Patient Preferences in Adjuvant and Palliative Treatment of Advanced Melanoma: A Discrete Choice Experiment.
In conclusion, patients with advanced melanoma consider efficacy of treatment options most important, followed by safety, but preferences vary with individual and disease-related characteristics. PMID: 32057087 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 13, 2020 Category: Dermatology Authors: Weilandt J, Diehl K, Schaarschmidt ML, Kieker F, Sasama B, Pronk M, Ohletz J, Könnecke A, Müller V, Utikal J, Hillen U, Harth W, Peitsch WK Tags: Acta Derm Venereol Source Type: research

A Family with Palmar and Plantar Hyperkeratosis: A Quiz.
r J PMID: 32052849 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 12, 2020 Category: Dermatology Authors: Juratli HA, Jägle S, Happle R, Avci P, Didona D, Fischer J Tags: Acta Derm Venereol Source Type: research

The p53 Signalling Pathway in Cutaneous Basal Cell Carcinoma: An Immunohistochemical Description.
PMID: 32052850 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 12, 2020 Category: Dermatology Authors: Oh ST, Stark A, Reichrath J Tags: Acta Derm Venereol Source Type: research

Prevalence of Pruritus in a Single Cohort of Long-term Kidney Transplant Recipients.
PMID: 32052851 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 12, 2020 Category: Dermatology Authors: Schricker S, Weisshaar E, Kupfer J, Mettang T Tags: Acta Derm Venereol Source Type: research

Collagen XVII Processing and Blistering Skin Diseases.
Abstract Collagen XVII (COL17) is a hemidesmosomal transmembrane protein in the skin, which, in several autoimmune blistering skin diseases, may be targeted by autoantibodies. In addition, loss-of-function mutations in the COL17A1 gene induce a subtype of junctional epidermolysis bullosa. The extracellular domain of COL17 can be physiologically cleaved from the cell surface by ADAM family proteins in a process known as ectodomain shedding. COL17 ectodomain shedding is thought to be associated with the migration and proliferation of keratinocytes. Furthermore, the C-terminal cleavage of COL17 may be associated with...
Source: Acta Dermato-Venereologica - February 5, 2020 Category: Dermatology Authors: Nishie W Tags: Acta Derm Venereol Source Type: research

Skin Fragility: Perspectives on Evidence-based Therapies.
This article reviews different approaches to curative and symptom-relief therapies, and appraises their status and perspectives for clinical implementation. PMID: 32039456 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - February 5, 2020 Category: Dermatology Authors: Bruckner-Tuderman L Tags: Acta Derm Venereol Source Type: research

Current Concepts of Dermatitis Herpetiformis.
Abstract Dermatitis herpetiformis (DH) is an autoimmune skin disease that causes itchy, blistering rash, typically on the elbows, knees and buttocks. DH and coeliac disease share the same genetic background, gluten-dependent enteropathy and antibody response against tissue transglutaminase. DH is currently considered a cutaneous manifestation of coeliac disease, and the prevailing hypothesis is that DH develops as a late manifestation of subclinical coeliac disease. The incidence of DH is decreasing contemporarily with the increasing incidence of coeliac disease. The IgA immune response in DH skin is directed agai...
Source: Acta Dermato-Venereologica - February 5, 2020 Category: Dermatology Authors: Salmi T, Hervonen K Tags: Acta Derm Venereol Source Type: research

Drug Development in Pemphigoid Diseases.
Abstract Pemphigoid diseases are organ-specific autoimmune diseases of the skin and/or mucous membranes. They are caused by autoantibodies targeting adhesion molecules located at the dermal-epidermal junction. While the diagnostics of pemphigoid diseases and insights into their pathogenesis have improved significantly, the development of novel treatments that are effective and safe remains an unmet medical need. However, numerous pre-clinical studies and early clinical trials have recently been launched. This review summarizes some pathways leading to drug development in pemphigoid diseases, namely: (i) hypothesis...
Source: Acta Dermato-Venereologica - February 5, 2020 Category: Dermatology Authors: Bieber K, Ludwig RJ Tags: Acta Derm Venereol Source Type: research

