 2018 Category: Dermatology Authors: Pinzani C, Bouaziz JD Tags: Acta Derm Venereol Source Type: research

Porokeratosis Ptychotropica on the Penis and Scrotum: A Case Report.
PMID: 30328473 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 17, 2018 Category: Dermatology Authors: Qian YT, Vano-Galvan S, Liu JW, Liu W, Ma DL Tags: Acta Derm Venereol Source Type: research

Skin Lesions Suggesting Type 2 Segmental Mosaicism in Noonan Syndrome.
PMID: 30320868 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 15, 2018 Category: Dermatology Authors: Happle R Tags: Acta Derm Venereol Source Type: research

Aberrant B Cell Subsets and Immunoglobulin Levels in Patients with Moderate-to-severe Psoriasis.
n A PMID: 30320869 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 15, 2018 Category: Dermatology Authors: Kahlert K, Grän F, Muhammad K, Benoit S, Serfling E, Goebeler M, Kerstan A Tags: Acta Derm Venereol Source Type: research

Assessing Punctuate Administration of Beta-alanine as a Potential Human Model of Non-histaminergic Itch.
PMID: 30320870 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 15, 2018 Category: Dermatology Authors: Christensen JD, Lo Vecchio S, Elberling J, Arendt-Nielsen L, Andersen HH Tags: Acta Derm Venereol Source Type: research

Digital Education for Health Professions in the Field of Dermatology: A Systematic Review by Digital Health Education Collaboration.
This study employed a Cochrane review approach to assess the evidence for the effectiveness of health professions' digital education in dermatology to improve knowledge, skills, attitudes and satisfaction. Twelve trials (n = 955 health professionals) met our eligibility criteria. Nine studies evaluated knowledge; of those two reported that digital education improved the outcome. Five studies evaluated skill; of those 3 studies stated that digital education improved this outcome whereas 2 showed no difference when compared with control. Of the 5 studies measuring learners' satisfaction, three studies claimed h...
Source: Acta Dermato-Venereologica - October 15, 2018 Category: Dermatology Authors: Xu X, Posadzki PP, Lee GE, Car J, Smith HE Tags: Acta Derm Venereol Source Type: research

Keratinocyte Transcriptome in Psoriasis: Pathways Related to Immune Responses, Cell Cycle and Keratinization.
oly E Abstract Psoriasis is a common immune-mediated disease resulting from altered cross-talk between keratinocytes and immune cells. Previous transcriptomic studies have identified thousands of deregulated genes in psoriasis skin; however, the transcriptomic changes confined to the epidermal compartment remained poorly characterized. The aim of this study was to characterize the transcriptomic landscape of psoriatic keratinocytes, using sorted CD45neg epidermal cells. Genes with functions in innate immunity, type I interferon response, cell cycle and keratinization were enriched among deregulated genes in psoria...
Source: Acta Dermato-Venereologica - October 15, 2018 Category: Dermatology Authors: Pasquali L, Srivastava A, Meisgen F, Das Mahapatra K, Xia P, Xu Landén N, Pivarcsi A, Sonkoly E Tags: Acta Derm Venereol Source Type: research

Rashes, Erosions and Purulent Fluid in the Intertriginous Areas: A Quiz.
PMID: 30320873 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 15, 2018 Category: Dermatology Authors: Sun Y, Zhang F Tags: Acta Derm Venereol Source Type: research

Measuring Patient Needs and Benefits in Dermatology using the Patient Benefit Index 2.0: A Validation Study.
This study investigated the validity and feasibility of the Patient Benefit Index 2.0 (PBI 2.0), a short instrument to assess patient-relevant treatment benefit. In a cross-sectional study, patients with skin diseases completed the PBI 2.0 alongside instruments on quality of life and disease-specific PBI long versions to assess convergent validity. Feasibility questions appraise comprehensibility, completeness, length, and readability. Data from a longitudinal study were used to explore responsiveness and test-retest reliability. Most patients rated the PBI 2.0 easy to understand, complete, legible, and not too long. The a...
Source: Acta Dermato-Venereologica - October 11, 2018 Category: Dermatology Authors: Topp J, Augustin M, von Usslar K, Gosau R, Reich K, Reusch M, Blome C Tags: Acta Derm Venereol Source Type: research

Pruritus in Chronic Liver Disease: A Questionnaire Survey on 216 Patients.
PMID: 30307026 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 11, 2018 Category: Dermatology Authors: Kido-Nakahara M, Nakahara T, Furusyo N, Shimoda S, Koto K, Kato M, Hayashi J, Koyanagi T, Furue M Tags: Acta Derm Venereol Source Type: research

Influence of Itch and Pain on Sleep Quality in Atopic Dermatitis and Psoriasis.
This study assessed the impact of itch and pain on sleep quality among 100 patients with atopic dermatitis and 100 patients with psoriasis, compared with 50 controls. The Athens Insomnia Scale (AIS) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate a spectrum of sleep disturbances. Co-existence of insomnia was indicated in the majority of patients; atopic dermatitis (82%), psoriasis (62%). PSQI total scores for patients with atopic dermatitis (8.3 ± 4.2 points) and those with psoriasis (8.1 ± 4.8 points) qualified them, in 80% of cases, as poor sleepers and were signi...
Source: Acta Dermato-Venereologica - October 11, 2018 Category: Dermatology Authors: Kaaz K, Szepietowski JC, Matusiak Ł Tags: Acta Derm Venereol Source Type: research

A Case of Generalized Interstitial Granuloma Annulare and Arthritis Associated with Breast Cancer.
ier M PMID: 30281136 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 3, 2018 Category: Dermatology Authors: Clapé A, Vanhaecke C, Durlach A, Bernard P, Jouannaud C, Kpodar L, Cribier B, Viguier M Tags: Acta Derm Venereol Source Type: research

Paraneoplastic Opsoclonus-myoclonus Syndrome Preceding a Mucosal Malignant Melanoma.
PMID: 30281137 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 3, 2018 Category: Dermatology Authors: Dresco F, Aubin F, Deveza E, Revenco E, Tavernier L, Puzenat E Tags: Acta Derm Venereol Source Type: research

A Case of Perforating Folliculitis Induced by Vemurafenib.
PMID: 30281138 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 3, 2018 Category: Dermatology Authors: Shiraishi K, Masunaga T, Tohyama M, Sayama K Tags: Acta Derm Venereol Source Type: research

Comparison of the Treatment Outcome of Oral Tofacitinib with Other Conventional Therapies in Refractory Alopecia Totalis and Universalis: A Retrospective Study.
In conclusion, oral tofacitinib was more effective than diphenylcyclopropenone immunotherapy and more tolerable than conventional oral treatment after 6 months of treatment. PMID: 30281139 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 3, 2018 Category: Dermatology Authors: Shin JW, Huh CH, Kim MW, Lee JS, Kwon O, Cho S, Park HS Tags: Acta Derm Venereol Source Type: research

Induced Vitiligo due to Talimogene Laherparepvec Injection for Metastatic Melanoma Associated with Long-term Complete Response.
PMID: 30281140 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - October 3, 2018 Category: Dermatology Authors: Iglesias P, Ribero S, Barreiro A, Podlipnik S, Carrera C, Malvehy J, Puig S Tags: Acta Derm Venereol Source Type: research