Bullous Drug Reactions.
Abstract Bullous drug eruptions are infrequent, but because they pose a challenge both to affected patients and to treating physicians they are considered to be the most severe cutaneous adverse reactions (SCAR). It is important to recognize these conditions and to differentiate them from other clinical entities involving blister formation. There may be early signs and symptoms that indicate a severe bullous drug eruption even before blisters and erosions of the skin and mucous membranes become obvious. Once the diagnosis is suspected, appropriate diagnostic procedures and adequate management must be initiated. Th...
Source: Acta Dermato-Venereologica - February 5, 2020 Category: Dermatology Authors: Mockenhaupt M Tags: Acta Derm Venereol Source Type: research

Sleep Disturbance in Patients with Urticaria and Atopic Dermatitis: An Underestimated Burden.
This study examined the relationship between insomnia and the frequent itching skin diseases, atopic dermatitis and chronic urticaria. Patients with chronic inflammatory dermatological diseases with pruritus were evaluated for insomnia (Insomnia Severity Index; ISI) and impairment in dermatological quality of life (Dermatology Life Quality Index; DLQI). Disease activity was measured using validated scores. A total of 61 patients participated in the study. Patients with atopic dermatitis had a mean ISI score of 8.7 before and 16 when a flare occurred. The mean DLQI score was 11.4. The mean ISI score in patients with chronic...
Source: Acta Dermato-Venereologica - February 3, 2020 Category: Dermatology Authors: Mann C, Dreher M, Weeß HG, Staubach P Tags: Acta Derm Venereol Source Type: research

Autoantibody Profile of a Cohort of 54 Italian Patients with Linear IgA Bullous Dermatosis: LAD-1 Denoted as a Major Auto-antigen of the Lamina Lucida Subtype.
Abstract Linear IgA bullous dermatosis (LABD) is characterized by presence of multiple IgA autoantibodies, and a comparatively lesser number of IgG antibodies, directed against different hemidesmosomal antigens. The main autoantigens are LAD-1, LABD-97, BP180 and BP230, type VII collagen and laminin 332. We retrospectively studied the serology of 54 Italian patients with LABD using enzyme-linked immunosorbent assay (ELISA), immunoblotting assay, and indirect immunofluorescence on monkey oesophagus and salt-split skin. Among these, indirect immunofluorescence of salt-split skin elicits the greatest sensitivity. Six...
Source: Acta Dermato-Venereologica - February 2, 2020 Category: Dermatology Authors: Cozzani E, Di Zenzo G, Gasparini G, Salemme A, Agnoletti AF, Vassallo C, Caproni M, Antiga E, Marzano AV, Cavalli R, Ocella C, de Simone C, Parodi A Tags: Acta Derm Venereol Source Type: research

Herpetiform Manifestation of Primary Syphilis: A Case Series.
PMID: 32011725 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 30, 2020 Category: Dermatology Authors: Larsen CN, Larsen HK Tags: Acta Derm Venereol Source Type: research

Myxoid Nodule on the Leg of an Immunosuppressed Man: A Quiz.
PMID: 31996928 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 29, 2020 Category: Dermatology Authors: Mitri F, Hartmann J, Mentzel T, Enk A, Toberer F Tags: Acta Derm Venereol Source Type: research

Low-dose Methotrexate Treatment for Solitary or Localized Primary Cutaneous Anaplastic Large Cell Lymphoma: A Long-term Follow-up Study.
Abstract Although low-dose methotrexate (MTX) has been used widely in treatment of a variety of dermatological diseases, including multifocal primary cutaneous anaplastic large cell lymphoma (PCALCL), it has not been established for use in the treatment guidelines for solitary or localized PCALCL. Furthermore, there has been no report of long-term follow-up data in Asian patients with PCALCL treated with low-dose MTX. To investigate the effectiveness and clinical outcome of treatment with low-dose MTX, clinical and long-term follow-up data of 7 patients with solitary or localized PCALCL were analysed retrospective...
Source: Acta Dermato-Venereologica - January 29, 2020 Category: Dermatology Authors: Park JB, Yang MH, Kwon DI, Seong SH, Jang JY, Suh KS, Jang MS Tags: Acta Derm Venereol Source Type: research

Comorbidities of Alopecia Areata in Finland between 1987 and 2016.
PMID: 31996930 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 29, 2020 Category: Dermatology Authors: Laitinen I, Jokelainen J, Tasanen K, Huilaja L Tags: Acta Derm Venereol Source Type: research

Psychosocial Aspects of Adult Acne: Data from 13 European Countries.
Kupfer J Abstract The link between acne and psychiatric morbidities has been demonstrated in many studies; however, large scale studies aiming to reveal the psychosocial impact of acne are rare. The aim of this study was to assess the psychological burden of adult acne patients. This analysis was based on a multicenter study including 213 acne patients and 213 controls from 13 European countries. The Hospital Anxiety and Depression Scale (HADS), Dermatology Life Quality Index, and EuroQol 5 dimensions 3 levels scores of the patients with acne were analyzed. Patients with acne (n = 213) had higher HA...
Source: Acta Dermato-Venereologica - January 28, 2020 Category: Dermatology Authors: Altunay IK, Özkur E, Dalgard FJ, Gieler U, Aragones LT, Lien L, Poot F, Jemec GB, Misery L, Szabó C, Linder D, Sampogna F, Evers AWM, Halvorsen JA, Balieva F, Szepietowski JC, Romanov DV, Marron SE, Finlay AY, Salek S, Kupfer J Tags: Acta Derm Venereol Source Type: research

A Challenging Case of Subcutaneous and Mucosal Haemorrhage Caused by Urticarial Vasculitis (Urticaria Haemorrhagica Profunda).
PMID: 31993673 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 28, 2020 Category: Dermatology Authors: Simonsen AB, Larsen MHH, von Buchwald C, Kofoed K Tags: Acta Derm Venereol Source Type: research

Pustular Psoriasis: The Dawn of a New Era.
Abstract Pustular psoriasis is a clinically heterogeneous entity of different, orphan disease subtypes, among which the most clearly defined are generalized pustular psoriasis, palmoplantar psoriasis, and acrodermatitis continua of Hallopeau. Although phenotypically and genetically distinct from psoriasis vulgaris, these subtypes may be associated with plaque psoriasis lesions, establishing the rationale for their inclusion in the psoriasis spectrum. Unlike psoriasis, however, their genetic background is thought to be mainly monogenic, as shown by the recent identification of mutations in 3 different genes of the ...
Source: Acta Dermato-Venereologica - January 22, 2020 Category: Dermatology Authors: Bachelez H Tags: Acta Derm Venereol Source Type: research

Psoriasis and Treatment: Past, Present and Future Aspects.
Abstract The management of psoriasis has evolved considerably over the past 100 years. This has occurred in parallel with our understanding of the pathogenesis of this common, complex and enigmatic disease. It should be celebrated as an outstanding example of successful translational research. With precise targeting of immune pathways for the treatment of psoriasis with new biologics and small molecules has come the realisation that the most effective approach to patient management is a holistic one which encompasses the biopsychosocial nature of the disease. This involves a stratified medicine approach to identif...
Source: Acta Dermato-Venereologica - January 22, 2020 Category: Dermatology Authors: Reid C, Griffiths CEM Tags: Acta Derm Venereol Source Type: research

Psoriasis and Co-morbidity.
Abstract Psoriasis is associated with multiple co-morbid medical conditions. The purpose of this study is to evaluate the relationships between psoriasis and cardiovascular disease, psoriatic arthritis, mental health conditions, and immune-mediated diseases, respectively. A literature search was performed during the study period January 1, 2015 to December 18, 2018. Of 2,499 records identified, 28 met our criteria selection and were included in this review. The relationships between psoriasis and these multiple comorbid disease conditions are discussed and are important to consider when developing the treatment pl...
Source: Acta Dermato-Venereologica - January 22, 2020 Category: Dermatology Authors: Amin M, Lee EB, Tsai TF, Wu JJ Tags: Acta Derm Venereol Source Type: research

Psoriasis and Genetics.
Abstract Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power of genetic analyses for disease stratification. Psoriasis can be stratified by phenotype (common plaque versus rare pustular variants), or by outcome (prognosis, comorbidities, response to treatment); recent progress has been made in delineating the genetic contribution in each of these areas. We also highlight ...
Source: Acta Dermato-Venereologica - January 22, 2020 Category: Dermatology Authors: Dand N, Mahil SK, Capon F, Smith CH, Simpson MA, Barker JN Tags: Acta Derm Venereol Source Type: research

The Woronoff Ring in Psoriasis and the Mechanisms of Postinflammatory Hypopigmentation.
Abstract The Woronoff ring is a ring-like hypopigmentation zone around regressing psoriasis lesions. Although it was first described more than 100 years ago, its aetiology has remained a mystery. Recent insights into the pathogenesis of psoriasis can now explain the origin of the Woronoff ring. Psoriasis involves an HLA-class I-restricted autoimmune response of CD8+ T cells against melanocytes in the epidermis. The pathogenic CD8+ T cells are not cytotoxic, but are characterized by the production of interleukin-17, interleukin-22 and tumour necrosis factor-α. Interleukin-17 and tumour necrosis factor-α...
Source: Acta Dermato-Venereologica - January 22, 2020 Category: Dermatology Authors: Prinz JC Tags: Acta Derm Venereol Source Type: research

Patterns among Patients with Chronic Pruritus: A Retrospective Analysis of 170 Patients.
This study provides a complex analysis of chronic pruritus and thus basic principles for a clinical work-up. PMID: 31950196 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 16, 2020 Category: Dermatology Authors: Lehmann M, Cazzaniga S, Simon D, Perruchoud D, Borradori L, Rammlmair A Tags: Acta Derm Venereol Source Type: research

Coexistence of Oncogenic Human Papillomavirus Genotypes in Condylomata Acuminata among Children and Adolescents.
PMID: 31950197 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 16, 2020 Category: Dermatology Authors: Marsela E, Fischbeck AJ, Hildebrand JA, Aoki R, French LE, Wollenberg A, Schmoeckel E, Reinholz M Tags: Acta Derm Venereol Source Type: research

Phenotypic Variability with SLURP1 Mutations and Diffuse Palmoplantar Keratoderma.
i K PMID: 31944258 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 15, 2020 Category: Dermatology Authors: Harjama L, Kettunen K, Elomaa O, Einarsdottir E, Heikkilä H, Kivirikko S, Lappalainen K, Saarela J, Alby C, Ranki A, Kere J, Hadj-Rabia S, Hannula-Jouppi K Tags: Acta Derm Venereol Source Type: research

Mechanisms and Management of Itch in Dry Skin.
Abstract Chronic itch is a burdensome clinical problem that often accompanies pathological dry skin-based conditions, such as atopic dermatitis, and systemic disorders, such as kidney diseases, with an unclear pathomechanism and treatments. One of the basic mouse models to investigate mechanisms of itch associated with dry skin is a mixture of acetone and ether followed by water. Animal studies using the acetone and ether followed by water model have revealed that many mediators and receptors, e.g. mas-related G protein-coupled receptor family, transient receptor potential, and chemokines, are responsible for itch...
Source: Acta Dermato-Venereologica - January 14, 2020 Category: Dermatology Authors: Moniaga CS, Tominaga M, Takamori K Tags: Acta Derm Venereol Source Type: research

Necrotic Arachnidism in Germany due to Bite of a Dysderidae Spider Probably Imported from South Tyrol, Italy.
PMID: 31934728 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 13, 2020 Category: Dermatology Authors: Zink A, Zink A, Gebhardt M, Engst R, Ring J Tags: Acta Derm Venereol Source Type: research

Increased Expression of Delta-like Ligand 4 in Mycosis Fungoides.
This study investigated the roles of Delta-like ligand 4 in mycosis fungoides. Delta-like ligand 4 mRNA levels in lesional skin of patients with mycosis fungoides were significantly elevated compared with those of normal controls, and correlated with disease-specific mortality. Immunohistochemical staining demonstrated prominent expression of Delta-like ligand 4 on vascular endothelial cells and tumour cells in mycosis fungoides lesional skin. In addition, Delta-like ligand 4 augmented the proliferation of cutaneous T-cell lym-phoma cell lines. These results suggest that enhanced Delta-like ligand 4 expression may contribu...
Source: Acta Dermato-Venereologica - January 12, 2020 Category: Dermatology Authors: Boki H, Miyagaki T, Shono Y, Kamijo H, Oka T, Suga H, Asano Y, Sugaya M, Sato S Tags: Acta Derm Venereol Source Type: research

Amelanotic Melanoma Concealed by Psoriasis.
JD PMID: 31930427 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - January 1, 2020 Category: Dermatology Authors: Curman P, Lapins J, Radros N, Krynitz B, Wikström JD Tags: Acta Derm Venereol Source Type: research

Comparison of Cytokine Expression in Paediatric and Adult Psoriatic Skin.
PMID: 31930425 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 17, 2019 Category: Dermatology Authors: Kim JC, Kim SM, Soh BW, Lee ES Tags: Acta Derm Venereol Source Type: research

Recurrent Phaeohyphomycosis due to Phaeoacremonium alvesii Identified with Internal Transcribed Spacer and Beta-tubulin Gene Sequencing.
PMID: 31930424 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 15, 2019 Category: Dermatology Authors: Kimura R, Yamada N, Yoshida Y, Ito A, Horie T, Anzawa K, Mochizuki T, Yamamoto O Tags: Acta Derm Venereol Source Type: research

Patches, Bumps, Purplish Macules and Papules in a Patient with Pruritus: A Quiz.
PMID: 31834416 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 9, 2019 Category: Dermatology Authors: Yan X, Yu M, Zhou G, Zhang F Tags: Acta Derm Venereol Source Type: research

Association of Primary Hyperhidrosis with Depression and Anxiety: A Systematic Review.
PMID: 31821514 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 9, 2019 Category: Dermatology Authors: Kristensen JK, Vestergaard DG, Swartling C, Bygum A Tags: Acta Derm Venereol Source Type: research

Multiple Eruptive Pyogenic Granulomas on the Proximal Nail Folds Following Cast Immobilization: A Case Report with Nail Unit Ultrasound Findings.
ol RM PMID: 31821515 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 9, 2019 Category: Dermatology Authors: Lopez-Castillo D, Curto-Barredo L, Sánchez-Schmidt JM, Pujol RM Tags: Acta Derm Venereol Source Type: research

Efficacy and Safety of Treatment with Oral Alitretinoin and Oral Cyclosporine for Chronic Hand Eczema: A Retrospective Review of 118 Cases.
PMID: 31821516 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 9, 2019 Category: Dermatology Authors: Jang YJ, Yoon JH, Park EJ, Kim KJ, Kim KH Tags: Acta Derm Venereol Source Type: research

An Intimate Relationship Between Intralesional Depigmentation and Peripheral Nervous System in Lichen Simplex Chronicus.
PMID: 31821517 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 9, 2019 Category: Dermatology Authors: Ichiki T, Sugita K, Furue M, Yamamoto O Tags: Acta Derm Venereol Source Type: research

BRAF Mutation Heterogeneity in Melanoma Lesions.
PMID: 31821518 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - December 9, 2019 Category: Dermatology Authors: Sakaizawa K, Ashida A, Kiniwa Y, Okuyama R Tags: Acta Derm Venereol Source Type: research

Comparison of Chemical Matricectomy with Trichloroacetic Acid, Phenol, or Sodium Hydroxide for Ingrown Toenails: A Systematic Review and Network Meta-Analysis.
PMID: 31776585 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 26, 2019 Category: Dermatology Authors: Chang HC, Lin MH Tags: Acta Derm Venereol Source Type: research

Recruitment and Retention in a Randomized Control Trial of Increased Dietary Protein-to-Carbohydrate Ratios in Patients with Psoriasis.
sby B PMID: 31774541 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 26, 2019 Category: Dermatology Authors: Schultz ANØ, Jensen P, Zibert JR, Stigsby MF, Malmstedt-Miller M, Petersen EBM, Skov L, Stigsby B Tags: Acta Derm Venereol Source Type: research

Plaque-like Cutaneous Lupus Mucinosis as the First Sign of Systematic Lupus Erythematosus.
PMID: 31774542 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 26, 2019 Category: Dermatology Authors: Gao M, Sheng N, Yang X, Jiang Y Tags: Acta Derm Venereol Source Type: research

Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases.
This study evaluated the intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between 30 primary melanomas and 39 related metastases, using molecular analysis and immunohistochemistry. BRAF mutations were identified in 46.7% of primary melanomas and 48.7% of metastases and NRAS mutations in 20% and 25.6%, respectively. Intra-patient heterogeneity was detected in 13.3% of patients for both BRAF and NRAS genes and was not associated with clinico-pathological characteristics of melanomas or metastases. High consistency was observed between immunostaining and molecular methods for BRAFV600E (k = 0.90; p 
Source: Acta Dermato-Venereologica - November 26, 2019 Category: Dermatology Authors: Pellegrini C, Cardelli L, De Padova M, Di Nardo L, Ciciarelli V, Rocco T, Cipolloni G, Clementi M, Cortellini A, Ventura A, Leocata P, Fargnoli MC Tags: Acta Derm Venereol Source Type: research

Comparative Pharmacokinetic Profiles of a Novel Low-dose Micronized-isotretinoin 32 mg Formulation and Lidose-isotretinoin 40 mg in Fed and Fasted Conditions: Two Open-label, Randomized, Crossover Studies in Healthy Adult Participants.
Abstract Two open-label, crossover studies compared the bioavailability of micronized-isotretinoin 32 mg and Lidose-isotretinoin 40 mg in healthy adults. In the fed bioequivalence/food-effect study, participants (n = 71) received single doses of fed-state micronized-isotretinoin 32 mg, fed-state Lidose-isotretinoin 40 mg and fasted-state micronized-isotretinoin 32 mg. In the fasting study, participants (n = 8) received single doses of fasted-state micronized-isotretinoin 32 mg and fasted-state Lidose-isotretinoin 40 mg. Bioavailability was assessed by isotretinoin LnAUC0-t, LnAUC0-&infi...
Source: Acta Dermato-Venereologica - November 26, 2019 Category: Dermatology Authors: Madan S, Kumar S, Segal J Tags: Acta Derm Venereol Source Type: research

Dysregulated Expression of Antimicrobial Peptides in Skin Lesions of Patients with Cutaneous T-cell Lymphoma.
Abstract Mycosis fungoides and Sézary syndrome belong to the group of primary cutaneous T-cell lymphomas. Because of the inflammatory appearance of the skin lesions, we hypothesized that antimicrobial peptides might be dysregulated in these conditions, similar to in inflammatory skin conditions. Samples from 20 patients with cutaneous T-cell lymphoma were analysed using immunohistochemistry and enzyme-linked immunoassay (ELISA) of skin washing fluids of hBD-2, hBD-3, RNase 7 and psoriasin. Immunohistochemistry results were compared with previous analyses of healthy and psoriatic skin. ELISA and immunohistoc...
Source: Acta Dermato-Venereologica - November 18, 2019 Category: Dermatology Authors: Wehkamp U, Jost M, Wehkamp K, Harder J Tags: Acta Derm Venereol Source Type: research

Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis.
PMID: 31742645 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 18, 2019 Category: Dermatology Authors: van den Munckhof EHA, Niemeyer-van der Kolk T, van der Wall H, van Alewijk DCJG, van Doorn MBA, Burggraaf J, Buters TP, Becker MJ, Feiss GL, Quint WGV, van Doorn LJ, Knetsch CW, Rissmann R Tags: Acta Derm Venereol Source Type: research

A Case of Four Synchronous Cutaneous Melanomas: Melanocortin 1 Receptor Polymorphisms and Excessive Sun Exposure.
PMID: 31742646 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 18, 2019 Category: Dermatology Authors: Gasparini G, Ciccarese G, Cozzani E, Bruno W, Cabiddu F, Cioni M, Paudice M, Parodi A Tags: Acta Derm Venereol Source Type: research

Association of Vascular Endothelial Growth Factor Subtypes with Melanoma Patients' Characteristics and Survival: A Semantic Connectivity Map Analysis.
PMID: 31742647 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 18, 2019 Category: Dermatology Authors: Cazzaniga S, Wiedmer C, Frangež Ž, Shafighi M, Beltraminelli H, Weber B, Simon D, Naldi L, Simon HU, Hunger RE, Seyed Jafari SM Tags: Acta Derm Venereol Source Type: research

Psoriasis and Mental Health Workshop Report: Exploring the Links between Psychosocial Factors, Psoriasis, Neuroinflammation and Cardiovascular Disease Risk.
Abstract Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and /or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggest a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, "Psoriasis a...
Source: Acta Dermato-Venereologica - November 18, 2019 Category: Dermatology Authors: Kleyn CE, Talbot PS, Mehta NN, Sampogna F, Bundy C, Ashcroft DM, Kimball AB, Kerkhof PCM, Griffiths CEM, Valenzuela F, van der Walt JM, Aberra T, Puig L Tags: Acta Derm Venereol Source Type: research

Sensitive Skin in Children.
r C PMID: 31742650 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 18, 2019 Category: Dermatology Authors: Misery L, Taïeb C, Brenaut E, Huet F, Abasq-Thomas C, Sayag M, Bodemer C Tags: Acta Derm Venereol Source Type: research

Complex Muco-cutaneous Manifestations of CARMIL2-associated Combined Immunodeficiency: A Novel Presentation of Dysfunctional Epithelial Barriers.
PMID: 31709449 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - November 7, 2019 Category: Dermatology Authors: Marangi G, Garcovich S, Di Sante G, Orteschi D, Frangella S, Scaldaferri F, Genuardi M, Peris K, Gurrieri F, Zollino M Tags: Acta Derm Venereol Source Type: research

Clinical Management of Atopic Dermatitis in Adults: Mapping of Expert Opinion in 4 Nordic Countries using a Modified Delphi Process.
Remitz A Abstract Similarities and differences in the everyday clinical management of moderate-to-severe atopic dermatitis in Nordic countries are unknown. Using a modified Delphi approach, 15 dermatologists from Denmark, Finland, Norway and Sweden completed face-to-face and online questionnaires and participated in summary discussions to map expert opinion on the clinical management of moderate-to-severe atopic dermatitis in these Nordic countries. Through discussions, 6 adult patient profiles, reflecting common disease presentations of atopic dermatitis, were identified. Using these case profiles, diagnostic wo...
Source: Acta Dermato-Venereologica - November 7, 2019 Category: Dermatology Authors: Thyssen JP, Berents T, Bradley M, Deleuran M, Grimstad Ø, Korhonen L, Langeland T, Särnhult T, Thomsen SF, Thune T, Wahlgren CF, Vestergaard C, von Kobyletzki LB, Remitz A Tags: Acta Derm Venereol Source Type: research